Search Results - "Garambois, Veronique"

Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody‐dependent HER4 intracellular domain trafficking by Lanotte, Romain, Garambois, Véronique, Gaborit, Nadège, Larbouret, Christel, Musnier, Astrid, Martineau, Pierre, Pèlegrin, André, Chardès, Thierry

“…Human epidermal growth factor receptor 4 (HER4) isoforms have oncogenic or tumor suppressor functions depending on their susceptibility to proteolytic cleavage…”
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Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects against tumor rechallenge in mice by Fauvre, Alexandra, Ursino, Chiara, Garambois, Veronique, Culerier, Elodie, Milazzo, Louis-Antoine, Vezzio-Vié, Nadia, Jeanson, Laura, Marchive, Candice, Andrade, Augusto Faria, Combes, Eve, Atis, Salima, Lossaint, Gérald, Quenet, François, Michaud, Henri-Alexandre, Khellaf, Lakhdar, Corbeau, Ileana, Tosi, Diego, Houede, Nadine, Bonnefoy, Nathalie, Sgarbura, Olivia, Gongora, Céline, Faget, Julien

“…BackgroundColorectal cancer (CRC) is the third most common cancer type and one of the leading causes of cancer-related death worldwide. The treatment of…”
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STING‐ATF3/type I interferon crosstalk: A potential target to improve anti‐tumour immunity in chemotherapy‐treated urothelial carcinoma by Fauvre, Alexandra, Machu, Margot, Merienne, Audrey, Vie, Nadia, Bessede, Thomas, Robin, Mathilde, Garambois, Veronique, Taffoni, Clara, Laguette, Nadine, Gervois‐Segain, Nadine, Jarry, Anne, Labarriere, Nathalie, Allory, Yves, Larbouret, Christel, Gros, Laurent, Tosi, Diego, Solit, David B., Pourquier, Philippe, Houédé, Nadine, Gongora, Celine

“…Upper Tract Urothelial Carcinomas (UTUC) are extremely aggressive and immunosuppressed tumors of the ureter or renal pelvis with a high relapse rate (>50%)…”
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Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related ( ATR ) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer by Combès, Eve, Andrade, Augusto F, Tosi, Diego, Michaud, Henri-Alexandre, Coquel, Flavie, Garambois, Veronique, Desigaud, Delphine, Jarlier, Marta, Coquelle, Arnaud, Pasero, Philippe, Bonnefoy, Nathalie, Moreaux, Jerome, Martineau, Pierre, Del Rio, Maguy, Beijersbergen, Roderick L, Vezzio-Vie, Nadia, Gongora, Celine

“…Although many patients with colorectal cancer initially respond to the chemotherapeutic agent oxaliplatin, acquired resistance to this treatment remains a…”
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An auristatin‐based antibody‐drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer by Bourillon, Laura, Bourgier, Céline, Gaborit, Nadège, Garambois, Véronique, Llès, Eva, Zampieri, Alexandre, Ogier, Charline, Jarlier, Marta, Radosevic‐Robin, Nina, Orsetti, Béatrice, Delpech, Hélène, Theillet, Charles, Colombo, Pierre‐Emmanuel, Azria, David, Pèlegrin, André, Larbouret, Christel, Chardès, Thierry

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer characterized by poor response to chemotherapy and radiotherapy due to the lack of efficient…”
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Anti-Müllerian hormone (AMH) autocrine signaling promotes survival and proliferation of ovarian cancer cells by Chauvin, Maëva, Garambois, Véronique, Colombo, Pierre-Emmanuel, Chentouf, Myriam, Gros, Laurent, Brouillet, Jean-Paul, Robert, Bruno, Jarlier, Marta, Dumas, Karen, Martineau, Pierre, Navarro-Teulon, Isabelle, Pépin, David, Chardès, Thierry, Pèlegrin, André

