Search Results - "Henneman, Peter"

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression by Naue, Jana, Hoefsloot, Huub C.J., Mook, Olaf R.F., Rijlaarsdam-Hoekstra, Laura, van der Zwalm, Marloes C.H., Henneman, Peter, Kloosterman, Ate D., Verschure, Pernette J.

“…•An epigenetic age prediction tool for blood was developed based on MPS, and the DNA methylation levels of 13 markers.•Random forest regression (RFR) was used…”
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Faecal Microbiota transplantation affects liver DNA methylation in Non-alcoholic fatty liver disease: a multi-omics approach by Stols-Gonçalves, Daniela, Mak, Anne Linde, Madsen, Mette S., van der Vossen, Eduard W. J., Bruinstroop, Eveline, Henneman, Peter, Mol, Femke, Scheithauer, Torsten P. M., Smits, Loek, Witjes, Julia, Meijnikman, Abraham Stijn, Verheij, Joanne, Nieuwdorp, Max, Holleboom, Adriaan G., Levin, Evgeni

“…Individuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota composition. Moreover, hepatic DNA methylation may be altered in the…”
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Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198 by Molenaar, Remco J, Botman, Dennis, Smits, Myrthe A, Hira, Vashendriya V, van Lith, Sanne A, Stap, Jan, Henneman, Peter, Khurshed, Mohammed, Lenting, Krissie, Mul, Adri N, Dimitrakopoulou, Dionysia, van Drunen, Cornelis M, Hoebe, Ron A, Radivoyevitch, Tomas, Wilmink, Johanna W, Maciejewski, Jaroslaw P, Vandertop, W Peter, Leenders, William P, Bleeker, Fonnet E, van Noorden, Cornelis J

“…Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of…”
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HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages by Ghiboub, Mohammed, Zhao, Jing, Li Yim, Andrew Y. F., Schilderink, Ronald, Verseijden, Caroline, van Hamersveld, Patricia H. P., Duarte, Jose M., Hakvoort, Theodorus B. M., Admiraal, Iris, Harker, Nicola R., Tough, David F., Henneman, Peter, de Winther, Menno P. J., de Jonge, Wouter J.

“…Histone deacetylases (HDACs) are a group of enzymes that control histone deacetylation and bear potential to direct expression of large gene sets. We…”
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Molecular signatures in Mendelian neurodevelopment: a focus on ubiquitination driven DNA methylation aberrations by van der Laan, Liselot, ten Voorde, Nicky, Mannens, Marcel M. A. M., Henneman, Peter

“…Mendelian disorders, arising from pathogenic variations within single genetic loci, often manifest as neurodevelopmental disorders (NDDs), affecting a…”
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ImprintCap, a powerful NGS-based technology to investigate the molecular background of imprinting disorders by Brioude, Frédéric, Haagmans, Martin A., Mannens, Marcel, Netchine, Irene, Alders, Marielle, Henneman, Peter, Bliek, Jet

“…Introduction Imprinting disorders (IDs) are a rare class of diseases caused by the disruption of imprinted genes, i.e., genes with a specific pattern of…”
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Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome by Metselaar, Paula I., Mendoza-Maldonado, Lucero, Li Yim, Andrew Yung Fong, Abarkan, Ilias, Henneman, Peter, te Velde, Anje A., Schönhuth, Alexander, Bosch, Jos A., Kraneveld, Aletta D., Lopez-Rincon, Alejandro

“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disorder characterized by disabling fatigue. Several studies have sought to identify…”
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Improved epigenetic age prediction models by combining sex chromosome and autosomal markers by Wan, Zhong, Henneman, Peter, Hoefsloot, Huub C. J., Kloosterman, Ate D., Verschure, Pernette J.

“…Background Alterations in epigenetic DNA methylation (DNAm) can be used as an accurate and robust method for biological age prediction. We assessed the…”
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Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients by Hageman, Ishtu, Mol, Femke, Atiqi, Sadaf, Joustra, Vincent, Sengul, Hilal, Henneman, Peter, Visman, Ingrid, Hakvoort, Theodorus, Nurmohamed, Mike, Wolbink, Gertjan, Levin, Evgeni, Li Yim, Andrew Y.F., D’Haens, Geert, de Jonge, Wouter J.

“…Rheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα)…”
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Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo by Chen, Hung-Jen, Li Yim, Andrew Y. F., Griffith, Guillermo R., de Jonge, Wouter J., Mannens, Marcel M. A. M., Ferrero, Enrico, Henneman, Peter, de Winther, Menno P. J.

“…Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While macrophage models have been used to study diseases…”
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Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates by Henneman, Peter, Bouman, Arjan, Mul, Adri, Knegt, Lia, van der Kevie-Kersemaekers, Anne-Marie, Zwaveling-Soonawala, Nitash, Meijers-Heijboer, Hanne E. J., van Trotsenburg, A. S. Paul, Mannens, Marcel M.

