Výsledky vyhľadávania - "Inheritance Patterns - Genetics"

OMIM.org: leveraging knowledge across phenotype–gene relationships Autor Amberger, Joanna S, Bocchini, Carol A, Scott, Alan F, Hamosh, Ada

“…Abstract For over 50 years Mendelian Inheritance in Man has chronicled the collective knowledge of the field of medical genetics. It initially cataloged the…”
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Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations Autor Sales, Vicencia Micheline, Ferguson-Smith, Anne C, Patti, Mary-Elizabeth

“…Both human and animal studies indicate that environmental exposures experienced during early life can robustly influence risk for adult disease. Moreover,…”
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Transgenerational Epigenetic Inheritance Autor Bošković, Ana, Rando, Oliver J

“…Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can…”
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The Somatic Impact on Inheritance and the Germline Control of the Soma Autor Ishikawa, Shoma, Schumacher, Björn

“…The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August…”
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Molecular genetics of osteosarcoma Autor Rickel, Kirby, Fang, Fang, Tao, Jianning

“…Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent progress made in molecular genetic studies of osteosarcoma has…”
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Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications Autor Chen, Qi, Yan, Wei, Duan, Enkui

“…Key Points Recent evidence increasingly supports the idea that certain ancestral life experiences acquired in the environment can be inherited by offspring;…”
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Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort Autor Bai, Dan, Yip, Benjamin Hon Kei, Windham, Gayle C, Sourander, Andre, Francis, Richard, Yoffe, Rinat, Glasson, Emma, Mahjani, Behrang, Suominen, Auli, Leonard, Helen, Gissler, Mika, Buxbaum, Joseph D, Wong, Kingsley, Schendel, Diana, Kodesh, Arad, Breshnahan, Michaeline, Levine, Stephen Z, Parner, Erik T, Hansen, Stefan N, Hultman, Christina, Reichenberg, Abraham, Sandin, Sven

“…The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic,…”
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LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation Autor Brind’Amour, Julie, Kobayashi, Hisato, Richard Albert, Julien, Shirane, Kenjiro, Sakashita, Akihiko, Kamio, Asuka, Bogutz, Aaron, Koike, Tasuku, Karimi, Mohammad M., Lefebvre, Louis, Kono, Tomohiro, Lorincz, Matthew C.

“…De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long…”
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Intergenerational Transmission of Stress in Humans Autor Bowers, Mallory E, Yehuda, Rachel

“…The hypothesis that offspring are affected by parental trauma or stress exposure, first noted anecdotally, is now supported empirically by data from Holocaust…”
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Intergenerational and transgenerational epigenetic inheritance in animals Autor Perez, Marcos Francisco, Lehner, Ben

“…Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what…”
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Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks Autor Ruzzo, Elizabeth K, Pérez-Cano, Laura, Jung, Jae-Yoon, Wang, Lee-Kai, Kashef-Haghighi, Dorna, Hartl, Chris, Singh, Chanpreet, Xu, Jin, Hoekstra, Jackson N, Leventhal, Olivia, Leppä, Virpi M, Gandal, Michael J, Paskov, Kelley, Stockham, Nate, Polioudakis, Damon, Lowe, Jennifer K, Prober, David A, Geschwind, Daniel H, Wall, Dennis P

“…We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals…”
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Unreduced gametes: meiotic mishap or evolutionary mechanism? Autor Mason, Annaliese S., Pires, J. Chris

“…•The ability to produce unreduced gametes facilitates polyploid speciation.•Unreduced gamete production is under genetic control.•Stress and interspecific…”
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CRISPR-Cas9 Targeted Mutagenesis Leads to Simultaneous Modification of Different Homoeologous Gene Copies in Polyploid Oilseed Rape ( Brassica napus ) Autor Braatz, Janina, Harloff, Hans-Joachim, Mascher, Martin, Stein, Nils, Himmelbach, Axel, Jung, Christian

