Výsledky vyhľadávania - "Greenplate, Allison R."

High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity Autor Setliff, Ian, Shiakolas, Andrea R, Pilewski, Kelsey A, Murji, Amyn A, Mapengo, Rutendo E, Janowska, Katarzyna, Richardson, Simone, Oosthuysen, Charissa, Raju, Nagarajan, Ronsard, Larance, Kanekiyo, Masaru, Qin, Juliana S, Kramer, Kevin J, Greenplate, Allison R, McDonnell, Wyatt J, Graham, Barney S, Connors, Mark, Lingwood, Daniel, Acharya, Priyamvada, Morris, Lynn, Georgiev, Ivelin S

“…B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to infection and vaccination, but it provides limited information about…”
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Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy Autor Johnson, Douglas B., Estrada, Monica V., Salgado, Roberto, Sanchez, Violeta, Doxie, Deon B., Opalenik, Susan R., Vilgelm, Anna E., Feld, Emily, Johnson, Adam S., Greenplate, Allison R., Sanders, Melinda E., Lovly, Christine M., Frederick, Dennie T., Kelley, Mark C., Richmond, Ann, Irish, Jonathan M., Shyr, Yu, Sullivan, Ryan J., Puzanov, Igor, Sosman, Jeffrey A., Balko, Justin M.

“…Anti-PD-1 therapy yields objective clinical responses in 30–40% of advanced melanoma patients. Since most patients do not respond, predictive biomarkers to…”
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Characterizing cell subsets using marker enrichment modeling Autor Diggins, Kirsten E, Greenplate, Allison R, Leelatian, Nalin, Wogsland, Cara E, Irish, Jonathan M

“…Marker enrichment modeling (MEM) provides an objective metric for characterizing cell populations from high-content single-cell analysis. The MEM score…”
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Automated cytometric gating with human-level performance using bivariate segmentation Autor Chen, Jiong, Ionita, Matei, Feng, Yanbo, Lu, Yinfeng, Orzechowski, Patryk, Garai, Sumita, Hassinger, Kenneth, Bao, Jingxuan, Wen, Junhao, Duong-Tran, Duy, Wagenaar, Joost, McKeague, Michelle L., Painter, Mark M., Mathew, Divij, Pattekar, Ajinkya, Meyer, Nuala J., Wherry, E. John, Greenplate, Allison R., Shen, Li

“…Recent advances in cytometry have enabled high-throughput data collection with multiple single-cell protein expression measurements. The significant biological…”
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Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells Autor Leelatian, Nalin, Sinnaeve, Justine, Mistry, Akshitkumar M, Barone, Sierra M, Brockman, Asa A, Diggins, Kirsten E, Greenplate, Allison R, Weaver, Kyle D, Thompson, Reid C, Chambless, Lola B, Mobley, Bret C, Ihrie, Rebecca A, Irish, Jonathan M

“…A goal of cancer research is to reveal cell subsets linked to continuous clinical outcomes to generate new therapeutic and biomarker hypotheses. We introduce a…”
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Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function Autor Grugan, Katharine D, McCabe, Francis L, Kinder, Michelle, Greenplate, Allison R, Harman, Benjamin C, Ekert, Jason E, van Rooijen, Nico, Anderson, G Mark, Nemeth, Jeffrey A, Strohl, William R, Jordan, Robert E, Brezski, Randall J

“…Tumor-associated macrophages (TAMs) have been shown to promote tumor progression, and increased TAM infiltration often correlates with poor prognosis. However,…”
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Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry Autor Nicholas, Katherine J., Greenplate, Allison R., Flaherty, David K., Matlock, Brittany K., Juan, Juan San, Smith, Rita M., Irish, Jonathan M., Kalams, Spyros A.

“…Mass and fluorescence cytometry are quantitative single cell flow cytometry approaches that are powerful tools for characterizing diverse tissues and cellular…”
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An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells Autor Nicolas, Alexandre, Sannier, Gérémy, Dubé, Mathieu, Nayrac, Manon, Tauzin, Alexandra, Painter, Mark M., Goel, Rishi R., Laporte, Mélanie, Gendron-Lepage, Gabrielle, Medjahed, Halima, Williams, Justine C., Brassard, Nathalie, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Tremblay, Cécile, Martel-Laferrière, Valérie, Finzi, Andrés, Greenplate, Allison R., Wherry, E. John, Kaufmann, Daniel E.

