Výsledky vyhľadávania - "Herrador, Raquel"

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells Autor Zellweger, Ralph, Dalcher, Damian, Mutreja, Karun, Berti, Matteo, Schmid, Jonas A, Herrador, Raquel, Vindigni, Alessandro, Lopes, Massimo

“…Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in…”
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Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity Autor Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A, Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L, Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo

“…DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis,…”
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Topoisomerase I poisoning results in PARP-mediated replication fork reversal Autor Ray Chaudhuri, Arnab, Hashimoto, Yoshitami, Herrador, Raquel, Neelsen, Kai J, Fachinetti, Daniele, Bermejo, Rodrigo, Cocito, Andrea, Costanzo, Vincenzo, Lopes, Massimo

“…Topoisomerase 1 (Top1) inhibition is believed to mediate cellular toxicity by trapping Top1 on nicked DNA, leading to double-strand break formation during…”
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A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells Autor Ahuja, Akshay K., Jodkowska, Karolina, Teloni, Federico, Bizard, Anna H., Zellweger, Ralph, Herrador, Raquel, Ortega, Sagrario, Hickson, Ian D., Altmeyer, Matthias, Mendez, Juan, Lopes, Massimo

“…Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active…”
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Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates Autor Neelsen, Kai J, Zanini, Isabella M Y, Herrador, Raquel, Lopes, Massimo

“…Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes…”
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Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template Autor Neelsen, Kai J, Zanini, Isabella M Y, Mijic, Sofija, Herrador, Raquel, Zellweger, Ralph, Ray Chaudhuri, Arnab, Creavin, Kevin D, Blow, J Julian, Lopes, Massimo

“…Deregulated origin licensing and rereplication promote genome instability and tumorigenesis by largely elusive mechanisms. Investigating the consequences of…”
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Visualization and interpretation of eukaryotic DNA replication intermediates in vivo by electron microscopy Autor Neelsen, Kai J, Chaudhuri, Arnab Ray, Follonier, Cindy, Herrador, Raquel, Lopes, Massimo

“…The detailed understanding of the DNA replication process requires structural insight. The combination of psoralen cross-linking and electron microscopy has…”
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Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions Autor Follonier, Cindy, Oehler, Judith, Herrador, Raquel, Lopes, Massimo

“…Friedreich's ataxia is one of several hereditary neurodegenerative disorders caused expansion of trinucleotide repeats, but the mechanism of their genomic…”
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Poly(ADP-Ribosyl) Glycohydrolase Prevents the Accumulation of Unusual Replication Structures during Unperturbed S Phase Autor Ray Chaudhuri, Arnab, Ahuja, Akshay Kumar, Herrador, Raquel, Lopes, Massimo

“…Poly(ADP-ribosyl)ation (PAR) has been implicated in various aspects of the cellular response to DNA damage and genome stability. Although 17 human…”
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P101 NURSING VISIT UTILITY PRIOR TO SCS Autor Munoz, Alba Vivas, Pérez, Miriam, Monzón, Eva, Abad, Cristina, Herrador, Raquel, Diaz-Hellín, Helena, Fernández, Monica, Abejón, David

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