Suchergebnisse - "Hartley, Suzanne"

Can stand-alone computer-based interventions reduce alcohol consumption? A systematic review von Khadjesari, Zarnie, Murray, Elizabeth, Hewitt, Catherine, Hartley, Suzanne, Godfrey, Christine

“… ABSTRACT Aim  To determine the effects of computer‐based interventions aimed at reducing alcohol consumption in adult populations. Methods  The review was …”
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Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells von Okada, Takaharu, Miller, Mark J, Parker, Ian, Krummel, Matthew F, Neighbors, Margaret, Hartley, Suzanne B, O'Garra, Anne, Cahalan, Michael D, Cyster, Jason G

“… Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon …”
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An adaptable implementation package targeting evidence-based indicators in primary care: A pragmatic cluster-randomised evaluation von Willis, Thomas A., Collinson, Michelle, Glidewell, Liz, Farrin, Amanda J., Holland, Michael, Meads, David, Hulme, Claire, Petty, Duncan, Alderson, Sarah, Hartley, Suzanne, Vargas-Palacios, Armando, Carder, Paul, Johnson, Stella, Foy, Robbie

“… In primary care, multiple priorities and system pressures make closing the gap between evidence and practice challenging. Most implementation studies focus on …”
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Management of diarrhoea in patients with stable ulcerative colitis with low FODMAP diet, amitriptyline, ondansetron or loperamide: the MODULATE RCT von Moreau, Lauren A, Ford, Alexander Charles, Brookes, Matthew James, Graca, Sandra, Guthrie, Elspeth, Hartley, Suzanne, Houghton, Lesley, Kemp, Karen, Kennedy, Nicholas A, McKenzie, Yvonne, Muir, Delia, Loo Ow, Pei, Probert, Christopher, Pryde, Emma, Taylor, Christopher, Willis, Thomas A, Wright-Hughes, Alexandra, Farrin, Amanda J

“… Many patients with ulcerative colitis report ongoing diarrhoea even when their disease is stable and in remission. MODULATE was a pragmatic, multicentre, …”
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The detection and management of attempted fraud during an online randomised trial von Willis, Thomas A., Wright-Hughes, Alexandra, Skinner, Clare, Farrin, Amanda J., Hartley, Suzanne, Walwyn, Rebecca, Weller, Ana, Althaf, Mohamed, Wilson, Stephanie, Gale, Chris P., Foy, Robbie

“… Background Online studies offer an efficient method of recruiting participants and collecting data. Whilst delivering an online randomised trial, we detected …”
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Low-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT von Wright-Hughes, Alexandra, Ford, Alexander C, Alderson, Sarah L, Ow, Pei Loo, Ridd, Matthew J, Foy, Robbie, Bishop, Felicity L, Chaddock, Matthew, Cook, Heather, Cooper, Deborah, Fernandez, Catherine, Guthrie, Elspeth A, Hartley, Suzanne, Herbert, Amy, Howdon, Daniel, Muir, Delia P, Newman, Sonia, Taylor, Christopher A, Teasdale, Emma J, Thornton, Ruth, Everitt, Hazel A, Farrin, Amanda J

“… Irritable bowel syndrome, characterised by abdominal pain and a change in stool form or frequency, is most often managed in primary care. When first-line …”
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Approaches and experiences implementing remote, electronic consent at the Leeds Clinical Trials Research Unit von Cragg, William J, Taylor, Chris, Moreau, Lauren, Collier, Howard, Gilberts, Rachael, McKigney, Niamh, Dennett, Joanna, Graca, Sandra, Wheeler, Ian, Bishop, Liam, Barrett, Adam, Hartley, Suzanne, Greenwood, John P, Swoboda, Peter P, Farrin, Amanda J

“… Background Use of electronic methods to support informed consent (‘eConsent’) is increasingly popular in clinical research. This commentary reports the …”
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Explaining variable effects of an adaptable implementation package to promote evidence-based practice in primary care: a longitudinal process evaluation von Glidewell, Liz, Hunter, Cheryl, Ward, Vicky, McEachan, Rosemary R. C., Lawton, Rebecca, Willis, Thomas A., Hartley, Suzanne, Collinson, Michelle, Holland, Michael, Farrin, Amanda J., Foy, Robbie

