Suchergebnisse - "Herman, Allison B"

Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging von Hwang, Hyun Jung, Kim, Nayeon, Herman, Allison B., Gorospe, Myriam, Lee, Jae-Seon

“… Aging causes a progressive decline in the structure and function of organs. With advancing age, an accumulation of senescent endothelial cells (ECs) …”
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Integrated lncRNA function upon genomic and epigenomic regulation von Herman, Allison B, Tsitsipatis, Dimitrios, Gorospe, Myriam

“… Although some long noncoding (lnc)RNAs are known since the 1950s, the past 25 years have uncovered myriad lncRNAs with diverse sequences, structures, and …”
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A BDNF-TrkB autocrine loop enhances senescent cell viability von Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Cui, Chang-Yi, De, Supriyo, Abdelmohsen, Kotb, de Cabo, Rafael, Gorospe, Myriam

“… Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells …”
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Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases von Herman, Allison B, Autieri, Michael V

“… Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies, and will increase with an aging and increasingly …”
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Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis von Herman, Allison B, Anerillas, Carlos, Harris, Sophia C, Munk, Rachel, Martindale, Jennifer L, Yang, Xiaoling, Mazan-Mamczarz, Krystyna, Zhang, Yongqing, Heckenbach, Indra J, Scheibye-Knudsen, Morten, De, Supriyo, Sen, Payel, Abdelmohsen, Kotb, Gorospe, Myriam

“… Abstract A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, …”
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Transcriptomes of human primary skin fibroblasts of healthy individuals reveal age‐associated mRNAs and long noncoding RNAs von Tsitsipatis, Dimitrios, Martindale, Jennifer L., Mazan‐Mamczarz, Krystyna, Herman, Allison B., Piao, Yulan, Banskota, Nirad, Yang, Jen‐Hao, Cui, Linna, Anerillas, Carlos, Chang, Ming‐Wen, Kaileh, Mary, Munk, Rachel, Yang, Xiaoling, Ubaida‐Mohien, Ceereena, Chia, Chee W., Karikkineth, Ajoy C., Zukley, Linda, D'Agostino, Jarod, Abdelmohsen, Kotb, Basisty, Nathan, De, Supriyo, Ferrucci, Luigi, Gorospe, Myriam

“… Changes in the transcriptomes of human tissues with advancing age are poorly cataloged. Here, we sought to identify the coding and long noncoding RNAs present …”
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Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest von Rossi, Martina, Anerillas, Carlos, Idda, Maria Laura, Munk, Rachel, Shin, Chang Hoon, Donega, Stefano, Tsitsipatis, Dimitrios, Herman, Allison B, Martindale, Jennifer L, Yang, Xiaoling, Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Ferrucci, Luigi, Johnson, Peter F, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam

“… Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP) …”
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Author Correction: A BDNF-TrkB autocrine loop enhances senescent cell viability von Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Cui, Chang-Yi, De, Supriyo, Abdelmohsen, Kotb, de Cabo, Rafael, Gorospe, Myriam

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FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway von Hwang, Hyun Jung, Kang, Donghee, Kim, Jae-Ryong, Choi, Joon Hyuk, Ryu, Ji-Kan, Herman, Allison B., Ko, Young-Gyu, Park, Heon Joo, Gorospe, Myriam, Lee, Jae-Seon

“… The roles of fibronectin leucine-rich transmembrane protein 2 (FLRT2) in physiological and pathological processes are not well known. Here, we identify a …”
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Molecular tools for analysing in vivo senescence von Herman, Allison B, Gorospe, Myriam

“… Enrichment of senescent cells from organs holds great promise for studying cell senescence and ageing, and for identifying therapeutic vulnerabilities …”
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Senescence: An Overlooked VSMC Phenotype and Therapeutic Opportunity? von Herman, Allison B, Gresova, Katarina, Maragkakis, Manolis, Autieri, Michael V

