Výsledky vyhľadávania - "Gorospe, Myriam"

Functional interactions among microRNAs and long noncoding RNAs Autor Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam

“…•LncRNA stability and function can be potently regulated by miRNAs.•LncRNAs can function as miRNA decoys, derepressing miRNA target mRNAs.•LncRNAs can compete…”
Získať plný text

Posttranscriptional Gene Regulation by Long Noncoding RNA Autor Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam

“…Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of…”
Získať plný text

Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging Autor Rossi, Martina, Gorospe, Myriam

“…Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can…”
Získať plný text

Posttranslational control of HuR function Autor Grammatikakis, Ioannis, Abdelmohsen, Kotb, Gorospe, Myriam

“…The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts, coding and noncoding, and controls their splicing, localization, stability,…”
Získať plný text

RNA-binding protein nucleolin in disease Autor Abdelmohsen, Kotb, Gorospe, Myriam

“…Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in…”
Získať plný text

Transcriptome signature of cellular senescence Autor Casella, Gabriel, Munk, Rachel, Kim, Kyoung Mi, Piao, Yulan, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam

“…Abstract Cellular senescence, an integral component of aging and cancer, arises in response to diverse triggers, including telomere attrition, macromolecular…”
Získať plný text

NSUN2‐Mediated m5C Methylation and METTL3/METTL14‐Mediated m6A Methylation Cooperatively Enhance p21 Translation Autor Li, Qiu, Li, Xiu, Tang, Hao, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong

“…ABSTRACT N6‐methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is…”
Získať plný text

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model Autor Zhang, Peisu, Kishimoto, Yuki, Grammatikakis, Ioannis, Gottimukkala, Kamalvishnu, Cutler, Roy G, Zhang, Shiliang, Abdelmohsen, Kotb, Bohr, Vilhelm A, Misra Sen, Jyoti, Gorospe, Myriam, Mattson, Mark P

“…Neuritic plaques, a pathological hallmark in Alzheimer's disease (AD) brains, comprise extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating…”
Získať plný text

Posttranscriptional regulation of cancer traits by HuR Autor Abdelmohsen, Kotb, Gorospe, Myriam

“…Cancer‐related gene expression programs are strongly influenced by posttranscriptional mechanisms. The RNA‐binding protein HuR is highly abundant in many…”
Získať plný text

RNA in extracellular vesicles Autor Kim, Kyoung Mi, Abdelmohsen, Kotb, Mustapic, Maja, Kapogiannis, Dimitrios, Gorospe, Myriam

“…Cells release a range of membrane‐enclosed extracellular vesicles (EVs) into the environment. Among them, exosomes and microvesicles (collectively measuring…”
Získať plný text

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria Autor Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi

“…A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline…”
Získať plný text

Regulation of senescence traits by MAPKs Autor Anerillas, Carlos, Abdelmohsen, Kotb, Gorospe, Myriam

“…A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease…”
Získať plný text

Cytoplasmic functions of long noncoding RNAs Autor Noh, Ji Heon, Kim, Kyoung Mi, McClusky, Waverly G., Abdelmohsen, Kotb, Gorospe, Myriam

“…Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found throughout the cell that lack protein‐coding function. Their functions are…”
Získať plný text

Noncoding RNAs in Alzheimer's disease Autor Idda, M. Laura, Munk, Rachel, Abdelmohsen, Kotb, Gorospe, Myriam

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Despite intense efforts to…”
Získať plný text

Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging Autor Hwang, Hyun Jung, Kim, Nayeon, Herman, Allison B., Gorospe, Myriam, Lee, Jae-Seon

“…Aging causes a progressive decline in the structure and function of organs. With advancing age, an accumulation of senescent endothelial cells (ECs)…”
Získať plný text

Skeletal muscle transcriptome in healthy aging Autor Tumasian, Robert A., Harish, Abhinav, Kundu, Gautam, Yang, Jen-Hao, Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Kaileh, Mary, Zukley, Linda M., Chia, Chee W., Lyashkov, Alexey, Wood, William H., Piao, Yulan, Coletta, Christopher, Ding, Jun, Gorospe, Myriam, Sen, Ranjan, De, Supriyo, Ferrucci, Luigi

“…Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve…”
Získať plný text

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 Autor Abdelmohsen, Kotb, Panda, Amaresh C., Munk, Rachel, Grammatikakis, Ioannis, Dudekula, Dawood B., De, Supriyo, Kim, Jiyoung, Noh, Ji Heon, Kim, Kyoung Mi, Martindale, Jennifer L., Gorospe, Myriam

“…HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to…”
Získať plný text

Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations Autor Krasniewski, Linda K, Chakraborty, Papiya, Cui, Chang-Yi, Mazan-Mamczarz, Krystyna, Dunn, Christopher, Piao, Yulan, Fan, Jinshui, Shi, Changyou, Wallace, Tonya, Nguyen, Cuong, Rathbun, Isabelle A, Munk, Rachel, Tsitsipatis, Dimitrios, De, Supriyo, Sen, Payel, Ferrucci, Luigi, Gorospe, Myriam

“…Tissue-resident macrophages represent a group of highly responsive innate immune cells that acquire diverse functions by polarizing toward distinct…”
Získať plný text

Noncoding RNA control of cellular senescence Autor Abdelmohsen, Kotb, Gorospe, Myriam

“…Senescent cells accumulate in normal tissues with advancing age and arise by long‐term culture of primary cells. Senescence develops following exposure to a…”
Získať plný text

Translational Control during Cellular Senescence Autor Payea, Matthew J., Anerillas, Carlos, Tharakan, Ravi, Gorospe, Myriam

“…Senescence is a state of long-term cell cycle arrest that arises in cells that have incurred sublethal damage. While senescent cells no longer replicate, they…”
Získať plný text