Výsledky vyhľadávania - "Hille, Bertil"

Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids Autor Dickson, Eamonn J, Hille, Bertil

“…Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small…”
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Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage Autor Vivas, Oscar, Moreno, Claudia M, Santana, Luis F, Hille, Bertil

“…CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional…”
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Optogenetic control of phosphoinositide metabolism Autor Idevall-Hagren, Olof, Dickson, Eamonn J, Hille, Bertil, Toomre, Derek K, De Camilli, Pietro

“…Phosphoinositides (PIs) are lipid components of cell membranes that regulate a wide variety of cellular functions. Here we exploited the blue light-induced…”
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Fatty-acyl chain profiles of cellular phosphoinositides Autor Traynor-Kaplan, Alexis, Kruse, Martin, Dickson, Eamonn J., Dai, Gucan, Vivas, Oscar, Yu, Haijie, Whittington, Dale, Hille, Bertil

“…Phosphoinositides are rapidly turning-over phospholipids that play key roles in intracellular signaling and modulation of membrane effectors. Through technical…”
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Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current Autor Dickson, Eamonn J, Jensen, Jill B, Hille, Bertil

“…Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regulates the activity of many ion channels and other membrane-associated proteins. To…”
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High membrane permeability for melatonin Autor Yu, Haijie, Dickson, Eamonn J, Jung, Seung-Ryoung, Koh, Duk-Su, Hille, Bertil

“…The pineal gland, an endocrine organ in the brain, synthesizes and secretes the circulating night hormone melatonin throughout the night. The literature states…”
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The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins Autor Lauckner, Jane E, Hille, Bertil, Mackie, Ken

“…Central nervous system responses to cannabis are primarily mediated by CB(1) receptors, which couple preferentially to G(i/o) G proteins. Here, we used calcium…”
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GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current Autor Lauckner, Jane E, Jensen, Jill B, Chen, Huei-Ying, Lu, Hui-Chen, Hille, Bertil, Mackie, Ken

“…The CB(1) cannabinoid receptor mediates many of the psychoactive effects of Delta(9)THC, the principal active component of cannabis. However, ample evidence…”
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Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides Autor Dickson, Eamonn J, Jensen, Jill B, Vivas, Oscar, Kruse, Martin, Traynor-Kaplan, Alexis E, Hille, Bertil

“…Endoplasmic reticulum-plasma membrane (ER-PM) contact sites play an integral role in cellular processes such as excitation-contraction coupling and…”
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Regulation of voltage-gated potassium channels by PI(4,5)P2 Autor Kruse, Martin, Hammond, Gerald R V, Hille, Bertil

“…Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) regulates activities of numerous ion channels including inwardly rectifying potassium (K(ir)) channels,…”
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Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells Autor Falkenburger, Björn H, Jensen, Jill B, Hille, Bertil

“…G protein-coupled receptors (GPCRs) mediate responses to external stimuli in various cell types. Early events, such as the binding of ligand and G proteins to…”
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Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding Autor Jung, Seung-Ryoung, Kushmerick, Christopher, Seo, Jong Bae, Koh, Duk-Su, Hille, Bertil

“…Binding of agonists to G-protein-coupled receptors (GPCRs) activates heterotrimeric G proteins and downstream signaling. Agonist-bound GPCRs are then…”
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Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate Autor Suh, Byung-Chang, Hille, Bertil

“…Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being…”
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Functional stoichiometry of the unitary calcium-release-activated calcium channel Autor Ji, Wei, Xu, Pingyong, Li, Zhengzheng, Lu, Jingze, Liu, Lin, Zhan, Yi, Chen, Yu, Hille, Bertil, Xu, Tao, Chen, Liangyi

“…Two proteins, STIM1 in the endoplasmic reticulum and Orai1 in the plasma membrane, are required for the activation of Ca(2+) release-activated Ca(2+) (CRAC)…”
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Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis Autor Walter, Alexander M, Müller, Rainer, Tawfik, Bassam, Wierda, Keimpe DB, Pinheiro, Paulo S, Nadler, André, McCarthy, Anthony W, Ziomkiewicz, Iwona, Kruse, Martin, Reither, Gregor, Rettig, Jens, Lehmann, Martin, Haucke, Volker, Hille, Bertil, Schultz, Carsten, Sørensen, Jakob Balslev

“…Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism,…”
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Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation Autor Myeong, Jongyun, de la Cruz, Lizbeth, Jung, Seung-Ryoung, Yeon, Jun-Hee, Suh, Byung-Chang, Koh, Duk-Su, Hille, Bertil

“…The dynamic metabolism of membrane phosphoinositide lipids involves several cellular compartments including the ER, Golgi, and plasma membrane. There are…”
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Reinterpretation of the substrate specificity of the voltage-sensing phosphatase during dimerization Autor Kruse, Martin, Kohout, Susy C, Hille, Bertil

“…Voltage-sensing phosphatases (VSPs) cleave both 3- and 5-phosphates from inositol phospholipids in response to membrane depolarization. When low concentrations…”
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Nerve growth factor sensitizes adult sympathetic neurons to the proinflammatory peptide bradykinin Autor Vivas, Oscar, Kruse, Martin, Hille, Bertil

“…Levels of nerve growth factor (NGF) are elevated in inflamed tissues. In sensory neurons, increases in NGF augment neuronal sensitivity (sensitization) to…”
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Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence Autor Keum, Dongil, Kruse, Martin, Kim, Dong-Il, Hille, Bertil, Suh, Byung-Chang

“…Voltage-sensing phosphatases (VSPs) are homologs of phosphatase and tensin homolog (PTEN), a phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] and…”
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Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis Autor Suh, Byung-Chang, Hille, Bertil

“…Suppression of M current channels by muscarinic receptors enhances neuronal excitability. Little is known about the molecular mechanism of this inhibition…”
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