“…In ovarian carcinoma, anti-Müllerian hormone (AMH) type II receptor (AMHRII) and the AMH/AMHRII signaling pathway are potential therapeutic targets. Here, AMH…”
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ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment by Bruciamacchie, Marine, Garambois, Véronique, Vie, Nadia, Bessede, Thomas, Michaud, Henri-Alexandre, Chepeaux, Laure-Agnès, Gros, Laurent, Bonnefoy, Nathalie, Robin, Mathilde, Brager, Dorian, Bigot, Kevin, Evrard, Alexandre, Pourquier, Philippe, Colinge, Jacques, Mathonnet, Muriel, Belhabib, Ismahane, Jean, Christine, Bousquet, Corinne, Colombo, Pierre-Emmanuel, Jarlier, Marta, Tosi, Diégo, Gongora, Céline, Larbouret, Christel

“…In pancreatic ductal adenocarcinoma (PDAC), the dense stroma rich in cancer-associated fibroblasts (CAFs) and the immunosuppressive microenvironment confer…”
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Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models by Bigot, Kévin, Patinote, Cindy, Garambois, Véronique, Chouchou, Adrien, Gayraud-Paniagua, Stéphanie, Vie, Nadia, Maggipinto, Yann, Smyej, Elias, Robin, Mathilde, Machu, Margot, Bruciamacchie, Marine, Colombo, Pierre-Emmanuel, Bousquet, Corinne, Mathonnet, Muriel, Levy-Augé, Ela, Tosi, Diego, Bonnet, Pierre-Antoine, Gongora, Céline, Deleuze-Masquéfa, Carine, Larbouret, Christel

“…The Imiqualines family is an original group of small heterocyclic compounds, diversely substituted around different scaffolds. Among these compounds, the lead…”
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Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer by Ogier, Charline, Colombo, Pierre-Emmanuel, Bousquet, Corinne, Canterel-Thouennon, Lucile, Sicard, Pierre, Garambois, Véronique, Thomas, Gaëlle, Gaborit, Nadège, Jarlier, Marta, Pirot, Nelly, Pugnière, Martine, Vie, Nadia, Gongora, Céline, Martineau, Pierre, Robert, Bruno, Pèlegrin, André, Chardès, Thierry, Larbouret, Christel

“…Neuregulin 1 (NRG1), a ligand for HER3 and HER4 receptors, is secreted by both pancreatic tumor cells (PC) and cancer-associated fibroblasts (CAFs), the latter…”
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SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery by Gutowski, Marian, Framery, Bérénice, Boonstra, Martin C., Garambois, Véronique, Quenet, François, Dumas, Karen, Scherninski, François, Cailler, Françoise, Vahrmeijer, Alexander L., Pèlegrin, André

“…Fluorescence-guided surgery (FGS) provides surgeons with new opportunities to improve real-time cancer nodule detection and tumor margin visualization…”
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Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells by Cherradi, Sara, Garambois, Véronique, Marines, Johanna, Andrade, Augusto Faria, Fauvre, Alexandra, Morand, Olivia, Fargal, Manon, Mancouri, Ferial, Ayrolles-Torro, Adeline, Vezzo-Vié, Nadia, Jarlier, Marta, Loussaint, Gerald, Huvelle, Steve, Joubert, Nicolas, Mazard, Thibault, Gongora, Céline, Pourquier, Philippe, Boissière-Michot, Florence, Rio, Maguy Del

“…Background Tumor resistance is a frequent cause of therapy failure and remains a major challenge for the long-term management of colorectal cancer (CRC). The…”
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Design and selection of optimal ErbB-targeting bispecific antibodies in pancreatic cancer by Rabia, Emilia, Garambois, Véronique, Dhommée, Christine, Larbouret, Christel, Lajoie, Laurie, Buscail, Yoan, Jimenez-Dominguez, Gabriel, Choblet-Thery, Sylvie, Liaudet-Coopman, Emmanuelle, Cerutti, Martine, Jarlier, Marta, Ravel, Patrice, Gros, Laurent, Pirot, Nelly, Thibault, Gilles, Zhukovsky, Eugene A., Gérard, Pierre-Emmanuel, Pèlegrin, André, Colinge, Jacques, Chardès, Thierry

“…The ErbB family of receptor tyrosine kinases is a primary target for small molecules and antibodies for pancreatic cancer treatment. Nonetheless, the current…”
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Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells by Darido, Charbel, Buchert, Michael, Pannequin, Julie, Bastide, Pauline, Zalzali, Hassan, Mantamadiotis, Theo, Bourgaux, Jean-François, Garambois, Véronique, Jay, Philippe, Blache, Philippe, Joubert, Dominique, Hollande, Frédéric

