Search Results - "Grinnell, Brian W"

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets by Han, May H., Hwang, Sun-Il, Roy, Dolly B., Lundgren, Deborah H., Price, Jordan V., Ousman, Shalina S., Fernald, Guy Haskin, Gerlitz, Bruce, Robinson, William H., Baranzini, Sergio E., Grinnell, Brian W., Raine, Cedric S., Sobel, Raymond A., Han, David K., Steinman, Lawrence

“…Understanding the neuropathology of multiple sclerosis (MS) is essential for improved therapies. Therefore, identification of targets specific to pathological…”
Get full text

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis by Isermann, Berend, Vinnikov, Ilya A, Madhusudhan, Thati, Herzog, Stefanie, Kashif, Muhammed, Blautzik, Janusch, Corat, Marcus A F, Zeier, Martin, Blessing, Erwin, Oh, Jun, Gerlitz, Bruce, Berg, David T, Grinnell, Brian W, Chavakis, Triantafyllos, Esmon, Charles T, Weiler, Hartmut, Bierhaus, Angelika, Nawroth, Peter P

“…Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we…”
Get full text

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes by Madhusudhan, Thati, Wang, Hongjie, Straub, Beate K, Gröne, Elisabeth, Zhou, Qianxing, Shahzad, Khurrum, Müller-Krebs, Sandra, Schwenger, Vedat, Gerlitz, Bruce, Grinnell, Brian W, Griffin, John H, Reiser, Jochen, Gröne, Hermann-Josef, Esmon, Charles T, Nawroth, Peter P, Isermann, Berend

“…The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the receptors and signaling mechanism through which aPC conveys…”
Get more information

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2 by Gupta, Akanksha, Rhodes, George J, Berg, David T, Gerlitz, Bruce, Molitoris, Bruce A, Grinnell, Brian W

“…Endothelial dysfunction contributes significantly to acute renal failure (ARF) during inflammatory diseases including septic shock. Previous studies have shown…”
Get more information

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease by Scaldaferri, Franco, Sans, Miquel, Vetrano, Stefania, Graziani, Cristina, De Cristofaro, Raimondo, Gerlitz, Bruce, Repici, Alessandro, Arena, Vincenzo, Malesci, Alberto, Panes, Julian, Grinnell, Brian W., Danese, Silvio

“…Endothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high levels in the resting microvasculature and convert protein C (PC) into its…”
Get full text

Levels of Protein C and Soluble Thrombomodulin in Critically Ill Patients with Acute Kidney Injury: A Multicenter Prospective Observational Study by Bouchard, Josée, Malhotra, Rakesh, Shah, Shamik, Kao, Yu-Ting, Vaida, Florin, Gupta, Akanksha, Berg, David T., Grinnell, Brian W., Stofan, Brenda, Tolwani, Ashita J., Mehta, Ravindra L.

“…Endothelial dysfunction contributes to the development of acute kidney injury (AKI) in animal models of ischemia reperfusion injury and sepsis. There are…”
Get full text

Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation by O'Brien, Lee A, Richardson, Mark A, Mehrbod, Sean F, Berg, David T, Gerlitz, Bruce, Gupta, Akanksha, Grinnell, Brian W

“…Background- APC is an antithrombotic and antiinflammatory serine protease that plays an important role in vascular function. We report that APC can suppress…”
Get more information

Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice by Rajashekhar, Gangaraju, Gupta, Akanksha, Marin, Abby, Friedrich, Jessica, Willuweit, Antje, Berg, David T, Cramer, Martin S, Sandusky, George E, Sutton, Timothy A, Basile, David P, Grinnell, Brian W, Clauss, Matthias

“…Chronic kidney disease pathogenesis involves both tubular and vascular injuries. Despite abundant investigations to identify the risk factors, the involvement…”
Get more information

Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia by Schouten, Marcel, van 't Veer, Cornelis, van den Boogaard, Florry E, Gerlitz, Bruce, Grinnell, Brian W, Roelofs, Joris J T H, Levi, Marcel, van der Poll, Tom

