Suchergebnisse - "Goh, K. C."

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies von Hart, S, Goh, K C, Novotny-Diermayr, V, Hu, C Y, Hentze, H, Tan, Y C, Madan, B, Amalini, C, Loh, Y K, Ong, L C, William, A D, Lee, A, Poulsen, A, Jayaraman, R, Ong, K H, Ethirajulu, K, Dymock, B W, Wood, J W

“… SB1518 is an innovative pyrimidine-based macrocycle that shows a unique kinase profile with selective inhibition of Janus Kinase-2 (JAK2; IC 50 =23 and 19 n M …”
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An Investigation on Noisy Environments in Evolutionary Multiobjective Optimization von Goh, C.K., Tan, K.C.

“… In addition to satisfying several competing objectives, many real-world applications are also characterized by a certain degree of noise, manifesting itself in …”
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Solving multiobjective vehicle routing problem with stochastic demand via evolutionary computation von Tan, K.C., Cheong, C.Y., Goh, C.K.

“… This paper considers the routing of vehicles with limited capacity from a central depot to a set of geographically dispersed customers where actual demand is …”
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An evolutionary artificial immune system for multi-objective optimization von Tan, K.C., Goh, C.K., Mamun, A.A., Ei, E.Z.

“… In this paper, an evolutionary artificial immune system for multi-objective optimization which combines the global search ability of evolutionary algorithms …”
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A distributed Cooperative coevolutionary algorithm for multiobjective optimization von Tan, K.C., Yang, Y.J., Goh, C.K.

“… Recent advances in evolutionary algorithms show that coevolutionary architectures are effective ways to broaden the use of traditional evolutionary algorithms …”
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TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties von Goh, K C, Novotny-Diermayr, V, Hart, S, Ong, L C, Loh, Y K, Cheong, A, Tan, Y C, Hu, C, Jayaraman, R, William, A D, Sun, E T, Dymock, B W, Ong, K H, Ethirajulu, K, Burrows, F, Wood, J M

“… TG02 is a novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3. It dose-dependently inhibits signaling …”
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Balancing exploration and exploitation with adaptive variation for evolutionary multi-objective optimization von Tan, K.C., Chiam, S.C., Mamun, A.A., Goh, C.K.

“… Although recent studies have shown that evolutionary algorithms are effective tools for solving multi-objective optimization problems, their performances are …”
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p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons von Goh, Kee Chuan, Haque, S.Jaharul, Williams, Bryan R.G.

“… Activation of cytosolic phospholipase A 2 (cPLA 2 ) is a prerequisite for the formation of the transcription factor complex interferon‐stimulated gene factor 3 …”
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The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin von Goh, Kee Chuan, deVeer, Michael J., Williams, Bryan R.G.

“… Protein kinase RNA‐regulated (PKR) is an established component of innate antiviral immunity. Recently, PKR has been shown to be essential for signal …”
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Geriatric Services Hub — A Collaborative Frailty Management Model between The Hospital and Community Providers von Tan, Li Feng, Teng, J, Chew, Z.J, Choong, A, Hong, L, Aroos, R, Menon, P.V, Sumner, J, Goh, K.C, Seetharaman, S.K

“… AbstractBackgroundFrailty is an important geriatric syndrome especially with ageing populations. Frailty can be managed or even reversed with community-based …”
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Evolving better population distribution and exploration in evolutionary multi-objective optimization von Tan, K.C., Goh, C.K., Yang, Y.J., Lee, T.H.

“… The aim of multi-objective evolutionary optimization is to minimize the distance between the solution set and the true Pareto front, to distribute the …”
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On solving multiobjective bin packing problems using evolutionary particle swarm optimization von Liu, D.S., Tan, K.C., Huang, S.Y., Goh, C.K., Ho, W.K.

“… The bin packing problem is widely found in applications such as loading of tractor trailer trucks, cargo airplanes and ships, where a balanced load provides …”
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Examining Risk as Guideline in Design Stage for Green Retrofits Projects: A Review von Lee, M S N, Masrom, M A N, Mohamed, S, Goh, KC, Sarpin, N, Manap, N

“… Green buildings have generally been adopted as strategy towards sustainable development to reduce greenhouse gas. The implementation of green concept recently …”
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Influence of Milling Media on the Physicochemicals and Catalytic Properties of Mechanochemical Treated Vanadium Phosphate Catalysts von Taufiq-Yap, Y. H, Goh, C. K, Hutchings, G. J, Dummer, N, Bartley, J. K

“… VOHPO₄·0.5H₂O synthesized via the alcohol reduction of VOPO₄·2H₂O was mechanochemical treated for 30 min in three different media, i.e. cyclohexane, ethanol …”
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Dependence of n-Butane Activation on Active Site of Vanadium Phosphate Catalysts von Taufiq-Yap, Y. H, Goh, C. K, Hutchings, G. J, Dummer, N, Bartley, J

“… The nature and the role of oxygen species and vanadium oxidation states on the activation of n-butane for selective oxidation to maleic anhydride were …”
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A competitive and cooperative co-evolutionary approach to multi-objective particle swarm optimization algorithm design von Goh, C.K., Tan, K.C., Liu, D.S., Chiam, S.C.

“… Multi-objective particle swarm optimization (MOPSO) is an optimization technique inspired by bird flocking, which has been steadily gaining attention from the …”
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A hybrid evolutionary algorithm for attribute selection in data mining von Tan, K.C., Teoh, E.J., Yu, Q., Goh, K.C.

“… Real life data sets are often interspersed with noise, making the subsequent data mining process difficult. The task of the classifier could be simplified by …”
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Impact of pharmacist‐involved collaborative care on the clinical, humanistic and cost outcomes of high‐risk patients with type 2 diabetes (IMPACT): a randomized controlled trial von Siaw, M. Y. L., Ko, Y., Malone, D. C., Tsou, K. Y. K., Lew, Y.‐J., Foo, D., Tan, E., Chan, S. C., Chia, A., Sinaram, S. S., Goh, K. C., Lee, J. Y.‐C.

“… Summary What is known and objective With the increasing prevalence of diabetes, the physician‐centred model is challenged to deliver holistic care in Asia …”
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Effects of different surface modification and contents on municipal solid waste incineration fly ash/epoxy composites von Goh, C.K., Valavan, S.E., Low, T.K., Tang, L.H.

“… [Display omitted] •Surface modified of 10–30% MSWI fly ash improved flexural and tensile modulus of composite.•Colloidal mesoporous silica enhanced bonding of …”
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Identification of unique and common low abundance tumour-specific transcripts by suppression subtractive hybridization and oligonucleotide probe array analysis von Liu, B H, Goh, C H K, Ooi, L L P J, Hui, K M

“… Most human cancers are characterized by genetic aberrations accompanied by altered expression and function of numerous genes. Applying genome-wide, microarray …”
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