Výsledky vyhľadávania - "Ghosh, Chandra C"

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance Autor Jang, Cholsoon, Oh, Sungwhan F, Wada, Shogo, Rowe, Glenn C, Liu, Laura, Chan, Mun Chun, Rhee, James, Hoshino, Atsushi, Kim, Boa, Ibrahim, Ayon, Baca, Luisa G, Kim, Esl, Ghosh, Chandra C, Parikh, Samir M, Jiang, Aihua, Chu, Qingwei, Forman, Daniel E, Lecker, Stewart H, Krishnaiah, Saikumari, Rabinowitz, Joshua D, Weljie, Aalim M, Baur, Joseph A, Kasper, Dennis L, Arany, Zoltan

“…Fatty acid transport from blood vessels to skeletal muscle, across endothelial cells, is regulated by the branched chain amino acid metabolite…”
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Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis Autor David, Sascha, Mukherjee, Aditi, Ghosh, Chandra C, Yano, Midori, Khankin, Eliyahu V, Wenger, Julia B, Karumanchi, S Ananth, Shapiro, Nathan I, Parikh, Samir M

“…: In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms that are incompletely understood. We hypothesized that angiopoietin-2, a partial…”
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Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense Autor David, Sascha, Ghosh, Chandra C, Mukherjee, Aditi, Parikh, Samir M

“…IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and by binding…”
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Emerging Advances of Nanotechnology in Drug and Vaccine Delivery against Viral Associated Respiratory Infectious Diseases (VARID) Autor Seyfoori, Amir, Shokrollahi Barough, Mahdieh, Mokarram, Pooneh, Ahmadi, Mazaher, Mehrbod, Parvaneh, Sheidary, Alireza, Madrakian, Tayyebeh, Kiumarsi, Mohammad, Walsh, Tavia, McAlinden, Kielan D., Ghosh, Chandra C., Sharma, Pawan, Zeki, Amir A., Ghavami, Saeid, Akbari, Mohsen

“…Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI)…”
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Pressure enabled drug delivery (PEDD) of nelitolimod increased therapeutic delivery, reduced immunosuppression, and improved efficacy in porcine and murine liver tumor models Autor Cournoyer, Lauren, Liu, Yujia, Jaroch, David B., Hullinger, Tom G., Cox, Bryan F., Katz, Steven C., LaPorte, Jason, Layman, Ilan B., Ballarin, Alizee, Ghosh, Chandra C., Guha, Prajna

“…Direct tumoral needle injection of nelitolimod, also known as SD-101, has been evaluated in patients with superficial malignancies, including cutaneous…”
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Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality Autor David, Sascha, Ghosh, Chandra C, Kümpers, Philipp, Shushakova, Nelli, Van Slyke, Paul, Khankin, Eliyahu V, Karumanchi, S Ananth, Dumont, Dan, Parikh, Samir M

“…A synthetic 7-mer, HHHRHSF, was recently identified by screening a phage display library for binding to the Tie-2 receptor. A polyethylene-oxide clustered…”
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Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax Autor Ghosh, Chandra C, Mukherjee, Aditi, David, Sascha, Knaus, Ulla G, Stearns-Kurosawa, Deborah J, Kurosawa, Shinichiro, Parikh, Samir M

“…The anthrax lethal toxin (LT) enters host cells and enzymatically cleaves MAPKKs or MEKs. How these molecular events lead to death from anthrax remains poorly…”
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Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases Autor Ghosh, Chandra C, Cournoyer, Lauren, Liu, Yujia, Ballarin, Alizee, Layman, Ilan B, LaPorte, Jason, Morrissey, Molly, Fraser, Kayla, Perati, Shriya, Cox, Bryan F, Yakirevich, Evgeny, Treaba, Diana O, Murtha, Timothy D, Guha, Prajna, Katz, Steven C, Davar, Diwakar

“…BackgroundToll-like receptor 9 (TLR9) agonists induce inflammatory responses that promote the killing of infectious micro-organisms, cancer cells and develop…”
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Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense Autor Ghosh, Chandra C., Mukherjee, Aditi, David, Sascha, Milam, Katelyn E., Hunter, Jon T., Parikh, Samir M.

“…Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that…”
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Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins Autor Lu, Robin A., Zeki, Amir A., Ram-Mohan, Sumati, Nguyen, Nhan, Bai, Yan, Chmiel, Kenneth, Pecic, Stevan, Ai, Xingbin, Krishnan, Ramaswamy, Ghosh, Chandra C.

