Výsledky vyhľadávania - "Gorbatenko, Andrej"

miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy Autor Rodriguez-Barrueco, Ruth, Nekritz, Erin A, Bertucci, François, Yu, Jiyang, Sanchez-Garcia, Felix, Zeleke, Tizita Z, Gorbatenko, Andrej, Birnbaum, Daniel, Ezhkova, Elena, Cordon-Cardo, Carlos, Finetti, Pascal, Llobet-Navas, David, Silva, Jose M

“…The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number…”
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Regulation and roles of bicarbonate transporters in cancer Autor Gorbatenko, Andrej, Olesen, Christina W., Boedtkjer, Ebbe, Pedersen, Stine F.

“…A unifying feature of solid tumors is a markedly altered pH profile compared to normal tissues. This reflects that solid tumors, despite completely different…”
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An IRAK1–PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy Autor Liu, Peter H., Shah, Richa B., Li, Yuanyuan, Arora, Arshi, Ung, Peter Man-Un, Raman, Renuka, Gorbatenko, Andrej, Kozono, Shingo, Zhou, Xiao Zhen, Brechin, Vincent, Barbaro, John M., Thompson, Ruth, White, Richard M., Aguirre-Ghiso, Julio A., Heymach, John V., Lu, Kun Ping, Silva, Jose M., Panageas, Katherine S., Schlessinger, Avner, Maki, Robert G., Skinner, Heath D., de Stanchina, Elisa, Sidi, Samuel

“…Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited by the single-agent toxicity of traditional radiosensitizers (for…”
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HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503 Autor Gorbatenko, Andrej, Søkilde, Rolf, Sorensen, Ester E., Newie, Inga, Persson, Helena, Morancho, Beatriz, Arribas, Joaquin, Litman, Thomas, Rovira, Carlos, Pedersen, Stine Falsig

“…The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit…”
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The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells Autor Flinck, Mette, Hagelund, Sofie, Gorbatenko, Andrej, Severin, Marc, Pedraz-Cuesta, Elena, Novak, Ivana, Stock, Christian, Pedersen, Stine Falsig

“…Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane…”
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A genome-wide screen to decipher regulation of membrane saturation in mammalian cells using a novel fluorescent reporter Autor Gorbatenko, Andrej, Zelcer, Noam

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Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in ehrlich lettré ascites cells through a mechanism involving p38 mitogen-activated protein kinase Autor Gorbatenko, Andrej, Wiwel, Maria, Klingberg, Henrik, Nielsen, Anni Bech, Kapus, András, Pedersen, Stine Falsig

“…Long‐term osmotic stress results in altered gene transcription, however, with the exception of the TonE/TonEBP system, the underlying mechanisms are poorly…”
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Glutamine sensing licenses cholesterol synthesis Autor Garcia, Bruna Martins, Melchinger, Philipp, Medeiros, Tania, Hendrix, Sebastian, Prabhu, Kavan, Corrado, Mauro, Kingma, Jenina, Gorbatenko, Andrej, Deshwal, Soni, Veronese, Matteo, Scorrano, Luca, Pearce, Erika, Giavalisco, Patrick, Zelcer, Noam, Pernas, Lena

“…The mevalonate pathway produces essential lipid metabolites such as cholesterol. Although this pathway is negatively regulated by metabolic intermediates,…”
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A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling Autor Li, Yuanyuan, Shah, Richa B, Sarti, Samanta, Belcher, Alicia L, Lee, Brian J, Gorbatenko, Andrej, Nemati, Francesca, Yu, Honglin, Stanley, Zoe, Rahman, Mahbuba, Shao, Zhengping, Silva, Jose M, Zha, Shan, Sidi, Samuel

“…Interleukin-1 receptor (IL-1R)-associated kinases (IRAKs) are core effectors of Toll-like receptors (TLRs) and IL-1R in innate immunity. Here, we found that…”
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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability Autor Willemsen, Lisa, Prange, Koen H.M., Neele, Annette E., van Roomen, Cindy P.A.A., Gijbels, Marion, Griffith, Guillermo R., Toom, Myrthe den, Beckers, Linda, Siebeler, Ricky, Spann, Nathanael J., Chen, Hung-Jen, Bosmans, Laura A., Gorbatenko, Andrej, van Wouw, Suzanne, Zelcer, Noam, Jacobs, Heinz, van Leeuwen, Fred, de Winther, Menno P.J.

“…Macrophages are critical immune cells in inflammatory diseases, and their differentiation and function are tightly regulated by histone modifications. H3K79…”
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ErbB2 upregulates the Na+,HCO3(-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4 Autor Gorbatenko, Andrej, Olesen, Christina W, Mørup, Nina, Thiel, Gerald, Kallunki, Tuula, Valen, Eivind, Pedersen, Stine F

“…Misregulation of acid-base transport plays central roles in cancer development. We previously demonstrated the strong up-regulation of the Na(+),HCO3(-)…”
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HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5 Autor Newie, Inga, Søkilde, Rolf, Persson, Helena, Jacomasso, Thiago, Gorbatenko, Andrej, Borg, Åke, de Hoon, Michiel, Pedersen, Stine F., Rovira, Carlos

“…We previously reported that the human HER2 gene encodes the intronic microRNA mir-4728, which is overexpressed together with its oncogenic host gene and may…”
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Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes Autor Gorbatenko, Andrej, Olesen, Christina W, Loebl, Nathalie, Sigurdsson, Haraldur H, Bianchi, Carolina, Pedraz-Cuesta, Elena, Christiansen, Jan, Pedersen, Stine Falsig

“…The Na -HCO cotransporter NBCn1 (SLC4A7) is up-regulated in breast cancer, important for tumor growth, and a single nucleotide polymorphism (SNP), rs4973768,…”
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Molecular mechanisms and binding partners controlling expression, localization and function of the Na+, HCO3- cotransporter NBCn1 in cancer Autor Stine, Pedersen, Andrej, Gorbatenko, Christina, Olesen, Anne, Andersen, Gitte, Lauritzen, Su Chii, Kong, Carolina, Bianchi, Jose, Moreira, Ebbe, Boedtkjer

“…Abstract only…”
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A Non-Canonical IRAK Signaling Pathway Triggered by DNA Damage Autor Li, Yuanyuan, Shah, Richa B, Sarti, Samanta, Belcher, Alicia L, Lee, Brian J, Gorbatenko, Andrej, Nemati, Francesca, Yu, Ian, Stanley, Zoe, Shao, Zhengping, Silva, Jose M, Zha, Shan, Sidi, Samuel

“…Interleukin-1 receptor (IL-1R)-associated kinases (IRAKs) are core effectors of Toll-like receptor (TLR) and IL-1R signaling, with no reported roles outside of…”
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Single-cell analysis identifies TCF4 and ID3 as a molecular switch of mammary epithelial stem cell differentiation Autor Koon-Kiu Yan, Nekritz, Erin, Ju, Bensheng, Dong, Xinran, Werner, Rachel, Alsina-Beauchamp, Dayanira, Rosencrance, Celeste, Mukhopadhyay, Partha, Pan, Qingfei, Gorbatenko, Andrej, Ding, Liang, Wang, Yanyan, Qian, Chenxi, Shi, Hao, Shaner, Bridget, Sivaraman Natarajan, Chi, Hongbo, Easton, John, Silva, Jose, Yu, Jiyang

“…It is well known that the expansion of the mammary epithelium during the ovarian cycles in female mammals is supported by the transient increase in mammary…”
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