Suchergebnisse - "Genes & development"

Mammalian sex determination: a molecular drama von Swain, A, Lovell-Badge, R

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TBP, a universal eukaryotic transcription factor? von Hernandez, N

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Senescence and the SASP: many therapeutic avenues von Birch, Jodie, Gil, Jesús

“… Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a …”
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Roles of the immune system in cancer: from tumor initiation to metastatic progression von Gonzalez, Hugo, Hagerling, Catharina, Werb, Zena

“… The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune …”
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Genetic and biological hallmarks of colorectal cancer von Li, Jiexi, Ma, Xingdi, Chakravarti, Deepavali, Shalapour, Shabnam, DePinho, Ronald A

“… Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk …”
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PARP and PARG inhibitors in cancer treatment von Slade, Dea

“… Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying genomic instability through radiotherapy and chemotherapy has been a …”
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Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences von McSwiggen, David T, Mir, Mustafa, Darzacq, Xavier, Tjian, Robert

“… The idea that liquid-liquid phase separation (LLPS) may be a general mechanism by which molecules in the complex cellular milieu may self-organize has …”
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Genetics and biology of prostate cancer von Wang, Guocan, Zhao, Di, Spring, Denise J, DePinho, Ronald A

“… Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer remains largely incurable even after intensive multimodal therapy …”
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Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer von Gimple, Ryan C, Bhargava, Shruti, Dixit, Deobrat, Rich, Jeremy N

“… Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display striking cellular heterogeneity, with stem-like glioblastoma stem cells …”
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Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation von Core, Leighton, Adelman, Karen

“… Precise spatio-temporal control of gene activity is essential for organismal development, growth, and survival in a changing environment. Decisive steps in …”
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Chronic tissue inflammation and metabolic disease von Lee, Yun Sok, Olefsky, Jerrold

“… Obesity is the most common cause of insulin resistance, and the current obesity epidemic is driving a parallel rise in the incidence of T2DM. It is now widely …”
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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence von Vizioli, Maria Grazia, Liu, Tianhui, Miller, Karl N, Robertson, Neil A, Gilroy, Kathryn, Lagnado, Anthony B, Perez-Garcia, Arantxa, Kiourtis, Christos, Dasgupta, Nirmalya, Lei, Xue, Kruger, Patrick J, Nixon, Colin, Clark, William, Jurk, Diana, Bird, Thomas G, Passos, João F, Berger, Shelley L, Dou, Zhixun, Adams, Peter D

“… Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable …”
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MITF-the first 25 years von Goding, Colin R, Arnheiter, Heinz

“… All transcription factors are equal, but some are more equal than others. In the 25 yr since the gene encoding the microphthalmia-associated transcription …”
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Regulation of lipid peroxidation and ferroptosis in diverse species von Conrad, Marcus, Kagan, Valerian E, Bayir, Hülya, Pagnussat, Gabriela C, Head, Brian, Traber, Maret G, Stockwell, Brent R

“… Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin …”
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Mechanisms of Hippo pathway regulation von Meng, Zhipeng, Moroishi, Toshiro, Guan, Kun-Liang

“… The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in …”
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Roles of vimentin in health and disease von Ridge, Karen M, Eriksson, John E, Pekny, Milos, Goldman, Robert D

“… More than 27 yr ago, the vimentin knockout ( ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal …”
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MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling von Venkatesh, Divya, O'Brien, Nicholas A, Zandkarimi, Fereshteh, Tong, David R, Stokes, Michael E, Dunn, Denise E, Kengmana, Everett S, Aron, Allegra T, Klein, Alyssa M, Csuka, Joleen M, Moon, Sung-Hwan, Conrad, Marcus, Chang, Christopher J, Lo, Donald C, D'Alessandro, Angelo, Prives, Carol, Stockwell, Brent R

“… MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has …”
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Recent insights into the function of autophagy in cancer von Amaravadi, Ravi, Kimmelman, Alec C, White, Eileen

“… Macroautophagy (referred to here as autophagy) is induced by starvation to capture and degrade intracellular proteins and organelles in lysosomes, which …”
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Role of TET enzymes in DNA methylation, development, and cancer von Rasmussen, Kasper Dindler, Helin, Kristian

“… The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in …”
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Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2 von Plys, Aaron J, Davis, Christopher P, Kim, Jongmin, Rizki, Gizem, Keenen, Madeline M, Marr, Sharon K, Kingston, Robert E

“… Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive …”
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