Suchergebnisse - "Imperiale, M"

Starting the fight in the tumor: expert recommendations for the development of human intratumoral immunotherapy (HIT-IT) von Marabelle, A, Andtbacka, R, Harrington, K, Melero, I, Leidner, R, de Baere, T, Robert, C, Ascierto, P A, Baurain, J -F, Imperiale, M, Rahimian, S, Tersago, D, Klumper, E, Hendriks, M, Kumar, R, Stern, M, Öhrling, K, Massacesi, C, Tchakov, I, Tse, A, Douillard, J -Y, Tabernero, J, Haanen, J, Brody, J

“… Abstract A European Society for Medical Oncology (ESMO)-sponsored expert meeting was held in Paris on 8 March 2018 which comprised 11 experts from academia, 11 …”
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Production of first generation adenovirus vectors: a review von Danthinne, X, Imperiale, M J

“… In the past decade, adenovirus vectors have generated tremendous interest, especially in gene therapy applications. In the so-called 'first generation' …”
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Enzyme replacement therapy for mucopolysaccharidosis VI: long-term cardiac effects of galsulfase (Naglazyme®) therapy von Braunlin, E., Rosenfeld, H., Kampmann, C., Johnson, J., Beck, M., Giugliani, R., Guffon, N., Ketteridge, D., Sá Miranda, C. M., Scarpa, M., Schwartz, I. V., Leão Teles, E., Wraith, J. E., Barrios, P., Dias da Silva, E., Kurio, G., Richardson, M., Gildengorin, G., Hopwood, J. J., Imperiale, M., Schatz, A., Decker, C., Harmatz, P.

“… Characteristic cardiac valve abnormalities and left ventricular hypertrophy are present in untreated patients with mucopolysaccharidosis type VI (MPS VI) …”
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Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway von McCabe, M T, Low, J A, Imperiale, M J, Day, M L

“… Many DNA tumor virus oncogenes are capable of activating and highjacking the host cell's DNA replication machinery for its own reproduction purposes through …”
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Adenovirus vectors: biology, design, and production von Imperiale, M J, Kochanek, S

“… The use of adenovirus as a gene transfer vehicle arose from early reports of recombinant viruses carrying heterologous DNA fragments. Adenovirus vectors offer …”
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Immortalized cementoblasts and periodontal ligament cells in culture von D’Errico, J.A, Ouyang, H, Berry, J.E, MacNeil, R.L, Strayhorn, C, Imperiale, M.J, Harris, N.L, Goldberg, H, Somerman, M.J

“… Cementum, a mineralized tissue lining the surface of the tooth root, is required for formation of a functional periodontal ligament attachment during …”
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Role for the adenovirus IVa2 protein in packaging of viral DNA von Zhang, W, Low, J A, Christensen, J B, Imperiale, M J

“… Although it has been demonstrated that the adenovirus IVa2 protein binds to the packaging domains on the viral chromosome and interacts with the viral L1 …”
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Efficient Generation of Recombinant Adenoviral Vectors by Cre-lox Recombination In Vitro von Aoki, Kazunori, Barker, Christopher, Danthinne, Xavier, Imperiale, Michael J., Nabel, Gary J.

“… Although recombinant adenovirus vectors are attractive for use in gene expression studies and therapeutic applications, the construction of these vectors …”
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Interaction of the adenovirus L1 52/55-kilodalton protein with the IVa2 gene product during infection von Gustin, K E, Lutz, P, Imperiale, M J

“… The adenovirus L1 52/55-kDa protein is expressed both in the early and late stages of infection, raising the possibility that it has multiple roles in the …”
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Oncogenic transformation by the human polyomaviruses von Imperiale, Michael J

“… ONCOGENE: (2001) 20, 7917-7923 …”
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Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression von Qin, L, Ding, Y, Pahud, D R, Chang, E, Imperiale, M J, Bromberg, J S

“… One of the major limitations to current gene therapy is the low-level and transient vector gene expression due to poorly defined mechanisms, possibly including …”
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Adeno-associated viral glutamate decarboxylase expression in the lateral nucleus of the rat hypothalamus reduces feeding behavior von Noordmans, A J, Song, D K, Noordmans, C J, Garrity-Moses, M, During, M J, Fitzsimons, H L, Imperiale, M J, Boulis, N M

“… In vivo gene transfer of glutamate decarboxylase (GAD) has been explored as a means of inducing or increasing the production of the inhibitory amino-acid …”
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Interaction of the adenovirus IVa2 protein with viral packaging sequences von Zhang, W, Imperiale, M J

“… We have demonstrated previously that the adenovirus L1 52/55-kDa protein binds to the viral IVa2 protein in infected cells. The significance of this …”
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Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen von Xie, Y C, Hwang, C, Overwijk, W, Zeng, Z, Eng, M H, Mulé, J J, Imperiale, M J, Restifo, N P, Sanda, M G

“… Evidence that simian virus 40 (SV40) is associated with human mesotheliomas, osteosarcomas, and brain tumors suggests that a recombinant vaccine directed …”
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Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit von DeZazzo, J D, Imperiale, M J

“… The adenovirus major late transcription unit (MLTU) encodes five colinear mRNA families, L1 through L5, each distinguished by a unique poly(A) site. Site …”
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Gene Therapy for Vascular Smooth Muscle Cell Proliferation After Arterial Injury von Ohno, Takeshi, Gordon, David, San, Hong, Pompili, Vincent J., Imperiale, Michael J., Nabel, Gary J., Nabel, Elizabeth G.

“… Accumulation of vascular smooth muscle cells as a consequence of arterial injury is a major feature of vascular proliferative disorders. Molecular approaches …”
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Encapsidation of viral DNA requires the adenovirus L1 52/55-kilodalton protein von Gustin, K E, Imperiale, M J

“… Previous work demonstrated that the adenovirus L1 52/55-kDa protein is required for assembly of viral particles, although its exact role in the assembly …”
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Processing mRNA 3' ends in vitro von Imperiale, M J

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BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control von Harris, K F, Christensen, J B, Imperiale, M J

“… BK virus (BKV) is a polyomavirus which infects a large percentage of the human population. It is a potent transforming agent and is tumorigenic in rodents. BKV …”
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Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity von Imperiale, M J, Kao, H T, Feldman, L T, Nevins, J R, Strickland, S

“… We have employed an antiserum specific to the 70-kilodalton human heat shock protein and a cDNA clone specific to the mRNA for this protein to analyze the …”
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