“…Spacing the first two doses of SARS-CoV-2 mRNA vaccines beyond 3–4 weeks raised initial concerns about vaccine efficacy. While studies have since shown that…”
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High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline Autor Wang, Guanning, Lyudovyk, Olga, Kim, Justin Y., Lin, Ya-Hui, Elhanati, Yuval, Mathew, Divij, Wherry, E. John, Herati, Ramin S., Greenplate, Allison R., Greenbaum, Benjamin, Vardhana, Santosha A., Huang, Alexander C.

“…The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects of novel…”
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Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination Autor Kahn, Benjamin, Apostolidis, Sokratis A., Bhatt, Vatsal, Greenplate, Allison R., Kallish, Staci, LaCava, Anthony, Lucas, Alfredo, Meyer, Nuala J., Negoianu, Dan, Ogdie, Alexis R., Shashaty, Michael G. S., Takach, Patricia A., Zuroff, Leah, Wherry, E. John, Anesi, George L.

“…Supplemental Digital Content is available in the text. BACKGROUND: The U.S. Food and Drug Administration has to date granted approval or emergency use…”
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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications Autor Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

“…Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional…”
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Validating a Proteomic Signature of Severe COVID-19 Autor Cosgriff, Christopher V., Miano, Todd A., Mathew, Divij, Huang, Alexander C., Giannini, Heather M., Kuri-Cervantes, Leticia, Pampena, M. Betina, Ittner, Caroline A. G., Weisman, Ariel R., Agyekum, Roseline S., Dunn, Thomas G., Oniyide, Oluwatosin, Turner, Alexandra P., D'Andrea, Kurt, Adamski, Sharon, Greenplate, Allison R., Anderson, Brian J., Harhay, Michael O., Jones, Tiffanie K., Reilly, John P., Mangalmurti, Nilam S., Shashaty, Michael G. S., Betts, Michael R., Wherry, E. John, Meyer, Nuala J.

“…OBJECTIVES: COVID-19 is a heterogenous disease. Biomarker-based approaches may identify patients at risk for severe disease, who may be more likely to benefit…”
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Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation Autor Abdel-Hakeem, Mohamed S., Manne, Sasikanth, Beltra, Jean-Christophe, Stelekati, Erietta, Chen, Zeyu, Nzingha, Kito, Ali, Mohammed-Alkhatim, Johnson, John L., Giles, Josephine R., Mathew, Divij, Greenplate, Allison R., Vahedi, Golnaz, Wherry, E. John

“…Exhausted CD8 T cells (T EX ) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such…”
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Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy Autor Apostolidis, Sokratis A., Kakara, Mihir, Painter, Mark M., Goel, Rishi R., Mathew, Divij, Lenzi, Kerry, Rezk, Ayman, Patterson, Kristina R., Espinoza, Diego A., Kadri, Jessy C., Markowitz, Daniel M., E. Markowitz, Clyde, Mexhitaj, Ina, Jacobs, Dina, Babb, Allison, Betts, Michael R., Prak, Eline T. Luning, Weiskopf, Daniela, Grifoni, Alba, Lundgreen, Kendall A., Gouma, Sigrid, Sette, Alessandro, Bates, Paul, Hensley, Scott E., Greenplate, Allison R., Wherry, E. John, Li, Rui, Bar-Or, Amit

“…SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune protection against COVID-19. However, little is known about SARS-CoV-2 mRNA…”
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Rapid induction of antigen-specific CD4 + T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination Autor Painter, Mark M, Mathew, Divij, Goel, Rishi R, Apostolidis, Sokratis A, Pattekar, Ajinkya, Kuthuru, Oliva, Baxter, Amy E, Herati, Ramin S, Oldridge, Derek A, Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Lundgreen, Kendall A, Kuri-Cervantes, Leticia, Adamski, Sharon, Hicks, Amanda, Korte, Scott, Giles, Josephine R, Weirick, Madison E, McAllister, Christopher M, Dougherty, Jeanette, Long, Sherea, D'Andrea, Kurt, Hamilton, Jacob T, Betts, Michael R, Bates, Paul, Hensley, Scott E, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Greenplate, Allison R, Wherry, E John

