Suchergebnisse - "Ho, A.W."

Human Bone Marrow‐Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis von Ho, Ivy A.W., Toh, Han C, Ng, Wai H., Teo, Yuan L., Guo, Chang M., Hui, Kam M., Lam, Paula Y.P.

“… Tumor tropism of human bone marrow‐derived mesenchymal stem cells (MSC) has been exploited for the delivery of therapeutic genes for anticancer therapy …”
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Relationship of Stress, Distress, and Inadequate Coping Behaviors to Periodontal Disease von Genco, R.J., Ho, A.W., Grossi, S.G., Dunford, R.G., Tedesco, L.A.

“… Background: The association of stress, distress, and coping behaviors with periodontal disease was assessed. Methods: A cross‐sectional study of 1,426 subjects …”
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Angiopoietin: a TIE(d) balance in tumor angiogenesis von Shim, Winston S N, Ho, Ivy A W, Wong, Philip E H

“… Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have wide-ranging effects on tumor malignancy that includes angiogenesis, …”
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Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss von Grossi, S G, Genco, R J, Machtei, E E, Ho, A W, Koch, G, Dunford, R, Zambon, J J, Hausmann, E

“… This study examined the risk indicators for alveolar bone loss associated with periodontal infection. A cross-section of 1,361 subjects aged 25 to 74 years, …”
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Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity von Ho, Ivy A. W., Shim, Winston

“… Glioblastoma is the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the heterogeneous nature of the tumor, which in addition …”
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The Impact of Metabolic Rewiring in Glioblastoma: The Immune Landscape and Therapeutic Strategies von Vijayanathan, Yuganthini, Ho, Ivy A. W.

“… Glioblastoma (GBM) is an aggressive brain tumor characterized by extensive metabolic reprogramming that drives tumor growth and therapeutic resistance. Key …”
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Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme von Newman, Jennifer P., Wang, Grace Y., Arima, Kazuhiko, Guan, Shou P., Waters, Michael R., Cavenee, Webster K., Pan, Edward, Aliwarga, Edita, Chong, Siao T., Kok, Catherine Y. L., Endaya, Berwini B., Habib, Amyn A., Horibe, Tomohisa, Ng, Wai H., Ho, Ivy A. W., Hui, Kam M., Kordula, Tomasz, Lam, Paula Y. P.

“… The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is …”
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Cigarette Smoking Increases the Risk for Subgingival Infection With Periodontal Pathogens von Zambon, J J, Grossi, S G, Machtei, E E, Ho, A W, Dunford, R, Genco, R J

“… Cigarette smoking has been found to increase the risk for periodontitis. The present study examined the association between cigarette smoking and subgingival …”
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Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness von Fadhlullah, Siti Farah Bte, Halim, Nurashikin Bte Abdul, Yeo, Jacqueline Y. T., Ho, Rachel L. Y., Um, Phoebe, Ang, Beng Ti, Tang, Carol, Ng, Wai H., Virshup, David M., Ho, Ivy A. W.

“… Glioblastoma (GBM) is the most aggressive tumor of the brain. NF1 , a tumor suppressor gene and RAS-GTPase, is one of the highly mutated genes in GBM …”
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Recent Advances in Glioma Therapy: Combining Vascular Normalization and Immune Checkpoint Blockade von Ho, Rachel L. Y., Ho, Ivy A. W.

“… Glioblastoma (GBM) accounts for more than 50% of all primary malignancies of the brain. Current standard treatment regimen for GBM includes maximal surgical …”
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Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling von Yulyana, Yulyana, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Toh, Xin Yi, Endaya, Berwini B, Chan, Jerry K Y, Gnecchi, Massimiliano, Huynh, Hung, Chung, Alexander Y F, Lim, Kiat Hon, Leong, Hui Sun, Iyer, Narayanan Gopalakrishna, Hui, Kam Man, Lam, Paula Y P

“… Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world. The multikinase inhibitor sorafenib only demonstrated marginal …”
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Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow‐Derived Mesenchymal Stem Cells Toward Human Glioma von Ho, Ivy A. W., Chan, Kelly Y. W., Ng, Wai‐Hoe, Guo, Chang M., Hui, Kam M., Cheang, Philip, Lam, Paula Y. P.

“… Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise …”
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Matrix metalloproteinase-1-mediated mesenchymal stem cell tumor tropism is dependent on crosstalk with stromal derived growth factor 1/C-X-C chemokine receptor 4 axis von Ho, Ivy A W, Yulyana, Yulyana, Sia, Kian C, Newman, Jennifer P, Guo, Chang M, Hui, Kam M, Lam, Paula Y P

“… Human bone marrow-derived mesenchymal stem cells (MSCs) have the unique ability to home toward injuries or tumor sites. We have previously shown that the …”
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Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme von Yulyana, Yulyana, Tovmasyan, Artak, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Ng, Wai Hoe, Guo, Chang Ming, Hui, Kam Man, Batinic-Haberle, Ines, Lam, Paula Y P

“… Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant …”
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Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status von Chong, Dawn Q, Toh, Xin Y, Ho, Ivy AW, Sia, Kian C, Newman, Jennifer P, Yulyana, Yulyana, Ng, Wai-Hoe, Lai, Siang H, Ho, Mac MF, Dinesh, Nivedh, Tham, Chee K, Lam, Paula YP

“… Background The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. The 5-year survival rate of patients with GBM is less than 3% …”
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Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma von Yulyana, Yulyana, Endaya, Berwini B, Ng, Wai H, Guo, Chang M, Hui, Kam M, Lam, Paula Y P, Ho, Ivy A W

“… Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme …”
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Nanosized bioceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen von Tan, K, Cheang, P, Ho, I A W, Lam, P Y P, Hui, K M

“… We have compared the ability of several nanosized bioceramic particles including negatively charged silica (SiO 2 ), neutrally charged hydroxyapatite (HA) and …”
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Isolation of peptide ligands that interact specifically with human glioma cells von Ho, Ivy A.W., Hui, Kam M., Lam, Paula Y.P.

“… Poor prognosis of high grade gliomas coupled with the difficulty of widespread delivery of therapeutic agents prompted the search into new molecular targets …”
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Hybrid herpes simplex virus/Epstein-Barr virus amplicon viral vectors confer enhanced transgene expression in primary human tumors and human bone marrow-derived mesenchymal stem cells von Sia, Kian Chuan, Chong, Wei Kin, Ho, Ivy A. W., Yulyana, Yulyana, Endaya, Berwini, Huynh, Hung, Lam, Paula Y. P.

“… Background Herpes simplex virus type‐1 (HSV‐1) amplicon vectors are attractive tools for gene transfer because of their large DNA insert capacity, their broad …”
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An Efficient and Safe Herpes Simplex Virus Type 1 Amplicon Vector for Transcriptionally Targeted Therapy of Human Hepatocellular Carcinomas von Lam, Paula YP, Sia, Kian Chuan, Khong, Jenn H, Geest, Bart De, Lim, Kar S, Ho, Ivy AW, Wang, Grace Y, Miao, Lv, Huynh, H, Hui, Kam M

“… Our previous studies have shown that transgene expression could be targeted to proliferating cells when cell cycle transcriptional regulatory elements were …”
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