Suchergebnisse - "Gene Expression Regulation"

(Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis von He, Fei, Fromion, Vincent, Westerhoff, Hans V

“… –demand theory has not yet considered gene-expression regulation explicitly whilst a variant of MCA, i.e …”
Volltext

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility von Li, M, Luo, X-j, Rietschel, M, Lewis, C M, Mattheisen, M, Müller-Myhsok, B, Jamain, S, Leboyer, M, Landén, M, Thompson, P M, Cichon, S, Nöthen, M M, Schulze, T G, Sullivan, P F, Bergen, S E, Donohoe, G, Morris, D W, Hargreaves, A, Gill, M, Corvin, A, Hultman, C, Toga, A W, Shi, L, Lin, Q, Shi, H, Gan, L, Meyer-Lindenberg, A, Czamara, D, Henry, C, Etain, B, Bis, J C, Ikram, M A, Fornage, M, Debette, S, Launer, L J, Seshadri, S, Erk, S, Walter, H, Heinz, A, Bellivier, F, Stein, J L, Medland, S E, Arias Vasquez, A, Hibar, D P, Franke, B, Martin, N G, Wright, M J, Su, B

“… Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64 888 subjects …”
Volltext

The pleiotropic roles of leptin in metabolism, immunity, and cancer von de Candia, Paola, Prattichizzo, Francesco, Garavelli, Silvia, Alviggi, Carlo, La Cava, Antonio, Matarese, Giuseppe

“… The discovery of the archetypal adipocytokine leptin and how it regulates energy homeostasis have represented breakthroughs in our understanding of the …”
Weitere Angaben

Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder von Arion, D, Corradi, J P, Tang, S, Datta, D, Boothe, F, He, A, Cacace, A M, Zaczek, R, Albright, C F, Tseng, G, Lewis, D A

“… Schizophrenia is associated with alterations in working memory that reflect dysfunction of dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory …”
Volltext

MicroRNA Expression Is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects von Smalheiser, Neil R., Lugli, Giovanni, Rizavi, Hooriyah S., Torvik, Vetle I., Turecki, Gustavo, Dwivedi, Yogesh

“… The present study was undertaken to examine whether the miRNA network is altered in the brain of depressed suicide subjects …”
Volltext

Mercury-induced inflammation and autoimmunity von Pollard, K. Michael, Cauvi, David M., Toomey, Christopher B., Hultman, Per, Kono, Dwight H.

“… Human exposure to mercury leads to a variety of pathologies involving numerous organ systems including the immune system. A paucity of epidemiological studies …”
Volltext

PDL1 Regulation by p53 via miR-34 von Cortez, Maria Angelica, Ivan, Cristina, Valdecanas, David, Wang, Xiaohong, Peltier, Heidi J, Ye, Yuping, Araujo, Luiz, Carbone, David P, Shilo, Konstantin, Giri, Dipak K, Kelnar, Kevin, Martin, Desiree, Komaki, Ritsuko, Gomez, Daniel R, Krishnan, Sunil, Calin, George A, Bader, Andreas G, Welsh, James W

“… Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non-small cell lung cancer (NSCLC), the regulation of PDL1 expression is …”
Weitere Angaben

Circulating adipocyte‐derived exosomal MicroRNAs associated with decreased insulin resistance after gastric bypass von Hubal, Monica J., Nadler, Evan P., Ferrante, Sarah C., Barberio, Matthew D., Suh, Jung‐Hyuk, Wang, Justin, Dohm, G. Lynis, Pories, Walter J., Mietus‐Snyder, Michelle, Freishtat, Robert J.

“… Methods African American female subjects with obesity (N = 6; age: 38.5 ± 6.8 years; BMI: 51.2 ± 8.8 kg/m2) were tested before and 1 year after surgery …”
Volltext

GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis von Guttman-Yassky, Emma, Pavel, Ana B., Zhou, Lisa, Estrada, Yeriel D., Zhang, Ning, Xu, Hui, Peng, Xiangyu, Wen, Huei-Chi, Govas, Panayiota, Gudi, Girish, CA, Vinu, Fang, Hui, Salhi, Yacine, Back, Jonathan, Reddy, Venkateshwar, Bissonnette, Robert, Maari, Catherine, Grossman, Fred, Wolff, Gerhard

