Výsledky vyhľadávania - "Higgins, Geoff S."

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy Autor Ashton, Thomas M, McKenna, W Gillies, Kunz-Schughart, Leoni A, Higgins, Geoff S

“…Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is…”
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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? Autor Wilson, Joseph D., Hammond, Ester M., Higgins, Geoff S., Petersson, Kristoffer

“…Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these…”
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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells Autor Belan, Ondrej, Sebald, Marie, Adamowicz, Marek, Anand, Roopesh, Vancevska, Aleksandra, Neves, Joana, Grinkevich, Vera, Hewitt, Graeme, Segura-Bayona, Sandra, Bellelli, Roberto, Robinson, Helen M R, Higgins, Geoff S, Smith, Graeme C M, West, Stephen C, Rueda, David S, Boulton, Simon J

“…POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic…”
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Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities Autor Machado, Nicole D, Heather, Lisa C, Harris, Adrian L, Higgins, Geoff S

“…In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation…”
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia Autor Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“…Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that…”
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Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging Autor Ray, Kevin J, Simard, Manon A, Larkin, James R, Coates, James, Kinchesh, Paul, Smart, Sean C, Higgins, Geoff S, Chappell, Michael A, Sibson, Nicola R

“…Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance…”
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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability Autor Ruggiano, Annamaria, Vaz, Bruno, Kilgas, Susan, Popović, Marta, Rodriguez-Berriguete, Gonzalo, Singh, Abhay N., Higgins, Geoff S., Kiltie, Anne E., Ramadan, Kristijan

“…DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are covalently attached to DNA. Unrepaired DPCs lead to genomic instability,…”
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A role for human homologous recombination factors in suppressing microhomology-mediated end joining Autor Ahrabi, Sara, Sarkar, Sovan, Pfister, Sophia X., Pirovano, Giacomo, Higgins, Geoff S., Porter, Andrew C.G., Humphrey, Timothy C.

“…DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually…”
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Dose and Fractionation in Radiation Therapy of Curative Intent for Non-Small Cell Lung Cancer: Meta-Analysis of Randomized Trials Autor Ramroth, Johanna, Cutter, David J, Darby, Sarah C, Higgins, Geoff S, McGale, Paul, Partridge, Mike, Taylor, Carolyn W

“…The optimum dose and fractionation in radiation therapy of curative intent for non-small cell lung cancer remains uncertain. We undertook a published data…”
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CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner Autor Prevo, Remko, Pirovano, Giacomo, Puliyadi, Rathi, Herbert, Katharine J., Rodriguez-Berriguete, Gonzalo, O'Docherty, Alice, Greaves, William, McKenna, W. Gillies, Higgins, Geoff S.

“…Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has…”
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Timing of hypoxia PET/CT imaging after 18F-fluoromisonidazole injection in non-small cell lung cancer patients Autor Bourigault, Pauline, Skwarski, Michael, Macpherson, Ruth E., Higgins, Geoff S., McGowan, Daniel R.

“…Positron emission tomography (PET)/computed tomography (CT) using the radiotracer 18F-Fluoromisonidazole (FMISO) has been widely employed to image tumour…”
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Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models Autor Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Machado, Nicole, Barberis, Alessandro, Prevo, Remko, McLaughlin, Martin, Buffa, Francesca M., Harrington, Kevin J., Higgins, Geoff S.

“…Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer…”
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Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials Autor Coleman, C Norman, Higgins, Geoff S, Brown, J Martin, Baumann, Michael, Kirsch, David G, Willers, Henning, Prasanna, Pataje G S, Dewhirst, Mark W, Bernhard, Eric J, Ahmed, Mansoor M

“…There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving…”
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Drug radiotherapy combinations: Review of previous failures and reasons for future optimism Autor Higgins, Geoff S., O’Cathail, Sean M., Muschel, Ruth J., McKenna, W. Gillies

“…•Combined chemo-radiotherapy typically improves clinical outcomes but increases side-effects.•Trials with targeted radiosensitising and hypoxia modifying drugs…”
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UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment Autor Suwa, Tatsuya, Lee, Kelly SW, Chai, Ian J., Clark, Heather O. L., MacLean, David J., Machado, Nicole, Rodriguez-Berriguete, Gonzalo, Singh, Lolita, Higgins, Geoff S., Hammond, Ester M., Olcina, Monica M.

“…Dysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be…”
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Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients Autor Bourigault, Pauline, Skwarski, Michael, Macpherson, Ruth E., Higgins, Geoff S., McGowan, Daniel R.

“…Background Tumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation that the…”
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Repurposing radiosensitising medicines for radiotherapy: an overview Autor Low, Jie Man, Rodriguez-Berriguete, Gonzalo, Higgins, Geoff S

“…Repurposing established non-cancer drugs for the treatment of cancer offers potential benefits such as speed of clinical translation and financial…”
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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown Autor Higgins, Geoff S, Prevo, Remko, Lee, Yin-Fai, Helleday, Thomas, Muschel, Ruth J, Taylor, Steve, Yoshimura, Michio, Hickson, Ian D, Bernhard, Eric J, McKenna, W Gillies

“…The effectiveness of radiotherapy treatment could be significantly improved if tumor cells could be rendered more sensitive to ionizing radiation (IR) without…”
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Data-driven gating (DDG)-based motion match for improved CTAC registration Autor Cook, Ella L., Su, Kuan-Hao, Higgins, Geoff S., Johnsen, Robert, Bouhnik, Jean-Paul, McGowan, Daniel R.

“…Background Respiratory motion artefacts are a pitfall in thoracic PET/CT imaging. A source of these motion artefacts within PET images is the CT used for…”
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Overexpression of POLQ confers a poor prognosis in early breast cancer patients Autor Higgins, Geoff S, Harris, Adrian L, Prevo, Remko, Helleday, Thomas, McKenna, W Gillies, Buffa, Francesca M

“…Depletion of POLQ (DNA polymerase theta) has recently been shown to render tumour cells more sensitive to radiotherapy whilst having little or no effect on…”
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