Suchergebnisse - "Gieger, Christian"

Genetic variation in metabolic phenotypes: study designs and applications von Suhre, Karsten, Gieger, Christian

“… Key Points Technical advances in mass spectrometry and NMR spectroscopy enable genome-wide screens to be carried out for the association between genetic …”
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Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation von Zeilinger, Sonja, Kühnel, Brigitte, Klopp, Norman, Baurecht, Hansjörg, Kleinschmidt, Anja, Gieger, Christian, Weidinger, Stephan, Lattka, Eva, Adamski, Jerzy, Peters, Annette, Strauch, Konstantin, Waldenberger, Melanie, Illig, Thomas

“… Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in …”
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Connecting genetic risk to disease end points through the human blood plasma proteome von Suhre, Karsten, Arnold, Matthias, Bhagwat, Aditya Mukund, Cotton, Richard J., Engelke, Rudolf, Raffler, Johannes, Sarwath, Hina, Thareja, Gaurav, Wahl, Annika, DeLisle, Robert Kirk, Gold, Larry, Pezer, Marija, Lauc, Gordan, El-Din Selim, Mohammed A., Mook-Kanamori, Dennis O., Al-Dous, Eman K., Mohamoud, Yasmin A., Malek, Joel, Strauch, Konstantin, Grallert, Harald, Peters, Annette, Kastenmüller, Gabi, Gieger, Christian, Graumann, Johannes

“… Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease …”
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease von Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

“… Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants …”
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Revealing the role of the human blood plasma proteome in obesity using genetic drivers von Zaghlool, Shaza B., Sharma, Sapna, Molnar, Megan, Matías-García, Pamela R., Elhadad, Mohamed A., Waldenberger, Melanie, Peters, Annette, Rathmann, Wolfgang, Graumann, Johannes, Gieger, Christian, Grallert, Harald, Suhre, Karsten

“… Blood circulating proteins are confounded readouts of the biological processes that occur in different tissues and organs. Many proteins have been linked to …”
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DNA methylation and body-mass index: a genome-wide analysis von Dick, Katherine J, Nelson, Christopher P, Tsaprouni, Loukia, Sandling, Johanna K, Aïssi, Dylan, Wahl, Simone, Meduri, Eshwar, Morange, Pierre-Emmanuel, Gagnon, France, Grallert, Harald, Waldenberger, Melanie, Peters, Annette, Erdmann, Jeanette, Hengstenberg, Christian, Cambien, Francois, Goodall, Alison H, Ouwehand, Willem H, Schunkert, Heribert, Thompson, John R, Spector, Tim D, Gieger, Christian, Trégouët, David-Alexandre, Deloukas, Panos, Samani, Nilesh J

“… Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between …”
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Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples von Matias-Garcia, Pamela R., Wilson, Rory, Mussack, Veronika, Reischl, Eva, Waldenberger, Melanie, Gieger, Christian, Anton, Gabriele, Peters, Annette, Kuehn-Steven, Andrea

“… Sample collection, processing, storage and isolation methods constitute pre-analytic factors that can influence the quality of samples used in research and …”
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Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota von Moitinho-Silva, Lucas, Degenhardt, Frauke, Rodriguez, Elke, Emmert, Hila, Juzenas, Simonas, Möbus, Lena, Uellendahl-Werth, Florian, Sander, Nicole, Baurecht, Hansjörg, Tittmann, Lukas, Lieb, Wolfgang, Gieger, Christian, Peters, Annette, Ellinghaus, David, Bang, Corinna, Franke, Andre, Weidinger, Stephan, Rühlemann, Malte Christoph

“… Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still …”
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Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease von Tzoulaki, Ioanna, Castagné, Raphaële, Boulangé, Claire L, Karaman, Ibrahim, Chekmeneva, Elena, Evangelou, Evangelos, Ebbels, Timothy M D, Kaluarachchi, Manuja R, Chadeau-Hyam, Marc, Mosen, David, Dehghan, Abbas, Moayyeri, Alireza, Ferreira, Diana L Santos, Guo, Xiuqing, Rotter, Jerome I, Taylor, Kent D, Kavousi, Maryam, de Vries, Paul S, Lehne, Benjamin, Loh, Marie, Hofman, Albert, Nicholson, Jeremy K, Chambers, John, Gieger, Christian, Holmes, Elaine, Tracy, Russell, Kooner, Jaspal, Greenland, Philip, Franco, Oscar H, Herrington, David, Lindon, John C, Elliott, Paul

