Výsledky vyhľadávania - "Hoogenkamp, Maarten"

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation Autor Goode, Debbie K, Obier, Nadine, Vijayabaskar, M S, Lie-A-Ling, Michael, Lilly, Andrew J, Hannah, Rebecca, Lichtinger, Monika, Batta, Kiran, Florkowska, Magdalena, Patel, Rahima, Challinor, Mairi, Wallace, Kirstie, Gilmour, Jane, Assi, Salam A, Cauchy, Pierre, Hoogenkamp, Maarten, Westhead, David R, Lacaud, Georges, Kouskoff, Valerie, Göttgens, Berthold, Bonifer, Constanze

“…Metazoan development involves the successive activation and silencing of specific gene expression programs and is driven by tissue-specific transcription…”
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PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia Autor Stanulović, Vesna S., Binhassan, Sarah, Jaber, Budoor A., Alazmi, Shimaa, Saleman, Fatma M.B., Potluri, Sandeep, Pratt, Guy, Ludwig, Christian, Ward, Douglas G., Hoogenkamp, Maarten

“…The transcriptional mediator LIM domain only 2 (LMO2) forms a large multi-protein complex together with TAL1/LYL1, HEB/E2A, LDB1 and GATA. This complex…”
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Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate Autor Obier, Nadine, Cauchy, Pierre, Assi, Salam A, Gilmour, Jane, Lie-A-Ling, Michael, Lichtinger, Monika, Hoogenkamp, Maarten, Noailles, Laura, Cockerill, Peter N, Lacaud, Georges, Kouskoff, Valerie, Bonifer, Constanze

“…The transmission of extracellular signals into the nucleus involves inducible transcription factors, but how different signalling pathways act in a cell…”
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The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival Autor Stanulović, Vesna S., Al Omair, Shorog, Reed, Michelle A.C., Roberts, Jennie, Potluri, Sandeep, Fulton-Ward, Taylor, Gudgeon, Nancy, Bishop, Emma L., Roels, Juliette, Perry, Tracey A., Sarkar, Sovan, Pratt, Guy, Taghon, Tom, Dimeloe, Sarah, Günther, Ulrich L., Ludwig, Christian, Hoogenkamp, Maarten

“…T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients have refractory…”
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Macrophage development from HSCs requires PU.1-coordinated microRNA expression Autor Ghani, Saeed, Riemke, Pia, Schönheit, Jörg, Lenze, Dido, Stumm, Jürgen, Hoogenkamp, Maarten, Lagendijk, Anne, Heinz, Sven, Bonifer, Constanze, Bakkers, Jeroen, Abdelilah-Seyfried, Salim, Hummel, Michael, Rosenbauer, Frank

“…The differentiation of HSCs into myeloid lineages requires the transcription factor PU.1. Whereas PU.1-dependent induction of myeloid-specific target genes has…”
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Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal Autor Ptasinska, Anetta, Assi, Salam A., Martinez-Soria, Natalia, Imperato, Maria Rosaria, Piper, Jason, Cauchy, Pierre, Pickin, Anna, James, Sally R., Hoogenkamp, Maarten, Williamson, Dan, Wu, Mengchu, Tenen, Daniel G., Ott, Sascha, Westhead, David R., Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze

“…Oncogenic transcription factors such as RUNX1/ETO, which is generated by the chromosomal translocation t(8;21), subvert normal blood cell development by…”
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C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis Autor van Oevelen, Chris, Collombet, Samuel, Vicent, Guillermo, Hoogenkamp, Maarten, Lepoivre, Cyrille, Badeaux, Aimee, Bussmann, Lars, Sardina, Jose Luis, Thieffry, Denis, Beato, Miguel, Shi, Yang, Bonifer, Constanze, Graf, Thomas

“…Transcription-factor-induced somatic cell conversions are highly relevant for both basic and clinical research yet their mechanism is not fully understood and…”
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Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome Autor Zatyka, Malgorzata, Rosenstock, Tatiana R., Sun, Congxin, Palhegyi, Adina M., Hughes, Georgina W., Lara-Reyna, Samuel, Astuti, Dewi, di Maio, Alessandro, Sciauvaud, Axel, Korsgen, Miriam E., Stanulovic, Vesna, Kocak, Gamze, Rak, Malgorzata, Pourtoy-Brasselet, Sandra, Winter, Katherine, Varga, Thiago, Jarrige, Margot, Polvèche, Hélène, Correia, Joao, Frickel, Eva-Maria, Hoogenkamp, Maarten, Ward, Douglas G., Aubry, Laetitia, Barrett, Timothy, Sarkar, Sovan

“…Mitochondrial dysfunction involving mitochondria-associated ER membrane (MAM) dysregulation is implicated in the pathogenesis of late-onset neurodegenerative…”
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Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells Autor Leddin, Mathias, Perrod, Chiara, Hoogenkamp, Maarten, Ghani, Saeed, Assi, Salam, Heinz, Sven, Wilson, Nicola K, Follows, George, Schönheit, Jörg, Vockentanz, Lena, Mosammam, Ali M, Chen, Wei, Tenen, Daniel G, Westhead, David R, Göttgens, Berthold, Bonifer, Constanze, Rosenbauer, Frank

