Výsledky vyhľadávania - "Gualano, Gina"

Coinfection of tuberculosis and COVID-19 limits the ability to in vitro respond to SARS-CoV-2 Autor Petrone, Linda, Petruccioli, Elisa, Vanini, Valentina, Cuzzi, Gilda, Gualano, Gina, Vittozzi, Pietro, Nicastri, Emanuele, Maffongelli, Gaetano, Grifoni, Alba, Sette, Alessandro, Ippolito, Giuseppe, Migliori, Giovanni Battista, Palmieri, Fabrizio, Goletti, Delia

“…•TB and COVID-19 coinfection does not affect M. tuberculosis-specific response.•TB and COVID-19 coinfection limits the ability to in vitro respond to…”
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Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study Autor Borisov, Sergey E, Dheda, Keertan, Enwerem, Martin, Romero Leyet, Rodolfo, D'Ambrosio, Lia, Centis, Rosella, Sotgiu, Giovanni, Tiberi, Simon, Alffenaar, Jan-Willem, Maryandyshev, Andrey, Belilovski, Evgeny, Ganatra, Shashank, Skrahina, Alena, Akkerman, Onno, Aleksa, Alena, Amale, Rohit, Artsukevich, Janina, Bruchfeld, Judith, Caminero, Jose A, Carpena Martinez, Isabel, Codecasa, Luigi, Dalcolmo, Margareth, Denholm, Justin, Douglas, Paul, Duarte, Raquel, Esmail, Aliasgar, Fadul, Mohammed, Filippov, Alexey, Davies Forsman, Lina, Gaga, Mina, Garcia-Fuertes, Julia-Amaranta, García-García, José-María, Gualano, Gina, Jonsson, Jerker, Kunst, Heinke, Lau, Jillian S, Lazaro Mastrapa, Barbara, Teran Troya, Jorge Lazaro, Manga, Selene, Manika, Katerina, González Montaner, Pablo, Mullerpattan, Jai, Oelofse, Suzette, Ortelli, Martina, Palmero, Domingo Juan, Palmieri, Fabrizio, Papalia, Antonella, Papavasileiou, Apostolos, Payen, Marie-Christine, Pontali, Emanuele, Robalo Cordeiro, Carlos, Saderi, Laura, Sadutshang, Tsetan Dorji, Sanukevich, Tatsiana, Solodovnikova, Varvara, Spanevello, Antonio, Topgyal, Sonam, Toscanini, Federica, Tramontana, Adrian R, Udwadia, Zarir Farokh, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, Migliori, Giovanni Battista

“…Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed to…”
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ERS/ECDC Statement: European Union standards for tuberculosis care, 2017 update Autor Migliori, Giovanni Battista, Sotgiu, Giovanni, Rosales-Klintz, Senia, Centis, Rosella, D'Ambrosio, Lia, Abubakar, Ibrahim, Bothamley, Graham, Caminero, Jose Antonio, Cirillo, Daniela Maria, Dara, Masoud, de Vries, Gerard, Aliberti, Stefano, Dinh-Xuan, Anh Tuan, Duarte, Raquel, Midulla, Fabio, Solovic, Ivan, Subotic, Dragan R, Amicosante, Massimo, Correia, Ana Maria, Cirule, Andra, Gualano, Gina, Kunst, Heinke, Palmieri, Fabrizio, Riekstina, Vija, Tiberi, Simon, Verduin, Remi, van der Werf, Marieke J

“…The International Standards for Tuberculosis Care define the essential level of care for managing patients who have or are presumed to have tuberculosis, or…”
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Spike is the most recognized antigen in the whole-blood platform in both acute and convalescent COVID-19 patients Autor Aiello, Alessandra, Najafi Fard, Saeid, Petruccioli, Elisa, Petrone, Linda, Vanini, Valentina, Farroni, Chiara, Cuzzi, Gilda, Navarra, Assunta, Gualano, Gina, Mosti, Silvia, Pierelli, Luca, Nicastri, Emanuele, Goletti, Delia

“…•Whole-blood interferon-γ-release assay (IGRA) enabled the response to SARS-CoV-2 peptides to be evaluated.•Spike protein was the best stimulus to discriminate…”
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Characterization of the immune impairment of patients with tuberculosis and COVID-19 coinfection Autor Najafi-Fard, Saeid, Aiello, Alessandra, Navarra, Assunta, Cuzzi, Gilda, Vanini, Valentina, Migliori, Giovanni Battista, Gualano, Gina, Cerva, Carlotta, Grifoni, Alba, Sette, Alessandro, Vaia, Francesco, Palmieri, Fabrizio, Goletti, Delia

