Suchergebnisse - "Huang, Alexander C."

A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance von Huang, Alexander C, Zappasodi, Roberta

“… Ten years since the immune checkpoint inhibitor ipilimumab was approved for advanced melanoma, it is time to reflect on the lessons learned regarding …”
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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade von Benci, Joseph L, Xu, Bihui, Qiu, Yu, Wu, Tony J, Dada, Hannah, Twyman-Saint Victor, Christina, Cucolo, Lisa, Lee, David S M, Pauken, Kristen E, Huang, Alexander C, Gangadhar, Tara C, Amaravadi, Ravi K, Schuchter, Lynn M, Feldman, Michael D, Ishwaran, Hemant, Vonderheide, Robert H, Maity, Amit, Wherry, E John, Minn, Andy J

“… Therapeutic blocking of the PD1 pathway results in significant tumor responses, but resistance is common. We demonstrate that prolonged interferon signaling …”
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BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma von Mehnert, Janice M, Mitchell, Tara C, Huang, Alexander C, Aleman, Tomas S, Kim, Benjamin J, Schuchter, Lynn M, Linette, Gerald P, Karakousis, Giorgos C, Mitnick, Sheryl, Giles, Lydia, Carberry, Mary, Frey, Noelle, Kossenkov, Andrew, Groisberg, Roman, Hernandez-Aya, Leonel F, Ansstas, George, Silk, Ann W, Chandra, Sunandana, Sosman, Jeffrey A, Gimotty, Phyllis A, Mick, Rosemarie, Amaravadi, Ravi K

“… Autophagy is a resistance mechanism to BRAF/MEK inhibition in BRAFV600-mutant melanoma. Here we used hydroxychloroquine (HCQ) to inhibit autophagy in …”
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Preclinical platforms to study therapeutic efficacy of human γδ T cells von Ou, Lingling, Wang, Huaishan, Huang, Hui, Zhou, Zhiyan, Lin, Qiang, Guo, Yeye, Mitchell, Tara, Huang, Alexander C., Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Guo, Wei, Salvino, Joseph, Herlyn, Meenhard, Xu, Xiaowei

“… Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory. Vδ2 …”
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Dichotomous and stable gamma delta T-cell number and function in healthy individuals von Ou, Lingling, Wang, Huaishan, Liu, Qin, Zhang, Jie, Lu, Hezhe, Luo, Liangping, Shi, Changzheng, Lin, Shaoqiang, Dong, Liyun, Guo, Yeye, Huang, Lili, Zhu, Jinjin, Yin, Xiangfan, Huang, Alexander C, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Zheng, Cathy, Fan, Yi, Guo, Wei, Xu, Xiaowei

“… BackgroundGamma-delta (γδ) T lymphocytes are primed to potently respond to pathogens and transformed cells by recognizing a broad range of antigens. However, …”
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Feasibility of monitoring advanced melanoma patients using cell‐free DNA from plasma von Gangadhar, Tara C., Savitch, Samantha L., Yee, Stephanie S., Xu, Wei, Huang, Alexander C., Harmon, Shannon, Lieberman, David B., Soucier, Devon, Fan, Ryan, Black, Taylor A., Morrissette, Jennifer J. D., Salathia, Neeraj, Waters, Jill, Zhang, Shile, Toung, Jonathan, Hummelen, Paul, Fan, Jian‐Bing, Xu, Xiaowei, Amaravadi, Ravi K., Schuchter, Lynn M., Karakousis, Giorgos C., Hwang, Wei‐Ting, Carpenter, Erica L.

“… Summary To determine the feasibility of liquid biopsy for monitoring of patients with advanced melanoma, cell‐free DNA was extracted from plasma for 25 Stage …”
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Alpha-Fetoprotein-Producing Lung Hepatoid Adenocarcinoma with Brain Metastasis Treated with S-1 von Muroyama, Yuki, Tamiya, Hiroyuki, Tanaka, Goh, Tanaka, Wakae, Huang, Alexander C., Oldridge, Derek A., Matsusaka, Keisuke, Takazawa, Yutaka, Jo, Taisuke, Ushiku, Tetsuo, Nagase, Takahide

“… Lung hepatoid adenocarcinoma (HAC) is a rare primary lung carcinoma pathologically characterized by hepatocellular carcinoma-like tumor cells, the majority of …”
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High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline von Wang, Guanning, Lyudovyk, Olga, Kim, Justin Y., Lin, Ya-Hui, Elhanati, Yuval, Mathew, Divij, Wherry, E. John, Herati, Ramin S., Greenplate, Allison R., Greenbaum, Benjamin, Vardhana, Santosha A., Huang, Alexander C.

“… The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects of novel …”
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Developmental Relationships of Four Exhausted CD8 + T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms von Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S, Kurachi, Makoto, Giles, Josephine R, Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K, Xu, Xiaowei, Karakousis, Giorgos C, Mitchell, Tara C, Schuchter, Lynn M, Huang, Alexander C, Wherry, E John

“… CD8 T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite this, the developmental biology of exhausted CD8 T cells (Tex) remains …”
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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion von Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John

“… Exhausted CD8 + T (T ex ) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive …”
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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response von Chen, Gang, Huang, Alexander C., Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F., Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H., Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Herlyn, Meenhard, Wherry, E. John, Xu, Xiaowei, Guo, Wei

“… Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 …”
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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision von Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C, Johnson, John, Staupe, Ryan P, Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S, Vella, Laura A, Baxter, Amy E, Wu, Jennifer E, Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R, Stelekati, Erietta, McLane, Laura M, Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L, Vahedi, Golnaz, Ji, Hongkai, Wherry, E John

“… TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway …”
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Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells von Bengsch, Bertram, Ohtani, Takuya, Khan, Omar, Setty, Manu, Manne, Sasikanth, O'Brien, Shaun, Gherardini, Pier Federico, Herati, Ramin Sedaghat, Huang, Alexander C, Chang, Kyong-Mi, Newell, Evan W, Bovenschen, Niels, Pe'er, Dana, Albelda, Steven M, Wherry, E John

“… Exhausted CD8 T (Tex) cells are immunotherapy targets in chronic infection and cancer, but a comprehensive assessment of Tex cell diversity in human disease is …”
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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade von Pauken, Kristen E, Sammons, Morgan A, Odorizzi, Pamela M, Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M, Chen, Zeyu, Sen, Debattama R, Kurachi, Makoto, Barnitz, R Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C, Schenkel, Jason M, Vahedi, Golnaz, Haining, W Nicholas, Berger, Shelley L, Wherry, E John

“… Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 T cells (T ) and improve control of chronic infections and cancer. However, whether blocking …”
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Shared and distinct biological circuits in effector, memory and exhausted CD8 + T cells revealed by temporal single-cell transcriptomics and epigenetics von Giles, Josephine R, Ngiow, Shin Foong, Manne, Sasikanth, Baxter, Amy E, Khan, Omar, Wang, Ping, Staupe, Ryan, Abdel-Hakeem, Mohamed S, Huang, Hua, Mathew, Divij, Painter, Mark M, Wu, Jennifer E, Huang, Yinghui Jane, Goel, Rishi R, Yan, Patrick K, Karakousis, Giorgos C, Xu, Xiaowei, Mitchell, Tara C, Huang, Alexander C, Wherry, E John

“… Naïve CD8 T cells can differentiate into effector (T ), memory (T ) or exhausted (T ) T cells. These developmental pathways are associated with distinct …”
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Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients von Mathew, Divij, Marmarelis, Melina E, Foley, Caitlin, Bauml, Joshua M, Ye, Darwin, Ghinnagow, Reem, Ngiow, Shin Foong, Klapholz, Max, Jun, Soyeong, Zhang, Zhaojun, Zorc, Robert, Davis, Christiana W, Diehn, Maximillian, Giles, Josephine R, Huang, Alexander C, Hwang, Wei-Ting, Zhang, Nancy R, Schoenfeld, Adam J, Carpenter, Erica L, Langer, Corey J, Wherry, E John, Minn, Andy J

“… Persistent inflammation driven by cytokines such as type-one interferon (IFN-I) can cause immunosuppression. We show that administration of the Janus kinase 1 …”
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A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma von Huang, Alexander C, Orlowski, Robert J, Xu, Xiaowei, Mick, Rosemarie, George, Sangeeth M, Yan, Patrick K, Manne, Sasikanth, Kraya, Adam A, Wubbenhorst, Bradley, Dorfman, Liza, D'Andrea, Kurt, Wenz, Brandon M, Liu, Shujing, Chilukuri, Lakshmi, Kozlov, Andrew, Carberry, Mary, Giles, Lydia, Kier, Melanie W, Quagliarello, Felix, McGettigan, Suzanne, Kreider, Kristin, Annamalai, Lakshmanan, Zhao, Qing, Mogg, Robin, Xu, Wei, Blumenschein, Wendy M, Yearley, Jennifer H, Linette, Gerald P, Amaravadi, Ravi K, Schuchter, Lynn M, Herati, Ramin S, Bengsch, Bertram, Nathanson, Katherine L, Farwell, Michael D, Karakousis, Giorgos C, Wherry, E John, Mitchell, Tara C

“… Immunologic responses to anti-PD-1 therapy in melanoma patients occur rapidly with pharmacodynamic T cell responses detectable in blood by 3 weeks. It is …”
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T-cell invigoration to tumour burden ratio associated with anti-PD-1 response von Huang, Alexander C., Postow, Michael A., Orlowski, Robert J., Mick, Rosemarie, Bengsch, Bertram, Manne, Sasikanth, Xu, Wei, Harmon, Shannon, Giles, Josephine R., Wenz, Brandon, Adamow, Matthew, Kuk, Deborah, Panageas, Katherine S., Carrera, Cristina, Wong, Phillip, Quagliarello, Felix, Wubbenhorst, Bradley, D’Andrea, Kurt, Pauken, Kristen E., Herati, Ramin S., Staupe, Ryan P., Schenkel, Jason M., McGettigan, Suzanne, Kothari, Shawn, George, Sangeeth M., Vonderheide, Robert H., Amaravadi, Ravi K., Karakousis, Giorgos C., Schuchter, Lynn M., Xu, Xiaowei, Nathanson, Katherine L., Wolchok, Jedd D., Gangadhar, Tara C., Wherry, E. John

“… Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical …”
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Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia von Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph

“… Tolerance to self-antigens prevents the elimination of cancer by the immune system 1 , 2 . We used synthetic chimeric antigen receptors (CARs) to overcome …”
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Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial von Abella, Benjamin S, Jolkovsky, Eliana L, Biney, Barbara T, Uspal, Julie E, Hyman, Matthew C, Frank, Ian, Hensley, Scott E, Gill, Saar, Vogl, Dan T, Maillard, Ivan, Babushok, Daria V, Huang, Alexander C, Nasta, Sunita D, Walsh, Jennifer C, Wiletyo, E Paul, Gimotty, Phyllis A, Milone, Michael C, Amaravadi, Ravi K

“… Health care workers (HCWs) caring for patients with coronavirus disease 2019 (COVID-19) are at risk of exposure to severe acute respiratory syndrome …”
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