Search Results - "Guo, Yongzheng"

Editorial: Mitochondria in metabolic reprogramming and immune activation: the key gene and therapeutic target by Guo, Yongzheng

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Palmitic acid promotes endothelial-to-mesenchymal transition via activation of the cytosolic DNA-sensing cGAS-STING pathway by Liu, Qian, Cheng, Zhe, Huang, Bi, Luo, Suxin, Guo, Yongzheng

“…Elevated levels of plasma free fatty acids (FFAs) lead to endothelial dysfunction, a process that is involved in the pathogenesis of atherosclerosis…”
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iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation by Guo, Yongzheng, Wen, Junjie, He, An, Qu, Can, Peng, Yuce, Luo, Suxin, Wang, Xiaowen

“…[Display omitted] •Combination of HDF and L-NAME induced cardiac mitochondrial dysfunction and HFpEF phenotype.•Both long-term and short-term iNOS inhibition…”
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Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction by Li, Guoxing, Zhao, Huilin, Cheng, Zhe, Liu, Junjin, Li, Gang, Guo, Yongzheng

“…[Display omitted] •We characterized the transcriptional landscape of non-cardiomyocytes in HFpEF hearts using scRNA-seq and bulk RNA-seq.•Fibroblasts in the…”
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Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice by Yu, Jiang, Zhao, Boying, Pi, Qiangzhong, Zhou, Guoxiang, Cheng, Zhe, Qu, Can, Wang, Xiaowen, Kong, Lingwen, Luo, Suxin, Du, Dingyuan, Guo, Yongzheng

“…Background We have reported a positive correlation between S100 calcium-binding protein (S100) A8/S100A9 and sepsis-induced lung damage before. However,…”
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Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart by Guo, Yongzheng, Wang, Zhen, Qin, Xinghua, Xu, Jie, Hou, Zuoxu, Yang, Hongyan, Mao, Xuechao, Xing, Wenjuan, Li, Xiaoliang, Zhang, Xing, Gao, Feng

“…Heart failure (HF) is characterized by reduced fatty acid (FA) utilization associated with mitochondrial dysfunction. Recent evidence has shown that enhancing…”
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Improved pulse high frequency voltage injection method based low-speed sensorless control of axial field flux-switching permanent magnet motors by Zhang, Wei, Tai, Ziyi, Jin, Huayang, Guo, Yongzheng, Liang, Xingyan

“…To enhance the operating performance of the axial field flux-switching permanent magnet motor (AFFSPMM) at low speeds and minimize the rotor position…”
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Inflammation in Heart Failure: Mechanisms and Therapeutic Strategies by Yu, Jiang, Zhou, Guoxiang, Guo, Yongzheng, Long, Yang

“…Cardiovascular disease remains a leading cause of death and disability worldwide. Heart failure (HF) is the end stage of various cardiovascular diseases…”
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Hypertonic stress modulates eNOS function through O-GlcNAc modification at Thr-866 by Li, Chang, He, An, Guo, Yongzheng, Yang, Xiyang, Luo, Minghao, Cheng, Zhe, Huang, Longxiang, Xia, Yong, Luo, Suxin

“…O-GlcNAcylation, an energy-sensitive posttranslational modification, can regulate the activity of endothelial nitric oxide synthase (eNOS). Previous studies…”
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Regulation of O-GlcNAcylation on endothelial nitric oxide synthase by glucose deprivation and identification of its O-GlcNAcylation sites by He, An, Hu, Shupeng, Pi, Qiangzhong, Guo, Yongzheng, Long, Yang, Luo, Suxin, Xia, Yong

“…As an energy-sensitive post-translational modification, O-GlcNAcylation plays a major role in endothelial nitric oxide synthase (eNOS) activity regulation…”
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Ketogenic diet aggravates cardiac remodeling in adult spontaneously hypertensive rats by You, Yuehua, Guo, Yongzheng, Jia, Ping, Zhuang, Biaobiao, Cheng, Yu, Deng, Hongpei, Wang, Xiaowen, Zhang, Cheng, Luo, Suxin, Huang, Bi

