Suchergebnisse - "Giavalisco, Patrick"

High‐resolution plant metabolomics: from mass spectral features to metabolites and from whole‐cell analysis to subcellular metabolite distributions von Kueger, Stephan, Steinhauser, Dirk, Willmitzer, Lothar, Giavalisco, Patrick

“… The main goal of metabolomics is the comprehensive qualitative and quantitative analysis of the time‐ and space‐resolved distribution of all metabolites …”
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Protocol: a fast, comprehensive and reproducible one-step extraction method for the rapid preparation of polar and semi-polar metabolites, lipids, proteins, starch and cell wall polymers from a single sample von Salem, Mohamed A., Jüppner, Jessica, Bajdzienko, Krzysztof, Giavalisco, Patrick

“… Background The elucidation of complex biological systems requires integration of multiple molecular parameters. Accordingly, high throughput methods like …”
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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function von Timper, Katharina, Del Río-Martín, Almudena, Cremer, Anna Lena, Bremser, Stephan, Alber, Jens, Giavalisco, Patrick, Varela, Luis, Heilinger, Christian, Nolte, Hendrik, Trifunovic, Aleksandra, Horvath, Tamas L, Kloppenburg, Peter, Backes, Heiko, Brüning, Jens C

“… Astrocytes represent central regulators of brain glucose metabolism and neuronal function. They have recently been shown to adapt their function in response to …”
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Target of Rapamycin Inhibition in Chlamydomonas reinhardtii Triggers de Novo Amino Acid Synthesis by Enhancing Nitrogen Assimilation von Mubeen, Umarah, Jüppner, Jessica, Alpers, Jessica, Hincha, Dirk K, Giavalisco, Patrick

“… The Target of Rapamycin (TOR) kinase is a central regulator of growth and metabolism in all eukaryotic organisms, including animals, fungi, and plants. Even …”
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Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders von Yu, Qianhui, He, Zhisong, Zubkov, Dmitry, Huang, Shuyun, Kurochkin, Ilia, Yang, Xiaode, Halene, Tobias, Willmitzer, Lothar, Giavalisco, Patrick, Akbarian, Schahram, Khaitovich, Philipp

“… Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in …”
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An improved extraction method enables the comprehensive analysis of lipids, proteins, metabolites and phytohormones from a single sample of leaf tissue under water‐deficit stress von Salem, Mohamed A., Yoshida, Takuya, Perez de Souza, Leonardo, Alseekh, Saleh, Bajdzienko, Krzysztof, Fernie, Alisdair R., Giavalisco, Patrick

“… Summary Phytohormones play essential roles in the regulation of growth and development in plants. Plant hormone profiling is therefore essential to understand …”
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Global analysis of the role of autophagy in cellular metabolism and energy homeostasis in Arabidopsis seedlings under carbon starvation von Avin-Wittenberg, Tamar, Bajdzienko, Krzysztof, Wittenberg, Gal, Alseekh, Saleh, Tohge, Takayuki, Bock, Ralph, Giavalisco, Patrick, Fernie, Alisdair R

“… Germination and early seedling establishment are developmental stages in which plants face limited nutrient supply as their photosynthesis mechanism is not yet …”
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Integration of transcriptomics and metabolomics data specifies the metabolic response of Chlamydomonas to rapamycin treatment von Kleessen, Sabrina, Irgang, Susann, Klie, Sebastian, Giavalisco, Patrick, Nikoloski, Zoran

“… Flux phenotypes predicted by constraint‐based methods can be refined by the inclusion of heterogeneous data. While recent advances facilitate the integration …”
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Systemic analysis of inducible target of rapamycin mutants reveal a general metabolic switch controlling growth in Arabidopsis thaliana von Caldana, Camila, Li, Yan, Leisse, Andrea, Zhang, Yi, Bartholomaeus, Lisa, Fernie, Alisdair R., Willmitzer, Lothar, Giavalisco, Patrick

“… Summary The target of rapamycin (TOR) pathway is a major regulator of growth in all eukaryotes, integrating energy, nutrient and stress signals into molecular …”
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Comprehensive dissection of spatiotemporal metabolic shifts in primary, secondary, and lipid metabolism during developmental senescence in Arabidopsis von Watanabe, Mutsumi, Balazadeh, Salma, Tohge, Takayuki, Erban, Alexander, Giavalisco, Patrick, Kopka, Joachim, Mueller-Roeber, Bernd, Fernie, Alisdair R, Hoefgen, Rainer

