Výsledky vyhľadávania - "Hulsman, Danielle"

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation Autor Sparmann, Anke, Xie, Yunli, Verhoeven, Els, Vermeulen, Michiel, Lancini, Cesare, Gargiulo, Gaetano, Hulsman, Danielle, Mann, Matthias, Knoblich, Juergen A, van Lohuizen, Maarten

“…Polycomb group (PcG) proteins form transcriptional repressor complexes with well‐established functions during cell‐fate determination. Yet, the mechanisms…”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells Autor Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“…Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification…”
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Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression Autor de Vries, Nienke A., Hulsman, Danielle, Akhtar, Waseem, de Jong, Johann, Miles, Denise C., Blom, Marleen, van Tellingen, Olaf, Jonkers, Jos, van Lohuizen, Maarten

“…EZH2 is frequently overexpressed in glioblastoma (GBM), suggesting an oncogenic function that could be a target for therapeutic intervention. However, reduced…”
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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice Autor Bruggeman, Sophia W M, Valk-Lingbeek, Merel E, van der Stoop, Petra P M, Jacobs, Jacqueline J L, Kieboom, Karin, Tanger, Ellen, Hulsman, Danielle, Leung, Carly, Arsenijevic, Yvan, Marino, Silvia, van Lohuizen, Maarten

“…The Polycomb group (PcG) gene Bmi1 promotes cell proliferation and stem cell self-renewal by repressing the Ink4a/Arf locus. We used a genetic approach to…”
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Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells Autor van der Stoop, Petra, Boutsma, Erwin A., Hulsman, Danielle, Noback, Sonja, Heimerikx, Mike, Kerkhoven, Ron M., Voncken, J. Willem, Wessels, Lodewyk F. A., van Lohuizen, Maarten

“…Polycomb repressive complex 1 (PRC1) core member Ring1b/Rnf2, with ubiquitin E3 ligase activity towards histone H2A at lysine 119, is essential for early…”
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Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma Autor Landman, Nick, Hulsman, Danielle, Badhai, Jitendra, Kopparam, Jawahar, Puppe, Julian, Pandey, Gaurav Kumar, van Lohuizen, Maarten

“…Background More than half of mesothelioma tumours show alterations in the tumour suppressor gene BAP1 . BAP1-deficient mesothelioma is shown to be sensitive to…”
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Phenotypic Mapping of Pathologic Cross-Talk between Glioblastoma and Innate Immune Cells by Synthetic Genetic Tracing Autor Schmitt, Matthias Jürgen, Company, Carlos, Dramaretska, Yuliia, Barozzi, Iros, Göhrig, Andreas, Kertalli, Sonia, Großmann, Melanie, Naumann, Heike, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Glass, Rainer, Squatrito, Massimo, Serresi, Michela, Gargiulo, Gaetano

“…Glioblastoma is a lethal brain tumor that exhibits heterogeneity and resistance to therapy. Our understanding of tumor homeostasis is limited by a lack of…”
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Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer Autor Serresi, Michela, Gargiulo, Gaetano, Proost, Natalie, Siteur, Bjorn, Cesaroni, Matteo, Koppens, Martijn, Xie, Huafeng, Sutherland, Kate D, Hulsman, Danielle, Citterio, Elisabetta, Orkin, Stuart, Berns, Anton, van Lohuizen, Maarten

“…Polycomb repressive complexes (PRC) are frequently implicated in human cancer, acting either as oncogenes or tumor suppressors. Here, we show that PRC2 is a…”
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In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis Autor Gargiulo, Gaetano, Cesaroni, Matteo, Serresi, Michela, de Vries, Nienke, Hulsman, Danielle, Bruggeman, Sophia W, Lancini, Cesare, van Lohuizen, Maarten

“…In mouse and human neural progenitor and glioblastoma "stem-like" cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq…”
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Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition Autor Serresi, Michela, Kertalli, Sonia, Li, Lifei, Schmitt, Matthias Jürgen, Dramaretska, Yuliia, Wierikx, Jikke, Hulsman, Danielle, Gargiulo, Gaetano

