Výsledky vyhledávání - "Infusions, Intravenous"

Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial Autor Hu, Chao, Ou, Xiaofeng, Teng, Yi, Shu, Shiqing, Wang, Ying, Zhu, Xiaohong, Kang, Yan, Miao, Jia

“…Introduction The effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated…”
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Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke Autor Honmou, Osamu, Houkin, Kiyohiro, Matsunaga, Takuya, Niitsu, Yoshiro, Ishiai, Sumio, Onodera, Rie, Waxman, Stephen G, Kocsis, Jeffery D

“…Transplantation of human mesenchymal stem cells has been shown to reduce infarct size and improve functional outcome in animal models of stroke. Here, we…”
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First-in-human study to evaluate the safety, tolerability, and population pharmacokinetic/pharmacodynamic target attainment analysis of FL058 alone and in combination with meropenem in healthy subjects Autor Huang, Zhiwei, Yang, Xinyi, Jin, Yi, Yu, Jicheng, Cao, Guoying, Wang, Jingjing, Hu, Yingying, Dai, Jingyi, Wu, Jufang, Wei, Qiong, Tian, Yan, Yu, Shuyan, Zhu, Xu, Mao, Xiaomeng, Liu, Wei, Liang, Hong, Zheng, Shansong, Ju, Yunfei, Wang, Zenghua, Zhang, Jing, Wu, Xiaojie

“…)/pharmacodynamic target attainment analysis of FL058 alone and in combination with meropenem in healthy subjects…”
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First-in-Human Phase I Clinical Trial of the Adenosine A1R/A3R Agonist AST-004 in Healthy Subjects Autor Manna, Lisa M, Hernandez, Juan, Hunt, Dawn E, Lakner, Géza, Matson, Mark A, Poe, Russell B, Korinek, William S, Lancey, Robert A, Liston, Theodore E

“… The primary objectives of this clinical phase I first-in-human study were to evaluate the safety and tolerability profile of single ascending intravenous doses in healthy subjects…”
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Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalating Phase I, Healthy Subjects Study of Intravenous OPN‐305, a Humanized Anti‐TLR2 Antibody Autor Reilly, M, Miller, R M, Thomson, M H, Patris, V, Ryle, P, McLoughlin, L, Mutch, P, Gilboy, P, Miller, C, Broekema, M, Keogh, B, McCormack, W, Wetering de Rooij, J

“…‐305 in 41 healthy male subjects (age range: 19–58 years) randomized to OPN‐305 or placebo across six cohorts. OPN…”
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A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers Autor Chowdhury, Abeed H, Cox, Eleanor F, Francis, Susan T, Lobo, Dileep N

“… Twelve healthy adult male subjects received 2-L intravenous infusions over 1 hour of 0.9% saline or Plasma-Lyte 148 in a randomized, double-blind manner…”
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Bioequivalence study of voriconazole for intravenous infusion in healthy Chinese subjects under fasting conditions Autor Xiang, Zhangqiang, Li, Mupeng, Cui, Shaoting, Gan, Chunyan, Liu, Fangfang, Huang, Qian, Mai, Gang, Fan, Lianlian

“… Eligible subjects randomly assigned for screening, receiving either the test or reference voriconazole for intravenous infusion during the first period, with alternative products administered during the second period…”
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CSL112 enhances biomarkers of reverse cholesterol transport after single and multiple infusions in healthy subjects Autor Gille, Andreas, Easton, Rachael, D'Andrea, Denise, Wright, Samuel D, Shear, Charles L

“… To gauge the potential of infused apoA-I to transport cholesterol, we quantified cholesterol transport markers in human subjects infused with a novel formulation of apoA-I (CSL112…”
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Phase I study of the pharmacokinetics and safety of rezafungin in subjects with moderate/severe hepatic impairment and matched control subjects Autor Flanagan, Shawn, Ong, Voon, Marbury, Thomas, Jandourek, Alena, Gandhi, Ronak G., Sandison, Taylor

“…‐dose, phase I study evaluated the pharmacokinetics (primary objective) and safety of rezafungin in subjects with moderate or severe hepatic impairment versus matched, healthy subjects with normal hepatic function…”
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A Prospective, Randomized, Double-Blinded Study of the Effect of Intravenous Ondansetron on the Effective Dose in 50% of Subjects of Prophylactic Phenylephrine Infusions for Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery Autor Xiao, Fei, Wei, Changna, Chang, Xiangyang, Zhang, Yinfa, Xue, Lili, Shen, Huaxiang, Ngan Kee, Warwick D, Chen, Xinzhong

