Suchergebnisse - "Hunger, Stephen P"

How I treat relapsed acute lymphoblastic leukemia in the pediatric population von Hunger, Stephen P, Raetz, Elizabeth A

“… Relapsed acute lymphoblastic leukemia (ALL) has remained challenging to treat in children, with survival rates lagging well behind those observed at initial …”
Weitere Angaben

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine von Hunger, Stephen P, Mullighan, Charles G

“… Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a leading cause of cancer death in the young. In the last decade, microarray …”
Weitere Angaben

Philadelphia chromosome-like acute lymphoblastic leukemia von Tasian, Sarah K, Loh, Mignon L, Hunger, Stephen P

“… Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as - -like ALL, is a high-risk subset with a gene expression profile …”
Weitere Angaben

Optimizing therapy in the modern age: differences in length of maintenance therapy in acute lymphoblastic leukemia von Teachey, David T, Hunger, Stephen P, Loh, Mignon L

“… A majority of children and young adults with acute lymphoblastic leukemia (ALL) are cured with contemporary multiagent chemotherapy regimens. The high rate of …”
Weitere Angaben

Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group von Hunger, Stephen P, Lu, Xiaomin, Devidas, Meenakshi, Camitta, Bruce M, Gaynon, Paul S, Winick, Naomi J, Reaman, Gregory H, Carroll, William L

“… To examine population-based improvements in survival and the impact of clinical covariates on outcome among children and adolescents with acute lymphoblastic …”
Weitere Angaben

Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group von Gupta, Sumit, Wang, Cindy, Raetz, Elizabeth A, Schore, Reuven, Salzer, Wanda L, Larsen, Eric C, Maloney, Kelly W, Mattano, Jr, Len A, Carroll, William L, Winick, Naomi J, Hunger, Stephen P, Loh, Mignon L, Devidas, Meenakshi

“… Asparaginase (ASNase) is an important component of acute lymphoblastic leukemia (ALL) treatment, but is often discontinued because of toxicity. ASNase ( ) …”
Weitere Angaben

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration von Pui, Ching-Hon, Yang, Jun J, Hunger, Stephen P, Pieters, Rob, Schrappe, Martin, Biondi, Andrea, Vora, Ajay, Baruchel, André, Silverman, Lewis B, Schmiegelow, Kjeld, Escherich, Gabriele, Horibe, Keizo, Benoit, Yves C M, Izraeli, Shai, Yeoh, Allen Eng Juh, Liang, Der-Cherng, Downing, James R, Evans, William E, Relling, Mary V, Mullighan, Charles G

“… To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. A …”
Weitere Angaben

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia von Gu, Zhaohui, Churchman, Michelle, Roberts, Kathryn, Li, Yongjin, Liu, Yu, Harvey, Richard C., McCastlain, Kelly, Reshmi, Shalini C., Payne-Turner, Debbie, Iacobucci, Ilaria, Shao, Ying, Chen, I-Ming, Valentine, Marcus, Pei, Deqing, Mungall, Karen L., Mungall, Andrew J., Ma, Yussanne, Moore, Richard, Marra, Marco, Stonerock, Eileen, Gastier-Foster, Julie M., Devidas, Meenakshi, Dai, Yunfeng, Wood, Brent, Borowitz, Michael, Larsen, Eric E., Maloney, Kelly, Mattano Jr, Leonard A., Angiolillo, Anne, Salzer, Wanda L., Burke, Michael J., Gianni, Francesca, Spinelli, Orietta, Radich, Jerald P., Minden, Mark D., Moorman, Anthony V., Patel, Bella, Fielding, Adele K., Rowe, Jacob M., Luger, Selina M., Bhatia, Ravi, Aldoss, Ibrahim, Forman, Stephen J., Kohlschmidt, Jessica, Mrózek, Krzysztof, Marcucci, Guido, Bloomfield, Clara D., Stock, Wendy, Kornblau, Steven, Kantarjian, Hagop M., Konopleva, Marina, Paietta, Elisabeth, Willman, Cheryl L., L. Loh, Mignon, P. Hunger, Stephen, Mullighan, Charles G.

“… Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements …”
Volltext

Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children's Oncology Group study AALL0232 von Borowitz, Michael J, Wood, Brent L, Devidas, Meenakshi, Loh, Mignon L, Raetz, Elizabeth A, Salzer, Wanda L, Nachman, James B, Carroll, Andrew J, Heerema, Nyla A, Gastier-Foster, Julie M, Willman, Cheryl L, Dai, Yunfeng, Winick, Naomi J, Hunger, Stephen P, Carroll, William L, Larsen, Eric

“… Minimal residual disease (MRD) is highly prognostic in pediatric B-precursor acute lymphoblastic leukemia (B-ALL). In Children's Oncology Group high-risk B-ALL …”
Weitere Angaben

Bortezomib reinduction chemotherapy in high‐risk ALL in first relapse: a report from the Children's Oncology Group von Horton, Terzah M., Whitlock, James A., Lu, Xiaomin, O'Brien, Maureen M., Borowitz, Michael J., Devidas, Meenakshi, Raetz, Elizabeth A., Brown, Patrick A., Carroll, William L., Hunger, Stephen P.

“… Summary While survival in paediatric acute lymphoblastic leukaemia (ALL) is excellent, survival following relapse is poor. Previous studies suggest proteasome …”
Volltext

Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group von Reshmi, Shalini C, Harvey, Richard C, Roberts, Kathryn G, Stonerock, Eileen, Smith, Amy, Jenkins, Heather, Chen, I-Ming, Valentine, Marc, Liu, Yu, Li, Yongjin, Shao, Ying, Easton, John, Payne-Turner, Debbie, Gu, Zhaohui, Tran, Thai Hoa, Nguyen, Jonathan V, Devidas, Meenakshi, Dai, Yunfeng, Heerema, Nyla A, Carroll, 3rd, Andrew J, Raetz, Elizabeth A, Borowitz, Michael J, Wood, Brent L, Angiolillo, Anne L, Burke, Michael J, Salzer, Wanda L, Zweidler-McKay, Patrick A, Rabin, Karen R, Carroll, William L, Zhang, Jinghui, Loh, Mignon L, Mullighan, Charles G, Willman, Cheryl L, Gastier-Foster, Julie M, Hunger, Stephen P

“… Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype characterized by genomic alterations that activate cytokine …”
Weitere Angaben

Integrated Risk Stratification Using Minimal Residual Disease and Sentinel Genetic Alterations in Pediatric Acute Lymphoblastic Leukemia von Hunger, Stephen P

Weitere Angaben

Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia von Tasian, Sarah K, Teachey, David T, Li, Yong, Shen, Feng, Harvey, Richard C, Chen, I-Ming, Ryan, Theresa, Vincent, Tiffaney L, Willman, Cheryl L, Perl, Alexander E, Hunger, Stephen P, Loh, Mignon L, Carroll, Martin, Grupp, Stephan A

“… Philadelphia chromosome (Ph)-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is associated with activated JAK/STAT, Abelson kinase (ABL), and/or …”
Weitere Angaben

Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia von Churchman, Michelle L, Qian, Maoxiang, Te Kronnie, Geertruy, Zhang, Ranran, Yang, Wenjian, Zhang, Hui, Lana, Tobia, Tedrick, Paige, Baskin, Rebekah, Verbist, Katherine, Peters, Jennifer L, Devidas, Meenakshi, Larsen, Eric, Moore, Ian M, Gu, Zhaohui, Qu, Chunxu, Yoshihara, Hiroki, Porter, Shaina N, Pruett-Miller, Shondra M, Wu, Gang, Raetz, Elizabeth, Martin, Paul L, Bowman, W Paul, Winick, Naomi, Mardis, Elaine, Fulton, Robert, Stanulla, Martin, Evans, William E, Relling, Mary V, Pui, Ching-Hon, Hunger, Stephen P, Loh, Mignon L, Handgretinger, Rupert, Nichols, Kim E, Yang, Jun J, Mullighan, Charles G

“… Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia …”
Weitere Angaben

Reduced Morbidity and Mortality in Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study von Dixon, Stephanie B, Chen, Yan, Yasui, Yutaka, Pui, Ching-Hon, Hunger, Stephen P, Silverman, Lewis B, Ness, Kirsten K, Green, Daniel M, Howell, Rebecca M, Leisenring, Wendy M, Kadan-Lottick, Nina S, Krull, Kevin R, Oeffinger, Kevin C, Neglia, Joseph P, Mertens, Ann C, Hudson, Melissa M, Robison, Leslie L, Armstrong, Gregory T, Nathan, Paul C

“… Risk-stratified therapy, which modifies treatment on the basis of clinical and biologic features, has improved 5-year overall survival of childhood acute …”
Weitere Angaben

Current Concepts in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia von Bernt, Kathrin M., Hunger, Stephen P.

“… The t(9;22)(q34;q11) or Philadelphia chromosome creates a BCR-ABL1 fusion gene encoding for a chimeric BCR-ABL1 protein. It is present in 3-4% of pediatric …”
Volltext

Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium von Buchmann, Swantje, Schrappe, Martin, Baruchel, Andre, Biondi, Andrea, Borowitz, Michael, Campbell, Myriam, Cario, Gunnar, Cazzaniga, Giovanni, Escherich, Gabriele, Harrison, Christine J, Heyman, Mats, Hunger, Stephen P, Kiss, Csongor, Liu, Hsi-Che, Locatelli, Franco, Loh, Mignon L, Manabe, Atsushi, Mann, Georg, Pieters, Rob, Pui, Ching-Hon, Rives, Susana, Schmiegelow, Kjeld, Silverman, Lewis B, Stary, Jan, Vora, Ajay, Brown, Patrick

“… Comparison of treatment strategies in de novo pediatric acute lymphoblastic leukemia (ALL) requires standardized measures of efficacy. Key parameters that …”
Weitere Angaben

FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children’s Oncology Group trial AALL0631 von Brown, Patrick A., Kairalla, John A., Hilden, Joanne M., Dreyer, ZoAnn E., Carroll, Andrew J., Heerema, Nyla A., Wang, Cindy, Devidas, Meenakshi, Gore, Lia, Salzer, Wanda L., Winick, Naomi J., Carroll, William L., Raetz, Elizabeth A., Borowitz, Michael J., Small, Donald, Loh, Mignon L., Hunger, Stephen P.

“… Infants with KMT2A ‐rearranged acute lymphoblastic leukemia ( KMT2A -r ALL) have a poor prognosis. KMT2A -r ALL overexpresses FLT3, and the FLT3 inhibitor …”
Volltext

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia von Shojaee, Seyedmehdi, Caeser, Rebecca, Buchner, Maike, Park, Eugene, Swaminathan, Srividya, Hurtz, Christian, Geng, Huimin, Chan, Lai N, Klemm, Lars, Hofmann, Wolf-Karsten, Qiu, Yi Hua, Zhang, Nianxiang, Coombes, Kevin R, Paietta, Elisabeth, Molkentin, Jeffery, Koeffler, H Phillip, Willman, Cheryl L, Hunger, Stephen P, Melnick, Ari, Kornblau, Steven M, Müschen, Markus

“… Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast …”
Weitere Angaben

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children von Qian, Maoxiang, Cao, Xueyuan, Devidas, Meenakshi, Yang, Wenjian, Cheng, Cheng, Dai, Yunfeng, Carroll, Andrew, Heerema, Nyla A, Zhang, Hui, Moriyama, Takaya, Gastier-Foster, Julie M, Xu, Heng, Raetz, Elizabeth, Larsen, Eric, Winick, Naomi, Bowman, W Paul, Martin, Paul L, Mardis, Elaine R, Fulton, Robert, Zambetti, Gerard, Borowitz, Michael, Wood, Brent, Nichols, Kim E, Carroll, William L, Pui, Ching-Hon, Mullighan, Charles G, Evans, William E, Hunger, Stephen P, Relling, Mary V, Loh, Mignon L, Yang, Jun J

“… Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline …”
Weitere Angaben