Search Results - "Haining, W Nicholas"

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity by Juneja, Vikram R, McGuire, Kathleen A, Manguso, Robert T, LaFleur, Martin W, Collins, Natalie, Haining, W Nicholas, Freeman, Gordon J, Sharpe, Arlene H

“…It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three…”
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Normalizing the environment recapitulates adult human immune traits in laboratory mice by Beura, Lalit K., Hamilton, Sara E., Bi, Kevin, Schenkel, Jason M., Odumade, Oludare A., Casey, Kerry A., Thompson, Emily A., Fraser, Kathryn A., Rosato, Pamela C., Filali-Mouhim, Ali, Sekaly, Rafick P., Jenkins, Marc K., Vezys, Vaiva, Haining, W. Nicholas, Jameson, Stephen C., Masopust, David

“…The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system…”
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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade by Miller, Brian C., Sen, Debattama R., Al Abosy, Rose, Bi, Kevin, Virkud, Yamini V., LaFleur, Martin W., Yates, Kathleen B., Lako, Ana, Felt, Kristen, Naik, Girish S., Manos, Michael, Gjini, Evisa, Kuchroo, Juhi R., Ishizuka, Jeffrey J., Collier, Jenna L., Griffin, Gabriel K., Maleri, Seth, Comstock, Dawn E., Weiss, Sarah A., Brown, Flavian D., Panda, Arpit, Zimmer, Margaret D., Manguso, Robert T., Hodi, F. Stephen, Rodig, Scott J., Sharpe, Arlene H., Haining, W. Nicholas

“…T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor…”
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Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation by Godec, Jernej, Tan, Yan, Liberzon, Arthur, Tamayo, Pablo, Bhattacharya, Sanchita, Butte, Atul J, Mesirov, Jill P, Haining, W Nicholas

“…Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when…”
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Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans by Yates, Kathleen B., Tonnerre, Pierre, Martin, Genevieve E., Gerdemann, Ulrike, Al Abosy, Rose, Comstock, Dawn E., Weiss, Sarah A., Wolski, David, Tully, Damien C., Chung, Raymond T., Allen, Todd M., Kim, Arthur Y., Fidler, Sarah, Fox, Julie, Frater, John, Lauer, Georg M., Haining, W. Nicholas, Sen, Debattama R.

“…T cell exhaustion is an induced state of dysfunction that arises in response to chronic infection and cancer. Exhausted CD8 + T cells acquire a distinct…”
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PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity by LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Miller, Brian C., Yates, Kathleen B., Gillis, Jacob E., Sen, Debattama R., Gaudiano, Emily F., Al Abosy, Rose, Freeman, Gordon J., Haining, W. Nicholas, Sharpe, Arlene H.

“…CD8 + T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6 + progenitor…”
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A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system by LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Yates, Kathleen B., Trombley, Justin D., Weiss, Sarah A., Brown, Flavian D., Gillis, Jacob E., Coxe, Daniel J., Doench, John G., Haining, W. Nicholas, Sharpe, Arlene H.

“…Therapies that target the function of immune cells have significant clinical efficacy in diseases such as cancer and autoimmunity. Although functional genomics…”
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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival by Wang, Haizhen, Nicolay, Brandon N., Chick, Joel M., Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A., Suski, Jan M., Keibler, Mark A., Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M., Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J., Sicinski, Piotr

“…The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in…”
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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation by Deng, Jiehui, Wang, Eric S, Jenkins, Russell W, Li, Shuai, Dries, Ruben, Yates, Kathleen, Chhabra, Sandeep, Huang, Wei, Liu, Hongye, Aref, Amir R, Ivanova, Elena, Paweletz, Cloud P, Bowden, Michaela, Zhou, Chensheng W, Herter-Sprie, Grit S, Sorrentino, Jessica A, Bisi, John E, Lizotte, Patrick H, Merlino, Ashley A, Quinn, Max M, Bufe, Lauren E, Yang, Annan, Zhang, Yanxi, Zhang, Hua, Gao, Peng, Chen, Ting, Cavanaugh, Megan E, Rode, Amanda J, Haines, Eric, Roberts, Patrick J, Strum, Jay C, Richards, William G, Lorch, Jochen H, Parangi, Sareh, Gunda, Viswanath, Boland, Genevieve M, Bueno, Raphael, Palakurthi, Sangeetha, Freeman, Gordon J, Ritz, Jerome, Haining, W Nicholas, Sharpless, Norman E, Arthanari, Haribabu, Shapiro, Geoffrey I, Barbie, David A, Gray, Nathanael S, Wong, Kwok-Kin

“…Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance the…”
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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells by Kurachi, Makoto, Barnitz, R Anthony, Yosef, Nir, Odorizzi, Pamela M, DiIorio, Michael A, Lemieux, Madeleine E, Yates, Kathleen, Godec, Jernej, Klatt, Martin G, Regev, Aviv, Wherry, E John, Haining, W Nicholas

“…The transcription factor BATF is required for differentiation of certain helper T cell subsets. Haining and colleagues show that BATF crucially regulates CD8 +…”
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Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response by Reese, Tiffany A, Bi, Kevin, Kambal, Amal, Filali-Mouhim, Ali, Beura, Lalit K, Bürger, Matheus C, Pulendran, Bali, Sekaly, Rafick-Pierre, Jameson, Stephen C, Masopust, David, Haining, W Nicholas, Virgin, Herbert W