“… GBR 830 is a humanized mAb against OX40, a costimulatory receptor on activated T cells. OX40 inhibition might have a therapeutic role in T cell–mediated …”
Volltext

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis von Powell, Nicole D, Sloan, Erica K, Bailey, Michael T, Arevalo, Jesusa M G, Miller, Gregory E, Chen, Edith, Kobor, Michael S, Reader, Brenda F, Sheridan, John F, Cole, Steven W

“… Transcriptome representation analyses showed relative expansion of the immature proinflammatory monocyte transcriptome in peripheral blood mononuclear cells from people subject to chronic social stress …”
Weitere Angaben

Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells von Sarveswaran, Sivalokanathan, Chakraborty, Debrup, Chitale, Dhananjay, Sears, Rosalie, Ghosh, Jagadananda

“… Myc is up-regulated in almost all cancer types and is the subject of intense investigation because of its pleiotropic effects controlling a broad spectrum of cell functions …”
Weitere Angaben

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids von Peters, Michael C., Kerr, Sheena, Dunican, Eleanor M., Woodruff, Prescott G., Fajt, Merritt L., Levy, Bruce D., Israel, Elliot, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Wenzel, Sally E., Fahy, John V.

“… ]) in induced sputum cells from healthy control subjects, patients with severe asthma receiving ICSs (n = 174 …”
Volltext

Pectin-coated boron nitride nanotubes: In vitro cyto-/immune-compatibility on RAW 264.7 macrophages von Rocca, Antonella, Marino, Attilio, Del Turco, Serena, Cappello, Valentina, Parlanti, Paola, Pellegrino, Mario, Golberg, Dmitri, Mattoli, Virgilio, Ciofani, Gianni

“… Boron nitride nanotubes (BNNTs) represent a new opportunity for drug delivery and clinical therapy. The present work has the objective to investigate …”
Volltext

The interface between metabolic and stress signalling von Hey, Sandra J, Byrne, Edward, Halford, Nigel G

“… It is becoming increasingly clear that stress and metabolic signalling networks interact and that this interaction is important in plant responses to …”
Weitere Angaben

The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory von Raveh, Eli, Matouk, Imad J., Gilon, Michal, Hochberg, Abraham

“… Its role in tumor initiation and progression has long been a subject of controversy, although accumulating data suggest that H19 is one of the major genes in cancer …”
Volltext

The gene encoding Arabidopsis acyl-CoA-binding protein 3 is pathogen inducible and subject to circadian regulation von Zheng, Shu-Xiao, Xiao, Shi, Chye, Mee-Len

“… In Arabidopsis thaliana, acyl-CoA-binding protein 3 ( ACBP3), one of six ACBPs, is unique in terms of the C-terminal location of its acyl-CoA-binding domain …”
Weitere Angaben

Basic biology and therapeutic implications of lncRNA von Khorkova, O., Hsiao, J., Wahlestedt, C.

“… Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have been a subject of intense investigation in the past decade …”
Volltext

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level von Bauer, Daniel E, Kamran, Sophia C, Lessard, Samuel, Xu, Jian, Fujiwara, Yuko, Lin, Carrie, Shao, Zhen, Canver, Matthew C, Smith, Elenoe C, Pinello, Luca, Sabo, Peter J, Vierstra, Jeff, Voit, Richard A, Yuan, Guo-Cheng, Porteus, Matthew H, Stamatoyannopoulos, John A, Lettre, Guillaume, Orkin, Stuart H

“… Genome-wide association studies (GWASs) have ascertained numerous trait-associated common genetic variants, frequently localized to regulatory DNA. We found …”
Weitere Angaben

Tissue-specific and developmentally regulated expression of a cluster of tandemly arrayed cell wall-associated kinase-like kinase genes in arabidopsis von Verica, J.A, Chae, L, Tong, H.Y, Ingmire, P, He, Z.H

“… The Arabidopsis cell wall-associated kinase (WAK) and WAK-like kinase (WAKL) family of receptor-like kinase genes encodes transmembrane proteins with a …”
Volltext

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages von Schroder, Kate, Irvine, Katharine M, Taylor, Martin S, Bokil, Nilesh J, Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I, Semple, Colin A, Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J, Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O, Kawaji, Hideya, McLachlan, Geoffrey J, Goldman, Nick, Grimmond, Sean M, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A, Sweet, Matthew J

“… Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune …”
Weitere Angaben