Suchergebnisse - "INTRANASAL administration"

Intranasal H102 Peptide-Loaded Liposomes for Brain Delivery to Treat Alzheimer’s Disease von Zheng, Xiaoyao, Shao, Xiayan, Zhang, Chi, Tan, Yuanzhen, Liu, Qingfeng, Wan, Xu, Zhang, Qizhi, Xu, Shumei, Jiang, Xinguo

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Evaluation of intranasal delivery route of drug administration for brain targeting von Erdő, Franciska, Bors, Luca Anna, Farkas, Dániel, Bajza, Ágnes, Gizurarson, Sveinbjörn

“… [Display omitted] •The two main pathways of intranasal drug absorption are the olfactory and trigeminal routes.•The intranasal drugs can bypass the blood-brain …”
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Air-liquid interface (ALI) impact on different respiratory cell cultures von Silva, Soraia, Bicker, Joana, Falcão, Amílcar, Fortuna, Ana

“… [Display omitted] The intranasal route has been receiving greater attention from the scientific community not only for systemic drug delivery but also for the …”
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On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles von Formica, María L., Real, Daniel A., Picchio, Matías L., Catlin, Elise, Donnelly, Ryan F., Paredes, Alejandro J.

“… •The difficulty in the treatment of several diseases which affect the central nervous system (CNS) is related to the low permeation of therapeutic agents …”
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Metal-organic framework nanoagent induces cuproptosis for effective immunotherapy of malignant glioblastoma von Huang, Qian-Xiao, Liang, Jun-Long, Chen, Qi-Wen, Jin, Xiao-Kang, Niu, Mei-Ting, Dong, Cheng-Yuan, Zhang, Xian-Zheng

“… Glioblastoma (GBM) is an aggressive brain cancer with an immunosuppressive tumor microenvironment. Here, a copper-based nanoplatform BSO-CAT@MOF-199 @DDM …”
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Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation von Le Floc’h, Audrey, Allinne, Jeanne, Nagashima, Kirsten, Scott, George, Birchard, Dylan, Asrat, Seblewongel, Bai, Yu, Lim, Wei Keat, Martin, Joel, Huang, Tammy, Potocky, Terra B., Kim, Jee H., Rafique, Ashique, Papadopoulos, Nicholas J., Stahl, Neil, Yancopoulos, George D., Murphy, Andrew J., Sleeman, Matthew A., Orengo, Jamie M.

“… Background Dupilumab, a fully human monoclonal antibody that binds IL‐4Rα and inhibits signaling of both IL‐4 and IL‐13, has shown efficacy across multiple …”
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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates von Brown, Kirk M., Nair, Jayaprakash K., Janas, Maja M., Anglero-Rodriguez, Yesseinia I., Dang, Lan T. H., Peng, Haiyan, Theile, Christopher S., Castellanos-Rizaldos, Elena, Brown, Christopher, Foster, Donald, Kurz, Jeffrey, Allen, Jeffrey, Maganti, Rajanikanth, Li, Jing, Matsuda, Shigeo, Stricos, Matthew, Chickering, Tyler, Jung, Michelle, Wassarman, Kelly, Rollins, Jeff, Woods, Lauren, Kelin, Alex, Guenther, Dale C., Mobley, Melissa W., Petrulis, John, McDougall, Robin, Racie, Timothy, Bombardier, Jessica, Cha, Diana, Agarwal, Saket, Johnson, Lei, Jiang, Yongfeng, Lentini, Scott, Gilbert, Jason, Nguyen, Tuyen, Chigas, Samantha, LeBlanc, Sarah, Poreci, Urjana, Kasper, Anne, Rogers, Arlin B., Chong, Saeho, Davis, Wendell, Sutherland, Jessica E., Castoreno, Adam, Milstein, Stuart, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Keating, Mark, Manoharan, Muthiah, Fitzgerald, Kevin, Wu, Jing-Tao, Maier, Martin A., Jadhav, Vasant

“… Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional …”
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Intranasally delivered colostrum-derived small extracellular vesicles mitigate acute neuroinflammation in periventricular leukomalacia von Ture, Beyza, Erdogan, Funda, Armagan, Coskun, Tastan, Bora, Gonul, Ceren Perihan, Guducu, Yusuf, Akyildiz, Can, Duman, Nuray, Genc, Sermin, Ozkan, Hasan

“… [Display omitted] •This article demonstrates that intranasally delivered colostrum-derived sEVs can reach the neonatal brain.•The results suggest that …”
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Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes von Dhaliwal, Harkiranpreet Kaur, Fan, Yingfang, Kim, Jonghan, Amiji, Mansoor M

“… Nucleic acid-based therapeutics, including the use of messenger RNA (mRNA) as a drug molecule, has tremendous potential in the treatment of chronic diseases, …”
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Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial von Xu, Guolin, Tian, Zhuhong, Ding, Yong, Ma, Jingjing, Li, Rui

