Suchergebnisse - "Gon, Stéphanie"

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart von Berti, Matteo, Teloni, Federico, Mijic, Sofija, Ursich, Sebastian, Fuchs, Jevgenij, Palumbieri, Maria Dilia, Krietsch, Jana, Schmid, Jonas A., Garcin, Edwige B., Gon, Stéphanie, Modesti, Mauro, Altmeyer, Matthias, Lopes, Massimo

“… Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability, …”
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Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells von Garcin, Edwige B., Gon, Stéphanie, Sullivan, Meghan R., Brunette, Gregory J., Cian, Anne De, Concordet, Jean-Paul, Giovannangeli, Carine, Dirks, Wilhelm G., Eberth, Sonja, Bernstein, Kara A., Prakash, Rohit, Jasin, Maria, Modesti, Mauro

“… Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi …”
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Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli von Gon, Stéphanie, Napolitano, Rita, Rocha, Walter, Coulon, Stéphane, Fuchs, Robert P

“… Exposure of Escherichia coli to UV light increases expression of NrdAB, the major ribonucleotide reductase leading to a moderate increase in dNTP levels. The …”
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In vivo requirement for glutaredoxins and thioredoxins in the reduction of the ribonucleotide reductases of Escherichia coli von Gon, Stéphanie, Faulkner, Melinda J, Beckwith, Jon

“… Escherichia coli expresses three types of ribonucleotide reductases (RNRs) that utilize the redox chemistry of cysteine to catalyze the reduction of …”
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RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination von Baldock, Robert A., Pressimone, Catherine A., Baird, Jared M., Khodakov, Anton, Luong, Thong T., Grundy, McKenzie K., Smith, Chelsea M., Karpenshif, Yoav, Bratton-Palmer, Dominique S., Prakash, Rohit, Jasin, Maria, Garcin, Edwige B., Gon, Stéphanie, Modesti, Mauro, Bernstein, Kara A.

“… •Only RAD51D isoform 1 rescues HR-deficiency observed in RAD51D knock-out cell lines.•The RAD51D Walker A motif is important for its HR-function and …”
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Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes von Gon, Stéphanie, Loosveld, Marie, Crouzet, Thomas, Potier, Delphine, Bonnet, Mélanie, Morin, Stéphanie O., Michel, Gérard, Vey, Norbert, Nunès, Jacques A., Malissen, Bernard, Roncagalli, Romain, Nadel, Bertrand, Payet-Bornet, Dominique

“… Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell …”
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Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways von Faulkner, Melinda J, Veeravalli, Karthik, Gon, Stéphanie, Georgiou, George, Beckwith, Jon

“… In Escherichia coli, the glutathione/glutaredoxin and thioredoxin pathways are essential for the reduction of cytoplasmic protein disulfide bonds, including …”
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Repurposing lipoic acid changes electron flow in two important metabolic pathways of Escherichia coli von Feeney, Morgan Anne, Veeravalli, Karthik, Boyd, Dana, Gon, Stéphanie, Faulkner, Melinda Jo, Georgiou, George, Beckwith, Jonathan

“… In bacteria, cysteines of cytoplasmic proteins, including the essential enzyme ribonucleotide reductase (RNR), are maintained in the reduced state by the …”
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The bacterial ATPase SecA functions as a monomer in protein translocation von Or, Eran, Boyd, Dana, Gon, Stéphanie, Beckwith, Jonathan, Rapoport, Tom

“… The ATPase SecA drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can …”
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A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli von Gon, Stéphanie, Camara, Johanna E, Klungsøyr, Hege K, Crooke, Elliott, Skarstad, Kirsten, Beckwith, Jon

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Ribonucleotide reductases: influence of environment on synthesis and activity von Gon, Stéphanie, Beckwith, Jon

