Suchergebnisse - "Gerlitz, Bruce"

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets von Han, May H., Hwang, Sun-Il, Roy, Dolly B., Lundgren, Deborah H., Price, Jordan V., Ousman, Shalina S., Fernald, Guy Haskin, Gerlitz, Bruce, Robinson, William H., Baranzini, Sergio E., Grinnell, Brian W., Raine, Cedric S., Sobel, Raymond A., Han, David K., Steinman, Lawrence

“… Understanding the neuropathology of multiple sclerosis (MS) is essential for improved therapies. Therefore, identification of targets specific to pathological …”
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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis von Isermann, Berend, Vinnikov, Ilya A, Madhusudhan, Thati, Herzog, Stefanie, Kashif, Muhammed, Blautzik, Janusch, Corat, Marcus A F, Zeier, Martin, Blessing, Erwin, Oh, Jun, Gerlitz, Bruce, Berg, David T, Grinnell, Brian W, Chavakis, Triantafyllos, Esmon, Charles T, Weiler, Hartmut, Bierhaus, Angelika, Nawroth, Peter P

“… Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we …”
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Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes von Madhusudhan, Thati, Wang, Hongjie, Straub, Beate K, Gröne, Elisabeth, Zhou, Qianxing, Shahzad, Khurrum, Müller-Krebs, Sandra, Schwenger, Vedat, Gerlitz, Bruce, Grinnell, Brian W, Griffin, John H, Reiser, Jochen, Gröne, Hermann-Josef, Esmon, Charles T, Nawroth, Peter P, Isermann, Berend

“… The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the receptors and signaling mechanism through which aPC conveys …”
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Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2 von Gupta, Akanksha, Rhodes, George J, Berg, David T, Gerlitz, Bruce, Molitoris, Bruce A, Grinnell, Brian W

“… Endothelial dysfunction contributes significantly to acute renal failure (ARF) during inflammatory diseases including septic shock. Previous studies have shown …”
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Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease von Scaldaferri, Franco, Sans, Miquel, Vetrano, Stefania, Graziani, Cristina, De Cristofaro, Raimondo, Gerlitz, Bruce, Repici, Alessandro, Arena, Vincenzo, Malesci, Alberto, Panes, Julian, Grinnell, Brian W., Danese, Silvio

“… Endothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high levels in the resting microvasculature and convert protein C (PC) into its …”
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Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation von O'Brien, Lee A, Richardson, Mark A, Mehrbod, Sean F, Berg, David T, Gerlitz, Bruce, Gupta, Akanksha, Grinnell, Brian W

“… Background- APC is an antithrombotic and antiinflammatory serine protease that plays an important role in vascular function. We report that APC can suppress …”
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Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia von Schouten, Marcel, van 't Veer, Cornelis, Roelofs, Joris J T H, Gerlitz, Bruce, Grinnell, Brian W, Levi, Marcel, van der Poll, Tom

“… Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis …”
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Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response von Richardson, Mark A, Gupta, Akanksha, O'Brien, Lee A, Berg, David T, Gerlitz, Bruce, Syed, Samreen, Sharma, Ganesh R, Cramer, Martin S, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W

“… The protein C (PC) pathway plays an important role in vascular and immune function, and acquired deficiency during sepsis is associated with increased …”
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Engineering the proteolytic specificity of activated protein C improves its pharmacological properties von Berg, David T, Gerlitz, Bruce, Shang, Jing, Smith, Tommy, Santa, Paula, Richardson, Mark A, Kurz, Ken D, Grinnell, Brian W, Mace, Ken, Jones, Bryan E

“… Human activated protein C (APC) is an antithrombotic, antiinflammatory serine protease that plays a central role in vascular homeostasis, and activated …”
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FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis von Berg, David T, Gerlitz, Bruce, Sharma, Ganesh R, Richardson, Mark A, Stephens, Eddie J, Grubbs, Renee L, Holmes, Kimberly C, Fynboe, Kelly, Montani, Dominick, Cramer, Martin S, Engle, Steven D, Jakubowski, Joseph A, Heuer, Josef G, Grinnell, Brian W

“… Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, …”
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Recombinant thrombomodulin inhibits arterial smooth muscle cell proliferation induced by thrombin von Li, J, Garnette, C S, Cahn, M, Claytor, R B, Rohrer, M J, Dobson, Jr, J G, Gerlitz, B, Cutler, B S

“… Restenosis after angioplasty or bypass grafting to restore circulation to ischemic organs is still an unsolved problem. Thrombin generated in high …”
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Polymeric coatings that mimic the endothelium: Combining nitric oxide release with surface-bound active thrombomodulin and heparin von Wu, Biyun, Gerlitz, Bruce, Grinnell, Brian W., Meyerhoff, Mark E.

“… Multi-functional bilayer polymeric coatings are prepared with both controlled nitric oxide (NO) release and surface-bound active thrombomodulin (TM) alone or …”
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Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin von Gerlitz, B, Grinnell, B W

“… Activated protein C (aPC) is an important feedback regulator of the clotting cascade. In vivo, the conversion of protein C (PC) from its zymogen to activated …”
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Distinct functions of activated protein C differentially attenuate acute kidney injury von Gupta, Akanksha, Gerlitz, Bruce, Richardson, Mark A, Bull, Christopher, Berg, David T, Syed, Samreen, Galbreath, Elizabeth J, Swanson, Barbara A, Jones, Bryan E, Grinnell, Brian W

“… Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and …”
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Role of protein C in renal dysfunction after polymicrobial sepsis von Gupta, Akanksha, Berg, David T, Gerlitz, Bruce, Sharma, Ganesh R, Syed, Samreen, Richardson, Mark A, Sandusky, George, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W

“… Protein C (PC) plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased mortality in both animal models …”
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Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia von Schouten, Marcel, van 't Veer, Cornelis, van den Boogaard, Florry E, Gerlitz, Bruce, Grinnell, Brian W, Roelofs, Joris J T H, Levi, Marcel, van der Poll, Tom

“… Recombinant human activated protein C (APC) improves survival of patients with severe sepsis; this beneficial effect is especially apparent in patients with …”
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Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study von Schouten, Marcel, van der Sluijs, Koenraad F, Gerlitz, Bruce, Grinnell, Brian W, Roelofs, Joris JTH, Levi, Marcel M, van 't Veer, Cornelis, Poll, Tom van der

“… Introduction Influenza accounts for 5 to 10% of community-acquired pneumonias and is a major cause of mortality. Sterile and bacterial lung injuries are …”
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Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis von Heuer, Josef G, Sharma, Ganesh R, Gerlitz, Bruce, Zhang, Tonghai, Bailey, Dianna L, Ding, Chunjin, Berg, David T, Perkins, Douglas, Stephens, Eddie J, Holmes, Kimberly C, Grubbs, Renee L, Fynboe, Kelly A, Chen, Yun-Fei, Grinnell, Brian, Jakubowski, Joseph A

“… To evaluate protein C and other factors associated with the septic response as predictors of mortality in a clinically relevant animal model of sepsis …”
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Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by α1-antitrypsin von Glasscock, Laura N., Gerlitz, Bruce, Cooper, Scott T., Grinnell, Brian W., Church, Frank C.

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Study of plasma protein C and inflammatory pathways: Biomarkers for dimethylnitrosamine-induced liver fibrosis in rats von Saha, Joy K., Xia, Jinqi, Sandusky, George E., Chen, Yun-Fei, Gerlitz, Bruce, Grinnell, Brian, Jakubowski, Joseph A.

“… The present investigation was designed to identify potential biomarker(s) and assess the involvement of inflammatory pathway in dimethylnitrosamine …”
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