“… Abstract Aims To characterize serum metabolic signatures associated with atherosclerosis in the coronary or carotid arteries and subsequently their association …”
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Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease von Petzold, Tobias, Zhang, Zhe, Ballesteros, Iván, Saleh, Inas, Polzin, Amin, Thienel, Manuela, Liu, Lulu, Ul Ain, Qurrat, Ehreiser, Vincent, Weber, Christian, Kilani, Badr, Mertsch, Pontus, Götschke, Jeremias, Cremer, Sophie, Fu, Wenwen, Lorenz, Michael, Ishikawa-Ankerhold, Hellen, Raatz, Elisabeth, El-Nemr, Shaza, Görlach, Agnes, Marhuenda, Esther, Stark, Konstantin, Pircher, Joachim, Stegner, David, Gieger, Christian, Schmidt-Supprian, Marc, Gaertner, Florian, Almendros, Isaac, Kelm, Malte, Schulz, Christian, Hidalgo, Andrés, Massberg, Steffen

“… Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their interaction can also trigger thrombotic complications. We report …”
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies von Do, Kieu Trinh, Wahl, Simone, Raffler, Johannes, Molnos, Sophie, Laimighofer, Michael, Adamski, Jerzy, Suhre, Karsten, Strauch, Konstantin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Stewart, Isobel D., Theis, Fabian J., Grallert, Harald, Kastenmüller, Gabi, Krumsiek, Jan

“… Background Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in …”
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A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study von Duschek, Elena, Forer, Lukas, Schönherr, Sebastian, Gieger, Christian, Peters, Annette, Kronenberg, Florian, Grallert, Harald, Lamina, Claudia

“… The availability of polygenic scores for type 2 diabetes (T2D) raises the question, whether assessing family history might become redundant. However, family …”
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Prevalence of refractive error in Europe: the European Eye Epidemiology (E³) Consortium von Williams, Katie M., Verhoeven, Virginie J. M., Cumberland, Phillippa, Bertelsen, Geir, Wolfram, Christian, Buitendijk, Gabriëlle H. S., Hofman, Albert, van Duijn, Cornelia M., Vingerling, Johannes R., Kuijpers, Robert W. A. M., Höhn, René, Mirshahi, Alireza, Khawaja, Anthony P., Luben, Robert N., Erke, Maja Gran, von Hanno, Therese, Mahroo, Omar, Hogg, Ruth, Gieger, Christian, Cougnard-Grégoire, Audrey, Anastasopoulos, Eleftherios, Bron, Alain, Dartigues, Jean-François, Korobelnik, Jean-François, Creuzot-Garcher, Catherine, Topouzis, Fotis, Delcourt, Cécile, Rahi, Jugnoo, Meitinger, Thomas, Fletcher, Astrid, Foster, Paul J., Pfeiffer, Norbert, Klaver, Caroline C. W., Hammond, Christopher J.

“… To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from …”
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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population von Sekula, Peggy, Goek, Oemer-Necmi, Quaye, Lydia, Barrios, Clara, Levey, Andrew S, Römisch-Margl, Werner, Menni, Cristina, Yet, Idil, Gieger, Christian, Inker, Lesley A, Adamski, Jerzy, Gronwald, Wolfram, Illig, Thomas, Dettmer, Katja, Krumsiek, Jan, Oefner, Peter J, Valdes, Ana M, Meisinger, Christa, Coresh, Josef, Spector, Tim D, Mohney, Robert P, Suhre, Karsten, Kastenmüller, Gabi, Köttgen, Anna

“… Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and …”
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A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms von Mack, Salome, Coassin, Stefan, Rueedi, Rico, Yousri, Noha A, Seppälä, Ilkka, Gieger, Christian, Schönherr, Sebastian, Forer, Lukas, Erhart, Gertraud, Marques-Vidal, Pedro, Ried, Janina S, Waeber, Gerard, Bergmann, Sven, Dähnhardt, Doreen, Stöckl, Andrea, Raitakari, Olli T, Kähönen, Mika, Peters, Annette, Meitinger, Thomas, Strauch, Konstantin, Kedenko, Ludmilla, Paulweber, Bernhard, Lehtimäki, Terho, Hunt, Steven C, Vollenweider, Peter, Lamina, Claudia, Kronenberg, Florian

