Suchergebnisse - "Guo, Xiuqing"

Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis von Tian, Wenjie, Jiang, Wanlin, Yao, Jie, Nicholson, Christopher J., Li, Rebecca H., Sigurslid, Haakon H., Wooster, Luke, Rotter, Jerome I., Guo, Xiuqing, Malhotra, Rajeev

“… Mortality rates of coronavirus disease‐2019 (COVID‐19) continue to rise across the world. Information regarding the predictors of mortality in patients with …”
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Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy von Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.

“… Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been …”
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The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study von Schmitz, Lauren L., Zhao, Wei, Ratliff, Scott M., Goodwin, Julia, Miao, Jiacheng, Lu, Qiongshi, Guo, Xiuqing, Taylor, Kent D., Ding, Jingzhong, Liu, Yongmei, Levine, Morgan, Smith, Jennifer A.

“… Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted …”
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Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events von Khan, Sadiya S, Post, Wendy S, Guo, Xiuqing, Tan, Jingyi, Zhu, Fang, Bos, Daniel, Sedaghati-Khayat, Bahar, van Rooij, Jeroen, Aday, Aaron, Allen, Norrina B, Bos, Maxime M, Uitterlinden, André G, Budoff, Matthew J, Lloyd-Jones, Donald M, Mosley, Jonathan D, Rotter, Jerome I, Greenland, Philip, Kavousi, Maryam

“… Coronary artery calcium score and polygenic risk score have each separately been proposed as novel markers to identify risk of coronary heart disease (CHD), …”
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Genetic architecture of gene expression traits across diverse populations von Mogil, Lauren S., Andaleon, Angela, Badalamenti, Alexa, Dickinson, Scott P., Guo, Xiuqing, Rotter, Jerome I., Johnson, W. Craig, Im, Hae Kyung, Liu, Yongmei, Wheeler, Heather E.

“… For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the genetic architectures of complex traits vary between populations …”
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Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans von Crawford, Jacob E, Amaru, Ricardo, Song, Jihyun, Julian, Colleen G, Racimo, Fernando, Cheng, Jade Yu, Guo, Xiuqing, Yao, Jie, Ambale-Venkatesh, Bharath, Lima, João A, Rotter, Jerome I, Stehlik, Josef, Moore, Lorna G, Prchal, Josef T, Nielsen, Rasmus

“… The increase in red blood cell mass (polycythemia) due to the reduced oxygen availability (hypoxia) of residence at high altitude or other conditions is …”
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Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease von Paranjpe, Manish D., Chaffin, Mark, Zahid, Sohail, Ritchie, Scott, Rotter, Jerome I., Rich, Stephen S., Gerszten, Robert, Guo, Xiuqing, Heckbert, Susan, Tracy, Russ, Danesh, John, Lander, Eric S., Inouye, Michael, Kathiresan, Sekar, Butterworth, Adam S., Khera, Amit V.

“… For Alzheimer’s disease–a leading cause of dementia and global morbidity–improved identification of presymptomatic high-risk individuals and identification of …”
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Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation von Moore, Mary P., Wang, Xiaobo, Kennelly, John Paul, Shi, Hongxue, Ishino, Yuki, Kano, Kuniyuki, Aoki, Junken, Cherubini, Alessandro, Ronzoni, Luisa, Guo, Xiuqing, Chalasani, Naga P., Khalid, Shareef, Saleheen, Danish, Mitsche, Matthew A., Rotter, Jerome I., Yates, Katherine P., Valenti, Luca, Kono, Nozomu, Tontonoz, Peter, Tabas, Ira

“… The common genetic variant rs641738 C>T is a risk factor for metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated …”
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Adiposity‐Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans von Ehrhardt, Nicole, Cui, Jinrui, Dagdeviren, Sezin, Saengnipanthkul, Suchaorn, Goodridge, Helen S., Kim, Jason K., Lantier, Louise, Guo, Xiuqing, Chen, Yii‐Der I., Raffel, Leslie J., Buchanan, Thomas A., Hsueh, Willa A., Rotter, Jerome I., Goodarzi, Mark O., Péterfy, Miklós

“… Objective Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 diabetes. However, it remains unclear whether …”
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Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4 von Luan, Bing, Goodarzi, Mark O, Phillips, Naomi G, Guo, Xiuqing, Chen, Yii-Der I, Yao, Jie, Allison, Matthew, Rotter, Jerome I, Shaw, Reuben, Montminy, Marc

“… Obesity promotes systemic insulin resistance through inflammatory changes that lead to the release of cytokines from activated macrophages. Although the …”
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Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction von Culler, Kasen L., Sinha, Arjun, Filipp, Mallory, Giro, Pedro, Allen, Norrina B., Taylor, Kent D., Guo, Xiuqing, Thorp, Ed, Freed, Benjamin H., Greenland, Philip, Post, Wendy S., Bertoni, Alain, Herrington, David, Gao, Chen, Wang, Yibin, Shah, Sanjiv J., Patel, Ravi B.

