Výsledky vyhľadávania - "Hebenstreit, Daniel"

Synergising single-cell resolution and 4sU labelling boosts inference of transcriptional bursting Autor Edwards, David M., Davies, Philip, Hebenstreit, Daniel

“…Despite the recent rise of RNA-seq datasets combining single-cell (sc) resolution with 4-thiouridine (4sU) labelling, analytical methods exploiting their power…”
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RNA sequencing reveals two major classes of gene expression levels in metazoan cells Autor Hebenstreit, Daniel, Fang, Miaoqing, Gu, Muxin, Charoensawan, Varodom, van Oudenaarden, Alexander, Teichmann, Sarah A

“…The expression level of a gene is often used as a proxy for determining whether the protein or RNA product is functional in a cell or tissue. Therefore, it is…”
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3 ′-5 ′ crosstalk contributes to transcriptional bursting Autor Cavallaro, Massimo, Walsh, Mark D., Jones, Matt, Teahan, James, Tiberi, Simone, Finkenstädt, Bärbel, Hebenstreit, Daniel

“…Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid…”
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CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses Autor Haussmann, Irmgard U., Wu, Yanying, Nallasivan, Mohanakarthik P., Archer, Nathan, Bodi, Zsuzsanna, Hebenstreit, Daniel, Waddell, Scott, Fray, Rupert, Soller, Matthias

“…Cap-adjacent nucleotides of animal, protist and viral mRNAs can be O -methylated at the 2‘ position of the ribose (cOMe). The functions of cOMe in animals,…”
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Bayesian inference of polymerase dynamics over the exclusion process Autor Cavallaro, Massimo, Wang, Yuexuan, Hebenstreit, Daniel, Dutta, Ritabrata

“…Transcription is a complex phenomenon that permits the conversion of genetic information into phenotype by means of an enzyme called RNA polymerase, which…”
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Single-Cell RNA Sequencing Reveals T Helper Cells Synthesizing Steroids De Novo to Contribute to Immune Homeostasis Autor Mahata, Bidesh, Zhang, Xiuwei, Kolodziejczyk, Aleksandra A., Proserpio, Valentina, Haim-Vilmovsky, Liora, Taylor, Angela E., Hebenstreit, Daniel, Dingler, Felix A., Moignard, Victoria, Göttgens, Berthold, Arlt, Wiebke, McKenzie, Andrew N.J., Teichmann, Sarah A.

“…T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there…”
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Fast TV-PRO-seq: Accelerated and Streamlined Protocol for Timing RNA Polymerase Pausing Autor Zhang, Jie, Liang, Zhixian, Sun, Mingxin, Hebenstreit, Daniel, Zhang, Shaohui

“…Transcriptional pausing dynamically regulates spatiotemporal gene expression during cellular differentiation, development, and environmental adaptation…”
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LiBiNorm: an htseq-count analogue with improved normalisation of Smart-seq2 data and library preparation diagnostics Autor Dyer, Nigel P., Shahrezaei, Vahid, Hebenstreit, Daniel

“…Protocols for preparing RNA sequencing (RNA-seq) libraries, most prominently “Smart-seq” variations, introduce global biases that can have a significant impact…”
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The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci Autor Singh, Anand K, Choudhury, Subhendu Roy, De, Sandip, Zhang, Jie, Kissane, Stephen, Dwivedi, Vibha, Ramanathan, Preethi, Petric, Marija, Orsini, Luisa, Hebenstreit, Daniel, Brogna, Saverio

“…UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the…”
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N-terminal tagging of RNA Polymerase II shapes transcriptomes more than C-terminal alterations Autor Callan-Sidat, Adam, Zewdu, Emmanuel, Cavallaro, Massimo, Liu, Juntai, Hebenstreit, Daniel

“…RNA polymerase II (Pol II) has a C-terminal domain (CTD) that is unstructured, consisting of a large number of heptad repeats, and whose precise function…”
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Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma Autor Chortis, Vasileios, Taylor, Angela E, Doig, Craig L, Walsh, Mark D, Meimaridou, Eirini, Jenkinson, Carl, Rodriguez-Blanco, Giovanny, Ronchi, Cristina L, Jafri, Alisha, Metherell, Louise A, Hebenstreit, Daniel, Dunn, Warwick B, Arlt, Wiebke, Foster, Paul A

“…Abstract Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. In this study, we evaluated a potential new treatment…”
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Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension Autor Westgate, Connar S.J., Botfield, Hannah F., Alimajstorovic, Zerin, Yiangou, Andreas, Walsh, Mark, Smith, Gabrielle, Singhal, Rishi, Mitchell, James L., Grech, Olivia, Markey, Keira A., Hebenstreit, Daniel, Tennant, Daniel A., Tomlinson, Jeremy W., Mollan, Susan P., Ludwig, Christian, Akerman, Ildem, Lavery, Gareth G., Sinclair, Alexandra J.

“…BACKGROUNDIdiopathic intracranial hypertension (IIH) is a condition predominantly affecting obese women of reproductive age. Recent evidence suggests that IIH…”
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AID induces intraclonal diversity and genomic damage in CD86+ chronic lymphocytic leukemia cells Autor Huemer, Michael, Rebhandl, Stefan, Zaborsky, Nadja, Gassner, Franz J., Hainzl, Stefan, Weiss, Lukas, Hebenstreit, Daniel, Greil, Richard, Geisberger, Roland

“…The activation‐induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines…”
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The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding Autor Xie, Xin, Stubbington, Michael J. T., Nissen, Jesper K., Andersen, Kristian G., Hebenstreit, Daniel, Teichmann, Sarah A., Betz, Alexander G.

“…The lineage factor Foxp3 is essential for the development and maintenance of regulatory T cells, but little is known about the mechanisms involved. Here, we…”
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Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae Autor Zanin, Onofrio, Eastham, Matthew, Winczura, Kinga, Ashe, Mark, Martinez-Nunez, Rocio T., Hebenstreit, Daniel, Grzechnik, Pawel

“…Most functional eukaryotic mRNAs contain a 5′ 7-methylguanosine (m 7 G) cap. Although capping is essential for many biological processes including mRNA…”
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IL‐4 induces expression of TARC/CCL17 via two STAT6 binding sites Autor Wirnsberger, Gerald, Hebenstreit, Daniel, Posselt, Gernot, Horejs‐Hoeck, Jutta, Duschl, Albert

“…A cardinal feature of allergic disorders and immune responses is enhanced leukocyte trafficking. This is largely orchestrated by chemokines. The CC chemokine…”
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Transcriptional bursting: from fundamentals to novel insights Autor Hebenstreit, Daniel, Karmakar, Pradip

“…Transcription occurs as irregular bursts in a very wide range of systems, including numerous different species and many genes within these. In this review, we…”
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Are gene loops the cause of transcriptional noise? Autor Hebenstreit, Daniel

“…•Many genes produce mRNA irregularly, resulting in infrequent transcription bursts.•Transcriptional bursting is a major source of noise, but its cause is…”
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LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element Autor Hebenstreit, Daniel, Giaisi, Marco, Treiber, Monika K, Zhang, Xiao-Bin, Mi, Huai-Feng, Horejs-Hoeck, Jutta, Andersen, Kristian G, Krammer, Peter H, Duschl, Albert, Li-Weber, Min

“…Lymphoid enhancer-binding factor 1 (LEF-1) and T cell factor (TCF-1) are downstream effectors of the Wnt signaling pathway and are involved in the regulation…”
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Funding: Would Mendel have won it? Autor Hebenstreit, Daniel

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