“…Immune responses differ between laboratory mice and humans. Chronic infection with viruses and parasites are common in humans, but are absent in laboratory…”
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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory by Tonnerre, Pierre, Wolski, David, Subudhi, Sonu, Aljabban, Jihad, Hoogeveen, Ruben C., Damasio, Marcos, Drescher, Hannah K., Bartsch, Lea M., Tully, Damien C., Sen, Debattama R., Bean, David J., Brown, Joelle, Torres-Cornejo, Almudena, Robidoux, Maxwell, Kvistad, Daniel, Alatrakchi, Nadia, Cui, Ang, Lieb, David, Cheney, James A., Gustafson, Jenna, Lewis-Ximenez, Lia L., Massenet-Regad, Lucile, Eisenhaure, Thomas, Aneja, Jasneet, Haining, W. Nicholas, Chung, Raymond T., Hacohen, Nir, Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.

“…T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and…”
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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells by Gupta, Prakash K., Godec, Jernej, Wolski, David, Adland, Emily, Yates, Kathleen, Pauken, Kristen E., Cosgrove, Cormac, Ledderose, Carola, Junger, Wolfgang G., Robson, Simon C., Wherry, E. John, Alter, Galit, Goulder, Philip J. R., Klenerman, Paul, Sharpe, Arlene H., Lauer, Georg M., Haining, W. Nicholas

“…Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of…”
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection by Pauken, Kristen E., Godec, Jernej, Odorizzi, Pamela M., Brown, Keturah E., Yates, Kathleen B., Ngiow, Shin Foong, Burke, Kelly P., Maleri, Seth, Grande, Shannon M., Francisco, Loise M., Ali, Mohammed-Alkhatim, Imam, Sabrina, Freeman, Gordon J., Haining, W. Nicholas, Wherry, E. John, Sharpe, Arlene H.

“…The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here,…”
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Densely interconnected transcriptional circuits control cell states in human hematopoiesis by Novershtern, Noa, Subramanian, Aravind, Lawton, Lee N, Mak, Raymond H, Haining, W Nicholas, McConkey, Marie E, Habib, Naomi, Yosef, Nir, Chang, Cindy Y, Shay, Tal, Frampton, Garrett M, Drake, Adam C B, Leskov, Ilya, Nilsson, Bjorn, Preffer, Fred, Dombkowski, David, Evans, John W, Liefeld, Ted, Smutko, John S, Chen, Jianzhu, Friedman, Nir, Young, Richard A, Golub, Todd R, Regev, Aviv, Ebert, Benjamin L

“…Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis…”
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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control by Weiss, Sarah A., Huang, Amy Y., Fung, Megan E., Martinez, Daniela, Chen, Alex C. Y., LaSalle, Thomas J., Miller, Brian C., Scharer, Christopher D., Hegde, Mudra, Nguyen, Thao H., Rowe, Jared H., Osborn, Jossef F., Patterson, Dillon G., Sifnugel, Natalia, Mei-An Nolan, C., Davidson, Richard A., Schwartz, Marc A., Bally, Alexander P. R., Neeld, Dennis K., LaFleur, Martin W., Boss, Jeremy M., Doench, John G., Nicholas Haining, W., Sharpe, Arlene H., Sen, Debattama R.

“…PD-1 is a key negative regulator of CD8 + T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1…”
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Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling by Brown, Flavian D., Sen, Debattama R., LaFleur, Martin W., Godec, Jernej, Lukacs-Kornek, Veronika, Schildberg, Frank A., Kim, Hye-Jung, Yates, Kathleen B., Ricoult, Stéphane J. H., Bi, Kevin, Trombley, Justin D., Kapoor, Varun N., Stanley, Illana A., Cremasco, Viviana, Danial, Nika N., Manning, Brendan D., Sharpe, Arlene H., Haining, W. Nicholas, Turley, Shannon J.

“…Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing nitric oxide, which inhibits T cell proliferation and…”
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Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load by West, Erin E, Youngblood, Ben, Tan, Wendy G, Jin, Hyun-Tak, Araki, Koichi, Alexe, Gabriela, Konieczny, Bogumila T, Calpe, Silvia, Freeman, Gordon J, Terhorst, Cox, Haining, W Nicholas, Ahmed, Rafi

“…To design successful vaccines for chronic diseases, an understanding of memory CD8(+) T cell responses to persistent antigen restimulation is critical…”
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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system by LaFleur, Martin W., Lemmen, Ashlyn M., Streeter, Ivy S. L., Nguyen, Thao H., Milling, Lauren E., Derosia, Nicole M., Hoffman, Zachary M., Gillis, Jacob E., Tjokrosurjo, Qin, Markson, Samuel C., Huang, Amy Y., Anekal, Praju V., Montero Llopis, Paula, Haining, W. Nicholas, Doench, John G., Sharpe, Arlene H.

“…Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consuming and low throughput. We previously…”
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Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans by Ruparelia, Neil, Godec, Jernej, Lee, Regent, Chai, Joshua T, Dall'Armellina, Erica, McAndrew, Debra, Digby, Janet E, Forfar, J Colin, Prendergast, Bernard D, Kharbanda, Rajesh K, Banning, Adrian P, Neubauer, Stefan, Lygate, Craig A, Channon, Keith M, Haining, Nicholas W, Choudhury, Robin P

“…Monocytes play critical roles in tissue injury and repair following acute myocardial infarction (AMI). Specifically targeting inflammatory monocytes in…”
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