Výsledky vyhľadávania - "Haematologica (Roma)"

Iron metabolism and iron disorders revisited in the hepcidin era Autor Camaschella, Clara, Nai, Antonella, Silvestri, Laura

“…Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell and systemic levels to prevent both deficiency and…”
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The regulation and function of CD20: an “enigma” of B-cell biology and targeted therapy Autor Pavlasova, Gabriela, Mraz, Marek

“…The introduction of anti-CD20 monoclonal antibodies such as rituximab, ofatumumab, or obinutuzumab improved the therapy of B-cell malignancies even though the…”
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One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors Autor Niederwieser, Dietger, Baldomero, Helen, Bazuaye, Nosa, Bupp, Caitrin, Chaudhri, Naeem, Corbacioglu, Selim, Elhaddad, Alaa, Frutos, Cristóbal, Galeano, Sebastian, Hamad, Nada, Hamidieh, Amir Ali, Hashmi, Shahrukh, Ho, Aloysius, Horowitz, Mary M., Iida, Minako, Jaimovich, Gregorio, Karduss, Amado, Kodera, Yoshihisa, Kröger, Nicolaus, Péffault de Latour, Regis, Lee, Jong Wook, Martínez-Rolón, Juliana, Pasquini, Marcelo C., Passweg, Jakob, Paulson, Kristjan, Seber, Adriana, Snowden, John A., Srivastava, Alok, Szer, Jeff, Weisdorf, Daniel, Worel, Nina, Koh, Mickey B.C., Aljurf, Mahmoud, Greinix, Hildegard, Atsuta, Yoshiko, Saber, Wael

“…The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by…”
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Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) Autor Yakoub-Agha, Ibrahim, Chabannon, Christian, Bader, Peter, Basak, Grzegorz W., Bonig, Halvard, Ciceri, Fabio, Corbacioglu, Selim, Duarte, Rafael F., Einsele, Hermann, Hudecek, Michael, Kersten, Marie José, Köhl, Ulrike, Kuball, Jürgen, Mielke, Stephan, Mohty, Mohamad, Murray, John, Nagler, Arnon, Robinson, Stephen, Saccardi, Riccardo, Sanchez-Guijo, Fermin, Snowden, John A., Srour, Micha, Styczynski, Jan, Urbano-Ispizua, Alvaro, Hayden, Patrick J., Kröger, Nicolaus

“…Chimeric antigen receptor (CAR) T cells are a novel class of anti-cancer therapy in which autologous or allogeneic T cells are engineered to express a CAR…”
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Immune reconstitution and associated infections following axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma Autor Logue, Jennifer M, Zucchetti, Elisa, Bachmeier, Christina A, Krivenko, Gabriel S, Larson, Victoria, Ninh, Daniel, Grillo, Giovanni, Cao, Biwei, Kim, Jongphil, Chavez, Julio C, Baluch, Aliyah, Khimani, Farhad, Lazaryan, Aleksandr, Nishihori, Taiga, Liu, Hien D, Pinilla-Ibarz, Javier, Shah, Bijal D, Faramand, Rawan, Coghill, Anna E, Davila, Marco L, Dholaria, Bhagirathbhai R, Jain, Michael D, Locke, Frederick L

“…CD19 CAR T-cell therapy with axicabtagene ciloleucel (axi-cel) for relapsed or refractory (R/R) large B cell lymphoma (LBCL) may lead to durable remissions,…”
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Leukemic stem cells and therapy resistance in acute myeloid leukemia Autor Stelmach, Patrick, Trumpp, Andreas

“…A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or relapse after achieving remission. The latter arises from a few…”
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Gemtuzumab ozogamicin for de novo acute myeloid leukemia: final efficacy and safety updates from the open-label, phase III ALFA-0701 trial Autor Lambert, Juliette, Pautas, Cécile, Terré, Christine, Raffoux, Emmanuel, Turlure, Pascal, Caillot, Denis, Legrand, Ollivier, Thomas, Xavier, Gardin, Claude, Gogat-Marchant, Karïn, Rubin, Stephen D., Benner, Rebecca J., Bousset, Pierre, Preudhomme, Claude, Chevret, Sylvie, Dombret, Herve, Castaigne, Sylvie

“…The randomized, phase III ALFA-0701 trial showed that a reduced and fractionated dose of gemtuzumab ozogamicin added to standard front-line chemotherapy…”
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Fibrin(ogen) in human disease: both friend and foe Autor Vilar, Rui, Fish, Richard J., Casini, Alessandro, Neerman-Arbez, Marguerite

“…Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with…”
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The clinical impact of the molecular landscape of acute myeloid leukemia Autor Kayser, Sabine, Levis, Mark J.

“…Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has led to remarkable advances in our understanding of the disease…”
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First-line treatment of chronic lymphocytic leukemia with ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab: final analysis of the randomized, phase III iLLUMINATE trial Autor Moreno, Carol, Greil, Richard, Demirkan, Fatih, Tedeschi, Alessandra, Anz, Bertrand, Larratt, Loree, Simkovic, Martin, Novak, Jan, Strugov, Vladimir, Gill, Devinder, Gribben, John G., Kwei, Kevin, Dai, Sandra, Hsu, Emily, Dean, James P., Flinn, Ian W.

