Výsledky vyhledávání - "Immunity & ageing"

Toll-like receptor 4 (TLR4): new insight immune and aging Autor Kim, Hyo-Jin, Kim, Hyemin, Lee, Jeong-Hyung, Hwangbo, Cheol

“…TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s…”
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Gut microbiota as the key controllers of “healthy” aging of elderly people Autor Ragonnaud, Emeline, Biragyn, Arya

“…Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human healthy aging, and thus, longevity. They do so by targeting at…”
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Immunosenescence and human vaccine immune responses Autor Crooke, Stephen N., Ovsyannikova, Inna G., Poland, Gregory A., Kennedy, Richard B.

“…The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased…”
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Role of immune cells in the removal of deleterious senescent cells Autor Kale, Abhijit, Sharma, Amit, Stolzing, Alexandra, Desprez, Pierre-Yves, Campisi, Judith

“…Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The…”
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Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging Autor Thomas, Rachel, Wang, Weikan, Su, Dong-Ming

“…Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the…”
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RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease Autor Cui, Guo-hong, Guo, Hai-dong, Li, Han, Zhai, Yu, Gong, Zhang-bin, Wu, Jing, Liu, Jian-sheng, Dong, You-rong, Hou, Shuang-xing, Liu, Jian-ren

“…Background Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs)…”
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Aging and chronic inflammation: highlights from a multidisciplinary workshop Autor Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuris, Niedernhofer, Laura J., Pereira, Karla, Robbins, Paul D., Silva, Alexa, Suarez, Gisela M., Berghe, Wim Vanden, von Zglinicki, Thomas, Pawelec, Graham, Lage, Agustín

“…Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social…”
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Obesity and COVID-19: what makes obese host so vulnerable? Autor Mohammad, Sameer, Aziz, Rafia, Al Mahri, Saeed, Malik, Shuja Shafi, Haji, Esraa, Khan, Altaf Husain, Khatlani, Tanvir Saleem, Bouchama, Abderrezak

“…The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of…”
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Age related human T cell subset evolution and senescence Autor Li, Mingde, Yao, Danlin, Zeng, Xiangbo, Kasakovski, Dimitri, Zhang, Yikai, Chen, Shaohua, Zha, Xianfeng, Li, Yangqiu, Xu, Ling

“…T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and…”
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Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study Autor Puzianowska-Kuźnicka, Monika, Owczarz, Magdalena, Wieczorowska-Tobis, Katarzyna, Nadrowski, Pawel, Chudek, Jerzy, Slusarczyk, Przemyslaw, Skalska, Anna, Jonas, Marta, Franek, Edward, Mossakowska, Malgorzata

“…Background In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data…”
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Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation Autor Koelman, Liselot, Pivovarova-Ramich, Olga, Pfeiffer, Andreas F. H., Grune, Tilman, Aleksandrova, Krasimira

“…Background There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be…”
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The correlation between the Th17/Treg cell balance and bone health Autor Zhu, Lei, Hua, Fei, Ding, Wenge, Ding, Kai, Zhang, Yige, Xu, Chenyang

“…With the ageing of the world population, osteoporosis has become a problem affecting quality of life. According to the traditional view, the causes of…”
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Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia Autor Han, Hao, Zhao, Yawei, Du, Junda, Wang, Sushan, Yang, Xuehan, Li, Weijie, Song, Jiayi, Zhang, Siwei, Zhang, Ziyi, Tan, Yongfei, Hatch, Grant M., Zhang, Ming, Chen, Li

“…Background Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the…”
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The immune response to influenza in older humans: beyond immune senescence Autor McElhaney, Janet E., Verschoor, Chris P., Andrew, Melissa K., Haynes, Laura, Kuchel, George A., Pawelec, Graham

“…Despite widespread influenza vaccination programs, influenza remains a major cause of morbidity and mortality in older adults. Age-related changes in multiple…”
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Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination Autor Frasca, Daniela, Blomberg, Bonnie B.

“…Background Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to…”
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Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells Autor Zhang, Qiang, Yang, Guanhu, Luo, Yuan, Jiang, Lai, Chi, Hao, Tian, Gang

“…Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation, neurodegeneration, and…”
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Ageing: from inflammation to cancer Autor Leonardi, Giulia C., Accardi, Giulia, Monastero, Roberto, Nicoletti, Ferdinando, Libra, Massimo

“…Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic…”
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Aging, inflammaging and immunosenescence as risk factors of severe COVID-19 Autor Tizazu, Anteneh Mehari, Mengist, Hylemariam Mihiretie, Demeke, Gebreselassie

“…Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms Autor Trovato Salinaro, Angela, Pennisi, Manuela, Di Paola, Rosanna, Scuto, Maria, Crupi, Rosalia, Cambria, Maria Teresa, Ontario, Maria Laura, Tomasello, Mario, Uva, Maurizio, Maiolino, Luigi, Calabrese, Edward J., Cuzzocrea, Salvatore, Calabrese, Vittorio

“…Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore,…”
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Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice Autor Ding, Ye, Ren, Jingyi, Yu, Hongqiang, Yu, Weixian, Zhou, Yanmin

“…Background A possible relationship between periodontitis and Alzheimer’s disease (AD) has been reported. However, there is limited information on the…”
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