“…Tight junctions have recently emerged as essential signaling regulators of proliferation and differentiation in epithelial tissues. Here, we aimed to identify…”
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TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer by Morano, Laura, Vezzio-Vié, Nadia, Aissanou, Adam, Egger, Tom, Aze, Antoine, Fiachetti, Solène, Bordignon, Benoit, Hassen-khodja, Cedric, Seitz, Hervé, Milazzo, Louis-Antoine, Garambois, Véronique, Chaloin, Laurent, Bonnefoy, Nathalie, Gongora, Céline, Constantinou, Angelos, Basbous, Jihane

“…In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of…”
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Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells by Bourillon, Laura, Demontoy, Sylvain, Lenglet, Alexis, Zampieri, Alexandre, Fraisse, Julien, Jarlier, Marta, Boissière-Michot, Florence, Perrochia, Hélène, Rathat, Gauthier, Garambois, Véronique, Bonnefoy, Nathalie, Michaud, Henri-Alexandre, Chardès, Thierry, Tosi, Diego, Pèlegrin, André, Azria, David, Larbouret, Christel, Bourgier, Céline

“…The outcome of locally advanced cervical cancer (LACC) is dismal. Biomarkers are needed to individualize treatments and to improve patient outcomes. Here, we…”
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Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival by Chauvin, Maëva, Garambois, Véronique, Choblet, Sylvie, Colombo, Pierre-Emmanuel, Chentouf, Myriam, Gros, Laurent, De Brauwere, David-Paul, Duonor-Cerutti, Martine, Dumas, Karen, Robert, Bruno, Jarlier, Marta, Martineau, Pierre, Navarro-Teulon, Isabelle, Pépin, David, Chardès, Thierry, Pèlegrin, André

“…Anti-Müllerian hormone (AMH) type II receptor (AMHRII) and the AMH/AMHRII signaling pathway are potential therapeutic targets in ovarian carcinoma. Conversely,…”
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Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells by Corvaglia, Valentina, Ait Mohamed Amar, Imène, Garambois, Véronique, Letast, Stéphanie, Garcin, Aurélie, Gongora, Céline, Del Rio, Maguy, Denevault-Sabourin, Caroline, Joubert, Nicolas, Huc, Ivan, Pourquier, Philippe

“…Inhibition of protein–DNA interactions represents an attractive strategy to modulate essential cellular functions. We reported the synthesis of unique…”
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Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models by Rabia, Emilia, Garambois, Véronique, Hubert, Julie, Bruciamacchie, Marine, Pirot, Nelly, Delpech, Hélène, Broyon, Morgane, Theillet, Charles, Colombo, Pierre-Emmanuel, Vie, Nadia, Tosi, Diego, Gongora, Celine, Khellaf, Lakhdar, Jarlier, Marta, Radosevic-Robin, Nina, Chardès, Thierry, Pèlegrin, André, Larbouret, Christel

“…Chemoresistance, particularly to gemcitabine, is a major challenge in pancreatic cancer. The epidermal growth factor receptor (EGFR) and human epidermal growth…”
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Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors by Morano, Laura, Vie, Nadia, Aissanou, Adam, Hodroj, Dana, Garambois, Véronique, Fauvre, Alexandra, Promonet, Alexy, Egger, Tom, Bordignon, Benoît, Hassen-Khodja, Cédric, Fiachetti, Solène, Basbous, Jihane, Gongora, Céline, Constantinou, Angelos

“…Abstract Human topoisomerase IIβ binding protein 1 (TopBP1) is a scaffold protein involved in DNA replication initiation, DNA repair, transcription regulation,…”
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Symplekin promotes tumorigenicity by up-regulating claudin-2 expression by Buchert, Michael, Papin, Marina, Bonnans, Caroline, Darido, Charbel, Raye, Warren S, Garambois, Véronique, Pélegrin, André, Bourgaux, Jean-François, Pannequin, Julie, Joubert, Dominique, Hollande, Frédéric

“…Symplekin is a ubiquitously expressed protein involved in cytoplasmic RNA polyadenylation and transcriptional regulation and is localized at tight junctions…”
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