“…Down syndrome (DS) is the most frequent genetic cause of intellectual disability. Despite the fact that more than 50 years have passed since the discovery of…”
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Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses by Demirkan, Ayşe, Henneman, Peter, Verhoeven, Aswin, Dharuri, Harish, Amin, Najaf, van Klinken, Jan Bert, Karssen, Lennart C., de Vries, Boukje, Meissner, Axel, Göraler, Sibel, van den Maagdenberg, Arn M. J. M., Deelder, André M., C ’t Hoen, Peter A., van Duijn, Cornelia M., van Dijk, Ko Willems

“…Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association…”
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An exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn’s disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes by Li Yim, Andrew Yung Fong, Hageman, Ishtu, Joustra, Vincent W., Elfiky, Ahmed M. I. M., Ghiboub, Mohammed, Levin, Evgeni, Verhoeff, Jan, Verseijden, Caroline, Admiraal, Iris, de Krijger, Manon, Wildenberg, Manon E., Mannens, Marcel, Jakobs, Marja E., Kenter, Susan B., Adams, Alex T., Satsangi, Jack, D’Haens, Geert R., de Jonge, Wouter J., Henneman, Peter

“…Vedolizumab (VDZ) is a monoclonal antibody approved for the treatment of Crohn's disease (CD). Despite its efficacy, non-response to VDZ is common in clinical…”
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Effects of fecal microbiota transplant on DNA methylation in subjects with metabolic syndrome by van der Vossen, Eduard W. J., Bastos, Diogo, Stols-Gonçalves, Daniela, de Goffau, Marcus C., Davids, Mark, Pereira, Joao P. B., Li Yim, Andrew Y. F., Henneman, Peter, Netea, Mihai G., de Vos, Willem M., de Jonge, Wouter, Groen, Albert K., Nieuwdorp, Max, Levin, Evgeni

“…Accumulating evidence shows that microbes with their theater of activity residing within the human intestinal tract (i.e., the gut microbiome) influence host…”
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Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study by Agyemang, Charles, van der Linden, Eva L, Antwi-Berko, Daniel, Nkansah Darko, Samuel, Twumasi-Ankrah, Sampson, Meeks, Karlijn, van den Born, Bert-Jan H, Henneman, Peter, Owusu-Dabo, Ellis, Beune, Erik

“…PurposeThe Research on Obesity and Diabetes among African Migrants (RODAM) prospective (RODAM-Pros) cohort study was established to identify key changes in…”
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Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder by Ensink, Judith B. M., Henneman, Peter, Venema, Andrea, Zantvoord, Jasper B., den Kelder, Rosanne op, Mannens, Marcel M. A. M., Lindauer, Ramón J. L.

“…In youth with posttraumatic stress disorder (PTSD) non-response rates after treatment are often high. Epigenetic mechanisms such as DNA methylation (DNAm) have…”
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Gut microbiota shift in Ghanaian individuals along the migration axis: the RODAM-Pros cohort by Verhaar, Barbara J. H., van der Linden, Eva L., Hayfron-Benjamin, Charles F., Owusu-Dabo, Ellis, Darko, Samuel N., Twumasi-Ankrah, Sampson, Henneman, Peter, Beune, Erik, Meeks, Karlijn A.C., Nieuwdorp, Max, Herrema, Hilde, van den Born, Bert-Jan H., Agyemang, Charles

“…Migration is associated with a substantial change in environmental exposures and health outcomes. We aimed to investigate the shift in gut microbiota…”
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Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability by Struijk, Robert B., Dorssers, Lambert C. J., Henneman, Peter, Rijlaarsdam, Martin A., Venema, Andrea, Jongejan, Aldo, Mannens, Marcel M. A. M., Looijenga, Leendert H. J., Repping, Sjoerd, van Pelt, Ans M. M.

“…Autologous transplantation of spermatogonial stem cells is a promising new avenue to restore fertility in infertile recipients. Expansion of the initial…”
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A metabolomic profile is associated with the risk of incident coronary heart disease by Vaarhorst, Anika A.M., Verhoeven, Aswin, Weller, Claudia M., Böhringer, Stefan, Göraler, Sibel, Meissner, Axel, Deelder, André M., Henneman, Peter, Gorgels, Anton P.M., van den Brandt, Piet A., Schouten, Leo J., van Greevenbroek, Marleen M., Merry, Audrey H.H., Verschuren, W.M. Monique, van den Maagdenberg, Arn M.J.M., van Dijk, Ko Willems, Isaacs, Aaron, Boomsma, Dorret, Oostra, Ben A., van Duijn, Cornelia M., Jukema, J. Wouter, Boer, Jolanda M.A., Feskens, Edith, Heijmans, Bastiaan T., Slagboom, P. Eline

“…Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been…”
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Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy by Harder, Aster V. E., Vijfhuizen, Lisanne S., Henneman, Peter, Willems van Dijk, Ko, van Duijn, Cornelia M., Terwindt, Gisela M., van den Maagdenberg, Arn M. J. M.

“…Background Migraine is a common brain disorder but reliable diagnostic biomarkers in blood are still lacking. Our aim was to identify, using proton nuclear…”
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