Výsledky vyhľadávania - "Henen, Morkos A."

Structure and Formation of Z-DNA and Z-RNA Autor Krall, Jeffrey B., Nichols, Parker J., Henen, Morkos A., Vicens, Quentin, Vögeli, Beat

“…Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations…”
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Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion Autor Tengesdal, Isak W, Menon, Dinoop R, Osborne, Douglas G, Neff, Charles P, Powers, Nicholas E, Gamboni, Fabia, Mauro, Adolfo G, D'Alessandro, Angelo, Stefanoni, Davide, Henen, Morkos A, Mills, Taylor S, De Graaf, Dennis M, Azam, Tania, Vogeli, Beat, Palmer, Brent E, Pietras, Eric M, DeGregori, James, Tan, Aik-Choon, Joosten, Leo A B, Fujita, Mayumi, Dinarello, Charles A, Marchetti, Carlo

“…Interleukin-1β (IL-1β)-mediated inflammation suppresses antitumor immunity, leading to the generation of a tumor-permissive environment, tumor growth, and…”
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Ligand-specific conformational change drives interdomain allostery in Pin1 Autor Born, Alexandra, Soetbeer, Janne, Henen, Morkos A., Breitgoff, Frauke, Polyhach, Yevhen, Jeschke, Gunnar, Vögeli, Beat

“…Pin1 is a two-domain cell regulator that isomerizes peptidyl-prolines. The catalytic domain (PPIase) and the other ligand-binding domain (WW) sample extended…”
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PBRM1 bromodomains associate with RNA to facilitate chromatin association Autor De Silva, Saumya M, Dhiman, Alisha, Sood, Surbhi, Mercedes, Kilsia F, Simmons, William J, Henen, Morkos A, Vögeli, Beat, Dykhuizen, Emily C, Musselman, Catherine A

“…Abstract PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40–50% of clear cell renal cell carcinoma patients. It is thought to…”
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A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport Autor Celestino, Ricardo, Henen, Morkos A., Gama, José B., Carvalho, Cátia, McCabe, Maxwell, Barbosa, Daniel J., Born, Alexandra, Nichols, Parker J., Carvalho, Ana X., Gassmann, Reto, Vögeli, Beat

“…All animal cells use the motor cytoplasmic dynein 1 (dynein) to transport diverse cargo toward microtubule minus ends and to organize and position microtubule…”
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Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor Autor Wang, Ruth X., Henen, Morkos A., Lee, J. Scott, Vögeli, Beat, Colgan, Sean P.

“…The gut microbiota is essential for human health. Microbial supply of short-chain fatty acids (SCFAs), particularly butyrate, is a well-established contributor…”
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Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer Autor El-Khouly, Omar A., Henen, Morkos A., El-Sayed, Magda A.-A., El-Messery, Shahenda M.

“…Design and synthesis of a new series of benzofuran derivatives has been performed. 1 H-NMR, 13 C-NMR, elemental analysis, and IR were used to confirm the…”
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New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies Autor Nashaat, Samira, Henen, Morkos A., El-Messery, Shahenda M., Eisa, Hassan

“…Benzimidazole derivatives are known to be key players in the development of novel anticancer agents. Herein, we aimed to synthesize novel derivatives to target…”
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Reconstruction of Coupled Intra- and Interdomain Protein Motion from Nuclear and Electron Magnetic Resonance Autor Born, Alexandra, Soetbeer, Janne, Breitgoff, Frauke, Henen, Morkos A, Sgourakis, Nikolaos, Polyhach, Yevhen, Nichols, Parker J, Strotz, Dean, Jeschke, Gunnar, Vögeli, Beat

“…Proteins composed of multiple domains allow for structural heterogeneity and interdomain dynamics that may be vital for function. Intradomain structures and…”
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Promiscuity of response regulators for thioredoxin steers bacterial virulence Autor Kim, Ju-Sim, Born, Alexandra, Till, James Karl A., Liu, Lin, Kant, Sashi, Henen, Morkos A., Vögeli, Beat, Vázquez-Torres, Andrés

“…The exquisite specificity between a sensor kinase and its cognate response regulator ensures faithful partner selectivity within two-component pairs…”
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Reducing the measurement time of exact NOEs by non-uniform sampling Autor Nichols, Parker J., Born, Alexandra, Henen, Morkos A., Strotz, Dean, Jones, David N., Delaglio, Frank, Vögeli, Beat

“…We have previously reported on the measurement of exact NOEs (eNOEs), which yield a wealth of additional information in comparison to conventional NOEs. We…”
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Solution NMR Backbone Assignment of the C-Terminal Region of Human Dynein Light Intermediate Chain 2 (LIC2-C) Unveils Structural Resemblance with Its Homologue LIC1-C Autor Henen, Morkos A., Paukovich, Natasia, Prekeris, Rytis, Vögeli, Beat

“…Dynein, a homodimeric protein complex, plays a pivotal role in retrograde transportation along microtubules within cells. It consists of various subunits,…”
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The Exact Nuclear Overhauser Enhancement: Recent Advances Autor Nichols, Parker, Born, Alexandra, Henen, Morkos, Strotz, Dean, Orts, Julien, Olsson, Simon, Güntert, Peter, Chi, Celestine, Vögeli, Beat

“…Although often depicted as rigid structures, proteins are highly dynamic systems, whose motions are essential to their functions. Despite this, it is difficult…”
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Extending the Applicability of Exact Nuclear Overhauser Enhancements to Large Proteins and RNA Autor Nichols, Parker J., Born, Alexandra, Henen, Morkos A., Strotz, Dean, Celestine, Chi N., Güntert, Peter, Vögeli, Beat

“…Distance‐dependent nuclear Overhauser enhancements (NOEs) are one of the most popular and important experimental restraints for calculating NMR structures…”
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Solution NMR backbone assignments of the N-terminal Zα-linker-Zβ segment from Homo sapiens ADAR1p150 Autor Nichols, Parker J., Henen, Morkos A., Vicens, Quentin, Vögeli, Beat

“…Adenosine-to-inosine (A-to-I) editing of a subset of RNAs in a eukaryotic cell is required in order to avoid triggering the innate immune system. Editing is…”
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On the use of residual dipolar couplings in multi-state structure calculation of two-domain proteins Autor Born, Alexandra, Henen, Morkos A., Nichols, Parker J., Vögeli, Beat

“…Residual dipolar couplings (RDCs) are powerful nuclear magnetic resonance (NMR) probes for the structure calculation of biomacromolecules. Typically, an…”
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Solution NMR backbone assignments of disordered Olduvai protein domain CON1 employing Hα-detected experiments Autor Paukovich, Natasia, Henen, Morkos A., Hussain, Alya, Issaian, Aaron, Sikela, James M., Hansen, Kirk C., Vögeli, Beat

“…Olduvai protein domains, encoded by the NBPF gene family, are responsible for the largest increase in copy number of any protein-coding region in the human…”
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High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints Autor Nichols, Parker J., Henen, Morkos A., Born, Alexandra, Strotz, Dean, Güntert, Peter, Vögeli, Beat

“…RNA not only translates the genetic code into proteins, but also carries out important cellular functions. Understanding such functions requires knowledge of…”
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Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family Autor Kim, Sun Kyung, Henen, Morkos A, Hinck, Andrew P

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Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains Autor Issaian, Aaron, Schmitt, Lauren, Born, Alexandra, Nichols, Parker J., Sikela, James, Hansen, Kirk, Vögeli, Beat, Henen, Morkos A.

“…Olduvai protein domains, encoded primarily by NBPF genes, have been linked to both human brain evolution and cognitive diseases such as autism and…”
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