“… High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) …”
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Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach von Menni, Cristina, Fauman, Eric, Erte, Idil, Perry, John R B, Kastenmüller, Gabi, Shin, So-Youn, Petersen, Ann-Kristin, Hyde, Craig, Psatha, Maria, Ward, Kirsten J, Yuan, Wei, Milburn, Mike, Palmer, Colin N A, Frayling, Timothy M, Trimmer, Jeff, Bell, Jordana T, Gieger, Christian, Mohney, Rob P, Brosnan, Mary Julia, Suhre, Karsten, Soranzo, Nicole, Spector, Tim D

“… Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we searched for novel molecular markers that arise before and after hyperglycemia …”
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Gender-specific pathway differences in the human serum metabolome von Krumsiek, Jan, Mittelstrass, Kirstin, Do, Kieu Trinh, Stückler, Ferdinand, Ried, Janina, Adamski, Jerzy, Peters, Annette, Illig, Thomas, Kronenberg, Florian, Friedrich, Nele, Nauck, Matthias, Pietzner, Maik, Mook-Kanamori, Dennis O., Suhre, Karsten, Gieger, Christian, Grallert, Harald, Theis, Fabian J., Kastenmüller, Gabi

“… The susceptibility for various diseases as well as the response to treatments differ considerably between men and women. As a basis for a gender-specific …”
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Novel biomarkers for pre‐diabetes identified by metabolomics von Wang‐Sattler, Rui, Yu, Zhonghao, Herder, Christian, Messias, Ana C, Floegel, Anna, He, Ying, Heim, Katharina, Campillos, Monica, Holzapfel, Christina, Thorand, Barbara, Grallert, Harald, Xu, Tao, Bader, Erik, Huth, Cornelia, Mittelstrass, Kirstin, Döring, Angela, Meisinger, Christa, Gieger, Christian, Prehn, Cornelia, Roemisch‐Margl, Werner, Carstensen, Maren, Xie, Lu, Yamanaka‐Okumura, Hisami, Xing, Guihong, Ceglarek, Uta, Thiery, Joachim, Giani, Guido, Lickert, Heiko, Lin, Xu, Li, Yixue, Boeing, Heiner, Joost, Hans‐Georg, de Angelis, Martin Hrabé, Rathmann, Wolfgang, Suhre, Karsten, Prokisch, Holger, Peters, Annette, Meitinger, Thomas, Roden, Michael, Wichmann, H‐Erich, Pischon, Tobias, Adamski, Jerzy, Illig, Thomas

“… Type 2 diabetes (T2D) can be prevented in pre‐diabetic individuals with impaired glucose tolerance (IGT). Here, we have used a metabolomics approach to …”
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Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study von Chambers, John C, Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R, Rota, Federica, Scott, William R, Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C, Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, François, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole, Bertazzi, Pier Alberto, Blancher, Christine, Caiazzo, Robert, Danesh, John, Gaunt, Tom R, de Lusignan, Simon, Gieger, Christian, Illig, Thomas, Jha, Sujeet, Jones, Simon, Jowett, Jeremy, Kangas, Antti J, Kasturiratne, Anuradhani, Kato, Norihiro, Kotea, Navaratnam, Kowlessur, Sudhir, Pitkäniemi, Janne, Punjabi, Prakash, Saleheen, Danish, Schafmayer, Clemens, Soininen, Pasi, Tai, E-Shyong, Thorand, Barbara, Tuomilehto, Jaakko, Wickremasinghe, Ananda Rajitha, Kyrtopoulos, Soterios A, Aitman, Timothy J, Herder, Christian, Hampe, Jochen, Cauchi, Stéphane, Relton, Caroline L, Froguel, Philippe, Soong, Richie, Vineis, Paolo, Jarvelin, Marjo-Riitta, Scott, James, Grallert, Harald, Bollati, Valentina, Elliott, Paul, McCarthy, Mark I, Kooner, Jaspal S

“… Indian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …”
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The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers von Wilson, Rory, Wahl, Simone, Pfeiffer, Liliane, Ward-Caviness, Cavin K., Kunze, Sonja, Kretschmer, Anja, Reischl, Eva, Peters, Annette, Gieger, Christian, Waldenberger, Melanie

“… Background The evidence for epigenome-wide associations between smoking and DNA methylation continues to grow through cross-sectional studies. However, few …”
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