Výsledky vyhľadávania - "Guyonnet, Léa"

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia Autor Wierz, Marina, Pierson, Sandrine, Guyonnet, Léa, Viry, Elodie, Lequeux, Audrey, Oudin, Anaïs, Niclou, Simone P, Ollert, Markus, Berchem, Guy, Janji, Bassam, Guérin, Coralie, Paggetti, Jerome, Moussay, Etienne

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Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis Autor Lenoir, Olivia, Jasiek, Magali, Hénique, Carole, Guyonnet, Léa, Hartleben, Björn, Bork, Tillmann, Chipont, Anna, Flosseau, Kathleen, Bensaada, Imane, Schmitt, Alain, Massé, Jean-Marc, Souyri, Michèle, Huber, Tobias B, Tharaux, Pierre-Louis

“…The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while…”
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A novel role for myeloid endothelin-B receptors in hypertension Autor Czopek, Alicja, Moorhouse, Rebecca, Guyonnet, Léa, Farrah, Tariq, Lenoir, Olivia, Owen, Elizabeth, van Bragt, Job, Costello, Hannah M, Menolascina, Filippo, Baudrie, Véronique, Webb, David J, Kluth, David C, Bailey, Matthew A, Tharaux, Pierre-Louis, Dhaun, Neeraj

“…Abstract Aims Hypertension is common. Recent data suggest that macrophages (Mφ) contribute to, and protect from, hypertension. Endothelin-1 (ET-1) is the most…”
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The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease Autor Koehl, Bérengère, Nivoit, Pierre, El Nemer, Wassim, Lenoir, Olivia, Hermand, Patricia, Pereira, Catia, Brousse, Valentine, Guyonnet, Léa, Ghinatti, Giulia, Benkerrou, Malika, Colin, Yves, Le Van Kim, Caroline, Tharaux, Pierre-Louis

“…Although the primary origin of sickle cell disease is a hemoglobin disorder, many types of cells contribute considerably to the pathophysiology of the disease…”
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Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension Autor Luque, Yosu, Lenoir, Olivia, Bonnin, Philippe, Hardy, Lise, Chipont, Anna, Placier, Sandrine, Vandermeersch, Sophie, Xu-Dubois, Yi-Chun, Robin, Blaise, Lazareth, Hélène, Souyri, Michèle, Guyonnet, Léa, Baudrie, Véronique, Camerer, Eric, Rondeau, Eric, Mesnard, Laurent, Tharaux, Pierre-Louis

“…FSGS, the most common primary glomerular disorder causing ESRD, is a complex disease that is only partially understood. Progressive sclerosis is a hallmark of…”
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Elevated Circulating Stem Cells Level is Observed One Month After Implantation of Carmat Bioprosthetic Total Artificial Heart Autor Guyonnet, Léa, Detriché, Grégoire, Gendron, Nicolas, Philippe, Aurélien, Latremouille, Christian, Soret, Lou, Capel, Antoine, Peronino, Christophe, Jansen, Piet, Ivak, Peter, Carpentier, Alain, Mirault, Tristan, Netuka, Ivan, Guerin, Coralie L., Smadja, David M.

“…The Aeson® total artificial heart (A-TAH) has been developed as a total heart replacement for patients at risk of death from biventricular failure. We…”
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Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells Autor Guerin, Coralie L., Guyonnet, Léa, Goudot, Guillaume, Revets, Dominique, Konstantinou, Maria, Chipont, Anna, Chocron, Richard, Blandinieres, Adeline, Khider, Lina, Rancic, Jeanne, Peronino, Christophe, Debuc, Benjamin, Cras, Audrey, Knosp, Camille, Latremouille, Christian, Capel, Antoine, Ollert, Markus, Diehl, Jean-Luc, Jansen, Piet, Planquette, Benjamin, Sanchez, Olivier, Gaussem, Pascale, Mirault, Tristan, Carpentier, Alain, Gendron, Nicolas, Smadja, David M.

