Search Results - "Gigoux, Mathieu"

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine by Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.

“…Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different…”
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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers by Gruosso, Tina, Gigoux, Mathieu, Manem, Venkata Satya Kumar, Bertos, Nicholas, Zuo, Dongmei, Perlitch, Irina, Saleh, Sadiq Mehdi Ismail, Zhao, Hong, Souleimanova, Margarita, Johnson, Radia Marie, Monette, Anne, Ramos, Valentina Muñoz, Hallett, Michael Trevor, Stagg, John, Lapointe, Réjean, Omeroglu, Atilla, Meterissian, Sarkis, Buisseret, Laurence, Van den Eyden, Gert, Salgado, Roberto, Guiot, Marie-Christine, Haibe-Kains, Benjamin, Park, Morag

“…Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC)…”
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity by Lu, Sydney X, De Neef, Emma, Thomas, James D, Sabio, Erich, Rousseau, Benoit, Gigoux, Mathieu, Knorr, David A, Greenbaum, Benjamin, Elhanati, Yuval, Hogg, Simon J, Chow, Andrew, Ghosh, Arnab, Xie, Abigail, Zamarin, Dmitriy, Cui, Daniel, Erickson, Caroline, Singer, Michael, Cho, Hana, Wang, Eric, Lu, Bin, Durham, Benjamin H, Shah, Harshal, Chowell, Diego, Gabel, Austin M, Shen, Yudao, Liu, Jing, Jin, Jian, Rhodes, Matthew C, Taylor, Richard E, Molina, Henrik, Wolchok, Jedd D, Merghoub, Taha, Diaz, Jr, Luis A, Abdel-Wahab, Omar, Bradley, Robert K

“…Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within…”
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PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy by Zamarin, Dmitriy, Ricca, Jacob M., Sadekova, Svetlana, Oseledchyk, Anton, Yu, Ying, Blumenschein, Wendy M., Wong, Jerelyn, Gigoux, Mathieu, Merghoub, Taha, Wolchok, Jedd D.

“…Intralesional therapy with oncolytic viruses (OVs) leads to the activation of local and systemic immune pathways, which may present targets for further…”
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Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase by Gigoux, Mathieu, Shang, Jijun, Pak, Youngshil, Xu, Minghong, Choe, Jongseon, Mak, Tak W, Suh, Woong-Kyung

“…The T-cell costimulatory receptors, CD28 and the inducible costimulator (ICOS), are required for the generation of follicular B helper T cells (T(FH)) and…”
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Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma by Budhu, Sadna, Giese, Rachel, Gupta, Aditi, Fitzgerald, Kelly, Zappasodi, Roberta, Schad, Sara, Hirschhorn, Daniel, Campesato, Luis Felipe, De Henau, Olivier, Gigoux, Mathieu, Liu, Cailian, Mazo, Gregory, Deng, Liang, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha

“…Phosphatidylserine (PS) is exposed on the surface of apoptotic cells and is known to promote immunosuppressive signals in the tumor microenvironment (TME)…”
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PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy by Zamarin, Dmitriy, Ricca, Jacob M., Sadekova, Svetlana, Oseledchyk, Anton, Yu, Ying, Blumenschein, Wendy M., Wong, Jerelyn, Gigoux, Mathieu, Merghoub, Taha, Wolchok, Jedd D.

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Identification of Interacting Stromal Axes in Triple-Negative Breast Cancer by Saleh, Sadiq M I, Bertos, Nicholas, Gruosso, Tina, Gigoux, Mathieu, Souleimanova, Margarita, Zhao, Hong, Omeroglu, Atilla, Hallett, Michael T, Park, Morag

“…Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to treat. Despite the role it may play in tumor progression and…”
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CrosstalkNet: A Visualization Tool for Differential Co-expression Networks and Communities by Manem, Venkata, Adam, George Alexandru, Gruosso, Tina, Gigoux, Mathieu, Bertos, Nicholas, Park, Morag, Haibe-Kains, Benjamin