“…iLLUMINATE is a randomized, open-label phase III study of ibrutinib plus obinutuzumab (n=113) versus chlorambucil plus obinutuzumab (n=116) as first-line…”
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Hemophilia therapy: the future has begun Autor Mannucci, Pier Mannuccio

“…The success story of hemophilia care first began in the 1970s, when the availability of plasma-derived concentrates of coagulation factor VIII (FVIII) and…”
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Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women Autor Stoffel, Nicole U., Zeder, Christophe, Brittenham, Gary M., Moretti, Diego, Zimmermann, Michael B.

“…In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin (SHep) that persists for 24 hours, decreasing iron absorption…”
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Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma Autor Strati, Paolo, Varma, Ankur, Adkins, Sherry, Nastoupil, Loretta J, Westin, Jason, Hagemeister, Fredrick B, Fowler, Nathan H, Lee, Hun J, Fayad, Luis E, Samaniego, Felipe, Ahmed, Sairah, Chen, Yiming, Horowitz, Sandra, Arafat, Sara, Johncy, Swapna, Kebriaei, Partow, Mulanovich, Victor Eduardo, Ariza Heredia, Ella, Neelapu, Sattva S

“…Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 may be associated with long-term adverse effects such as cytopenia and immune deficiency. In…”
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Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity Autor D'Alessandro, Angelo, Fu, Xiaoyun, Kanias, Tamir, Reisz, Julie A, Culp-Hill, Rachel, Guo, Yuelong, Gladwin, Mark T, Page, Grier, Kleinman, Steven, Lanteri, Marion, Stone, Mars, Busch, Michael P, Zimring, James C

“…Red blood cell storage in the blood bank promotes the progressive accumulation of metabolic alterations that may ultimately impact the erythrocyte capacity to…”
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Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia Autor Tausch, Eugen, Close, William, Dolnik, Anna, Bloehdorn, Johannes, Chyla, Brenda, Bullinger, Lars, Döhner, Hartmut, Mertens, Daniel, Stilgenbauer, Stephan

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Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models Autor Singh Mali, Raghuveer, Zhang, Qi, DeFilippis, Rosa Anna, Cavazos, Antonio, Kuruvilla, Vinitha Mary, Raman, Jayant, Mody, Vidhi, Choo, Edna F, Dail, Monique, Shah, Neil P, Konopleva, Marina, Sampath, Deepak, Lasater, Elisabeth A

“…FLT3 internal tandem duplication (FLT3-ITD) mutations account for ~25% of adult acute myeloid leukemia cases and are associated with poor prognosis…”
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CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide Autor Gurney, Mark, Stikvoort, Arwen, Nolan, Emma, Kirkham-McCarthy, Lucy, Khoruzhenko, Stanislav, Shivakumar, Rama, Zweegman, Sonja, Van de Donk, Niels W.C.J., Mutis, Tuna, Szegezdi, Eva, Sarkar, Subhashis, O’Dwyer, Michael

“…There is a strong biological rationale for the augmentation of allogeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to enhance…”
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Zanubrutinib monotherapy for patients with treatment-naïve chronic lymphocytic leukemia and 17p deletion Autor Tam, Constantine S., Robak, Tadeusz, Ghia, Paolo, Kahl, Brad S., Walker, Patricia, Janowski, Wojciech, Simpson, David, Shadman, Mazyar, Ganly, Peter S., Laurenti, Luca, Opat, Stephen, Tani, Monica, Ciepluch, Hanna, Verner, Emma, Šimkovič, Martin, Österborg, Anders, Trněný, Marek, Tedeschi, Alessandra, Paik, Jason C., Kuwahara, Sowmya B., Feng, Shibao, Ramakrishnan, Vanitha, Cohen, Aileen, Huang, Jane, Hillmen, Peter, Brown, Jennifer R.

“…Patients with chronic lymphocytic leukemia or small lymphocytic lymphoma whose tumors carry deletion of chromosome 17p13.1 [del(17p)] have an unfavorable…”
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Understanding intrinsic hematopoietic stem cell aging Autor Mejia-Ramirez, Eva, Florian, Maria Carolina

“…Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an organism. It is of extreme importance that these cells maintain…”
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Bortezomib with standard chemotherapy for children with acute myeloid leukemia does not improve treatment outcomes: a report from the Children’s Oncology Group Autor Aplenc, Richard, Meshinchi, Soheil, Sung, Lillian, Alonzo, Todd, Choi, John, Fisher, Brian, Gerbing, Robert, Hirsch, Betsy, Horton, Terzah, Kahwash, Samir, Levine, John, Loken, Michael, Brodersen, Lisa, Pollard, Jessica, Raimondi, Susana, Kolb, Edward Anders, Gamis, Alan

“…New therapeutic strategies are needed for pediatric acute myeloid leukemia (AML) to reduce disease recurrence and treatment-related morbidity. The Children's…”
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