“…Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening…”
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Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets Autor DaSilva, Nicholas A., Barlock, Benjamin J., Guha, Prajna, Ghosh, Chandra C., Trebino, Catherine E., Camberg, Jodi L., Katz, Steven C., Rowley, David C.

“…Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and…”
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Aspergillus fumigatus –Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma Autor Redes, Jamie L, Basu, Trisha, Ram-Mohan, Sumati, Ghosh, Chandra C, Chan, Eunice C, Sek, Albert C, Zhao, Ming, Krishnan, Ramaswamy, Rosenberg, Helene F, Druey, Kirk M

“…The hallmark features of allergic asthma are type 2 (eosinophilic) inflammation and airways hyperresponsiveness (AHR). Although these features often comanifest…”
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Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity Autor Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O’Connell, Kyle P., Lopes, Mikayla C., Rabinowitz, Benjamin A., Ghosh, Chandra C., Guha, Prajna, Jaroch, David, Cox, Bryan F., Katz, Steven C.

“…Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional…”
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Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome) Autor Xie, Zhihui, Ghosh, Chandra C, Patel, Roshni, Iwaki, Shoko, Gaskins, Donna, Nelson, Celeste, Jones, Nina, Greipp, Philip R, Parikh, Samir M, Druey, Kirk M

“…The systemic capillary leak syndrome (SCLS) is a rare disorder characterized by transient episodes of hypotensive shock and anasarca thought to arise from…”
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PARP15 Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome) Autor Chan, Eunice C, Ablooglu, Ararat J, Ghosh, Chandra C, Desai, Abhishek, Schaible, Niccole, Chen, Xiuying, Zhao, Ming, Olano, M Renee, Ganesan, Sundar, Lack, Justin B, Krishnan, Ramaswamy, Parikh, Samir M, Druey, Kirk M

“…Vascular leakage is a deadly complication of severe infections, ranging from bacterial sepsis to malaria. Worldwide, septicemia is among the top 10 causes of…”
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Gene control of tyrosine kinase TIE2 and vascular manifestations of infections Autor Ghosh, Chandra C, David, Sascha, Zhang, Ruyang, Berghelli, Anthony, Milam, Katelyn, Higgins, Sarah J, Hunter, Jon, Mukherjee, Aditi, Wei, Yongyue, Tran, Mei, Suber, Freeman, Kobzik, Lester, Kain, Kevin C, Lu, Shulin, Santel, Ansgar, Yano, Kiichiro, Guha, Prajna, Dumont, Daniel J, Christiani, David C, Parikh, Samir M

“…Ligands of the endothelial-enriched tunica interna endothelial cell kinase 2 (Tie2) are markedly imbalanced in severe infections associated with vascular…”
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Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice Autor Widmeier, Eugen, Airik, Merlin, Hugo, Hannah, Schapiro, David, Wedel, Johannes, Ghosh, Chandra C, Nakayama, Makiko, Schneider, Ronen, Awad, Agape M, Nag, Anish, Cho, Jang, Schueler, Markus, Clarke, Catherine F, Airik, Rannar, Hildebrandt, Friedhelm

“…Although studies have identified >55 genes as causing steroid-resistant nephrotic syndrome (SRNS) and localized its pathogenesis to glomerular podocytes, the…”
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Calcineurin inhibitors augment endothelial-to-mesenchymal transition by enhancing proliferation in association with cytokine-mediated activation Autor Woda, Craig B., Bruneau, Sarah, Mak, Anne Linde, Haskova, Zdenka, Liu, Kaifeng, Ghosh, Chandra C., Briscoe, David M.

“…Calcineurin Inhibitors (CNIs) are routinely used for immunosuppression following solid organ transplantation. However, the prolonged use of these agents lead…”
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Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells Autor Agur, Timna, Wedel, Johannes, Bose, Sayantan, Sahankumari, A. G. Pramoda, Goodman, Daniel, Kong, Sek Won, Ghosh, Chandra C., Briscoe, David M.

“…The statin family of therapeutics is widely used clinically as cholesterol lowering agents, and their effects to target intracellular mevalonate production is…”
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Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis Autor Stiehl, Thomas, Thamm, Kristina, Kaufmann, Jörg, Schaeper, Ute, Kirsch, Torsten, Haller, Hermann, Santel, Ansgar, Ghosh, Chandra C, Parikh, Samir M, David, Sascha

“…Angiopoietin-2, a protein secreted by stimulated endothelium and an antagonist of the endothelium-stabilizing receptor Tie2, contributes to the pathophysiology…”
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