Suchergebnisse - "Huber, Tobias"

Autophagy in kidney disease and aging: lessons from rodent models von Lenoir, Olivia, Tharaux, Pierre-Louis, Huber, Tobias B

“… Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain …”
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CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease von Anders, Hans-Joachim, Huber, Tobias B, Isermann, Berend, Schiffer, Mario

“… The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) has prompted research efforts to tackle the growing …”
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The Evolving Complexity of the Podocyte Cytoskeleton von Schell, Christoph, Huber, Tobias B

“… Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The …”
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Boom, Bust, and Bitcoin: Bitcoin-Bubbles as Innovation Accelerators von Huber, Tobias A., Sornette, Didier

“… Bitcoin represents one of the most interesting technological breakthroughs and socio-economic experiments of the last decades. In this paper, we examine the …”
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COVID-19-associated nephritis: early warning for disease severity and complications? von Gross, Oliver, Moerer, Onnen, Weber, Manfred, Huber, Tobias B, Scheithauer, Simone

“… SARS-CoV-2 uses the receptor ACE2 for cell entry, and podocytes express ACE2.1 Glomerular changes and nephritis-like histology have been described in …”
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Regulation of Glucose Handling in the Kidney: New Layers of Complexity von Wanner, Nicola, Huber, Tobias B

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The podocyte slit diaphragm—from a thin grey line to a complex signalling hub von Grahammer, Florian, Schell, Christoph, Huber, Tobias B.

“… This article highlights the evolution in understanding of the podocyte slit diaphragm. Now appreciated as far more than a simple intercellular connection, the …”
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Podocytes maintain high basal levels of autophagy independent of mtor signaling von Bork, Tillmann, Liang, Wei, Yamahara, Kosuke, Lee, Philipp, Tian, Zhejia, Liu, Shuya, Schell, Christoph, Thedieck, Kathrin, Hartleben, Bjoern, Patel, Ketan, Tharaux, Pierre-Louis, Lenoir, Olivia, Huber, Tobias B.

“… While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve long-lived podocytes at the filtration barrier, MTOR regulates at the …”
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Insights into human kidney function from the study of Drosophila von Koehler, Sybille, Huber, Tobias B.

“… Biological and biomedical research using Drosophila melanogaster as a model organism has gained recognition through several Nobel prizes within the last …”
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Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors von Kaminski, Michael M., Tosic, Jelena, Kresbach, Catena, Engel, Hannes, Klockenbusch, Jonas, Müller, Anna-Lena, Pichler, Roman, Grahammer, Florian, Kretz, Oliver, Huber, Tobias B., Walz, Gerd, Arnold, Sebastian J., Lienkamp, Soeren S.

“… Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing …”
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Investigation of the shear behavior of RC beams on the basis of measured crack kinematics von Huber, Patrick, Huber, Tobias, Kollegger, Johann

“… •A test series on twenty reinforced concrete beams is presented.•Kinematics of the diagonal crack is investigated by using digital image correlation.•Measured …”
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Virtual and Augmented Reality in Liver Surgery von Lang, Hauke, Huber, Tobias

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Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition von Nazir, Sumra, Gadi, Ihsan, Al-Dabet, Moh'd Mohanad, Elwakiel, Ahmed, Kohli, Shrey, Ghosh, Sanchita, Manoharan, Jayakumar, Ranjan, Satish, Bock, Fabian, Braun-Dullaeus, Ruediger C, Esmon, Charles T, Huber, Tobias B, Camerer, Eric, Dockendorff, Chris, Griffin, John H, Isermann, Berend, Shahzad, Khurrum

“… Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by …”
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New Insights into Podocyte Biology in Glomerular Health and Disease von Assady, Suheir, Wanner, Nicola, Skorecki, Karl L, Huber, Tobias B

“… Podocyte and glomerular research is center stage for the development of improved preventive and therapeutic strategies for chronic progressive kidney diseases …”
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Update membranous nephropathy von Hoxha, Elion, Huber, Tobias B

“… Membranous nephropathy is an autoimmune disease caused in most cases by binding of circulating antibodies to antigens on podocytes. PLA R1 and THSD7A have been …”
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'Salvation and profit': deconstructing the clean-tech bubble von Giorgis, Vincent, Huber, Tobias A., Sornette, Didier

“… From 2004 to 2008, a bubble formed in clean technologies, such as solar, biofuels, batteries and other renewable energy sources. In this paper, we analyse this …”
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From podocyte biology to novel cures for glomerular disease von Torban, Elena, Braun, Fabian, Wanner, Nicola, Takano, Tomoko, Goodyer, Paul R, Lennon, Rachel, Ronco, Pierre, Cybulsky, Andrey V, Huber, Tobias B

“… The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common …”
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SARS-CoV-2 renal tropism associates with acute kidney injury von Braun, Fabian, Lütgehetmann, Marc, Pfefferle, Susanne, Wong, Milagros N, Carsten, Alexander, Lindenmeyer, Maja T, Nörz, Dominik, Heinrich, Fabian, Meißner, Kira, Wichmann, Dominic, Kluge, Stefan, Gross, Oliver, Pueschel, Klaus, Schröder, Ann S, Edler, Carolin, Aepfelbacher, Martin, Puelles, Victor G, Huber, Tobias B

“… SARS-CoV-2-mediated acute kidney injury might be explained by indirect factors (eg, cytokine-mediated injury) and by direct viral infection and replication in …”
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Multiorgan and Renal Tropism of SARS-CoV-2 von Puelles, Victor G, Lütgehetmann, Marc, Lindenmeyer, Maja T, Sperhake, Jan P, Wong, Milagros N, Allweiss, Lena, Chilla, Silvia, Heinemann, Axel, Wanner, Nicola, Liu, Shuya, Braun, Fabian, Lu, Shun, Pfefferle, Susanne, Schröder, Ann S, Edler, Carolin, Gross, Oliver, Glatzel, Markus, Wichmann, Dominic, Wiech, Thorsten, Kluge, Stefan, Pueschel, Klaus, Aepfelbacher, Martin, Huber, Tobias B

“… In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain …”
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Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury von Linkermann, Andreas, Bräsen, Jan H., Himmerkus, Nina, Liu, Shuya, Huber, Tobias B., Kunzendorf, Ulrich, Krautwald, Stefan

“… Loss of kidney function in renal ischemia/reperfusion injury is due to programmed cell death, but the contribution of necroptosis, a newly discovered form of …”
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