“… However, the magnitude of this effect has not been fully quantified. In this parallel-group, randomized, double-blinded study, we determined the effective dose in 50% of subjects (ED50…”
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Drug‐Drug Interaction between Oral Zamicastat and Continuous Epoprostenol Infusion at Steady‐State Conditions in Healthy Subjects Autor Fonseca, Marlene, Guimarães, Andreia, Gama, Helena, Magalhães, Luís, Henriques, Sara Carolina, Silva, Nuno, Almeida, Luis, Soares‐da‐Silva, Patrício

“…This study intended to evaluate the interactions between zamicastat and epoprostenol in healthy human subjects. This was a single‐center, open‐label, two‐period study…”
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Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study Autor Ellis, Joanne, Maurik, Andre, Fortunato, Lea, Gisbert, Sophie, Chen, Keguan, Schwartz, Ann, McHugh, Simon, Want, Andrew, Santos Franco, Sara, Oliveira, Joao‐Joaquim, Price, Jeffrey, Coles, Alasdair, Brown, Kim, Su, Donggang, Craigen, Jenny L., Yang, Jiansong, Brett, Sara, Davis, Bill, Cheriyan, Joseph, Kousin‐Ezewu, Onajite, Gray, Frank, Thompson, Paul W., Fernando, Disala

“…) or placebo was carried out in 18 healthy subjects over 24 weeks. Results GSK2618960 was well tolerated…”
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A randomized controlled trial assessing the use of ultrasound for nurse-performed IV placement in difficult access ED patients Autor Bahl, Amit, Pandurangadu, Ananda Vishnu, Tucker, Jared, Bagan, Michael

“… Phase 1 involved education/training of a cohort of nurses to perform US-guided IVs. This consisted of a didactic module and hands-on requirement of 10 proctored functional IVs on live subjects…”
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Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD) Autor Fava, Maurizio, Freeman, Marlene P, Flynn, Martina, Judge, Heidi, Hoeppner, Bettina B, Cusin, Cristina, Ionescu, Dawn F, Mathew, Sanjay J, Chang, Lee C, Iosifescu, Dan V, Murrough, James, Debattista, Charles, Schatzberg, Alan F, Trivedi, Madhukar H, Jha, Manish K, Sanacora, Gerard, Wilkinson, Samuel T, Papakostas, George I

“…Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient…”
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The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety Autor Foo, I., Macfarlane, A. J. R., Srivastava, D., Bhaskar, A., Barker, H., Knaggs, R., Eipe, N., Smith, A. F.

“…Summary Intravenous lidocaine is used widely for its effect on postoperative pain and recovery but it can be, and has been, fatal when used inappropriately and…”
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Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke Autor Levy, Michael L, Crawford, John R, Dib, Nabil, Verkh, Lev, Tankovich, Nikolai, Cramer, Steven C

“… Results- In phase 1 (n=15), each dose (0.5, 1.0, and 1.5 million cells/kg body weight) was found safe, so phase 2 subjects (n=21) received 1.5 million cells/kg…”
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Assessment of the Pharmacokinetics and Safety of Spesolimab, a Humanised Anti-interleukin-36 Receptor Monoclonal Antibody, in Healthy Non-Japanese and Japanese Subjects: Results from Phase I Clinical Studies Autor Joseph, David, Thoma, Christian, Haeufel, Thomas, Li, Xiujiang

“… We aimed to evaluate the pharmacokinetics, safety and tolerability of single and multiple doses of spesolimab in healthy non-Japanese and Japanese subjects…”
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Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease Autor Gurbel, Paul A, Bliden, Kevin P, Turner, Susan E, Tantry, Udaya S, Gesheff, Martin G, Barr, Travis P, Covic, Lidija, Kuliopulos, Athan

“… PZ-128 was administered by 1 to 2 hours continuous intravenous infusion (0.01-2 mg/kg) to 31 subjects with coronary artery disease or multiple coronary artery disease risk factors…”
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Neurotoxicity after CTL019 in a pediatric and young adult cohort Autor Gofshteyn, Jacqueline S., Shaw, Pamela A., Teachey, David T., Grupp, Stephan A., Maude, Shannon, Banwell, Brenda, Chen, Fang, Lacey, Simon F., Melenhorst, Jan J., Edmonson, MacKenzie J., Panzer, Jessica, Barrett, David M., McGuire, Jennifer L.

“… Methods We analyzed data on 51 subjects, 4 to 22 years old, who received CTL019, a chimeric antigen receptor–modified…”
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Comparison of pharmacokinetics and safety of albuvirtide in healthy subjects after intravenous drip and bolus injection Autor Qin, Huiling, Yao, Cheng, Zhang, Wei, Hu, Wei, Liu, Yuantao, Yu, Shuchang, Xie, Dong, Hu, Min, Ye, Jun

“…) bolus injection or intravenous drip in healthy Chinese subjects. A single-center, randomized, open-label, single-period, parallel phase I clinical trial was conducted…”
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