“…The transcription factor PU.1 occupies a central role in controlling myeloid and early B-cell development, and its correct lineage-specific expression is…”
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PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element Autor Ebralidze, Alexander K, Guibal, Florence C, Steidl, Ulrich, Zhang, Pu, Lee, Sanghoon, Bartholdy, Boris, Jorda, Meritxell Alberich, Petkova, Victoria, Rosenbauer, Frank, Huang, Gang, Dayaram, Tajhal, Klupp, Johanna, O'Brien, Karen B, Will, Britta, Hoogenkamp, Maarten, Borden, Katherine L B, Bonifer, Constanze, Tenen, Daniel G

“…The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and…”
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Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program Autor Hoogenkamp, Maarten, Lichtinger, Monika, Krysinska, Hanna, Lancrin, Christophe, Clarke, Deborah, Williamson, Andrew, Mazzarella, Luca, Ingram, Richard, Jorgensen, Helle, Fisher, Amanda, Tenen, Daniel G, Kouskoff, Valerie, Lacaud, Georges, Bonifer, Constanze

“…At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the…”
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Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature Autor Cauchy, Pierre, James, Sally R., Zacarias-Cabeza, Joaquin, Ptasinska, Anetta, Imperato, Maria Rosaria, Assi, Salam A., Piper, Jason, Canestraro, Martina, Hoogenkamp, Maarten, Raghavan, Manoj, Loke, Justin, Akiki, Susanna, Clokie, Samuel J., Richards, Stephen J., Westhead, David R., Griffiths, Michael J., Ott, Sascha, Bonifer, Constanze, Cockerill, Peter N.

“…Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect the epigenetic regulatory machinery and signaling molecules, leading to a…”
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The Histone Methyltransferase KMT2B Is Required for RNA Polymerase II Association and Protection from DNA Methylation at the MagohB CpG Island Promoter Autor Ladopoulos, Vasileios, Hofemeister, Helmut, Hoogenkamp, Maarten, Riggs, Arthur D., Stewart, A. Francis, Bonifer, Constanze

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A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene Autor Krysinska, Hanna, Hoogenkamp, Maarten, Ingram, Richard, Wilson, Nicola, Tagoh, Hiromi, Laslo, Peter, Singh, Harinder, Bonifer, Constanze

“…Hematopoietic stem cells and multipotent progenitors exhibit low-level transcription and partial chromatin reorganization of myeloid cell-specific genes…”
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Functional differences between the long terminal repeat transcriptional promoters of human immunodeficiency virus type 1 subtypes A through G Autor Jeeninga, R E, Hoogenkamp, M, Armand-Ugon, M, de Baar, M, Verhoef, K, Berkhout, B

“…The current human immunodeficiency virus type 1 (HIV-1) shows an increasing number of distinct viral subtypes, as well as viruses that are recombinants of at…”
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The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis Autor Hoogenkamp, Maarten, Krysinska, Hanna, Ingram, Richard, Huang, Gang, Barlow, Rachael, Clarke, Deborah, Ebralidze, Alexander, Zhang, Pu, Tagoh, Hiromi, Cockerill, Peter N, Tenen, Daniel G, Bonifer, Constanze

“…The Ets family transcription factor PU.1 is crucial for the regulation of hematopoietic development. Pu.1 is activated in hematopoietic stem cells and is…”
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cis-Regulatory Remodeling of the SCL Locus during Vertebrate Evolution Autor Göttgens, Berthold, Ferreira, Rita, Sanchez, Maria-José, Ishibashi, Shoko, Li, Juan, Spensberger, Dominik, Lefevre, Pascal, Ottersbach, Katrin, Chapman, Michael, Kinston, Sarah, Knezevic, Kathy, Hoogenkamp, Maarten, Follows, George A., Bonifer, Constanze, Amaya, Enrique, Green, Anthony R.

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Differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene Autor Lefevre, Pascal, Lacroix, Claire, Tagoh, Hiromi, Hoogenkamp, Maarten, Melnik, Svitlana, Ingram, Richard, Bonifer, Constanze

“…It is now well established that locus-wide chromatin remodeling and dynamic alterations of histone modifications are required for the developmentally regulated…”
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Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer Autor Hantusch, Brigitte, Kenner, Lukas, Stanulović, Vesna S., Hoogenkamp, Maarten, Brown, Geoffrey

“…The nuclear hormone family of receptors regulates gene expression. The androgen receptor (AR), upon ligand binding and homodimerization, shuttles from the…”
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The role of proximal-enhancer elements in the glucocorticoid regulation of carbamoylphosphate synthetase gene transcription from the upstream response unit Autor Schoneveld, Onard J.L.M., Gaemers, Ingrid C., Hoogenkamp, Maarten, Lamers, Wouter H.

“…As part of the urea cycle, carbamoylphosphate synthetase (CPS) converts toxic ammonia resulting from amino-acid catabolism into urea. Liver-specific and…”
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