Suchergebnisse - "Ijsselsteijn, Marieke E"

A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry von Ijsselsteijn, Marieke E., van der Breggen, Ruud, Farina Sarasqueta, Arantza, Koning, Frits, de Miranda, Noel F. C. C.

“… Multiplex immunophenotyping technologies are indispensable for a deeper understanding of biological systems. Until recently, high-dimensional cellular analyses …”
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High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity von de Vries, Natasja L, van Unen, Vincent, Ijsselsteijn, Marieke E, Abdelaal, Tamim, van der Breggen, Ruud, Farina Sarasqueta, Arantza, Mahfouz, Ahmed, Peeters, Koen C M J, Höllt, Thomas, Lelieveldt, Boudewijn P F, Koning, Frits, de Miranda, Noel F C C

“… ObjectiveA comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We …”
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Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients von Kenkhuis, Boyd, Somarakis, Antonios, de Haan, Lorraine, Dzyubachyk, Oleh, IJsselsteijn, Marieke E., de Miranda, Noel F. C. C., Lelieveldt, Boudewijn P. F., Dijkstra, Jouke, van Roon-Mom, Willeke M. C., Höllt, Thomas, van der Weerd, Louise

“… Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown …”
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NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology von Niewold, Paula, IJsselsteijn, Marieke E., Dijkman, Karin, de Miranda, Noel, Ottenhoff, Tom H. M., Verreck, Frank A. W., Joosten, Simone A.

“… Development of novel vaccines and treatment approaches against tuberculosis are hampered by limited knowledge of what constitutes a protective immune response …”
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An imaging mass cytometry immunophenotyping panel for non-human primate tissues von Niewold, Paula, Ijsselsteijn, Marieke E., Verreck, Frank A. W., Ottenhoff, Tom H. M., Joosten, Simone A.

“… It has recently become clear that spatial organization contributes to cellular function and that expanding our knowledge on cellular organization is essential …”
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Impact of Fusobacterium nucleatum on immune cell interactions and gene expression in colorectal cancer: a retrospective cohort study von Heregger, Ronald, Huemer, Florian, Greil, Richard, Canadas-Ortega, Marina, Posselt, Gernot, Ijsselsteijn, Marieke E, Plattner, Christina, Rieder, Dietmar, Trajanoski, Zlatko, Krogsdam, Anne, Klieser, Eckhard, Neureiter, Daniel, Wessler, Silja, Weiss, Lukas

“… Colorectal cancer (CRC) is a major global health concern. The presence of (Fn) in CRC can promote cancer progression by modulating the immune response and …”
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The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer von Trimaglio, Giulia, Sneperger, Tamara, Raymond, Benjamin, Gilles, Nelly, Näser, Emmanuelle, Locard-Paulet, Marie, Ijsselsteijn, Marieke, Brouwer, Thomas, Ecalard, Romain, Roelands, Jessica, Matsumoto, Naoki, Colom, André, Habch, Myriam, de Miranda, Noel, Vergnolle, Nathalie, Devaud, Christel, Neyrolles, Olivier, Rombouts, Yoann

“… Development and progression of malignancies are accompanied and influenced by alterations in the surrounding immune microenvironment. Understanding the …”
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Divergent therapeutic and prognostic impacts of immunogenic features in undifferentiated pleomorphic sarcoma and myxofibrosarcoma von van Oost, Siddh, Meijer, Debora M., Erdem, Zeynep B., IJsselsteijn, Marieke E., Roelands, Jessica, Lam, Suk Wai, Boejharat, Melissa S., van den Akker, Brendy E. W. M., van der Breggen, Ruud, Briare-de Bruijn, Inge H., Hawinkels, Lukas J. A. C., Kruiswijk, Anouk A., van der Ploeg, Manon, Wijers-Koster, Pauline M., Haas, Rick L., van den Sande, Michiel A. J., de Miranda, Noel F. C. C., Bovee, Judith V. M. G.

“… Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genetically complex soft tissue sarcomas with distinct morphological features …”
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Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4 von van den Bulk, Jitske, Verdegaal, Els M. E., Ruano, Dina, Ijsselsteijn, Marieke E., Visser, Marten, van der Breggen, Ruud, Duhen, Thomas, van der Ploeg, Manon, de Vries, Natasja L., Oosting, Jan, Peeters, Koen C. M. J., Weinberg, Andrew D., Farina-Sarasqueta, Arantza, van der Burg, Sjoerd H., de Miranda, Noel F. C. C.

“… Background The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch …”
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A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue von Guo, Nannan, van Unen, Vincent, Ijsselsteijn, Marieke E., Ouboter, Laura F., van der Meulen, Andrea E., Chuva de Sousa Lopes, Susana M., de Miranda, Noel F. C. C., Koning, Frits, Li, Na

“… Imaging mass cytometry (IMC) is able to quantify the expression of dozens of markers at sub-cellular resolution on a single tissue section by combining a novel …”
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Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer von Zhu, Hehuan, Roelands, Jessica, Ahmed, Eiman I., Stouten, Imke, Hoorntje, Rachel, van Vlierberghe, Ronald L. P., Ijsselsteijn, Marieke E., Lei, Xin, de Miranda, Noel F. C. C., Tollenaar, Rob A. E. M., Vahrmeijer, Alexander L., Bedognetti, Davide, Hendrickx, Wouter R. L., Kuppen, Peter J. K.

