Výsledky vyhľadávania - "Iranian journal of immunology"

Pathogenesis of Atopic Dermatitis: Current Paradigm Autor Furue, Masutaka, Ulzii, Dugarmaa, Vu, Yen Hai, Tsuji, Gaku, Kido-Nakahara, Makiko, Nakahara, Takeshi

“…Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of…”
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Immunogenicity of a Recombinant Subunit Vaccine Against Feline Coronavirus: A Comparative Study of Three Different Adjuvants Autor Dong, Bo, Hu, Wenqian, Zhang, Shuo, Zhang, Xiaodong, Zou, Weijie, Guo, Yina, Lin, Weiming

“…Currently, there is no effective vaccine against feline coronavirus infections. The coronavirus Spike (S) protein plays a critical role in viral binding to…”
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The Dual Role of Transforming Growth Factor-Beta (TGF-β) Signaling: Balancing Cellular Senescence and Tumor Progression for Precision Therapeutics Autor Liao, Junhua, Zhu, Tang, Wu, Jie, Huang, Mingyu, Luo, Xianxian

“…Transforming growth factor-β (TGF-β) signaling plays a complex and dual role in regulating cellular senescence and tumor progression. In normal tissues, TGF-β…”
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Toll-like Receptor 2 Signaling Abnormalities Are Associated with Clinical Manifestations in Common Variable Immunodeficiency Autor Abolhassani, Hassan, Rezaei, Nima, Yazdani, Reza, Aletaha, Somaye, Bokaie, Saied, Sharifi, Laleh, Mirshafiey, Abbas

“…Common variable immunodeficiency (CVID) is an inborn error of immunity characterized by a defect in terminal B cell differentiation, resulting in…”
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Bioinformatic Analysis and Recombinant Expression of the Stonustoxin β-Subunit for Polyclonal Antibody Development Autor Rahmani, Mohammadreza, Nazarian, Shahram, Samiei-Abianeh, Hossein, Aghaie, Seyed Mojtaba, Sadeghi, Davoud

“…Stonefish (Synanceia spp.) are among the most venomous marine organisms. Their venom contains stonustoxin (SNTX), a heterodimeric toxin that induces severe…”
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Therapeutic Potential of an Anti-PLAC1 Antibody-Drug Conjugate in a Mouse Model of Human Breast Cancer Autor Mahmoudian, Jafar, Ghods, Roya, Jeddi-Tehrani, Mahmood, Ghaffari-Tabrizi-Wizsy, Nassim, Nejadmoghaddam, Mohammad Reza, Ghahremanzadeh, Ramin, Ostad, Seyed Nasser, Zarnani, Amir-Hassan

“…Background:Placenta-specific 1 (PLAC1) is an oncoplacental genes aberrantly expressed in various malignancies. Antibody-drug conjugates (ADC) offer a promising…”
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Elevated Serum Levels of CTRP-6 and Asprosin in Systemic Lupus Erythematosus: Association with Oxidative Stress Markers and Clinical Manifestations Autor Hadi Nassar Al-Tamimi, Ali Hussein, Heydari, Nadia, Mohammadi, Saeed, Abdolahi, Nafiseh, Jafari, Seyyed Mehdi

“…Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that affects multiple organ systems. The resulting inflammation disrupts adipocyte…”
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Serum ACE2 and Anti-MMR Antibody Profiles in Pediatric Patients with and without SARS-CoV-2 Infection Autor Labbani-Motlagh, Zohre, Nozarian, Zohreh, Haghi Ashtiani, Mohammad Taghi, Movahedinia, Sajjadeh, Vasei, Mohammad, Hosseini Rouzbahani, Negin

“…Coronavirus Disease 2019 (COVID-19) typically manifests with milder symptoms and lower mortality rates in children when compared to adults. To investigate…”
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Influence of the Chemotherapeutic Agent Mitomycin C on In Vitro Dendritic Cell Maturation and Interleukin-12 Production in a Colorectal Cancer Model Autor Mohammed Abdullah, Trefa

“…Antitumor-targeting drugs can stimulate dendritic cells (DCs) indirectly through the shedding of dying tumor cells as part of what is referred to as a "danger…”
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Low-dose Radiation Improves Tumor Immune Microenvironment, Enhancing the Effects of Anti-CTLA-4 Therapy Autor Dong, Jigang, Qi, Ying, Sha, Sha

“…Radiotherapy destroys tumor cells primarily through direct DNA damage by high-energy particles or indirect DNA damage by free radicals. High-dose radiotherapy…”
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Extracellular Vesicles from miR-146a Overexpressing Mesenchymal Stem Cells Attenuate ‎Imiquimod-Induced Psoriasis by Regulating Cytokine Expression Autor Shao, Hongmei, Chen, Junjie

