Suchergebnisse - "Hoogendijk, A J"

Host defence during Klebsiella pneumonia relies on haematopoietic-expressed Toll-like receptors 4 and 2 von Wieland, C W, van Lieshout, M H P, Hoogendijk, A J, van der Poll, T

“… In this study, the relative roles of Toll-like receptor (TLR)2 and TLR4 were investigated independently and together. Moreover, we studied the role of …”
Weitere Angaben

Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients von Dickson, Robert P, Schultz, Marcus J, van der Poll, Tom, Schouten, Laura R, Falkowski, Nicole R, Luth, Jenna E, Sjoding, Michael W, Brown, Christopher A, Chanderraj, Rishi, Huffnagle, Gary B, Bos, Lieuwe D J

“… Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance …”
Weitere Angaben

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis von Bos, L D, Schouten, L R, van Vught, L A, Wiewel, M A, Ong, D S Y, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A J, van der Poll, T, Horn, J, Juffermans, N, Calfee, C S, Schultz, M J

“… RationaleWe hypothesised that patients with acute respiratory distress syndrome (ARDS) can be clustered based on concentrations of plasma biomarkers and that …”
Volltext

Specific proteome changes in platelets from individuals with GATA1-, GFI1B- and RUNX1-linked bleeding disorders von van Bergen, Maaike G J M, Marneth, Anna E, Hoogendijk, Arie J, van Alphen, Floris, van den Akker, Emile, Laros-van Gorkom, Britta, Hoeks, Marlijn, Simons, Annet, de Munnik, Sonja, Janssen, Jeroen Jwm, Martens, Joost, Jansen, Joop H, Meijer, Alexander B, Van der Reijden, Bert A

“… Mutations in the transcription factors GATA1, GFI1B and RUNX1 (GATA Binding Factor 1, Growth Factor Independence 1B, Runt-related transcription factor 1) cause …”
Weitere Angaben

Platelet and endothelial cell P‐selectin are required for host defense against Klebsiella pneumoniae‐induced pneumosepsis von Stoppelaar, S. F., Veer, C., Roelofs, J. J. T. H., Claushuis, T. A. M., Boer, O. J., Tanck, M. W. T., Hoogendijk, A. J., Poll, T.

“… Summary Background Sepsis is associated with activation of platelets and endothelial cells accompanied by enhanced P‐selectin surface expression. Both …”
Volltext

Hieratic, Demotic and Greek Studies and Text Editions: Of Making Many Books There Is No End: Festschrift in Honour of Sven P. Vleeming von Donker van Heel, K. (Koenraad), Hoogendijk, F. A. J., Martin, Cary J

“… This volume is a Festschrift in honour of Sven Vleeming containing the contributions of thirty-eight friends and colleagues, often renowned specialists in …”
Volltext

Alkaline phosphatase in pulmonary inflammation—a translational study in ventilated critically ill patients and rats von Juschten, Jenny, Ingelse, Sarah A., Bos, Lieuwe D. J., Girbes, Armand R. J., Juffermans, Nicole P., van der Poll, Tom, Schultz, Marcus J., Tuinman, Pieter Roel

“… Background Alkaline phosphatase (AP), a dephosphorylating enzyme, is involved in various physiological processes and has been shown to have anti-inflammatory …”
Volltext

Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response von Schouten, Laura R. A., Bos, Lieuwe D. J., Serpa Neto, A., van Vught, Lonneke A., Wiewel, Maryse A., Hoogendijk, Arie J., Bonten, Marc J. M., Cremer, Olaf L., Horn, Janneke, van der Poll, Tom, Schultz, Marcus J., Wösten-van Asperen, Roelie M.

“… Background Advanced age is associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. Preclinical studies suggest that the …”
Volltext

The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients von de Beer, Friso M., Wieske, Luuk, van Mierlo, Gerard, Wouters, Diana, Zeerleder, Sacha, Bos, Lieuwe D., Juffermans, Nicole P., Schultz, Marcus J., van der Poll, Tom, Lagrand, Wim K., Horn, Janneke

“… Background Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures …”
Volltext

Prognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia—insights from the MARS study von Simonis, Fabienne D., Schouten, Laura R. A., Cremer, Olaf L., Ong, David S. Y., Amoruso, Gabriele, Cinella, Gilda, Schultz, Marcus J., Bos, Lieuwe D.