“… Vascular smooth muscle cells (VSMCs) modulate their phenotype from a quiescent, contractile cell to a dedifferentiated, synthetic fibroproliferative cell in …”
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Survey of organ‐derived small extracellular vesicles and particles (sEVPs) to identify selective protein markers in mouse serum von Abdelmohsen, Kotb, Herman, Allison B., Carr, Angelica E., Henry‐Smith, Charnae’ A., Rossi, Martina, Meng, Qiong, Yang, Jen‐Hao, Tsitsipatis, Dimitrios, Bangura, Alhassan, Munk, Rachel, Martindale, Jennifer L., Nogueras‐Ortiz, Carlos J., Hao, Jon, Gong, Yi, Liu, Yie, Cui, Chang‐Yi, Hartnell, Lisa M., Price, Nathan L., Ferrucci, Luigi, Kapogiannis, Dimitrios, Cabo, Rafael, Gorospe, Myriam

“… Extracellular vesicles and particles (EVPs) are secreted by organs across the body into different circulatory systems, including the bloodstream, and reflect …”
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Identification and functional analysis of senescent cells in the cardiovascular system using omics approaches von Mahoney, Sophia A, Dey, Amit K, Basisty, Nathan, Herman, Allison B

“… Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and senescent cells have emerged as key contributors to its pathogenesis …”
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Leveraging pathway analysis in a human skin model of healthy aging von Tsitsipatis, Dimitrios, Gorospe, Myriam, Herman, Allison B

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Characterization of the Intact Proteomic Profile of Senescent-Associated Secretory Phenotype by Top-Down Mass Spectrometry von Boroumand, Mozhgan, Dey, Amit, Cupp-Sutton, Kellye, Pierce, Tomas, Tsitsipatis, Dimitrios, Herman, Allison B, Wu, Si, Basisty, Nathan

“… Cellular senescence is a stable state of cell-cycle arrest characterized by extensive remodeling of the secretome, known as the senescence-associated secretory …”
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AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production von Tsitsipatis, Dimitrios, Grammatikakis, Ioannis, Driscoll, Riley K, Yang, Xiaoling, Abdelmohsen, Kotb, Harris, Sophia C, Yang, Jen-Hao, Herman, Allison B, Chang, Ming-Wen, Munk, Rachel, Martindale, Jennifer L, Mazan-Mamczarz, Krystyna, De, Supriyo, Lal, Ashish, Gorospe, Myriam

“… Mammalian circRNAs can influence different cellular processes by interacting with proteins and other nucleic acids. Here, we used ribonucleoprotein …”
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RNA stability protein ILF3 mediates cytokine-induced angiogenesis von Vrakas, Christine N, Herman, Allison B, Ray, Mitali, Kelemen, Sheri E, Scalia, Rosario, Autieri, Michael V

“… Interleukin enhancer-binding factor 3 (ILF3), an RNA-binding protein, is best known for its role in innate immunity by participation in cellular antiviral …”
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Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis von Herman, Allison B, Silva Afonso, Milessa, Kelemen, Sheri E, Ray, Mitali, Vrakas, Christine N, Burke, Amy C, Scalia, Rosario G, Moore, Kathryn, Autieri, Michael V

“… Stress granules (SGs) are dynamic cytoplasmic aggregates containing mRNA, RNA-binding proteins, and translation factors that form in response to cellular …”
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Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19 -/- × Ldlr -/- Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R) von Ray, Mitali, Gabunia, Khatuna, Vrakas, Christine N, Herman, Allison B, Kako, Farah, Kelemen, Sheri E, Grisanti, Laurel A, Autieri, Michael V

“… To test the hypothesis that loss of IL-19 (interleukin-19) exacerbates atherosclerosis. APPROACH AND RESULTS: mice were crossed into (low-density lipoprotein …”
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DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice von Herman, Allison B., Tsitsipatis, Dimitrios, Anerillas, Carlos, Mazan-Mamczarz, Krystyna, Carr, Angelica E., Gregg, Jordan M., Wang, Mingyi, Zhang, Jing, Michel, Marc, Henry-Smith, Charnae’ A., Harris, Sophia C., Munk, Rachel, Martindale, Jennifer L., Piao, Yulan, Fan, Jinshui, Mattison, Julie A., De, Supriyo, Abdelmohsen, Kotb, Maul, Robert W., Tanaka, Toshiko, Moore, Ann Zenobia, DeMouth, Megan E., Sidoli, Simone, Ferrucci, Luigi, Liu, Yie, de Cabo, Rafael, Lakatta, Edward G., Gorospe, Myriam

“… Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age and tissue damage and secrete factors that promote atherosclerotic plaque …”
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