Suchergebnisse - "HCT116 Cells"

Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells von Saidu, Nathaniel Edward Bennett, Abu Asali, Imad, Czepukojc, Brigitte, Seitz, Berthold, Jacob, Claus, Montenarh, Mathias

“… Diallyl mono- and polysulfanes from garlic are known to induce an adaptive cell response and the formation of antioxidants in cancer cells. In the case of a …”
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Glypican-1 identifies cancer exosomes and detects early pancreatic cancer von Melo, Sonia A., Luecke, Linda B., Kahlert, Christoph, Fernandez, Agustin F., Gammon, Seth T., Kaye, Judith, LeBleu, Valerie S., Mittendorf, Elizabeth A., Weitz, Juergen, Rahbari, Nuh, Reissfelder, Christoph, Pilarsky, Christian, Fraga, Mario F., Piwnica-Worms, David, Kalluri, Raghu

“… + crExos were detected in the serum of patients with pancreatic cancer with absolute specificity and sensitivity, distinguishing healthy subjects and patients with a benign pancreatic disease …”
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Radiofluorinated Smart Probes for Noninvasive PET Imaging of Legumain Activity in Living Subjects von Qiu, Ling, Li, Xi, Lv, Gaochao, Seimbille, Yann, Li, Ke, Peng, Ying, Liu, Qingzhu, Xie, Minhao, Lin, Jianguo

“… %) and radiochemical purity (RCP > 99%) using a convenient "one-step" F-labeling method. The probes and exhibited high response to legumain activity and reductive environment and revealed comparable uptake in HCT116 cells (4.22% ± 0.14% and 4.64% ± 0.32 …”
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Inhibition of DDR1‐BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer von Jeitany, Maya, Leroy, Cédric, Tosti, Priscillia, Lafitte, Marie, Le Guet, Jordy, Simon, Valérie, Bonenfant, Debora, Robert, Bruno, Grillet, Fanny, Mollevi, Caroline, El Messaoudi, Safia, Otandault, Amaëlle, Canterel‐Thouennon, Lucile, Busson, Muriel, Thierry, Alain R, Martineau, Pierre, Pannequin, Julie, Roche, Serge, Sirvent, Audrey

“… The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. Here, we show that nilotinib, a clinically approved drug for chronic …”
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Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents von Acilan, Ceyda, Cevatemre, Buse, Adiguzel, Zelal, Karakas, Didem, Ulukaya, Engin, Ribeiro, Nádia, Correia, Isabel, Pessoa, João Costa

“… To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds …”
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Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c von Edelstein, Leonard C, Simon, Lukas M, Montoya, Raúl Teruel, Holinstat, Michael, Chen, Edward S, Bergeron, Angela, Kong, Xianguo, Nagalla, Srikanth, Mohandas, Narla, Cohen, David E, Dong, Jing-fei, Shaw, Chad, Bray, Paul F

“… Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black ( n = 70) and white ( n = 84) subjects …”
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Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo von Song, Hualong, Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah E., Kasparkova, Jana, Kostrhunova, Hana, Novohradsky, Vojtech, Phillips, Roger M., Pracharova, Jitka, Rogers, Nicola J., Shepherd, Samantha L., Scott, Peter

“… Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric FeII metallohelix, using CuAAC chemistry. The sixteen resulting architectures …”
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Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing von González Besteiro, Marina A, Calzetta, Nicolás L, Loureiro, Sofía M, Habif, Martín, Bétous, Rémy, Pillaire, Marie‐Jeanne, Maffia, Antonio, Sabbioneda, Simone, Hoffmann, Jean‐Sébastien, Gottifredi, Vanesa

“… The effectiveness of checkpoint kinase 1 (Chk1) inhibitors at killing cancer cells is considered to be fully dependent on their effect on DNA replication …”
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Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells von Palrasu, Manikandan, Zaika, Elena, El-Rifai, Wael, Garcia-Buitrago, Monica, Piazuelo, Maria Blanca, Wilson, Keith T., Peek, Richard M., Zaika, Alexander I.

“… To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H …”
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3D-bioprinted all-inclusive bioanalytical platforms for cell studies von Mazrouei, Roya, Velasco, Vanessa, Esfandyarpour, Rahim

“… Innovative drug screening platforms should improve the discovery of novel and personalized cancer treatment. Common models such as animals and 2D cell cultures …”
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Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability von Utani, Koichi, Fu, Haiqing, Jang, Sang-Min, Marks, Anna B., Smith, Owen K., Zhang, Ya, Redon, Christophe E., Shimizu, Noriaki, Aladjem, Mirit I.