“… Ribonucleotide reductases (RNRs) are enzymes that provide deoxyribonucleotides (dNTPs), the building blocks required for de novo DNA synthesis and repair. They …”
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RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement von Cieslak, Agata, Le Noir, Sandrine, Trinquand, Amélie, Lhermitte, Ludovic, Franchini, Don-Marc, Villarese, Patrick, Gon, Stéphanie, Bond, Jonathan, Simonin, Mathieu, Vanhille, Laurent, Vanhile, Laurent, Reimann, Christian, Verhoeyen, Els, Larghero, Jerome, Six, Emmanuelle, Spicuglia, Salvatore, André-Schmutz, Isabelle, Langerak, Anton, Nadel, Bertrand, Macintyre, Elizabeth, Payet-Bornet, Dominique, Asnafi, Vahid

“… V(D)J recombination of TCR loci is regulated by chromatin accessibility to RAG1/2 proteins, rendering RAG1/2 targeting a potentially important regulator of …”
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RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement von Cieslak, Agata, Le Noir, Sandrine, Trinquand, Amélie, Lhermitte, Ludovic, Franchini, Don-Marc, Villarese, Patrick, Gon, Stéphanie, Bond, Jonathan, Simonin, Mathieu, Vanhille, Laurent, Reimann, Christian, Verhoeyen, Els, Larghero, Jerome, Six, Emmanuelle, Spicuglia, Salvatore, André-Schmutz, Isabelle, Langerak, Anton, Nadel, Bertrand, Macintyre, Elizabeth, Payet-Bornet, Dominique, Asnafi, Vahid

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MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia von Loosveld, Marie, Bonnet, Mélanie, Gon, Stéphanie, Montpellier, Bertrand, Quilichini, Benoit, Navarro, Jean-Marc, Crouzet, Thomas, Goujart, Marie-Amélie, Chasson, Lionel, Morgado, Ester, Picard, Christophe, Hernandez, Lucie, Fossat, Chantal, Gabert, Jean, Michel, Gérard, Nadel, Bertrand, Payet-Bornet, Dominique

“… MYC is a potent oncogene involved in ∼70% of human cancers, inducing tumorigenesis with high penetrance and short latency in experimental transgenic models …”
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Interactions of glutaredoxins, ribonucleotide reductase, and components of the DNA replication system of Escherichia coli von Ortenberg, Ron, Gon, Stéphanie, Porat, Amir, Beckwith, Jon

“… A strain of Escherichia coli missing three members of the thioredoxin superfamily, thioredoxins 1 and 2 and glutaredoxin 1, is unable to grow, a phenotype …”
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Genes regulated by TorR, the trimethylamine oxide response regulator of Shewanella oneidensis von Bordi, Christophe, Ansaldi, Mireille, Gon, Stéphanie, Jourlin-Castelli, Cécile, Iobbi-Nivol, Chantal, Méjean, Vincent

“… The torECAD operon encoding the trimethylamine oxide (TMAO) respiratory system of Shewanella oneidensis is positively controlled by the TorS/TorR two-component …”
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Reconstitution of the trimethylamine oxide reductase regulatory elements of Shewanella oneidensis in Escherichia coli von Gon, Stéphanie, Patte, Jean-Claude, Dos Santos, Jean-Philippe, Méjean, Vincent

“… Several bacteria can grow by using small organic compounds such as trimethylamine oxide (TMAO) as electron acceptors. In Shewanella species, the TMAO reductase …”
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Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli von Gon, S, Giudici-Orticoni, M T, Méjean, V, Iobbi-Nivol, C

“… Reduction of trimethylamine N-oxide (E'(0(TMAO/TMA)) = +130 mV) in Escherichia coli is carried out by the Tor system, an electron transfer chain encoded by the …”
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An unsuspected autoregulatory pathway involving apocytochrome TorC and sensor TorS in Escherichia coli von Gon, S, Jourlin-Castelli, C, Théraulaz, L, Méjean, V

“… Trimethylamine N-oxide (TMAO) respiration is carried out mainly by the Tor system in Escherichia coli. This system is encoded by the torCAD operon and …”
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The torYZ (yecK bisZ) operon encodes a third respiratory trimethylamine N-oxide reductase in Escherichia coli von Gon, S, Patte, J C, Méjean, V, Iobbi-Nivol, C

“… The bisZ gene of Escherichia coli was previously described as encoding a minor biotin sulfoxide (BSO) reductase in addition to the main cytoplasmic BSO …”
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