Suchergebnisse - "Hicks, Andrew A"

A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics von Obergasteiger, Julia, Frapporti, Giulia, Pramstaller, Peter P., Hicks, Andrew A., Volta, Mattia

“… The combination of genetics and genomics in Parkinson´s disease has recently begun to unveil molecular mechanisms possibly underlying disease onset and …”
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Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids von Ameur, Adam, Enroth, Stefan, Johansson, Asa, Zaboli, Ghazal, Igl, Wilmar, Johansson, Anna C V, Rivas, Manuel A, Daly, Mark J, Schmitz, Gerd, Hicks, Andrew A, Meitinger, Thomas, Feuk, Lars, van Duijn, Cornelia, Oostra, Ben, Pramstaller, Peter P, Rudan, Igor, Wright, Alan F, Wilson, James F, Campbell, Harry, Gyllensten, Ulf

“… Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for the development and function of the human brain. They can be obtained …”
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Modeling Parkinson’s disease in midbrain-like organoids von Smits, Lisa M., Reinhardt, Lydia, Reinhardt, Peter, Glatza, Michael, Monzel, Anna S., Stanslowsky, Nancy, Rosato-Siri, Marcelo D., Zanon, Alessandra, Antony, Paul M., Bellmann, Jessica, Nicklas, Sarah M., Hemmer, Kathrin, Qing, Xiaobing, Berger, Emanuel, Kalmbach, Norman, Ehrlich, Marc, Bolognin, Silvia, Hicks, Andrew A., Wegner, Florian, Sterneckert, Jared L., Schwamborn, Jens C.

“… Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored …”
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Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegans von Vozdek, Roman, Pramstaller, Peter P., Hicks, Andrew A.

“… Idiopathic Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic (DA) neurons during aging. The pathological hallmark of PD is the Lewy …”
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Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease von Gilmozzi, Valentina, Gentile, Giovanna, Castelo Rueda, Maria Paulina, Hicks, Andrew A., Pramstaller, Peter P., Zanon, Alessandra, Lévesque, Martin, Pichler, Irene

“… Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease …”
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Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number von Koller, Adriana, Filosi, Michele, Weissensteiner, Hansi, Fazzini, Federica, Gorski, Mathias, Pattaro, Cristian, Schönherr, Sebastian, Forer, Lukas, Herold, Janina M., Stark, Klaus J., Döttelmayer, Patricia, Hicks, Andrew A., Pramstaller, Peter P., Würzner, Reinhard, Eckardt, Kai-Uwe, Heid, Iris M., Fuchsberger, Christian, Lamina, Claudia, Kronenberg, Florian

“… Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction associated with several diseases. Previous genome-wide association …”
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The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism von Demetz, Egon, Schroll, Andrea, Auer, Kristina, Heim, Christiane, Patsch, Josef R, Eller, Philipp, Theurl, Markus, Theurl, Igor, Theurl, Milan, Seifert, Markus, Lener, Daniela, Stanzl, Ursula, Haschka, David, Asshoff, Malte, Dichtl, Stefanie, Nairz, Manfred, Huber, Eva, Stadlinger, Martin, Moschen, Alexander R, Li, Xiaorong, Pallweber, Petra, Scharnagl, Hubert, Stojakovic, Tatjana, März, Winfried, Kleber, Marcus E, Garlaschelli, Katia, Uboldi, Patrizia, Catapano, Alberico L, Stellaard, Frans, Rudling, Mats, Kuba, Keiji, Imai, Yumiko, Arita, Makoto, Schuetz, John D, Pramstaller, Peter P, Tietge, Uwe J F, Trauner, Michael, Norata, Giuseppe D, Claudel, Thierry, Hicks, Andrew A, Weiss, Guenter, Tancevski, Ivan

“… Cholesterol metabolism is closely interrelated with cardiovascular disease in humans. Dietary supplementation with omega-6 polyunsaturated fatty acids …”
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The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease von Soyal, Selma M., Zara, Greta, Ferger, Boris, Felder, Thomas K., Kwik, Markus, Nofziger, Charity, Dossena, Silvia, Schwienbacher, Christine, Hicks, Andrew A., Pramstaller, Peter P., Paulmichl, Markus, Weis, Serge, Patsch, Wolfgang

“… Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. PGC-1α, encoded by PPARGC1A, is a transcriptional co-activator that has …”
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A multi-omics study of circulating phospholipid markers of blood pressure von Liu, Jun, de Vries, Paul S., Del Greco M., Fabiola, Johansson, Åsa, Schraut, Katharina E., Hayward, Caroline, van Dijk, Ko Willems, Franco, Oscar. H., Hicks, Andrew A., Vitart, Veronique, Rudan, Igor, Campbell, Harry, Polašek, Ozren, Pramstaller, Peter P., Wilson, James F., Gyllensten, Ulf, van Duijn, Cornelia M., Dehghan, Abbas, Demirkan, Ayşe

“… High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct …”
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Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study von Pichler, Irene, Del Greco M., Fabiola, Gögele, Martin, Lill, Christina M., Bertram, Lars, Do, Chuong B., Eriksson, Nicholas, Foroud, Tatiana, Myers, Richard H., Nalls, Michael, Keller, Margaux F., Benyamin, Beben, Whitfield, John B., Pramstaller, Peter P., Hicks, Andrew A., Thompson, John R., Minelli, Cosetta

“… Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron …”
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Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2 von Zanon, Alessandra, Guida, Marianna, Lavdas, Alexandros A., Corti, Corrado, Castelo Rueda, Maria Paulina, Negro, Alessandro, Pramstaller, Peter P., Domingues, Francisco S., Hicks, Andrew A., Pichler, Irene