“… Metabolic comorbidities, such as obesity and diabetes, are associated with subclinical alterations in both cardiac structure/function and natriuretic peptides …”
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Multi-generational impacts of arsenic exposure on genome-wide DNA methylation and the implications for arsenic-induced skin lesions von Guo, Xiaojuan, Chen, Xushen, Wang, Jie, Liu, Zhiyue, Gaile, Daniel, Wu, Hongmei, Yu, Guan, Mao, Guangyun, Yang, Zuopeng, Di, Zhen, Guo, Xiuqing, Cao, Li, Chang, Peiye, Kang, Binxian, Chen, Jinyu, Gao, Wen, Ren, Xuefeng

“… As a nonmutagenic human carcinogen, arsenic (As)'s carcinogenic activity is likely the result of epigenetic changes, particularly alterations in DNA …”
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Protein prediction for trait mapping in diverse populations von Schubert, Ryan, Geoffroy, Elyse, Gregga, Isabelle, Mulford, Ashley J., Aguet, Francois, Ardlie, Kristin, Gerszten, Robert, Clish, Clary, Van Den Berg, David, Taylor, Kent D., Durda, Peter, Johnson, W. Craig, Cornell, Elaine, Guo, Xiuqing, Liu, Yongmei, Tracy, Russell, Conomos, Matthew, Blackwell, Tom, Papanicolaou, George, Lappalainen, Tuuli, Mikhaylova, Anna V., Thornton, Timothy A., Cho, Michael H., Gignoux, Christopher R., Lange, Leslie, Lange, Ethan, Rich, Stephen S., Rotter, Jerome I., Manichaikul, Ani, Im, Hae Kyung, Wheeler, Heather E.

“… Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows …”
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Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys von Xu, Ning, Kwon, Soonil, Abbott, David H., Geller, David H., Dumesic, Daniel A., Azziz, Ricardo, Guo, Xiuqing, Goodarzi, Mark O.

“… The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) of female rhesus …”
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Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease von Li, Yi, Wang, Mengyao, Liu, Xue, Rong, Jian, Miller, Patricia Emogene, Joehanes, Roby, Huan, Tianxiao, Guo, Xiuqing, Rotter, Jerome I., Smith, Jennifer A., Yu, Bing, Nayor, Matthew, Levy, Daniel, Liu, Chunyu, Ma, Jiantao

“… Background Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and …”
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Machine learning enables new insights into genetic contributions to liver fat accumulation von Haas, Mary E., Pirruccello, James P., Friedman, Samuel N., Wang, Minxian, Emdin, Connor A., Ajmera, Veeral H., Simon, Tracey G., Homburger, Julian R., Guo, Xiuqing, Budoff, Matthew, Corey, Kathleen E., Zhou, Alicia Y., Philippakis, Anthony, Ellinor, Patrick T., Loomba, Rohit, Batra, Puneet, Khera, Amit V.

“… Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease and cardiometabolic diseases but often remains undiagnosed in …”
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Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations von Elgart, Michael, Lyons, Genevieve, Romero-Brufau, Santiago, Kurniansyah, Nuzulul, Brody, Jennifer A., Guo, Xiuqing, Lin, Henry J., Raffield, Laura, Gao, Yan, Chen, Han, de Vries, Paul, Lloyd-Jones, Donald M., Lange, Leslie A., Peloso, Gina M., Fornage, Myriam, Rotter, Jerome I., Rich, Stephen S., Morrison, Alanna C., Psaty, Bruce M., Levy, Daniel, Redline, Susan, Sofer, Tamar

“… Polygenic risk scores (PRS) are commonly used to quantify the inherited susceptibility for a trait, yet they fail to account for non-linear and interaction …”
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CRTC3 links catecholamine signalling to energy balance von Song, Youngsup, Altarejos, Judith, Goodarzi, Mark O., Inoue, Hiroshi, Guo, Xiuqing, Berdeaux, Rebecca, Kim, Jeong-Ho, Goode, Jason, Igata, Motoyuki, Paz, Jose C., Hogan, Meghan F., Singh, Pankaj K., Goebel, Naomi, Vera, Lili, Miller, Nina, Cui, Jinrui, Jones, Michelle R., Consortium, CHARGE, Consortium, GIANT, Chen, Yii-Der I., Taylor, Kent D., Hsueh, Willa A., Rotter, Jerome I., Montminy, Marc

“… The adipose-derived hormone leptin maintains energy balance in part through central nervous system-mediated increases in sympathetic outflow that enhance fat …”
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Predictors of incident stroke among individuals without coronary artery calcification: A pooled cohort analysis from the Multi-Ethnic Study of Atherosclerosis, Jackson Heart Study, and Framingham Heart Study von Hussain, Aliza, Johansen, Michelle C, Blaha, Michael J, Al-Mallah, Mouaz H, Cainzos-Achirica, Miguel, Nambi, Vijay, Rotter, Jerome I, Guo, Xiuqing, Yao, Jie, Rich, Stephen S, Patel, Jaideep, McEvoy, John W, Nasir, Khurram, Gottesman, Rebecca, Blumenthal, Roger S, Ballantyne, Christie M, Virani, Salim S, Al Rifai, Mahmoud

“… The absence of coronary artery calcium (CAC = 0) is associated with low risk of stroke events; however, predictors of incident stroke among those with CAC = 0 …”
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Body Adiposity Index versus Body Mass Index and Other Anthropometric Traits as Correlates of Cardiometabolic Risk Factors von Lichtash, Charlene T., Cui, Jinrui, Guo, Xiuqing, Chen, Yii-Der I., Hsueh, Willa A., Rotter, Jerome I., Goodarzi, Mark O.

“… The worldwide prevalence of obesity mandates a widely accessible tool to categorize adiposity that can best predict associated health risks. The body adiposity …”
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