“…Background Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac…”
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Ventriculoperitoneal shunt is associated with increased cerebrospinal fluid protein level in HIV-infected cryptococcal meningitis patients by Tao, Ran, Xu, Lijun, Guo, Yongzheng, Xu, Xiaoke, Zheng, Jiesheng, Zhu, Biao

“…Background The impact of ventriculoperitoneal shunt on cerebrospinal fluid (CSF) biochemical profiles in HIV-associated cryptococcal meningitis (HCM) patients…”
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Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study by Wan, Zhikai, Tao, Ran, Hui, Jiangjin, Liu, Xiang, Peng, Xiaorong, Guo, Yongzheng, Zhu, Xueling, Huang, Ying, Zhu, Biao

“…Background Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative…”
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Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling by Xue, Yuzhou, Luo, Minghao, Hu, Xiankang, Li, Xiang, Shen, Jian, Zhu, Wenyan, Huang, Longxiang, Hu, Yu, Guo, Yongzheng, Liu, Lin, Wang, Lingbang, Luo, Suxin

“…Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis progression, but the functional changes in VSMCs and the associated cellular…”
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Case report: Savolitinib induced severe adverse reactions resembling septic shock in an HIV-1–positive patient with advanced non-small cell lung cancer by Xiong, Ye, Cao, Qing, Guo, Yongzheng, Liu, Xiang, Zhu, Xueling, Dai, Bohao, Zhu, Biao

“…Savolitinib, a small-molecule inhibitor of the receptor tyrosine kinase mesenchymal-epithelial transition (MET) factor, was approved for the treatment of…”
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Identification of ageing-associated gene signatures in heart failure with preserved ejection fraction by integrated bioinformatics analysis and machine learning by Li, Guoxing, Zhou, Qingju, Xie, Ming, Zhao, Boying, Zhang, Keyu, Luo, Yuan, Kong, Lingwen, Gao, Diansa, Guo, Yongzheng

“…The incidence of heart failure with preserved ejection fraction (HFpEF) increases with the ageing of populations. This study aimed to explore ageing-associated…”
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Heart–brain team approach of acute myocardial infarction complicating acute stroke: Evidencing the knowledge gap by Li, Na, Tian, Xin, Guo, Yongzheng

“…[...]cardiovascular and bleeding outcomes in this study were subjected to be affected by variable guidelines for coronary revascularization and antithrombotic…”
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Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice by Zhao, Boying, Yu, Jiang, Luo, Yuan, Xie, Ming, Qu, Can, Shi, Qiong, Wang, Xiaowen, Zhao, Xingji, Kong, Lingwen, Zhao, Yu, Guo, Yongzheng

“…S100 calcium-binding protein A9 (S100A9) is a danger-associated molecular pattern molecule that mediates the inflammatory response. Inflammation is essential…”
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Epstein-Barr virus variation in people living with human immunodeficiency virus in southeastern China by Wan, Zhikai, Chen, Ying, Hui, Jiangjin, Guo, Yongzheng, Peng, Xiaorong, Wang, Mengyan, Hu, Caiqin, Xie, Yirui, Su, Junwei, Huang, Ying, Xu, Xiaoke, Xu, Yan, Zhu, Biao

“…Background Patients infected with HIV are at high risk of developing Epstein-Barr Virus (EBV)-related diseases. The genotype and viral biological behavior of…”
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Mitophagy deficiency activates stimulator of interferon genes activation and aggravates pathogenetic cardiac remodeling by Zhou, Guoxiang, Wang, Xiaowen, Guo, Mingyu, Qu, Can, Gao, Lei, Yu, Jiang, Li, Yuanjing, Luo, Suxin, Shi, Qiong, Guo, Yongzheng

“…Stimulator of interferon genes (STING) has recently been found to play a crucial role in cardiac sterile inflammation and dysfunction. The role of stimulator…”
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