“…Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but…”
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TLR or NOD receptor signaling skews monocyte fate decision via distinct mechanisms driven by mTOR and miR-155 Autor Coillard, Alice, Guyonnet, Léa, De Juan, Alba, Cros, Adeline, Segura, Elodie

“…Monocytes are rapidly recruited to inflamed tissues where they differentiate into monocyte-derived macrophages (mo-mac) or dendritic cells (mo-DC). At…”
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The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression Autor Lazareth, Hélène, Henique, Carole, Lenoir, Olivia, Puelles, Victor G., Flamant, Martin, Bollée, Guillaume, Fligny, Cécile, Camus, Marine, Guyonnet, Lea, Millien, Corinne, Gaillard, François, Chipont, Anna, Robin, Blaise, Fabrega, Sylvie, Dhaun, Neeraj, Camerer, Eric, Kretz, Oliver, Grahammer, Florian, Braun, Fabian, Huber, Tobias B., Nochy, Dominique, Mandet, Chantal, Bruneval, Patrick, Mesnard, Laurent, Thervet, Eric, Karras, Alexandre, Le Naour, François, Rubinstein, Eric, Boucheix, Claude, Alexandrou, Antigoni, Moeller, Marcus J., Bouzigues, Cédric, Tharaux, Pierre-Louis

“…The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain…”
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Chemical inhibition of exon junction complex assembly impairs mRNA localization and neural stem cells ciliogenesis Autor Villa, Tommaso, Pourcelot, Oriane, Dierks, David, Faucourt, Marion, Burel, Cindy, Slimani, Floric, Guyonnet, Léa, Spassky, Nathalie, Schwartz, Schraga, Bertrand, Edouard, Bensaude, Olivier, Le Hir, Hervé

“…Abstract The exon junction complex (EJC) is formed by the essential eIF4A3, MAGOH, and Y14 core proteins. It is universally deposited during splicing at…”
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Selective EGF-Receptor Inhibition in CD4 +  T Cells Induces Anergy and Limits Atherosclerosis Autor Zeboudj, Lynda, Maître, Mikael, Guyonnet, Lea, Laurans, Ludivine, Joffre, Jeremie, Lemarie, Jeremie, Bourcier, Simon, Nour-Eldine, Wared, Guérin, Coralie, Friard, Jonas, Wakkach, Abdelilah, Fabre, Elizabeth, Tedgui, Alain, Mallat, Ziad, Tharaux, Pierre-Louis, Ait-Oufella, Hafid

“…Several epidermal growth factor receptor (EGFR) inhibitors have been successfully developed for the treatment of cancer, limiting tumor growth and metastasis…”
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TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm Autor Vandestienne, Marie, Zhang, Yujiao, Santos-Zas, Icia, Al-Rifai, Rida, Joffre, Jeremie, Giraud, Andreas, Laurans, Ludivine, Esposito, Bruno, Pinet, Florence, Bruneval, Patrick, Raffort, Juliette, Lareyre, Fabien, Vilar, Jose, Boufenzer, Amir, Guyonnet, Lea, Guerin, Coralie, Clauser, Eric, Silvestre, Jean-Sébastien, Lang, Sylvie, Soulat-Dufour, Laurie, Tedgui, Alain, Mallat, Ziad, Taleb, Soraya, Boissonnas, Alexandre, Derive, Marc, Chinetti, Giulia, Ait-Oufella, Hafid

“…The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic…”
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Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis Autor Henique, Carole, Bollée, Guillaume, Loyer, Xavier, Grahammer, Florian, Dhaun, Neeraj, Camus, Marine, Vernerey, Julien, Guyonnet, Léa, Gaillard, François, Lazareth, Hélène, Meyer, Charlotte, Bensaada, Imane, Legrès, Luc, Satoh, Takashi, Akira, Shizuo, Bruneval, Patrick, Dimmeler, Stefanie, Tedgui, Alain, Karras, Alexandre, Thervet, Eric, Nochy, Dominique, Huber, Tobias B., Mesnard, Laurent, Lenoir, Olivia, Tharaux, Pierre-Louis