“… Colon cancer is a heterogeneous disease and consists of various molecular subtypes. Despite advances in high-throughput expression profiling, limitations …”
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CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden von van den Bulk, Jitske, van der Ploeg, Manon, Ijsselsteijn, Marieke E, Ruano, Dina, van der Breggen, Ruud, Duhen, Rebekka, Peeters, Koen C M J, Fariña-Sarasqueta, Arantza, Verdegaal, Els M E, van der Burg, Sjoerd H, Duhen, Thomas, de Miranda, Noel F C C

“… BackgroundExpression of CD103 and CD39 has been found to pinpoint tumor-reactive CD8+ T cells in a variety of solid cancers. We aimed to investigate whether …”
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Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival von Abdulrahman, Ziena, Santegoets, Saskia J, Sturm, Gregor, Charoentong, Pornpimol, Ijsselsteijn, Marieke E, Somarakis, Antonios, Höllt, Thomas, Finotello, Francesca, Trajanoski, Zlatko, van Egmond, Sylvia L, Mustafa, Dana A M, Welters, Marij J P, de Miranda, Noel F C C, van der Burg, Sjoerd H

“… BackgroundThe composition of the tumor immune microenvironment (TIME) associated with good prognosis generally also predicts the success of immunotherapy, and …”
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Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface von Krop, Juliette, van der Zwan, Anita, Ijsselsteijn, Marieke E., Kapsenberg, Hanneke, Luk, Sietse J., Hendriks, Sanne H., van der Keur, Carin, Verleng, Lotte J., Somarakis, Antonis, van der Meeren, Lotte, Haasnoot, Geert, Bos, Manon, de Miranda, Noel F.C.C., Chuva de Sousa Lopes, Susana M., van der Hoorn, Marie-Louise P., Koning, Frits, Claas, Frans H.J., Heidt, Sebastiaan, Eikmans, Michael

“… Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal …”
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IDO+ Endothelial Cells in Glomeruli of Kidney Transplantation Patients With Glomerulitis von Hendriks, Sanne H., Heidt, Sebastiaan, Krop, Juliette, IJsselsteijn, Marieke E., Eggermont, Jeroen, Kers, Jesper, Reinders, Marlies E.J., Koning, Frits, van Kooten, Cees

“… Background. Kidney transplantation is the preferred treatment option for patients with end-stage renal disease. However, long-term graft survival remains a …”
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Multimodal profiling of chordoma immunity reveals distinct immune contextures von van Oost, Siddh, Meijer, Debora M, Ijsselsteijn, Marieke E, Roelands, Jessica P, van den Akker, Brendy E M W, van der Breggen, Ruud, Briaire-de Bruijn, Inge H, van der Ploeg, Manon, Wijers-Koster, Pauline M, Polak, Samuel B, Peul, Wilco C, van der Wal, Robert J P, de Miranda, Noel F C C, Bovee, Judith V M G

“… BackgroundChordomas are rare cancers from the axial skeleton which present a challenging clinical management with limited treatment options due to their …”
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γδ T cells are effectors of immunotherapy in cancers with HLA class I defects von de Vries, Natasja L., van de Haar, Joris, Veninga, Vivien, Chalabi, Myriam, Ijsselsteijn, Marieke E., van der Ploeg, Manon, van den Bulk, Jitske, Ruano, Dina, van den Berg, Jose G., Haanen, John B., Zeverijn, Laurien J., Geurts, Birgit S., de Wit, Gijs F., Battaglia, Thomas W., Gelderblom, Hans, Verheul, Henk M. W., Schumacher, Ton N., Wessels, Lodewyk F. A., Koning, Frits, de Miranda, Noel F. C. C., Voest, Emile E.

“… DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune …”
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Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis von Roelands, Jessica, van der Ploeg, Manon, Ijsselsteijn, Marieke E, Dang, Hao, Boonstra, Jurjen J, Hardwick, James C H, Hawinkels, Lukas J A C, Morreau, Hans, de Miranda, Noel F C C

“… ObjectiveBiological insights into the stepwise development and progression of colorectal cancer (CRC) are imperative to develop tailored approaches for early …”
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Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial von Verschoor, Yara L., van de Haar, Joris, van den Berg, José G., van Sandick, Johanna W., Kodach, Liudmila L., van Dieren, Jolanda M., Balduzzi, Sara, Grootscholten, Cecile, IJsselsteijn, Marieke E., Veenhof, Alexander A. F. A., Hartemink, Koen J., Vollebergh, Marieke A., Jurdi, Adham, Sharma, Shruti, Spickard, Erik, Owers, Emilia C., Bartels-Rutten, Annemarieke, den Hartog, Peggy, de Miranda, Noel F. C. C., van Leerdam, Monique E., Haanen, John B. A. G., Schumacher, Ton N., Voest, Emile E., Chalabi, Myriam

“… Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite recent advancements, most patients die of their disease. Although …”
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Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling von Nunes, Joana B., Ijsselsteijn, Marieke E., Abdelaal, Tamim, Ursem, Rick, van der Ploeg, Manon, Giera, Martin, Everts, Bart, Mahfouz, Ahmed, Heijs, Bram, de Miranda, Noel F. C. C.

“… The integration of spatial omics technologies can provide important insights into the biology of tissues. Here we combined mass spectrometry imaging-based …”
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