“…Psoriasis is a chronic inflammatory skin disorder characterized by elevated levels of proinflammatory cytokines. Mesenchymal stem cells (MSCs) have…”
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A Novel Homozygous CGA > TGA Mutation at Codon 123 (Exon 6) of B-Linker Protein (BLNK) as a Potential Cause of ‎Hepatopathy and Rickets: A Case Report Autor Kose, Hulya, Karali, Yasin, Kilic, Sara Sebnem

“…BLNK deficiency is a subtype of autosomal recessive immune disorders that involves a lack of B cells, agammaglobulinemia, and recurrent infections. We present…”
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Interleukin-14 Prevents Cytarabine or Irradiation Induced Neutropenia via JAK/STAT3 Signaling Autor Xu, Shengnan, Ye, Chaoqiong, Wu, Zhihua, Wen, Chuying, Huang, Wenhui, Deng, Cong, Hua, Jiaye, Xie, Wei, Xiao, Min

“…Severe neutropenia significantly increases the risk of bacterial infections. Recent studies have shown that the cytokine interleukin 14 (IL-14) plays an…”
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Hypomethylation of OAS2 and OAS3 Gene Promoters: Insights into the ‎Pathogenesis of Systemic Lupus Erythematosus Autor Rigi Yousefabadi, Esmat, Ourang, Zahra, Gharibdoost, Farhad, Faezi, Seyedeh Tahereh, Saatchi, Mohammad, Gholami, Delnya, Esmaeilzadeh, Emran, Khorram Khorshid, Hamid Reza

“…DNA methylation plays a key role in systemic lupus erythematosus (SLE) by regulating gene expression and impacting immune system functions. In SLE, abnormal…”
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Modulation of the CD200/CD200R Axis by IFN-β Treatment in a Mouse Model of Experimental Autoimmune Encephalomyelitis Autor Haghmorad, Dariush, Rahimmi, Arman, Pazoki, Alireza, Namazi, Fatemeh, Rahmani, Mohammad Reza, Amini, Abbas Ali

“…Interferon-b (IFN-β), a glycoprotein released during viral infections, plays a crucial role in modulating T cells involved in multiple sclerosis (MS). CD200 is…”
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Altered Serum IL-35 Levels and IL-37 Gene Expression in Patients with Parkinson's Disease: Focus on Emerging Cytokines Autor Akbari Gavabari, Fariba, Rastegari-Pouyani, Mohsen, Afshar, Saied, Mazdeh, Mehrdokht, Talebi-Ghane, Elaheh, Eftekharian, Mohammad Mahdi

“…Parkinson's disease (PD) is increasingly recognized as a condition driven by both central and peripheral inflammatory responses, largely mediated by cytokine…”
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The relationship between serum levels of interleukin-2 and IL-8 with circulating microRNA-10b in patients with COVID-19 Autor Bagheri-Hosseinabadi, Zahra, Ostad Ebrahimi, Hamid, Bahrehmand, Fatemeh, Taghipour, Gholamhosein, Abbasifard, Mitra

“…The role of cytokine storm in the immunopathogenesis of coronavirus disease 2019 (COVID-19) has been implicated. To determine the association of microRNA…”
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Obituary: Professor Farrokh Modabber (1940–2025) – Architect of Leishmaniasis Immunology and Champion of Global Health Equity Autor Jafari, Reza, Bahrami, Fariborz, Arana, Byron, Rafati, Sima

“…Professor Farrokh Modabber, a prominent immunologist whose early research laid foundational insights into cellular immunology, passed away on May 31, 2025, at…”
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Does Endoplasmic Reticulum (ER) Stress Contribute to T-cell Exhaustion in B-ALL? Autor Kahrizi, Amir, Akbar, Armin, Najafi, Ahmad, Asgarian-Omran, Hossein, Karami, Hossein, Naderisorki, Mohammad, Karimi, Alireza, Tehrani, Mohsen

“…Glucose deprivation in T lymphocytes can trigger compensatory metabolic pathways, potentially contributing to T-cell exhaustion. Additionally, it may induce…”
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Design and Cytotoxicity Evaluation of a Cancer-targeting Immunotoxin Based on a Camelid Nanobody-PE Fusion Protein Autor Khoshbakht, Mona, Forghanifard, Mohammad Mahdi, Aghamollaei, Hossein, Amani, Jafar

“…Developing effective targeted treatment approaches to overcome drug resistance remains a crucial goal in cancer research. Immunotoxins have dual functionality…”
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