“…Crescentic rapidly progressive glomerulonephritis (RPGN) represents the most aggressive form of acquired glomerular disease. While most therapeutic approaches…”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age Autor Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“…Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce…”
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Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway Autor Licaj, Monika, Mhaidly, Rana, Kieffer, Yann, Croizer, Hugo, Bonneau, Claire, Meng, Arnaud, Djerroudi, Lounes, Mujangi-Ebeka, Kevin, Hocine, Hocine R., Bourachot, Brigitte, Magagna, Ilaria, Leclere, Renaud, Guyonnet, Lea, Bohec, Mylene, Guérin, Coralie, Baulande, Sylvain, Kamal, Maud, Le Tourneau, Christophe, Lecuru, Fabrice, Becette, Véronique, Rouzier, Roman, Vincent-Salomon, Anne, Gentric, Geraldine, Mechta-Grigoriou, Fatima

“…Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of chemotherapy on CAF populations remains poorly understood. Here we…”
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Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study Autor Pogorelov, Dimitrii, Bode, Sebastian Felix Nepomuk, He, Xin, Ramiro-Garcia, Javier, Hedin, Fanny, Ammerlaan, Wim, Konstantinou, Maria, Capelle, Christophe M., Zeng, Ni, Poli, Aurélie, Domingues, Olivia, Montamat, Guillem, Hunewald, Oliver, Ciré, Séverine, Baron, Alexandre, Longworth, Joseph, Demczuk, Agnieszka, Bazon, Murilo Luiz, Casper, Ingrid, Klimek, Ludger, Neuberger-Castillo, Lorie, Revets, Dominique, Guyonnet, Lea, Delhalle, Sylvie, Zimmer, Jacques, Benes, Vladimir, Codreanu-Morel, Françoise, Lehners-Weber, Christiane, Weets, Ilse, Alper, Pinar, Brenner, Dirk, Gutermuth, Jan, Guerin, Coralie, Morisset, Martine, Hentges, François, Schneider, Reinhard, Shamji, Mohamed H., Betsou, Fay, Wilmes, Paul, Glaab, Enrico, Cosma, Antonio, Goncalves, Jorge, Hefeng, Feng Q., Ollert, Markus

“…Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen…”
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Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis-Brief Report Autor Zeboudj, Lynda, Giraud, Andréas, Guyonnet, Lea, Zhang, Yujiao, Laurans, Ludivine, Esposito, Bruno, Vilar, Jose, Chipont, Anna, Papac-Milicevic, Nikolina, Binder, Christoph J, Tedgui, Alain, Mallat, Ziad, Tharaux, Pierre-Louis, Ait-Oufella, Hafid

“…To determine the consequences of specific inhibition of EGFR (epidermal growth factor receptor) in myeloid cells in atherosclerosis development…”
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Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated kidney, eye and vessel injury Autor Guyonnet, Léa, Czopek, Alicja, Farrah, Tariq E, Baudrie, Véronique, Bonnin, Philippe, Chipont, Anna, Lenoir, Olivia, Sennlaub, Florian, Roubeix, Christophe, Webb, David J, Kluth, David C, Bailey, Matthew A, Tharaux, Pierre-Louis, Dhaun, Neeraj

“…The endothelin system may be an important player in hypertensive end-organ injury as endothelin-1 increases blood pressure and is pro-inflammatory. The immune…”
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Update on crescentic glomerulonephritis Autor Hénique, Carole, Papista, Christina, Guyonnet, Léa, Lenoir, Olivia, Tharaux, Pierre-Louis

“…The recent years have seen a number of major progresses in the field of extracapillary glomerulonephritis. This entity is the final damage caused by unrelated…”
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Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation Autor Peronino, Christophe, Guerin, Coralie L, Ivak, Peter, Guyonnet, Léa, Chocron, Richard, Detriché, Grégoire, Latremouille, Christian, Gruest, Maxime, Philippe, Aurélien, Capel, Antoine, Pya, Yuri, Martin, Anne-Céline, Jansen, Piet, Gendron, Nicolas, Netuka, Ivan, Smadja, David M

“…The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory…”
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