“…SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed…”
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Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection Autor Anderson, Elizabeth M, Goodwin, Eileen C, Verma, Anurag, Arevalo, Claudia P, Bolton, Marcus J, Weirick, Madison E, Gouma, Sigrid, McAllister, Christopher M, Christensen, Shannon R, Weaver, JoEllen, Hicks, Philip, Manzoni, Tomaz B, Oniyide, Oluwatosin, Ramage, Holly, Mathew, Divij, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, D'Andrea, Kurt, Kuthuru, Oliva, Dougherty, Jeanette, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Apostolidis, Sokratis A, Huang, Alex C, Vella, Laura A, Kuri-Cervantes, Leticia, Pampena, M Betina, Betts, Michael R, Wherry, E John, Meyer, Nuala J, Cherry, Sara, Bates, Paul, Rader, Daniel J, Hensley, Scott E

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most…”
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Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals Autor Lederer, Katlyn, Bettini, Emily, Parvathaneni, Kalpana, Painter, Mark M, Agarwal, Divyansh, Lundgreen, Kendall A, Weirick, Madison, Muralidharan, Kavitha, Castaño, Diana, Goel, Rishi R, Xu, Xiaoming, Drapeau, Elizabeth M, Gouma, Sigrid, Ort, Jordan T, Awofolaju, Moses, Greenplate, Allison R, Le Coz, Carole, Romberg, Neil, Trofe-Clark, Jennifer, Malat, Gregory, Jones, Lisa, Rosen, Mark, Weiskopf, Daniela, Sette, Alessandro, Besharatian, Behdad, Kaminiski, Mary, Hensley, Scott E, Bates, Paul, Wherry, E John, Naji, Ali, Bhoj, Vijay, Locci, Michela

“…Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions…”
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In vivo CD8 + T cell CRISPR screening reveals control by Fli1 in infection and cancer Autor Chen, Zeyu, Arai, Eri, Khan, Omar, Zhang, Zhen, Ngiow, Shin Foong, He, Yuan, Huang, Hua, Manne, Sasikanth, Cao, Zhendong, Baxter, Amy E, Cai, Zhangying, Freilich, Elizabeth, Ali, Mohammed A, Giles, Josephine R, Wu, Jennifer E, Greenplate, Allison R, Hakeem, Mohamed A, Chen, Qingzhou, Kurachi, Makoto, Nzingha, Kito, Ekshyyan, Viktoriya, Mathew, Divij, Wen, Zhuoyu, Speck, Nancy A, Battle, Alexis, Berger, Shelley L, Wherry, E John, Shi, Junwei

“…Improving effector activity of antigen-specific T cells is a major goal in cancer immunotherapy. Despite the identification of several effector T cell (T…”
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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection Autor Painter, Mark M., Johnston, Timothy S., Lundgreen, Kendall A., Santos, Jefferson J. S., Qin, Juliana S., Goel, Rishi R., Apostolidis, Sokratis A., Mathew, Divij, Fulmer, Bria, Williams, Justine C., McKeague, Michelle L., Pattekar, Ajinkya, Goode, Ahmad, Nasta, Sean, Baxter, Amy E., Giles, Josephine R., Skelly, Ashwin N., Felley, Laura E., McLaughlin, Maura, Weaver, Joellen, Kuthuru, Oliva, Dougherty, Jeanette, Adamski, Sharon, Long, Sherea, Kee, Macy, Clendenin, Cynthia, da Silva Antunes, Ricardo, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Huang, Alexander C., Rader, Daniel J., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated individuals is increasingly common but rarely results in severe disease,…”
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Comprehensive mapping of immune perturbations associated with severe COVID-19 Autor Kuri-Cervantes, Leticia, Pampena, M Betina, Meng, Wenzhao, Rosenfeld, Aaron M, Ittner, Caroline A G, Weisman, Ariel R, Agyekum, Roseline S, Mathew, Divij, Baxter, Amy E, Vella, Laura A, Kuthuru, Oliva, Apostolidis, Sokratis A, Bershaw, Luanne, Dougherty, Jeanette, Greenplate, Allison R, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Gouma, Sigrid, Weirick, Madison E, Arevalo, Claudia P, Bolton, Marcus J, Goodwin, Eileen C, Anderson, Elizabeth M, Hensley, Scott E, Jones, Tiffanie K, Mangalmurti, Nilam S, Luning Prak, Eline T, Wherry, E John, Meyer, Nuala J, Betts, Michael R

“…Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we…”
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