“… Background Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have …”
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A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function von Neely, G Gregory, Kuba, Keiji, Cammarato, Anthony, Isobe, Kazuya, Amann, Sabine, Zhang, Liyong, Murata, Mitsushige, Elmén, Lisa, Gupta, Vaijayanti, Arora, Suchir, Sarangi, Rinku, Dan, Debasis, Fujisawa, Susumu, Usami, Takako, Xia, Cui-ping, Keene, Alex C, Alayari, Nakissa N, Yamakawa, Hiroyuki, Elling, Ulrich, Berger, Christian, Novatchkova, Maria, Koglgruber, Rubina, Fukuda, Keiichi, Nishina, Hiroshi, Isobe, Mitsuaki, Pospisilik, J Andrew, Imai, Yumiko, Pfeufer, Arne, Hicks, Andrew A, Pramstaller, Peter P, Subramaniam, Sai, Kimura, Akinori, Ocorr, Karen, Bodmer, Rolf, Penninger, Josef M

“… Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 …”
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Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort von Castelo Rueda, Maria Paulina, Raftopoulou, Athina, Gögele, Martin, Borsche, Max, Emmert, David, Fuchsberger, Christian, Hantikainen, Essi M., Vukovic, Vladimir, Klein, Christine, Pramstaller, Peter P., Pichler, Irene, Hicks, Andrew A.

“… Mutations in the Parkin ( PRKN ) gene are the most frequent cause of autosomal recessive early-onset Parkinson's disease (PD). Heterozygous PRKN mutation …”
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Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations von Hicks, Andrew A., Pramstaller, Peter P., Johansson, Åsa, Vitart, Veronique, Rudan, Igor, Ugocsai, Peter, Aulchenko, Yurii, Franklin, Christopher S., Liebisch, Gerhard, Erdmann, Jeanette, Jonasson, Inger, Zorkoltseva, Irina V., Pattaro, Cristian, Hayward, Caroline, Isaacs, Aaron, Hengstenberg, Christian, Campbell, Susan, Gnewuch, Carsten, Janssens, A. CecileJ.W., Kirichenko, Anatoly V., König, Inke R., Marroni, Fabio, Polasek, Ozren, Demirkan, Ayse, Kolcic, Ivana, Schwienbacher, Christine, Igl, Wilmar, Biloglav, Zrinka, Witteman, Jacqueline C. M., Pichler, Irene, Zaboli, Ghazal, Axenovich, Tatiana I., Peters, Annette, Schreiber, Stefan, Wichmann, H.-Erich, Schunkert, Heribert, Hastie, Nick, Oostra, Ben A., Wild, Sarah H., Meitinger, Thomas, Gyllensten, Ulf, van Duijn, Cornelia M., Wilson, James F., Wright, Alan, Schmitz, Gerd, Campbell, Harry

“… Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several …”
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Profiling of Parkin-Binding Partners Using Tandem Affinity Purification von Zanon, Alessandra, Rakovic, Aleksandar, Blankenburg, Hagen, Doncheva, Nadezhda T., Schwienbacher, Christine, Serafin, Alice, Alexa, Adrian, Weichenberger, Christian X., Albrecht, Mario, Klein, Christine, Hicks, Andrew A., Pramstaller, Peter P., Domingues, Francisco S., Pichler, Irene

“… Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting approximately 1-2% of the general population over age 60. It is characterized by …”
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Exome-wide association study of levodopa-induced dyskinesia in Parkinson’s disease von König, Eva, Nicoletti, Alessandra, Pattaro, Cristian, Annesi, Grazia, Melotti, Roberto, Gialluisi, Alessandro, Schwienbacher, Christine, Picard, Anne, Blankenburg, Hagen, Pichler, Irene, Modugno, Nicola, Ciullo, Marina, Esposito, Teresa, Domingues, Francisco S., Hicks, Andrew A., Zappia, Mario, Pramstaller, Peter P.

“… Levodopa is the standard long-term dopamine replacement therapy to treat Parkinson’s disease (PD) symptoms. With time, levodopa may induce debilitating …”
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Localising Loci underlying Complex Trait Variation Using Regional Genomic Relationship Mapping von Nagamine, Yoshitaka, Pong-Wong, Ricardo, Navarro, Pau, Vitart, Veronique, Hayward, Caroline, Rudan, Igor, Campbell, Harry, Wilson, James, Wild, Sarah, Hicks, Andrew A., Pramstaller, Peter P., Hastie, Nicholas, Wright, Alan F., Haley, Chris S.

“… The limited proportion of complex trait variance identified in genome-wide association studies may reflect the limited power of single SNP analyses to detect …”
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Silencing of CCR4-NOT complex subunits affects heart structure and function von Elmén, Lisa, Volpato, Claudia B., Kervadec, Anaïs, Pineda, Santiago, Kalvakuri, Sreehari, Alayari, Nakissa N., Foco, Luisa, Pramstaller, Peter P., Ocorr, Karen, Rossini, Alessandra, Cammarato, Anthony, Colas, Alexandre R., Hicks, Andrew A., Bodmer, Rolf

“… The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly …”
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The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology von Obergasteiger, Julia, Castonguay, Anne-Marie, Pizzi, Sara, Magnabosco, Stefano, Frapporti, Giulia, Lobbestael, Evy, Baekelandt, Veerle, Hicks, Andrew A., Pramstaller, Peter P., Gravel, Claude, Corti, Corrado, Lévesque, Martin, Volta, Mattia

“… In Parkinson’s disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The …”
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Role of Ceramides and Sphingolipids in Parkinson's Disease von Vos, Melissa, Klein, Christine, Hicks, Andrew A

“… [Display omitted] •Sphingolipids are altered in Parkinson’s disease.•Ceramides affect mitochondrial function in relation to Parkinson’s disease.•Sphingolipids …”
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