Search Results - "Itraconazole"

Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states by Abuhelwa, Ahmad Y, Foster, David J R, Mudge, Stuart, Hayes, David, Upton, Richard N

“…Itraconazole is an orally active antifungal agent that has complex and highly variable absorption kinetics that is highly affected by food…”
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Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial by Shenoy, Manjunath, De, Abhishek, Shah, Bela, Das, Anupam, Saraswat, Abir, Lahiri, Koushik, Yadav, Sheetal, Sarda, Aarti, Chakraborty, Disha, J, Dharmender, Kamat, Shruti, Doshi, Yashika, Gonsalves, Nelry, Choudhary, Ankita, Dhoot, Dhiraj, Mahadkar, Namrata, Bhushan, Sumit, Gadkari, Rujuta, Barkate, Hanmant

“…Introduction: Itraconazole follows non-linear pharmacokinetics and hence is recommended once daily, but in real-world practice, is commonly prescribed as twice daily…”
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Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects by Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi

“… Itraconazole and fluconazole are antifungal medications often used as typical inhibitors of cytochrome P450 3A (CYP3A…”
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Repurposing antifungals: population pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of a nanocrystal formulation by Jansen, Anouk M E, Ter Heine, Rob, Donnelly, J P, Blijlevens, Nicole, Brüggemann, Roger J M

“…Abstract Objectives To describe itraconazole and hydroxy-itraconazole pharmacokinetics following intravenous (IV…”
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Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects by Lindsay, Julian, Mudge, Stuart, Thompson, 3rd, George R

“…To address the limited bioavailability and intolerance of the conventional itraconazole (ITZ…”
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Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects by Huang, Lei, Jiang, Hao, Huang, Yuanyuan, Li, Juan

“… This open, fixed-sequence study evaluated its pharmacokinetic (PK) interaction with itraconazole, a strong CYP3A4 inhibitor. Subjects ( n  = 16…”
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Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects by Sane, Rucha S, Cheung, Kit Wun Kathy, Cho, Eunpi, Liederer, Bianca M, Hanover, Justin, Malhi, Vikram, Plise, Emile, Wong, Susan, Musib, Luna

“…) was conducted in healthy subjects to evaluate the effect of itraconazole (200-mg solution QD, 4 days…”
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Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects by Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi

“… 2.5 mg dose of esaxerenone (Days 1, 13), with itraconazole 200 mg twice daily (Day 8) and once daily (Days 9–16). In Study 2 (n = 12), subjects received a single oral 5 mg dose of esaxerenone…”
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Efficacy of generic forms of itraconazole capsule in treating subjects with chronic pulmonary aspergillosis by Sehgal, Inderpaul Singh, Vinay, Keshavamurthy, Dhooria, Sahajal, Muthu, Valliappan, Prasad, Kuruswamy Thurai, Aggarwal, Ashutosh Nath, Chakrabarti, Arunaloke, Rudramurthy, Shivaprakash M., Choudhary, Hansraj, Agarwal, Ritesh

“… Objective Whether the generic brands are as effective as the innovator itraconazole in treating subjects with chronic pulmonary aspergillosis (CPA) remains unclear…”
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P080 Comparison of efficacy of innovator molecule of itraconazole with generic forms of itraconazole in treatment naïve subjects with chronic pulmonary aspergillosis by Sehgal, Inderpaul, Vinay, Keshavamurth, Agarwal, Ritesh, Rudramurth, Shivaprakash

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Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects by Dai, David, Yang, Hua, Nabhan, Salah, Liu, Hua, Hickman, Denice, Liu, Guowen, Zacher, Jeffrey, Vutikullird, Apinya, Prakash, Chandra, Agresta, Samuel, Bowden, Chris, Fan, Bin