“… Background Implementing evidence-based recommendations is challenging in UK primary care, especially given system pressures and multiple guideline …”
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An individually randomised controlled multi-centre pragmatic trial with embedded economic and process evaluations of early vocational rehabilitation compared with usual care for stroke survivors: study protocol for the RETurn to work After stroKE (RETAKE) trial von Radford, Kathryn A., Craven, Kristelle, McLellan, Vicki, Sach, Tracey H., Brindle, Richard, Holloway, Ivana, Hartley, Suzanne, Bowen, Audrey, O’Connor, Rory, Stevens, Judith, Philips, Julie, Walker, Marion, Holmes, Jain, McKevitt, Christopher, Murray, John, Watkins, Caroline, Powers, Katie, Shone, Angela, Farrin, Amanda

“… Background Return to work (RTW) is achieved by less than 50% of stroke survivors. The rising incidence of stroke among younger people, the UK economic …”
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Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment (The ATLANTIS trial): protocol for a randomised double-blind placebo-controlled trial in primary care von Alderson, Sarah L., Wright-Hughes, Alexandra, Ford, Alexander C., Farrin, Amanda, Hartley, Suzanne, Fernandez, Catherine, Taylor, Christopher, Ow, Pei Loo, Teasdale, Emma, Howdon, Daniel, Guthrie, Elspeth, Foy, Robbie, Ridd, Matthew J., Bishop, Felicity L., Muir, Delia, Chaddock, Matthew, Herbert, Amy, Cooper, Deborah, Gibbins, Ruth, Newman, Sonia, Cook, Heather, Longo, Roberta, Everitt, Hazel

“… Background Irritable bowel syndrome (IBS) is a common functional bowel disorder that has a considerable impact on patient quality of life and substantial …”
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A cluster RCT and process evaluation of an implementation optimisation intervention to promote parental engagement enrolment and attendance in a childhood obesity prevention programme: results of the Optimising Family Engagement in HENRY (OFTEN) trial von Bryant, Maria, Burton, Wendy, Collinson, Michelle, Farrin, Amanda, Nixon, Jane, Stevens, June, Roberts, Kim, Foy, Robbie, Rutter, Harry, Copsey, Bethan, Hartley, Suzanne, Tubeuf, Sandy, Brown, Julia

“… Background Poor and variable implementation of childhood obesity prevention programmes reduces their population impact and sustainability. We drew upon …”
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A randomised fractional factorial screening experiment to predict effective features of audit and feedback von Wright-Hughes, Alexandra, Willis, Thomas A., Wilson, Stephanie, Weller, Ana, Lorencatto, Fabiana, Althaf, Mohamed, Seymour, Valentine, Farrin, Amanda J., Francis, Jillian, Brehaut, Jamie, Ivers, Noah, Alderson, Sarah L., Brown, Benjamin C., Feltbower, Richard G., Gale, Chris P., Stanworth, Simon J., Hartley, Suzanne, Colquhoun, Heather, Presseau, Justin, Walwyn, Rebecca, Foy, Robbie

“… Background Audit and feedback aims to improve patient care by comparing healthcare performance against explicit standards. It is used to monitor and improve …”
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Clinical trial management: a profession in crisis? von Mitchell, E. J., Goodman, K., Wakefield, N., Cochran, C., Cockayne, S., Connolly, S., Desai, R., Hartley, S., Lawton, S. A., Oatey, K., Rhodes, S., Savage, J. S., Taylor, J., Youssouf, N. F. J.

“… Clinical trial managers play a vital role in the design and conduct of clinical trials in the UK. There is a current recruitment and retention crisis for this …”
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Home-based Extended Rehabilitation for Older people (HERO): study protocol for an individually randomised controlled multi-centre trial to determine the clinical and cost-effectiveness of a home-based exercise intervention for older people with frailty as extended rehabilitation following acute illness or injury, including embedded process evaluation von Prescott, Matthew, Lilley-Kelly, Amanda, Cundill, Bonnie, Clarke, David, Drake, Sian, Farrin, Amanda J., Forster, Anne, Goodwin, Madeline, Goodwin, Victoria A., Hall, Abi J., Hartley, Suzanne, Holland, Mike, Hulme, Claire, Nikolova, Silviya, Parker, Catriona, Wright, Phil, Ziegler, Friederike, Clegg, Andrew

