Search Results - "Gladyshev, Vadim N"

Selenoproteins: molecular pathways and physiological roles by Labunskyy, Vyacheslav M, Hatfield, Dolph L, Gladyshev, Vadim N

“…Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects…”
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Mechanisms of cancer resistance in long-lived mammals by Seluanov, Andrei, Gladyshev, Vadim N, Vijg, Jan, Gorbunova, Vera

“…Cancer researchers have traditionally used the mouse and the rat as staple model organisms. These animals are very short-lived, reproduce rapidly and are…”
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Translation inhibitors cause abnormalities in ribosome profiling experiments by Gerashchenko, Maxim V., Gladyshev, Vadim N.

“…Ribosome profiling and high-throughput sequencing provide unprecedented opportunities for the analysis of mRNA translation. Using this novel method, several…”
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The long and winding road of reprogramming-induced rejuvenation by Yücel, Ali Doğa, Gladyshev, Vadim N.

“…Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by…”
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Biomarkers of aging for the identification and evaluation of longevity interventions by Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R, Justice, Jamie, Belsky, Daniel W, Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A, Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K, Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B, Snyder, Michael P, Sebastiano, Vittorio, Gladyshev, Vadim N

“…With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field…”
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Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces by Marino, Stefano M., Gladyshev, Vadim N.

“…Cysteine (Cys) is an enigmatic amino acid residue. Although one of the least abundant, it often occurs in the functional sites of proteins. Whereas free Cys is…”
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Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities by Galkin, Fedor, Mamoshina, Polina, Aliper, Alex, de Magalhães, João Pedro, Gladyshev, Vadim N., Zhavoronkov, Alex

“…[Display omitted] Telomere length, gene expression, blood chemical parameters and DNA-methylation status all undergo age-associated changes, which can be…”
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Analysis and functional prediction of reactive cysteine residues by Marino, Stefano M, Gladyshev, Vadim N

“…Cys is much different from other common amino acids in proteins. Being one of the least abundant residues, Cys is often observed in functional sites in…”
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The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan by Gladyshev, Vadim N.

“…Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every…”
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Methionine restriction and life-span control by Lee, Byung Cheon, Kaya, Alaattin, Gladyshev , Vadim N.

“…Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is…”
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DNA methylation aging clocks: challenges and recommendations by Bell, Christopher G., Lowe, Robert, Adams, Peter D., Baccarelli, Andrea A., Beck, Stephan, Bell, Jordana T., Christensen, Brock C., Gladyshev, Vadim N., Heijmans, Bastiaan T., Horvath, Steve, Ideker, Trey, Issa, Jean-Pierre J., Kelsey, Karl T., Marioni, Riccardo E., Reik, Wolf, Relton, Caroline L., Schalkwyk, Leonard C., Teschendorff, Andrew E., Wagner, Wolfgang, Zhang, Kang, Rakyan, Vardhman K.

“…Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular…”
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Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress by Gerashchenko, Maxim V, Lobanov, Alexei V, Gladyshev, Vadim N

“…Information on unique and coordinated regulation of transcription and translation in response to stress is central to the understanding of cellular…”
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Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions by Petkovich, Daniel A, Podolskiy, Dmitriy I, Lobanov, Alexei V, Lee, Sang-Goo, Miller, Richard A, Gladyshev, Vadim N

“…The DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age…”
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Comparative genetics of longevity and cancer: insights from long-lived rodents by Gorbunova, Vera, Seluanov, Andrei, Zhang, Zhengdong, Gladyshev, Vadim N., Vijg, Jan

“…Key Points Comparative biology provides a powerful tool for understanding mechanisms of longevity and cancer resistance. The rodent clade is particularly…”
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Accelerated transcriptional elongation during aging impairs longevity by Tyshkovskiy, Alexander, Zhang, Sirui, Gladyshev, Vadim N.

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LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation by Simon, Matthew, Van Meter, Michael, Ablaeva, Julia, Ke, Zhonghe, Gonzalez, Raul S, Taguchi, Taketo, De Cecco, Marco, Leonova, Katerina I, Kogan, Valeria, Helfand, Stephen L, Neretti, Nicola, Roichman, Asael, Cohen, Haim Y, Meer, Margarita V, Gladyshev, Vadim N, Antoch, Marina P, Gudkov, Andrei V, Sedivy, John M, Seluanov, Andrei, Gorbunova, Vera

“…Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that…”
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Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction by Sziráki, András, Tyshkovskiy, Alexander, Gladyshev, Vadim N.

“…Summary Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to…”
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Endogenous hydrogen sulfide production is essential for dietary restriction benefits by Hine, Christopher, Harputlugil, Eylul, Zhang, Yue, Ruckenstuhl, Christoph, Lee, Byung Cheon, Brace, Lear, Longchamp, Alban, Treviño-Villarreal, Jose H, Mejia, Pedro, Ozaki, C Keith, Wang, Rui, Gladyshev, Vadim N, Madeo, Frank, Mair, William B, Mitchell, James R

“…Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying…”
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A whole lifespan mouse multi-tissue DNA methylation clock by Meer, Margarita V, Podolskiy, Dmitriy I, Tyshkovskiy, Alexander, Gladyshev, Vadim N

“…Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks, have been developed for humans and extended to several other species…”
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Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1 by Kaya, Alaattin, Lee, Byung Cheon, Gladyshev, Vadim N

“…Protein structure and function can be regulated via post-translational modifications by numerous enzymatic and nonenzymatic mechanisms. Regulation involving…”
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