“… mg ivosidenib; then, in period 2, subjects received oral itraconazole (200 mg once daily) on days 1–18, plus 250 mg ivosidenib on day 5…”
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A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma by Agarwal, Ritesh, Dhooria, Sahajal, Singh Sehgal, Inderpaul, Aggarwal, Ashutosh N, Garg, Mandeep, Saikia, Biman, Behera, Digambar, Chakrabarti, Arunaloke

“… Treatment-naive subjects with ABPA complicating asthma (January 2012 to December 2013) were randomized to receive either oral itraconazole or prednisolone for 4 months…”
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Effect of Itraconazole or Rifampin on Itacitinib Pharmacokinetics When Administered Orally in Healthy Subjects by Barbour, April M., Punwani, Naresh, Epstein, Noam, Landman, Robert, Cimino, Evan, Yuska, Brad, Wang, Phillip, He, Kevin, Chen, Xuejun, Yeleswaram, Swamy

“…) tablets of itacitinib on days 1 and 6 and 200 mg itraconazole on days 2‐7. In cohort 2, subjects received 200…”
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Study on pharmacokinetic interactions between SHR2554 and itraconazole in healthy subjects: A single‐center, open‐label phase I trial by Deng, Kunhong, Zou, Yi, Zou, Chan, Wang, Hong, Xiang, Yuxia, Yang, Xiaoyan, Yang, Shuang, Cui, Chang, Yang, Guoping, Huang, Jie

“…‐label pharmacokinetic study of itraconazole on SHR2554 in 18 healthy Chinese subjects…”
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Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects by Mu, Song, Tang, Zhiyu, Novotny, William, Tawashi, Manal, Li, Ta-Kai, Ou, Ying, Sahasranaman, Srikumar

“… (a strong CYP3A inducer) and steady-state itraconazole (a strong CYP3A inhibitor) on the pharmacokinetics (PK…”
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A physiologically based biopharmaceutics modeling (PBBM) framework for characterizing formulation-dependent food effects: Paving the road towards fed state virtual BE studies for itraconazole amorphous solid dispersions by Rudolph, Niklas, Charbe, Nitin, Plano, David, Shoyaib, Abdullah Al, Pal, Arindom, Boyce, Heather, Zhao, Liang, Wu, Fang, Polli, James, Dressman, Jennifer, Cristofoletti, Rodrigo

“…This study leverages physiologically based biopharmaceutics modeling (PBBM) to predict the clinical performance of two itraconazole (ITRA…”
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Effects of itraconazole and rifampicin on the pharmacokinetics and safety of youkenafil, a novel phosphodiesterase type 5 inhibitor, in healthy Chinese subjects by Wang, Keli, Ding, Juefang, Li, Xianjing, Guo, Wenjing, Zhu, Xingyu, Su, Yue, Sun, Luning, Zhou, Huan, Ding, Li

“…•First report of in vivo and in vitro drug interaction studies on youkenafil.•First report of youkenafil pharmacokinetic parameters in healthy Chinese subjects…”
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Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects by Cui, Xiaoming, Chen, Xinhui, Pognan, Nathalie, Sengupta, Tirtha, Rahmanzadeh, Gholamreza, Kornberger, Ruediger, Giovannini, Monica

“…) 3A4 and aldehyde oxidase. Here, we investigated the effects of a strong CYP3A inhibitor (itraconazole…”
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Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study by Mohapatra, Liza, Dixit, Nibedita, Agrawal, Ishan, Kar, Bikash Ranjan, Singh, Bhabani S.T.P.

“…Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases…”
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High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole by Burgel, Pierre-Régis, Baixench, Marie-Thérèse, Amsellem, Michaël, Audureau, Etienne, Chapron, Jeanne, Kanaan, Reem, Honoré, Isabelle, Dupouy-Camet, Jean, Dusser, Daniel, Klaassen, Corné H, Meis, Jacques F, Hubert, Dominique, Paugam, André

“… Itraconazole is prescribed for allergic bronchopulmonary aspergillosis (ABPA) or Aspergillus bronchitis in CF subjects…”
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