“…•Tumor necrosis factor-α significantly discriminates tuberculosis (TB)-COVID-19 from COVID-19.•SARS-CoV-2-specific response is significantly impaired in…”
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In-vitro evaluation of the immunomodulatory effects of Baricitinib: Implication for COVID-19 therapy Autor Petrone, Linda, Petruccioli, Elisa, Alonzi, Tonino, Vanini, Valentina, Cuzzi, Gilda, Najafi Fard, Saeid, Castilletti, Concetta, Palmieri, Fabrizio, Gualano, Gina, Vittozzi, Pietro, Nicastri, Emanuele, Lepore, Luciana, Grifoni, Alba, Antinori, Andrea, Vergori, Alessandra, Ippolito, Giuseppe, Cantini, Fabrizio, Goletti, Delia

“…•Baricitinib has been suggested as a promising therapy for COVID-19.•Baricitinib modulates in vitro SARS-CoV-2-specific-response in a whole blood…”
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Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of adults with tuberculosis infection and disease Autor Repele, Federica, Alonzi, Tonino, Navarra, Assunta, Farroni, Chiara, Salmi, Andrea, Cuzzi, Gilda, Delogu, Giovanni, Gualano, Gina, Puro, Vincenzo, De Carli, Gabriella, Girardi, Enrico, Palmieri, Fabrizio, Martineau, Adrian R., Goletti, Delia

“…•Mycobacterium tuberculosis (Mtb) DNA is detected in the peripheral blood cells of donors with tuberculosis (TB) or TB infection.•Mtb DNA is detected in the…”
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3-Gene-TB-SCORE Accuracy for Tuberculosis Disease Diagnosis Is Not Affected by Immune-Mediated Inflammatory Disease Comorbidity Autor Petruccioli, Elisa, Alonzi, Tonino, Navarra, Assunta, Altera, Anna Maria Gerarda, Cuzzi, Gilda, Farroni, Chiara, Repele, Federica, Gualano, Gina, Lindestam Arlehamn, Cecilia S., Palmieri, Fabrizio, Salmi, Andrea, Vanini, Valentina, Goletti, Delia

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health threat. Approximately one-quarter of the world’s population has an…”
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New Antituberculosis Drugs: From Clinical Trial to Programmatic Use Autor Gualano, Gina, CAPONE, Susanna, MATTEELLI, Alberto, Palmieri, Fabrizio

“…Treatment of multidrug-resistant tuberculosis (MDR-TB) cases is challenging because it relies on second-line drugs that are less potent and more toxic than…”
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Clinical outcomes and adverse events of nontuberculous mycobacterial lung disease treated at an Italian tertiary referral center Autor Carli, Serena Maria, Mencarini, Paola, Licata, Maria Angela Vittoria, Musso, Maria, Cerva, Carlotta, Mastrobattista, Annelisa, Vittozzi, Pietro, Mosti, Silvia, Nisii, Carla, Mazzarelli, Antonio, Navarra, Assunta, De Carli, Gabriella, Ianniello, Stefania, Palmieri, Fabrizio, Gualano, Gina

“…Treatment of NTM lung disease (NTM-LD) is based on combinations of antimycobacterial drugs. It lasts 12 months if respiratory samples become culture negative,…”
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Putting in harm to cure: Drug related adverse events do not affect outcome of patients receiving treatment for multidrug-resistant Tuberculosis. Experience from a tertiary hospital in Italy Autor Gualano, Gina, Mencarini, Paola, Musso, Maria, Mosti, Silvia, Santangelo, Laura, Murachelli, Silvia, Cannas, Angela, Di Caro, Antonino, Navarra, Assunta, Goletti, Delia, Girardi, Enrico, Palmieri, Fabrizio

“…Treatment of multi-drug resistant Tuberculosis (MDR-TB) is challenging because it mostly relies on drugs with lower efficacy and greater toxicity than those…”
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Tuberculin skin test – Outdated or still useful for Latent TB infection screening? Autor Gualano, Gina, Mencarini, Paola, Lauria, Francesco Nicola, Palmieri, Fabrizio, Mfinanga, Sayoki, Mwaba, Peter, Chakaya, Jeremiah, Zumla, Alimuddin, Ippolito, Giuseppe