“…Recombinant human activated protein C (APC) improves survival of patients with severe sepsis; this beneficial effect is especially apparent in patients with…”
Get more information

Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response by Richardson, Mark A, Gupta, Akanksha, O'Brien, Lee A, Berg, David T, Gerlitz, Bruce, Syed, Samreen, Sharma, Ganesh R, Cramer, Martin S, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W

“…The protein C (PC) pathway plays an important role in vascular and immune function, and acquired deficiency during sepsis is associated with increased…”
Get more information

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties by Berg, David T, Gerlitz, Bruce, Shang, Jing, Smith, Tommy, Santa, Paula, Richardson, Mark A, Kurz, Ken D, Grinnell, Brian W, Mace, Ken, Jones, Bryan E

“…Human activated protein C (APC) is an antithrombotic, antiinflammatory serine protease that plays a central role in vascular homeostasis, and activated…”
Get more information

Polymeric coatings that mimic the endothelium: Combining nitric oxide release with surface-bound active thrombomodulin and heparin by Wu, Biyun, Gerlitz, Bruce, Grinnell, Brian W., Meyerhoff, Mark E.

“…Multi-functional bilayer polymeric coatings are prepared with both controlled nitric oxide (NO) release and surface-bound active thrombomodulin (TM) alone or…”
Get full text

Soluble thrombomodulin protects ischemic kidneys by Sharfuddin, Asif A, Sandoval, Ruben M, Berg, David T, McDougal, Grant E, Campos, Silvia B, Phillips, Carrie L, Jones, Bryan E, Gupta, Akanksha, Grinnell, Brian W, Molitoris, Bruce A

“…Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein…”
Get more information

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis by Joyce, D E, Gelbert, L, Ciaccia, A, DeHoff, B, Grinnell, B W

“…Human protein C is a natural anticoagulant factor, and a recombinant activated form of the molecule (rhAPC) is completing clinical evaluation for treatment of…”
Get more information

Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads by Sandusky, George, Berg, David T, Richardson, Mark A, Myers, Laura, Grinnell, Brian W

“…Protein C is a plasma protease that in its active form plays a central role in the regulation of vascular function by modulating thrombosis, inflammation, and…”
Get more information

Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11 by Berg, David T, Gupta, Akanksha, Richardson, Mark A, O'Brien, Lee A, Calnek, David, Grinnell, Brian W

“…Inducible nitric-oxide synthase (iNOS) plays a central role in the regulation of vascular function and response to injury. A central mediator controlling iNOS…”
Get more information

FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis by Berg, David T, Gerlitz, Bruce, Sharma, Ganesh R, Richardson, Mark A, Stephens, Eddie J, Grubbs, Renee L, Holmes, Kimberly C, Fynboe, Kelly, Montani, Dominick, Cramer, Martin S, Engle, Steven D, Jakubowski, Joseph A, Heuer, Josef G, Grinnell, Brian W

“…Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA,…”
Get more information

Distinct functions of activated protein C differentially attenuate acute kidney injury by Gupta, Akanksha, Gerlitz, Bruce, Richardson, Mark A, Bull, Christopher, Berg, David T, Syed, Samreen, Galbreath, Elizabeth J, Swanson, Barbara A, Jones, Bryan E, Grinnell, Brian W

“…Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and…”
Get more information

Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway by Joyce, David E, Nelson, David R, Grinnell, Brian W

“…To give an overview of leukocyte and endothelial cell interactions in sepsis and to explore the role of the protein C pathway in modulating the innate immune…”
Get more information

Role of protein C in renal dysfunction after polymicrobial sepsis by Gupta, Akanksha, Berg, David T, Gerlitz, Bruce, Sharma, Ganesh R, Syed, Samreen, Richardson, Mark A, Sandusky, George, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W

“…Protein C (PC) plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased mortality in both animal models…”
Get more information