“… BackgroundShivering during cesarean section under epidural anesthesia is common and may negatively affect maternal comfort, surgical conditions, and …”
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Stimuli-responsive In situ gelling system for nose-to-brain drug delivery von Agrawal, Mukta, Saraf, Shailendra, Saraf, Swarnlata, Dubey, Sunil K., Puri, Anu, Gupta, Umesh, Kesharwani, Prashant, Ravichandiran, V., Kumar, Pramod, Naidu, V.G.M., Murty, Upadhyayula Suryanarayana, Ajazuddin, Alexander, Amit

“… The diagnosis and treatment of neurological ailments always remain an utmost challenge for research fraternity due to the presence of BBB. The intranasal route …”
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Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson’s Disease von Peng, Huan, Li, Yan, Ji, Weihong, Zhao, Ruichen, Lu, Zhiguo, Shen, Jie, Wu, Yanyue, Wang, Jianze, Hao, Qiulian, Wang, Jingwen, Wang, Wenli, Yang, Jun, Zhang, Xin

“… The treatment of Parkinson’s disease (PD) has been hindered by the complex pathologies and multiple membrane barriers during drug delivery. Although exosomes …”
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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody von Li, Cheng, Zhan, Wuqiang, Yang, Zhenlin, Tu, Chao, Hu, Gaowei, Zhang, Xiang, Song, Wenping, Du, Shujuan, Zhu, Yuanfei, Huang, Keke, Kong, Yu, Zhang, Meng, Mao, Qiyu, Gu, Xiaodan, Zhang, Yi, Xie, Youhua, Deng, Qiang, Song, Yuanlin, Chen, Zhenguo, Lu, Lu, Jiang, Shibo, Wu, Yanling, Sun, Lei, Ying, Tianlei

“… The effectiveness of SARS-CoV-2 vaccines and therapeutic antibodies have been limited by the continuous emergence of viral variants and by the restricted …”
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The blood–brain barrier: Structure, regulation and drug delivery von Wu, Di, Chen, Qi, Chen, Xiaojie, Han, Feng, Chen, Zhong, Wang, Yi

“… Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence …”
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Alzheimer’s Disease: Treatment Strategies and Their Limitations von Passeri, Elodie, Elkhoury, Kamil, Morsink, Margaretha, Broersen, Kerensa, Linder, Michel, Tamayol, Ali, Malaplate, Catherine, Yen, Frances T., Arab-Tehrany, Elmira

“… Alzheimer’s disease (AD) is the most frequent case of neurodegenerative disease and is becoming a major public health problem all over the world. Many …”
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Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases von Huang, Qianqian, Chen, Yongke, Zhang, Weiwei, Xia, Xue, Li, Hanmei, Qin, Meng, Gao, Huile

“… Despite the increasing global incidence of brain disorders, achieving sufficient delivery towards the central nervous system (CNS) remains a formidable …”
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Intranasal administration of stem cell-derived exosomes for central nervous system diseases von Gotoh, Shuho, Kawabori, Masahito, Fujimura, Miki

“… Abstract Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various cells and play crucial roles in intercellular …”
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Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy von Yang, Xiaotong, Yang, Wenqin, Xia, Xue, Lei, Ting, Yang, Zhihang, Jia, Wenfeng, Zhou, Yang, Cheng, Guo, Gao, Huile

“… Alzheimer's disease (AD), as a progressive and irreversible brain disorder, remains the most universal neurodegenerative disease. No effective therapeutic …”
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A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2 von Hassan, Ahmed O, Kafai, Natasha M, Dmitriev, Igor P, Fox, Julie M, Smith, Brittany K, Harvey, Ian B, Chen, Rita E, Winkler, Emma S, Wessel, Alex W, Case, James Brett, Kashentseva, Elena, McCune, Broc T, Bailey, Adam L, Zhao, Haiyan, VanBlargan, Laura A, Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J, Shrihari, Swathi, Danis, Jonathan E, Gralinski, Lisa E, Hou, Yixuan J, Schäfer, Alexandra, Kim, Arthur S, Keeler, Shamus P, Weiskopf, Daniela, Baric, Ralph S, Holtzman, Michael J, Fremont, Daved H, Curiel, David T, Diamond, Michael S

“… The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a …”
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Intranasal Delivery of Temozolomide-Conjugated Gold Nanoparticles Functionalized with Anti-EphA3 for Glioblastoma Targeting von Wang, Liangxiao, Tang, Shengnan, Yu, Yawen, Lv, Yanan, Wang, Aiping, Yan, Xiuju, Li, Nuannuan, Sha, Chunjie, Sun, Kaoxiang, Li, Youxin

“… Glioblastoma multiforme (GBM) is a highly lethal and aggressive tumor of the brain that carries a poor prognosis. Temozolomide (TMZ) has been widely used as a …”
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