Výsledky vyhľadávania - "Hoang, Stephen A."

Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease Autor Hoang, Stephen A., Oseini, Abdul, Feaver, Ryan E., Cole, Banumathi K., Asgharpour, Amon, Vincent, Robert, Siddiqui, Mohammad, Lawson, Mark J., Day, Nathan C., Taylor, Justin M., Wamhoff, Brian R., Mirshahi, Faridoddin, Contos, Melissa J., Idowu, Michael, Sanyal, Arun J.

“…The heterogeneity of biological processes driving the severity of nonalcoholic fatty liver disease (NAFLD) as reflected in the transcriptome and the…”
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The Network Architecture of the Saccharomyces cerevisiae Genome Autor Hoang, Stephen A., Bekiranov, Stefan

“…We propose a network-based approach for surmising the spatial organization of genomes from high-throughput interaction data. Our strategy is based on methods…”
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Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis Autor Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.

“…Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared…”
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Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response Autor Roller, Devin G., Hoang, Stephen A., Rawls, Kristopher D., Owen, Katherine A., Simmers, Michael B., Figler, Robert A., Wulfkuhle, Julia D., Petricoin, Emanuel F., Wamhoff, Brian R., Gioeli, Daniel

“…Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs…”
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Quantification of histone modification ChIP-seq enrichment for data mining and machine learning applications Autor Hoang, Stephen A, Xu, Xiaojiang, Bekiranov, Stefan

“…Background The advent of ChIP-seq technology has made the investigation of epigenetic regulatory networks a computationally tractable problem. Several groups…”
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Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes Autor Collado, M. Sol, Armstrong, Allison J., Olson, Matthew, Hoang, Stephen A., Day, Nathan, Summar, Marshall, Chapman, Kimberly A., Reardon, John, Figler, Robert A., Wamhoff, Brian R.

“…Propionic acidemia (PA) and methylmalonic acidemia (MMA) are autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, which are caused by a…”
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Activin upregulation by NF-κB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer Autor Wamsley, J Jacob, Kumar, Manish, Allison, David F, Clift, Sheena H, Holzknecht, Caitlyn M, Szymura, Szymon J, Hoang, Stephen A, Xu, Xiaojiang, Moskaluk, Christopher A, Jones, David R, Bekiranov, Stefan, Mayo, Marty W

“…Soluble growth factors and cytokines within the tumor microenvironment aid in the induction of the epithelial-to-mesenchymal transition (EMT). Although EMT…”
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Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells Autor Gioeli, Daniel, Snow, Chelsi J, Simmers, Michael B, Hoang, Stephen A, Figler, Robert A, Allende, J Ashe, Roller, Devin G, Parsons, J Thomas, Wulfkuhle, Julia D, Petricoin, Emanuel F, Bauer, Todd W, Wamhoff, Brian R

“…The development of drugs to treat cancer is hampered by the inefficiency of translating pre-clinical in vitro monoculture and mouse studies into clinical…”
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Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia Autor Armstrong, Allison J, Henke, Brad R, Collado, Maria Sol, Taylor, Justin M, Pourtaheri, Taylor D, Dillberger, John E, Roper, Thomas D, Wamhoff, Brian R, Olson, Matthew W, Figler, Robert A, Hoang, Stephen A, Reardon, John E, Johns, Brian A

“…Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in…”
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A novel small molecule approach for the treatment of propionic and methylmalonic acidemias Autor Armstrong, Allison J., Collado, Maria Sol, Henke, Brad R., Olson, Matthew W., Hoang, Stephen A., Hamilton, Christin A., Pourtaheri, Taylor D., Chapman, Kimberly A., Summar, Marshall M., Johns, Brian A., Wamhoff, Brian R., Reardon, John E., Figler, Robert A.

“…Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine…”
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Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis Autor Feaver, Ryan E., Cole, Banumathi K., Lawson, Mark J., Hoang, Stephen A., Marukian, Svetlana, Blackman, Brett R., Figler, Robert A., Sanyal, Arun J., Wamhoff, Brian R., Dash, Ajit

“…A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver…”
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Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes Autor Chapman, Kimberly A., Collado, Maria S., Figler, Robert A., Hoang, Stephen A., Armstrong, Allison J., Cui, Wanxing, Purdy, Michael, Simmers, Michael B., Yazigi, Nada A., Summar, Marshall L., Wamhoff, Brian R., Dash, Ajit

“…Propionic acidemia (PA) is a disorder of intermediary metabolism with defects in the alpha or beta subunits of propionyl CoA carboxylase (PCCA and PCCB…”
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Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition Autor Cieślik, Marcin, Hoang, Stephen A, Baranova, Natalya, Chodaparambil, Sanjay, Kumar, Manish, Allison, David F, Xu, Xiaojiang, Wamsley, J Jacob, Gray, Lisa, Jones, David R, Mayo, Marty W, Bekiranov, Stefan

“…Background The epithelial-mesenchymal transition (EMT) is a de-differentiation process required for wound healing and development. In tumors of epithelial…”
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The Network Architecture of the Saccharomyces cerevisiae Genome: e81972 Autor Hoang, Stephen A, Bekiranov, Stefan

“…We propose a network-based approach for surmising the spatial organization of genomes from high-throughput interaction data. Our strategy is based on methods…”
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Hepatic isomiR landscaping reveals new biological insights into metabolic dysfunction in steatotic liver disease Autor Brion, Christian, Hoang, Stephen A., Wang, Guangliang, Mirshahi, Faridodin, Ang, Jessie, Long, Matthew R., Zhu, Zheng, Sakhamuri, Bhanu, Srour, Molly A., Siddiqui, Mohammad S., Asgharpour, Amon, Hayes, David J., Foster, Neal C., Salzman, David W., Sanyal, Arun J.

“…Post-transcriptionally modified microRNA (miRNA), called isomiRs, expand the repertoire of transcripts that can leveraged for therapeutic targets and…”
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