“…•Tuberculin skin test (TST) is over a century old but it continues to be used widely.•When IGRAs were introduced it was anticipated that they would rapidly…”
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Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection Autor Petruccioli, Elisa, Najafi Fard, Saeid, Navarra, Assunta, Petrone, Linda, Vanini, Valentina, Cuzzi, Gilda, Gualano, Gina, Pierelli, Luca, Bertoletti, Antonio, Nicastri, Emanuele, Palmieri, Fabrizio, Ippolito, Giuseppe, Goletti, Delia

“…Background Recent studies proposed the whole-blood based IFN-γ-release assay to study the antigen-specific SARS-CoV-2 response. Since the early prediction of…”
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Humoral and cellular responses to spike of δ SARS-CoV-2 variant in vaccinated patients with immune-mediated inflammatory diseases Autor Petrone, Linda, Picchianti-Diamanti, Andrea, Sebastiani, Gian Domenico, Aiello, Alessandra, Laganà, Bruno, Cuzzi, Gilda, Vanini, Valentina, Gualano, Gina, Grifoni, Alba, Ferraioli, Mario, Castilletti, Concetta, Meschi, Silvia, Vaia, Francesco, Nicastri, Emanuele, Sette, Alessandro, Goletti, Delia

“…•The cellular response to δ SARS-CoV-2 variant is present in vaccinated patients with immune-mediated inflammatory disease (IMID)•The cellular response…”
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Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay Autor Aiello, Alessandra, Coppola, Andrea, Vanini, Valentina, Petrone, Linda, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria Gerarda, Tortorella, Carla, Gualano, Gina, Gasperini, Claudio, Scolieri, Palma, Beccacece, Alessia, Vita, Serena, Bruzzese, Vincenzo, Lorenzetti, Roberto, Palmieri, Fabrizio, Nicastri, Emanuele, Goletti, Delia

“…•The QuantiFERON SARS-CoV-2 research use only assay response is mediated by CD4+ and CD8+ T cells.•Immune response to the antigen (Ag)2 tube is more accurate…”
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Diagnostic yield of induced sputum and Bronchoalveolar lavage in suspected pulmonary tuberculosis Autor Musso, Maria, Gualano, Gina, Mencarini, Paola, Mastrobattista, Annelisa, Licata, Maria Angela, Pareo, Carlo, Cerva, Carlotta, Mosti, Silvia, Di Bari, Virginia, Libertone, Raffaella, Nisii, Carla, Cannas, Angela, Navarra, Assunta, Goletti, Delia, Palmieri, Fabrizio

“…Aim of this study was to compare the diagnostic yield of induced sputum (IS) and bronchoalveolar lavage (BAL) in patients with suspected pulmonary tuberculosis…”
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Treatment Outcomes in Multidrug-Resistant Tuberculosis Autor Günther, Gunar, Lange, Christoph, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Danilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank

“…Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To…”
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Concurrent cavitary pulmonary tuberculosis and COVID-19 pneumonia with in vitro immune cell anergy Autor Musso, Maria, Di Gennaro, Francesco, Gualano, Gina, Mosti, Silvia, Cerva, Carlotta, Fard, Saeid Najafi, Libertone, Raffaella, Di Bari, Virginia, Cristofaro, Massimo, Tonnarini, Roberto, Castilletti, Concetta, Goletti, Delia, Palmieri, Fabrizio

“…Tuberculosis (TB) is top infectious disease killer caused by a single organism responsible for 1.5 million deaths in 2018. Both COVID-19 and the pandemic…”
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Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital Autor Di Gennaro, Francesco, Gualano, Gina, Timelli, Laura, Vittozzi, Pietro, Di Bari, Virginia, Libertone, Raffaella, Cerva, Carlotta, Pinnarelli, Luigi, Nisii, Carla, Ianniello, Stefania, Mosti, Silvia, Bevilacqua, Nazario, Iacomi, Fabio, Mondi, Annalisa, Topino, Simone, Goletti, Delia, Vaia, Francesco, Ippolito, Giuseppe, Girardi, Enrico, Palmieri, Fabrizio

“…Background: The WHO advised that the impact of COVID-19 pandemic on TB services was estimated to be dramatic due to the disruption of TB services. Methods: A…”
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Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis Autor Najafi-Fard, Saeid, Farroni, Chiara, Petrone, Linda, Altera, Anna Maria Gerarda, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Alonzi, Tonino, Nicastri, Emanuele, Gualano, Gina, Palmieri, Fabrizio, Piacentini, Mauro, Goletti, Delia

“…Cysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune…”
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