“… T530-pSIRT1 associates with replication origins and inhibits replication from a group of 'dormant' potential replication origins, which initiate replication only when cells are subject to replication stress …”
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Oat avenanthramide-C (2c) is biotransformed by mice and the human microbiota into bioactive metabolites von Wang, Pei, Chen, Huadong, Zhu, Yingdong, McBride, Jennifer, Fu, Junsheng, Sang, Shengmin

“… Avenanthramides (AVAs), which are found exclusively in oats, may play an important role in anti-inflammation and antiatherogenesis. Although the …”
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VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA von KONDKAR, A. A., BRAY, M. S., LEAL, S. M., NAGALLA, S., LIU, D. J., JIN, Y., DONG, J. F., REN, Q., WHITEHEART, S. W., SHAW, C., BRAY, P. F.

“… : To discover associations between interindividual platelet variability and the responsible platelet genes, and to begin to define the molecular mechanisms altering platelet gene expression. Subjects/methods …”
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MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy von Lu, Changming, Chen, Jianfeng, Xu, Hua-Guo, Zhou, Xianzheng, He, Qiongqiong, Li, Yu-Lin, Jiang, Guoqing, Shan, Yuxi, Xue, Boxin, Zhao, Rui-Xun, Wang, Yong, Werle, Kaitlin D, Cui, Rutao, Liang, Jiyong, Xu, Zhi-Xiang

“… Variants in genes that regulate autophagy have been associated with Crohn's disease (CD). Defects in autophagy-mediated removal of pathogenic microbes could …”
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CRISPR-Cas9 Mediated AGO2 Knockout inhibits tumorigenesis in human colorectal cancer cells von Zhu, Yizhi, Wang, Gengfang, Xu, Haoran, Guo, Yuan

“… ) assay in CRC tissues and normal adjacent tissues collected from 25 CRC patients. CRISPR/Cas9-mediated genome editing was used to knockout the AGO2 in HCT116 cells as a model system for colorectal cancers …”
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Feasibility of quantifying SDC2 methylation in stool DNA for early detection of colorectal cancer von Oh, Tae Jeong, Oh, Hyun Il, Seo, Yang Yei, Jeong, Dongjun, Kim, Changjin, Kang, Hyoun Woo, Han, Yoon Dae, Chung, Hyun Cheol, Kim, Nam Kyu, An, Sungwhan

“… Background Colorectal cancer (CRC) screening is the most efficient strategy to reduce disease-related mortality. Frequent aberrant DNA methylation is known to …”
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Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION von Realini, Natalia, Palese, Francesca, Pizzirani, Daniela, Pontis, Silvia, Basit, Abdul, Bach, Anders, Ganesan, Anand, Piomelli, Daniele

“… (keratinocytes and fibroblasts) and non-melanoma cancer cells. High AC expression was also observed in biopsies from human subjects with Stage II melanoma …”
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Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor von Lu, Gang, Zhang, Qing, Huang, Ying, Song, Jiaxi, Tomaino, Ross, Ehrenberger, Tobias, Lim, Elgene, Liu, Wenbin, Bronson, Roderick T, Bowden, Michaela, Brock, Jane, Krop, Ian E, Dillon, Deborah A, Gygi, Steven P, Mills, Gordon B, Richardson, Andrea L, Signoretti, Sabina, Yaffe, Michael B, Kaelin, Jr, William G

“… in vitro and tumor growth in vivo. These findings expand the list of potential COP1 substrates to include proteins whose COP1-binding sites are subject to regulatory …”
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Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression von Deng, Ruyuan, Wu, Huo, Ran, Hui, Kong, Xiang, Hu, Lei, Wang, Xiao, Su, Qing

“… It is well established that the risk of colorectal cancer (CRC) is significantly increased in diabetic patients. As one of main forms of the advanced glycation …”
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Backbone modified TBA analogues endowed with antiproliferative activity von Esposito, Veronica, Russo, Annapina, Amato, Teresa, Varra, Michela, Vellecco, Valentina, Bucci, Mariarosaria, Russo, Giulia, Virgilio, Antonella, Galeone, Aldo

“… The thrombin binding aptamer (TBA) is endowed with antiproliferative properties but its potential development is counteracted by the concomitant anticoagulant …”
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