“… Background Outcome prediction in patients with acute respiratory distress syndrome (ARDS) greatly improves when patients are reclassified based on predefined …”
Volltext

Reduced responsiveness of blood leukocytes to lipopolysaccharide does not predict nosocomial infections in critically ill patients von Van Vught, LA, Wiewel, MA, Hoogendijk, AJ, Scicluna, BP, Belkasim, H, Horn, J, Schultz, MJ, Van der Poll, T

“… Keywords: Tumor Necrosis Factor, Healthy Individual, Culture Supernatant, Systemic Inflammatory Response Syndrome, Nosocomial Infection …”
Volltext

Effect of admission hyperglycemia in sepsis patients with or without a history of diabetes von Vught, LA Van, Wiewel, MA, Klouwenberg, PM Klein, Hoogendijk, AJ, Ong, DS, Cremer, OL, Bonten, MJ, Schultz, MJ, Van der Poll, T

“… The objective of this study was to investigate whether hyperglycemia on admission to the ICU impacts presentation and outcome of sepsis patients and whether …”
Volltext

Antiplatelet therapy does not influence outcome or host response biomarkers during sepsis: a propensity-matched analysis von Wiewel, MA, De Stoppelaar, SF, Van Vught, LA, Frencken, JF, Hoogendijk, AJ, Klouwenberg, PM Klein, Horn, J, Bonten, MJ, Schultz, MJ, Zwinderman, AH, Cremer, OL, Van der Poll, T

“… Keywords: Clopidogrel, Propensity Score, Dipyridamole, Antiplatelet Therapy, Host Response …”
Volltext

Persistent alveolar inflammatory response in critically ill patients with COVID-19 is associated with mortality von de Brabander, Justin, Boers, Leonoor S, Kullberg, Robert F J, Zhang, Shiqi, Nossent, Esther J, Heunks, Leo M A, Vlaar, Alexander P J, Bonta, Peter I, Schultz, Marcus J, van der Poll, Tom, Duitman, JanWillem, Nossent, E J, Duitman, J W, Saris, A, de Vries, H, Meijboom, L J, Bos, L D J, Reijnders, T D Y, Bontkes, H, Vlaar, A P J, Wiersinga, W J, Lutter, R, van der Poll, T, Bogaard, H J, Heunks, L, Algera, A G, Baarle, F, Beudel, M, Bomers, M, Bonta, P, Bos, L D, Botta, M, de Brabander, J, de Bree, G, de Bruin, S, Bugiani, M, Bulle, E, Buis, D T P, Chouchane, O, Cloherty, A, Dijkstra, M, Dongelmans, D A, Dujardin, R W G, Elbers, P, Fleuren, L, Geerlings, S, Geijtenbeek, T, Girbes, A, Goorhuis, B, Harris, V, Hemke, R, Hermans, S M, Horn, J, de Jong, M D, Koning, R, Lim, E H T, van Mourik, N, Nellen, J, Paulus, F, Peters, E, Pina-Fuentes, D A I, Preckel, B, Prins, J M, Raasveld, J, Reijnders, T, J de Rotte, M C F, Schinkel, M, Schultz, M J, Schrauwen, F A P, Schuurman, A, Schuurmans, J, Sigaloff, K, Slim, M A, Smeele, P, Smit, M, Stijnis, C S, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A M, Tuinman, P R, van der Valk, M, Volleman, C, van Vugt, M, Wouters, D, Zwinderman, A H, Brouwer, M C, van de Beek, D, de Beer, F M, Claushuis, T A, Glas, G J, Hoogendijk, A J, van Hooijdonk, R T, Huson, M A, Juffermans, N P, Scicluna, B, Schouten, L R, van der Sluijs, K F, Wiewel, M A, Witteveen, E

“… IntroductionPatients with COVID-19-related acute respiratory distress syndrome (ARDS) show limited systemic hyperinflammation, but immunomodulatory treatments …”
Volltext

Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice von de Stoppelaar, S F, Van't Veer, C, van den Boogaard, F E, Nieuwland, R, Hoogendijk, A J, de Boer, O J, Roelofs, J J T H, van der Poll, T

“… Streptococcus pneumoniae is a common causative pathogen of pneumonia and sepsis. Pneumonia and sepsis are associated with enhanced activation of coagulation, …”
Weitere Angaben

Cyclin-dependent kinase inhibitor r-roscovitine reduces lipoteichoic acid lung inflammation and improves the resolution of antibiotic-treated Streptococcus pneumoniae pneumonia von Hoogendijk, AJ, Roelofs, JJTH, van Lieshout, MHP, Blok, DC, Poll, T van der, Wieland, CW

Volltext