Suchergebnisse - "Herrath, M."

CD4 T cell differentiation in type 1 diabetes von Walker, L. S. K., von Herrath, M.

“… Summary Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA) genes, implicating T cells in disease pathogenesis. In …”
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Progress in immune‐based therapies for type 1 diabetes von Herrath, M., Peakman, M., Roep, B.

“… Summary Immune‐based therapies that prevent type 1 diabetes or preserve metabolic function remaining at diagnosis have become a major objective for funding …”
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The diagnosis of insulitis in human type 1 diabetes von Campbell-Thompson, M. L., Atkinson, M. A., Butler, A. E., Chapman, N. M., Frisk, G., Gianani, R., Giepmans, B. N., von Herrath, M. G., Hyöty, H., Kay, T. W., Korsgren, O., Morgan, N. G., Powers, A. C., Pugliese, A., Richardson, S. J., Rowe, P. A., Tracy, S., In’t Veld, P. A.

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Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma von Coppieters, K. T., Wiberg, A., Tracy, S. M., von Herrath, M. G.

“… Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Metabolic diseases, host responses, cancer, autoinflammatory diseases, allergy …”
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Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group von Matthews, J.B, Staeva, T.P, Bernstein, P.L, Peakman, M, von Herrath, M

“… Like many other complex human disorders of unknown aetiology, autoimmune-mediated type 1 diabetes may ultimately be controlled via a therapeutic approach that …”
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Factors impeding the discovery of an intervention‐based treatment for type 1 diabetes von von Herrath, M. G., Korsgren, O., Atkinson, M. A.

“… Summary Type 1 diabetes (T1D) is one of the most common and severe chronic diseases affecting both children and adults. The aetiology of the disease remains …”
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Translational Mini-Review Series on Type 1 Diabetes: Immune-based therapeutic approaches for type 1 diabetes von Staeva-Vieira, T, Peakman, M, von Herrath, M

“… Type 1 diabetes (T1D) is often considered the prototype organ-specific autoimmune disease in clinical immunology circles. The key disease features - precise …”
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Dimorphic histopathology of long-standing childhood-onset diabetes von Gianani, R, Campbell-Thompson, M, Sarkar, S. A, Wasserfall, C, Pugliese, A, Solis, J. M, Kent, S. C, Hering, B. J, West, E, Steck, A, Bonner-Weir, S, Atkinson, M. A, Coppieters, K, von Herrath, M, Eisenbarth, G. S

“… Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells …”
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Moving towards efficient therapies in type 1 diabetes: To combine or not to combine? von Bresson, D., von Herrath, M.

“… Every year, thirty thousand people worldwide are diagnosed with type 1 diabetes mellitus (T1DM). T1DM, also called autoimmune diabetes, is a multifactorial …”
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Emerging immune therapies in type 1 diabetes and pancreatic islet transplantation von Schneider, D. A., Kretowicz, A. M., von Herrath, M. G.

“… In type 1 diabetes (T1D) the immune system attacks insulin‐producing pancreatic β‐cells. Unfortunately, our ability to curb this pathogenic autoimmune response …”
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IL-10 and the resolution of infections von Filippi, CM, von Herrath, MG

“… Chronic viral infections pose serious health concerns, as secondary complications such as immunodeficiencies and cancers are common. Treating such infections …”
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Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ von Fousteri, G, Dave, A, Bot, A, Juntti, T, Omid, S, von Herrath, M

“… Aims/hypothesis Subcutaneous immunisation with the 9-23 amino acid region of the insulin B chain (B:9-23) in incomplete Freund's adjuvant (IFA) can protect the …”
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How viral infections enhance or prevent type 1 diabetes-from mouse to man von von Herrath, M., Filippi, C., Coppieters, K.

“… More recent evidence shows that viral infections can enhance as well as prevent type 1 diabetes in experimental animal models [Filippi and von Herrath, 2010] …”
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Anti-thymoglobulin (ATG) treatment does not reverse type 1 diabetes in the acute virally induced rat insulin promoter-lymphocytic choriomeningitis virus (RIP-LCMV) model von Bresson, D, von Herrath, M.G

“… Immune modulators such as anti-thymoglobulin (ATG) are under clinical evaluation for the treatment of type 1 diabetes (T1D). Although such agents have cured …”
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P140 Les cellules alpha peuvent exprimer l’interleukine-1 (IL-1) bêta au cours du diabète de type 1 von Thivolet, C., Rodriguez Calvo, T., Von Herrath, M.

“… Le diabète 1 est une maladie bi-hormonale avec un déficit en insuline et une sécrétion de glucagon anormale. L’ensemble favorise l’instabilité glycémique. Dans …”
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99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Viruses, autoimmunity and immunoregulation von Filippi, C.M, von Herrath, M.G

“… Based on studies in animal models, viral infections, in particular by enteroviruses, can accelerate or halt type 1 diabetes (T1D) development. Among factors …”
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Incidental CD8 T cell reactivity against caspase‐cleaved apoptotic self‐antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen‐A2 transgenic non‐obese diabetic mice von Coppieters, K. T., Amirian, N., von Herrath, M. G.

“… Summary Apoptosis is known as a major mechanism which contributes to beta cell decay in type 1 diabetes. Commitment to this pathway generally involves …”
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Taking a closer look at the pancreas von Coppieters, K, von Herrath, M

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Mouse models for Type 1 Diabetes von Van Belle, T.L., Taylor, P., von Herrath, M.G.

“… Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s …”
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Animal models have little to teach us about Type 1 diabetes: 2. In opposition to this proposal von Leiter, E. H., von Herrath, M.

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