“… Background The majority of older people (> 65 years) in hospital have frailty and are at increased risk of readmission or death following discharge home. In …”
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Where do we go from here? – Opportunities and barriers to the career development of trial managers: a survey of UK-based trial management professionals von Mitchell, Eleanor, Goodman, Kirsteen, Hartley, Suzanne, Hickey, Helen, McDonald, Alison M., Meadows, Helen M., Rhodes, Shelley, Taylor, Jodi, Wakefield, Natalie, Farrell, Barbara

“… Background Clinical trials commonly have a dedicated trial manager and effective trial management is essential to the successful delivery of high-quality …”
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Using routine healthcare data to evaluate the impact of the Medicines at Transitions Intervention (MaTI) on clinical outcomes of patients hospitalised with heart failure: protocol for the Improving the Safety and Continuity Of Medicines management at Transitions of care (ISCOMAT) cluster randomised controlled trial with embedded process evaluation, health economics evaluation and internal pilot von Moreau, Lauren A, Holloway, Ivana, Fylan, Beth, Hartley, Suzanne, Cundill, Bonnie, Fergusson, Alison, Alderson, Sarah, Alldred, David Phillip, Bojke, Chris, Breen, Liz, Ismail, Hanif, Gardner, Peter, Mason, Ellen, Powell, Catherine, Silcock, Jonathan, Taylor, Andrew, Farrin, Amanda, Gale, Chris

“… IntroductionHeart failure affects 26 million people globally, approximately 900 thousand people in the UK, and is increasing in incidence. Appropriate …”
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RETurn to work After stroKE (RETAKE) Trial: protocol for a mixed-methods process evaluation using normalisation process theory von Radford, Kathryn A, McKevitt, Christopher, Clarke, Sara, Powers, Katie, Phillips, Julie, Craven, Kristelle, Watkins, Caroline, Farrin, Amanda, Holmes, Jain, Cripps, Rachel, McLellan, Vicki, Sach, Tracey, Brindle, Richard, Holloway, Ivana, Hartley, Suzanne, Bowen, Audrey, O'Connor, Rory J, Stevens, Judith, Walker, Marion, Murray, John, Shone, Angela, Clarke, David

“… ObjectivesThis mixed-method process evaluation underpinned by normalisation process theory aims to measure fidelity to the intervention, understand the social …”
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To what extent can behaviour change techniques be identified within an adaptable implementation package for primary care? A prospective directed content analysis von Glidewell, Liz, Willis, Thomas A., Petty, Duncan, Lawton, Rebecca, McEachan, Rosemary R. C., Ingleson, Emma, Heudtlass, Peter, Davies, Andrew, Jamieson, Tony, Hunter, Cheryl, Hartley, Suzanne, Gray-Burrows, Kara, Clamp, Susan, Carder, Paul, Alderson, Sarah, Farrin, Amanda J., Foy, Robbie

“… Background Interpreting evaluations of complex interventions can be difficult without sufficient description of key intervention content. We aimed to develop …”
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Self-management toolkit and delivery strategy for end-of-life pain: the mixed-methods feasibility study von Bennett, Michael I, Mulvey, Matthew R, Campling, Natasha, Latter, Sue, Richardson, Alison, Bekker, Hilary, Blenkinsopp, Alison, Carder, Paul, Closs, Jose, Farrin, Amanda, Flemming, Kate, Gallagher, Jean, Meads, David, Morley, Stephen, O’Dwyer, John, Wright-Hughes, Alexandra, Hartley, Suzanne

“… Pain affects most people approaching the end of life and can be severe for some. Opioid analgesia is effective, but evidence is needed about how best to …”
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Results of a feasibility study of the FReSH START intervention to improve quality of life and other outcomes in people who repeatedly self-harm (Function REplacement in repeated Self-Harm: Standardising Therapeutic Assessment and the Related Therapy) von Copsey, Bethan, Wright-Hughes, Alexandra, Farrin, Amanda, Gates, Cara, Farley, Kate, Brennan, Cathy, McMillan, Dean, Graham, Christopher D., Bojke, Chris, Mattock, Richard, Martin, Adam, Bijsterveld, Petra, Horrocks, Judith, Hartley, Suzanne, McAdam, Marsha, Hammond-Jones, Dafydd, Bryant, Louise D., House, Allan, Guthrie, Elspeth

“… Background Self-harm is a major public health challenge with estimated lifetime prevalence of 5–6% and 220,000 hospital attendances annually in England and …”
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