“…In polyploid species, altering a trait by random mutagenesis is highly inefficient due to gene redundancy. We have stably transformed tetraploid oilseed rape (…”
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Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases Autor Gusev, Alexander, Lee, S Hong, Trynka, Gosia, Finucane, Hilary, Vilhjálmsson, Bjarni J, Xu, Han, Zang, Chongzhi, Ripke, Stephan, Bulik-Sullivan, Brendan, Stahl, Eli, Kähler, Anna K, Hultman, Christina M, Purcell, Shaun M, McCarroll, Steven A, Daly, Mark, Pasaniuc, Bogdan, Sullivan, Patrick F, Neale, Benjamin M, Wray, Naomi R, Raychaudhuri, Soumya, Price, Alkes L

“…Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their…”
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Unraveling the processes shaping mammalian gut microbiomes over evolutionary time Autor Groussin, Mathieu, Mazel, Florent, Sanders, Jon G., Smillie, Chris S., Lavergne, Sébastien, Thuiller, Wilfried, Alm, Eric J.

“…Whether mammal–microbiome interactions are persistent and specific over evolutionary time is controversial. Here we show that host phylogeny and major dietary…”
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Enhancing the rate of genetic gain in public-sector plant breeding programs: lessons from the breeder’s equation Autor Cobb, Joshua N., Juma, Roselyne U., Biswas, Partha S., Arbelaez, Juan D., Rutkoski, Jessica, Atlin, Gary, Hagen, Tom, Quinn, Michael, Ng, Eng Hwa

“…Key message The integration of new technologies into public plant breeding programs can make a powerful step change in agricultural productivity when aligned…”
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Genetic analyses identify widespread sex-differential participation bias Autor Pirastu, Nicola, Cordioli, Mattia, Nandakumar, Priyanka, Mignogna, Gianmarco, Abdellaoui, Abdel, Hollis, Benjamin, Kanai, Masahiro, Rajagopal, Veera M., Parolo, Pietro Della Briotta, Baya, Nikolas, Carey, Caitlin E., Karjalainen, Juha, Als, Thomas D., Van der Zee, Matthijs D., Day, Felix R., Ong, Ken K., Morisaki, Takayuki, de Geus, Eco, Bellocco, Rino, Okada, Yukinori, Børglum, Anders D., Joshi, Peter, Auton, Adam, Hinds, David, Neale, Benjamin M., Walters, Raymond K., Nivard, Michel G., Perry, John R. B., Ganna, Andrea

“…Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic…”
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Multigenerational epigenetic inheritance: Transmitting information across generations Autor Burton, Nicholas O., Greer, Eric L.

“…Inherited epigenetic information has been observed to regulate a variety of complex organismal phenotypes across diverse taxa of life. This continually…”
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A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease Autor Barthélemy, Nicolas R., Li, Yan, Joseph-Mathurin, Nelly, Gordon, Brian A., Hassenstab, Jason, Benzinger, Tammie. L. S., Buckles, Virginia, Fagan, Anne M., Perrin, Richard J., Goate, Alison M., Morris, John C., Karch, Celeste M., Xiong, Chengjie, Allegri, Ricardo, Mendez, Patricio Chrem, Berman, Sarah B., Ikeuchi, Takeshi, Mori, Hiroshi, Shimada, Hiroyuki, Shoji, Mikio, Suzuki, Kazushi, Noble, James, Farlow, Martin, Chhatwal, Jasmeer, Graff-Radford, Neill R., Salloway, Stephen, Schofield, Peter R., Masters, Colin L., Martins, Ralph N., O’Connor, Antoinette, Fox, Nick C., Levin, Johannes, Jucker, Mathias, Gabelle, Audrey, Lehmann, Sylvain, Sato, Chihiro, Bateman, Randall J., McDade, Eric

“…Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the…”
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Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood Autor Ni, Guiyan, Moser, Gerhard, Wray, Naomi R, Lee, S Hong

“…Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current…”
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