“…Variations in physiological conditions can rewire molecular interactions between biological compartments, which can yield novel insights into gain or loss of…”
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Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer by Lebdai, Souhil, Gigoux, Mathieu, Alvim, Ricardo, Somma, Alexander, Nagar, Karan, Azzouzi, Abdel Rahmene, Cussenot, Olivier, Merghoub, Taha, Wolchok, Jedd D., Scherz, Avigdor, Kim, Kwanghee, Coleman, Jonathan

“…Vascular-targeted photodynamic therapy (VTP) induces rapid destruction of targeted tissues and is a promising therapy for prostate cancer. However, the…”
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Anti-Chlamydial Th17 Responses Are Controlled by the Inducible Costimulator Partially through Phosphoinositide 3-Kinase Signaling by Gao, Xiaoling, Gigoux, Mathieu, Yang, Jie, Leconte, Julien, Yang, Xi, Suh, Woong-Kyung

“…We previously showed that mice deficient in the Inducible Costimulator ligand (ICOSL-KO) develop more severe disease and lung pathology with delayed bacterial…”
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Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer by Lai, Andrea Z, Cory, Sean, Zhao, Hong, Gigoux, Mathieu, Monast, Anie, Guiot, Marie-Christine, Huang, Sidong, Tofigh, Ali, Thompson, Crista, Naujokas, Monica, Marcus, Victoria A, Bertos, Nicholas, Sehat, Bita, Perera, Rushika M, Bell, Emily S, Page, Brent D G, Gunning, Patrick T, Ferri, Lorenzo E, Hallett, Michael, Park, Morag

“…The Met receptor tyrosine kinase is activated or genetically amplified in some gastric cancers, but resistance to small-molecule inhibitors of Met often…”
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878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants by Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha

“…BackgroundThe immune system eliminates cancers in the early stages of malignant transformation. However, the presence of immune cells exerts selective pressure…”
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549 Characterizing double positive T cells in the tumor microenvironment: a tale of promiscuous cell fates by Schad, Sara, Chow, Andrew, Pan, Heng, Mangarin, Levi, Zappasodi, Roberta, Gigoux, Mathieu, Redmond, David, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Elemento, Olivier, Wolchok, Jedd, Merghoub, Taha

“…BackgroundCD4 and CD8 T cells are genetically and functionally distinct cell subsets of the adaptive immune system that play pivotal roles in immune…”
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99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants by Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha

“…BackgroundTargeted immune-based therapies such as adoptive T cell transfer (ACT) are often ineffective because tumors evolve over time and under selective…”
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Refusing to TAP out: 16 new human TEIPPs identified by Gigoux, Mathieu, Wolchok, Jedd

“…In this issue of , Marijt et al. (https://doi.org/10.1084/jem.20180577) report their discovery of 16 novel human TAP-independent TEIPP peptides, whereas only…”
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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants by Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J, Arora, Arshi, Panageas, Katherine S, Rizzuto, Gabrielle A, Duhen, Rebekka, Weinberg, Andrew D, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha

“…Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because tumors evolve to display antigen-loss-variant clones. Therapies that…”
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Neoantigen quality predicts immunoediting in survivors of pancreatic cancer by Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“…Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate…”
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Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade by Pai, Joy A, Hellmann, Matthew D, Sauter, Jennifer L, Mattar, Marissa, Rizvi, Hira, Woo, Hyung Jun, Shah, Nisargbhai, Nguyen, Evelyn M, Uddin, Fathema Z, Quintanal-Villalonga, Alvaro, Chan, Joseph M, Manoj, Parvathy, Allaj, Viola, Baine, Marina K, Bhanot, Umesh K, Jain, Mala, Linkov, Irina, Meng, Fanli, Brown, David, Chaft, Jamie E, Plodkowski, Andrew J, Gigoux, Mathieu, Won, Helen H, Sen, Triparna, Wells, Daniel K, Donoghue, Mark T A, de Stanchina, Elisa, Wolchok, Jedd D, Loomis, Brian, Merghoub, Taha, Rudin, Charles M, Chow, Andrew, Satpathy, Ansuman T

“…Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report…”
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Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions by Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha

“…Transcription factors ThPOK and Runx3 regulate the differentiation of "helper" CD4+ and "cytotoxic" CD8+ T cell lineages respectively, inducing single positive…”
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