“…Chromatin modulators with antagonistic functions on epithelial-mesenchymal interconversion regulate common pan-cancer genes. Epithelial-mesenchymal transition…”
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Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities Autor Serresi, Michela, Siteur, Bjorn, Hulsman, Danielle, Company, Carlos, Schmitt, Matthias J, Lieftink, Cor, Morris, Ben, Cesaroni, Matteo, Proost, Natalie, Beijersbergen, Roderick L, van Lohuizen, Maarten, Gargiulo, Gaetano

“…Kras-driven non-small-cell lung cancers (NSCLCs) are a leading cause of death with limited therapeutic options. Many NSCLCs exhibit high levels of Ezh2, the…”
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In vivo shRNA screens in solid tumors Autor Gargiulo, Gaetano, Serresi, Michela, Cesaroni, Matteo, Hulsman, Danielle, van Lohuizen, Maarten

“…Gargiulo et al . describe the use of shRNA libraries for functional screens in orthotopic mouse tumor models, using glioma and lung cancer as examples…”
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TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming Autor Miles, Denise Catherine, de Vries, Nienke Alexandra, Gisler, Santiago, Lieftink, Cor, Akhtar, Waseem, Gogola, Ewa, Pawlitzky, Inka, Hulsman, Danielle, Tanger, Ellen, Koppens, Martijn, Beijersbergen, Roderick Leonardus, van Lohuizen, Maarten

“…Since the discovery of induced pluripotent stem cells there has been intense interest in understanding the mechanisms that allow a somatic cell to be…”
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Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma Autor Bruggeman, Sophia W M, Hulsman, Danielle, Tanger, Ellen, Buckle, Tessa, Blom, Marleen, Zevenhoven, John, van Tellingen, Olaf, van Lohuizen, Maarten

“…The Polycomb group and oncogene Bmi1 is required for the proliferation of various differentiated cells and for the self-renewal of stem cells and leukemic…”
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USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells Autor van den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Pritchard, Colin, Song, Ji-Ying, Schmitt, Matthias Jürgen, Tanger, Ellen, Popp, Oliver, Mertins, Philipp, Huijbers, Ivo J., Jacobs, Heinz, van Lohuizen, Maarten, Gargiulo, Gaetano, Citterio, Elisabetta

“…Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of…”
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Combined Inhibition of EZH2 and FGFR is Synergistic in BAP1-deficient Malignant Mesothelioma Autor Badhai, Jitendra, Landman, Nick, Pandey, Gaurav Kumar, Song, Ji-Ying, Hulsman, Danielle, Krijgsman, Oscar, Chandrasekaran, Gayathri, Berns, Anton, van Lohuizen, Maarten

“…Malignant mesothelioma is a highly aggressive tumor with a survival of only 4-18 months after diagnosis. Treatment options for this disease are limited. Immune…”
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Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma Autor Pandey, Gaurav Kumar, Landman, Nick, Neikes, Hannah K., Hulsman, Danielle, Lieftink, Cor, Beijersbergen, Roderick, Kolluri, Krishna Kalyan, Janes, Sam M., Vermeulen, Michiel, Badhai, Jitendra, van Lohuizen, Maarten

“…More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive…”
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Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies Autor de Vries, Nienke A, Bruggeman, Sophia W, Hulsman, Danielle, de Vries, Hilda I, Zevenhoven, John, Buckle, Tessa, Hamans, Bob C, Leenders, William P, Beijnen, Jos H, van Lohuizen, Maarten, Berns, Anton J M, van Tellingen, Olaf

“…To develop a transgenic mouse model of glioma that can be conveniently used for testing therapy intervention strategies. High-grade glioma is a devastating and…”
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Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice Autor Lund, Anders H., Turner, Geoffrey, Trubetskoy, Alla, Verhoeven, Els, Wientjens, Ellen, Hulsman, Danielle, Russell, Robert, DePinho, Ronald A., Lenz, Jack, van Lohuizen, Maarten

“…We have used large-scale insertional mutagenesis to identify functional landmarks relevant to cancer in the recently completed mouse genome sequence. We…”
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Bmi1 deficient neural stem cells have increased Integrin dependent adhesion to self-secreted matrix Autor Bruggeman, Sophia W.M., Hulsman, Danielle, van Lohuizen, Maarten

“…Neural cells deficient for Polycomb group (PcG) protein Bmi1 are impaired in the formation and differentiation of high grade glioma, an incurable cancer of the…”
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