Suchergebnisse - "International Journal of Molecular Sciences"

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies von Juan, Celia Andrés, Pérez de la Lastra, José Manuel, Plou, Francisco J., Pérez-Lebeña, Eduardo

“… Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature …”
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Metabolic Syndrome: Updates on Pathophysiology and Management in 2021 von Fahed, Gracia, Aoun, Laurence, Bou Zerdan, Morgan, Allam, Sabine, Bou Zerdan, Maroun, Bouferraa, Youssef, Assi, Hazem I.

“… Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and …”
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Silver Nanoparticles and Their Antibacterial Applications von Bruna, Tamara, Maldonado-Bravo, Francisca, Jara, Paul, Caro, Nelson

“… Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The …”
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Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis von Rochette, Luc, Dogon, Geoffrey, Rigal, Eve, Zeller, Marianne, Cottin, Yves, Vergely, Catherine

“… Regulated cell death (RCD) has a significant impact on development, tissue homeostasis, and the occurrence of various diseases. Among different forms of RCD, …”
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Analytical Methods Used in Determining Antioxidant Activity: A Review von Munteanu, Irina Georgiana, Apetrei, Constantin

“… The study of antioxidants and their implications in various fields, from food engineering to medicine and pharmacy, is of major interest to the scientific …”
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Macrophage Polarization States in the Tumor Microenvironment von Boutilier, Ava J., Elsawa, Sherine F.

“… The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, …”
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The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis von Ghasemi, Mahshid, Turnbull, Tyron, Sebastian, Sonia, Kempson, Ivan

“… The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity; however, it is commonly applied and interpreted erroneously. We …”
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An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases von Teleanu, Daniel Mihai, Niculescu, Adelina-Gabriela, Lungu, Iulia Ioana, Radu, Crina Ioana, Vladâcenco, Oana, Roza, Eugenia, Costăchescu, Bogdan, Grumezescu, Alexandru Mihai, Teleanu, Raluca Ioana

“… Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review …”
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Pathophysiology of Type 2 Diabetes Mellitus von Galicia-Garcia, Unai, Benito-Vicente, Asier, Jebari, Shifa, Larrea-Sebal, Asier, Siddiqi, Haziq, Uribe, Kepa B., Ostolaza, Helena, Martín, César

“… Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by …”
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The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics von Jang, Dan-in, Lee, A-Hyeon, Shin, Hye-Yoon, Song, Hyo-Ryeong, Park, Jong-Hwi, Kang, Tae-Bong, Lee, Sang-Ryong, Yang, Seung-Hoon

“… Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have …”
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The Flavonoid Biosynthesis Network in Plants von Liu, Weixin, Feng, Yi, Yu, Suhang, Fan, Zhengqi, Li, Xinlei, Li, Jiyuan, Yin, Hengfu

“… Flavonoids are an important class of secondary metabolites widely found in plants, contributing to plant growth and development and having prominent …”
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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases von Cabral-Pacheco, Griselda A, Garza-Veloz, Idalia, Castruita-De la Rosa, Claudia, Ramirez-Acuña, Jesús M, Perez-Romero, Braulio A, Guerrero-Rodriguez, Jesús F, Martinez-Avila, Nadia, Martinez-Fierro, Margarita L

“… Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost …”
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Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases von Buonacera, Agata, Stancanelli, Benedetta, Colaci, Michele, Malatino, Lorenzo

“… Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of …”
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Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis von Portincasa, Piero, Bonfrate, Leonilde, Vacca, Mirco, De Angelis, Maria, Farella, Ilaria, Lanza, Elisa, Khalil, Mohamad, Wang, David Q.-H., Sperandio, Markus, Di Ciaula, Agostino

“… Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population …”
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Cytochrome P450 Enzymes and Drug Metabolism in Humans von Zhao, Mingzhe, Ma, Jingsong, Li, Mo, Zhang, Yingtian, Jiang, Bixuan, Zhao, Xianglong, Huai, Cong, Shen, Lu, Zhang, Na, He, Lin, Qin, Shengying

“… Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis …”
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Pathophysiology of Atherosclerosis von Jebari-Benslaiman, Shifa, Galicia-García, Unai, Larrea-Sebal, Asier, Olaetxea, Javier Rekondo, Alloza, Iraide, Vandenbroeck, Koen, Benito-Vicente, Asier, Martín, César

“… Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by …”
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Mechanisms of Oxidative Stress in Metabolic Syndrome von Masenga, Sepiso K, Kabwe, Lombe S, Chakulya, Martin, Kirabo, Annet

“… Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is …”
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A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics von Lamptey, Richard N. L., Chaulagain, Bivek, Trivedi, Riddhi, Gothwal, Avinash, Layek, Buddhadev, Singh, Jagdish

“… Neurodegenerative disorders are primarily characterized by neuron loss. The most common neurodegenerative disorders include Alzheimer’s and Parkinson’s …”
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Regulation of Plant Responses to Salt Stress von Zhao, Shuangshuang, Zhang, Qikun, Liu, Mingyue, Zhou, Huapeng, Ma, Changle, Wang, Pingping

“… Salt stress is a major environmental stress that affects plant growth and development. Plants are sessile and thus have to develop suitable mechanisms to adapt …”
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NRF2, a Transcription Factor for Stress Response and Beyond von He, Feng, Ru, Xiaoli, Wen, Tao

“… Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through …”
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