“… Developmental senescence is a coordinated physiological process in plants and is critical for nutrient redistribution from senescing leaves to newly formed …”
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Identification and mode of inheritance of quantitative trait loci for secondary metabolite abundance in tomato von Alseekh, Saleh, Tohge, Takayuki, Wendenberg, Regina, Scossa, Federico, Omranian, Nooshin, Li, Jie, Kleessen, Sabrina, Giavalisco, Patrick, Pleban, Tzili, Mueller-Roeber, Bernd, Zamir, Dani, Nikoloski, Zoran, Fernie, Alisdair R

“… A large-scale metabolic quantitative trait loci (mQTL) analysis was performed on the well-characterized Solanum pennellii introgression lines to investigate …”
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FAX1, a Novel Membrane Protein Mediating Plastid Fatty Acid Export von Li, Nannan, Gügel, Irene Luise, Giavalisco, Patrick, Zeisler, Viktoria, Schreiber, Lukas, Soll, Jürgen, Philippar, Katrin

“… Fatty acid synthesis in plants occurs in plastids, and thus, export for subsequent acyl editing and lipid assembly in the cytosol and endoplasmatic reticulum …”
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Differential remodeling of the lipidome during cold acclimation in natural accessions of Arabidopsis thaliana von Degenkolbe, Thomas, Giavalisco, Patrick, Zuther, Ellen, Seiwert, Bettina, Hincha, Dirk K, Willmitzer, Lothar

“… Freezing injury is a major factor limiting the geographical distribution of plant species and the growth and yield of crop plants. Plants from temperate …”
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The target of rapamycin kinase affects biomass accumulation and cell cycle progression by altering carbon/nitrogen balance in synchronized Chlamydomonas reinhardtii cells von Jüppner, Jessica, Mubeen, Umarah, Leisse, Andrea, Caldana, Camila, Wiszniewski, Andrew, Steinhauser, Dirk, Giavalisco, Patrick

“… Summary Several metabolic processes tightly regulate growth and biomass accumulation. A highly conserved protein complex containing the target of rapamycin …”
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Lipidome Evolution in Mammalian Tissues von Khrameeva, Ekaterina, Kurochkin, Ilia, Bozek, Katarzyna, Giavalisco, Patrick, Khaitovich, Philipp

“… Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues …”
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RAPTOR Controls Developmental Growth Transitions by Altering the Hormonal and Metabolic Balance von Salem, Mohamed A, Li, Yan, Bajdzienko, Krzysztof, Fisahn, Joachim, Watanabe, Mutsumi, Hoefgen, Rainer, Schöttler, Mark Aurel, Giavalisco, Patrick

“… Vegetative growth requires the systemic coordination of numerous cellular processes, which are controlled by regulatory proteins that monitor extracellular and …”
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Proteaceae from severely phosphorus-impoverished soils extensively replace phospholipids with galactolipids and sulfolipids during leaf development to achieve a high photosynthetic phosphorus-use-efficiency von Lambers, Hans, Cawthray, Gregory R., Giavalisco, Patrick, Kuo, John, Laliberté, Etienne, Pearse, Stuart J., Scheible, Wolf‐Rüdiger, Stitt, Mark, Teste, François, Turner, Benjamin L.

“… Proteaceae species in south-western Australia occur on severely phosphorus (P)-impoverished soils. They have very low leaf P concentrations, but relatively …”
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Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen von Mennuni, Mara, Filograna, Roberta, Felser, Andrea, Bonekamp, Nina A, Giavalisco, Patrick, Lytovchenko, Oleksandr, Larsson, Nils‐Göran

“… Cancer cells depend on mitochondria to sustain their increased metabolic need and mitochondria therefore constitute possible targets for cancer treatment. We …”
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Sulfur deficiency-induced genes affect seed protein accumulation and composition under sulfate deprivation von Aarabi, Fayezeh, Rakpenthai, Apidet, Barahimipour, Rouhollah, Gorka, Michal, Alseekh, Saleh, Zhang, Youjun, Salem, Mohamed A, Brückner, Franziska, Omranian, Nooshin, Watanabe, Mutsumi, Nikoloski, Zoran, Giavalisco, Patrick, Tohge, Takayuki, Graf, Alexander, Fernie, Alisdair R, Hoefgen, Rainer

“… Sulfur deficiency-induced proteins SDI1 and SDI2 play a fundamental role in sulfur homeostasis under sulfate-deprived conditions (-S) by downregulating …”
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The AtMYB60 transcription factor regulates stomatal opening by modulating oxylipin synthesis in guard cells von Simeoni, Fabio, Skirycz, Aleksandra, Simoni, Laura, Castorina, Giulia, de Souza, Leonardo Perez, Fernie, Alisdair R., Alseekh, Saleh, Giavalisco, Patrick, Conti, Lucio, Tonelli, Chiara, Galbiati, Massimo

“… Stomata are epidermal pores formed by pairs of specialized guard cells, which regulate gas exchanges between the plant and the atmosphere. Modulation of …”
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