Search Results - "Hendrix, Sebastian"

SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain by Hendrix, Sebastian, Dartigue, Vincent, Hall, Hailee, Bawaria, Shrankhla, Kingma, Jenina, Bajaj, Bilkish, Zelcer, Noam, Kober, Daniel L.

“…Site-one protease (S1P) conducts the first of two cleavage events in the Golgi to activate Sterol regulatory element binding proteins (SREBPs) and upregulate…”
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans by Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam

“…The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified…”
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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition by Niccolai, Rachele, Göbel, Camiel, Ndoj, Klevis, Kreft, Maaike, Kuiken, Hendrik J., Lieftink, Cor, Morris, Ben, Yska, Sietse D., Hendrix, Sebastian, van den Broek, Bram, Pappalardo, Vincent, Kersten, Marie José, Beijersbergen, Roderick L., Zelcer, Noam, van Leeuwen, Fred, Jacobs, Heinz

“…•GCB-DLBCL insensitive to EZH2 inhibition become dependent on cholesterol synthesis.•This dependency relates to altered LDLR subcellular localization and LDL…”
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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism by Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam

“…The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify…”
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A new SPRING in lipid metabolism by Hendrix, Sebastian, Zelcer, Noam

“…The SREBP transcription factors are master regulators of lipid homeostasis owing to their role in controlling cholesterol and fatty acid metabolism. The core…”
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Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor by Bullington, Ashley V, Micallo, Ilaria, Bajaj, Bilkish, Kumar, Pankaj, Schlamowitz, Netanya, Silva, Aurora, Hendrix, Sebastian, Zelcer, Noam, Kober, Daniel L

“…Site-one protease (S1P) carries out the first proteolytic step to activate membrane-bound effector proteins in the Golgi. S1P matures through an autocatalytic…”
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Glutamine sensing licenses cholesterol synthesis by Garcia, Bruna Martins, Melchinger, Philipp, Medeiros, Tania, Hendrix, Sebastian, Prabhu, Kavan, Corrado, Mauro, Kingma, Jenina, Gorbatenko, Andrej, Deshwal, Soni, Veronese, Matteo, Scorrano, Luca, Pearce, Erika, Giavalisco, Patrick, Zelcer, Noam, Pernas, Lena

“…The mevalonate pathway produces essential lipid metabolites such as cholesterol. Although this pathway is negatively regulated by metabolic intermediates,…”
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Sphingosine-1-phosphate metabolism and signaling attenuates vascular dysfunction at the feto-placental endothelium by Del Gaudio, Ilaria, Hendrix, Sebastian, Lang, Uwe, Wadsack, Christian

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Neonatal HDL Counteracts Placental Vascular Inflammation via S1P–S1PR1 Axis by Del Gaudio, Ilaria, Hendrix, Sebastian, Christoffersen, Christina, Wadsack, Christian

“…Placental inflammation and dysfunction during pregnancy are associated with short- and long-term adverse outcomes for the offspring. However, the mechanisms of…”
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SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P by Hendrix, Sebastian, Tan, Josephine M. E., Ndoj, Klevis, Kingma, Jenina, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Kober, Daniel L., Zelcer, Noam

“…SREBP transcription factors are central regulators of lipid metabolism. Their proteolytic activation requires ER to the Golgi translocation and subsequent…”
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Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity by Kane, Jamie, Jansen, Matthijs, Hendrix, Sebastian, Bosmans, Laura A., Beckers, Linda, Tiel, Claudia van, Gijbels, Marion, Zelcer, Noam, Vries, Carlie J. de, von Hundelshausen, Philipp, Vervloet, Marc, Eringa, Ed, Horrevoets, Anton J., Royen, Niels van, Lutgens, Esther

“…Abstract Background  Galectins have numerous cellular functions in immunity and inflammation. Short-term galectin-2 (Gal-2) blockade in ischemia-induced…”
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Intermolecular proteolytic processing of SPRING and Site-1-protease regulate SREBP signaling by Hendrix, Sebastian, Tan, Josephine M.E., Ndoj, Klevis, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Zelcer, Noam

“…The SREBP transcription factors are central regulators of fatty acid and cholesterol metabolism. Produced as membrane-resident precursor proteins in the ER,…”
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